Skip to main content
placeholder image

Dynamics studies of protein-protein and protein-drug complexes

Grant


Scheme


  • Access to Major Research Facility Program

Abstract


  • Understanding how proteins interact and behave in large dynamic multi-protein complexes is an important area of significance in many human diseases that are associated with faults in their interactions. Our first aim is to study the dynamics of the Dnal - DnaB complex to any the question of whether vibrational density and conformational dynamics changes are induced by the binding of Dnal to the helicase. Our aim for the second part is to measure the dynamics of human acetylcholinesterase/Huperzine A complexes as a function of temperature and high pressure.

Date/time Interval


  • 2010

Sponsor Award Id


  • 09/10-N-24

Local Award Id


  • 11973

Scheme


  • Access to Major Research Facility Program

Abstract


  • Understanding how proteins interact and behave in large dynamic multi-protein complexes is an important area of significance in many human diseases that are associated with faults in their interactions. Our first aim is to study the dynamics of the Dnal - DnaB complex to any the question of whether vibrational density and conformational dynamics changes are induced by the binding of Dnal to the helicase. Our aim for the second part is to measure the dynamics of human acetylcholinesterase/Huperzine A complexes as a function of temperature and high pressure.

Date/time Interval


  • 2010

Sponsor Award Id


  • 09/10-N-24

Local Award Id


  • 11973