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Ancient proteins and disease

Grant


Scheme


  • Project Grant

Abstract


  • Most diseases are much more common in the elderly. The reasons are poorly understood. We have evidence that the most common eye diseases, cataract and presbyopia, are due to the fact that the large molecules that make up the lens do not turnover. In lenses in older people proteins, which make up the bulk of the transparent tissue, become degraded. It turns out that very long lived proteins are quite common in the body. This proposal seeks to determine what role degradation of these ancient proteins has in other diseases of ageing.

Date/time Interval


  • 2011

Contributor


  • Mitchell, Todd - Chief Investigator
  • Truscott, Roger J. W. - Chief Investigator

Sponsor Award Id


  • APP1008667

Local Award Id


  • 11918

Contributor


  • Mitchell, Todd - Chief Investigator
  • Truscott, Roger J. W. - Chief Investigator

Scheme


  • Project Grant

Abstract


  • Most diseases are much more common in the elderly. The reasons are poorly understood. We have evidence that the most common eye diseases, cataract and presbyopia, are due to the fact that the large molecules that make up the lens do not turnover. In lenses in older people proteins, which make up the bulk of the transparent tissue, become degraded. It turns out that very long lived proteins are quite common in the body. This proposal seeks to determine what role degradation of these ancient proteins has in other diseases of ageing.

Date/time Interval


  • 2011

Contributor


  • Mitchell, Todd - Chief Investigator
  • Truscott, Roger J. W. - Chief Investigator

Sponsor Award Id


  • APP1008667

Local Award Id


  • 11918

Contributor


  • Mitchell, Todd - Chief Investigator
  • Truscott, Roger J. W. - Chief Investigator