Scheme
- Access to Major Research Facility Program
Dynamics studies of protein-protein and protein-drug complexes
GrantOverview
Abstract
- Understanding how proteins interact and behave in large dynamic multi-protein complexes is an important area of significance in many human diseases that are associated with faults in their interactions. Our first aim is to study the dynamics of the Dnal - DnaB complex to any the question of whether vibrational density and conformational dynamics changes are induced by the binding of Dnal to the helicase. Our aim for the second part is to measure the dynamics of human acetylcholinesterase/Huperzine A complexes as a function of temperature and high pressure.
Date/time Interval
- 2010
Research Areas
Awarded By
Contributor
- Tehei, Moeava - Chief Investigator
Sponsor Award Id
- 09/10-N-24
Local Award Id
- 11973
Affiliation
Contributor
- Tehei, Moeava - Chief Investigator
Other
Assigned By
- Australian Nuclear Science and Technology Organisation (ANSTO) Funding Organization
Overview
Scheme
- Access to Major Research Facility Program
Abstract
- Understanding how proteins interact and behave in large dynamic multi-protein complexes is an important area of significance in many human diseases that are associated with faults in their interactions. Our first aim is to study the dynamics of the Dnal - DnaB complex to any the question of whether vibrational density and conformational dynamics changes are induced by the binding of Dnal to the helicase. Our aim for the second part is to measure the dynamics of human acetylcholinesterase/Huperzine A complexes as a function of temperature and high pressure.
Date/time Interval
- 2010
Research Areas
Awarded By
Contributor
- Tehei, Moeava - Chief Investigator
Sponsor Award Id
- 09/10-N-24
Local Award Id
- 11973
Affiliation
Contributor
- Tehei, Moeava - Chief Investigator
Other
Assigned By
- Australian Nuclear Science and Technology Organisation (ANSTO) Funding Organization