Understanding how proteins interact and behave in large dynamic multi-protein complexes is an important area of significance in many human diseases that are associated with faults in their interactions. Our first aim is to study the dynamics of the Dnal - DnaB complex to any the question of whether vibrational density and conformational dynamics changes are induced by the binding of Dnal to the helicase. Our aim for the second part is to measure the dynamics of human acetylcholinesterase/Huperzine A complexes as a function of temperature and high pressure.
Understanding how proteins interact and behave in large dynamic multi-protein complexes is an important area of significance in many human diseases that are associated with faults in their interactions. Our first aim is to study the dynamics of the Dnal - DnaB complex to any the question of whether vibrational density and conformational dynamics changes are induced by the binding of Dnal to the helicase. Our aim for the second part is to measure the dynamics of human acetylcholinesterase/Huperzine A complexes as a function of temperature and high pressure.