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Targeting lagging strand DNA replication in model and pathogenic bacteria

Grant


Scheme


  • Project Grant

Abstract


  • In this project, we will begin to target two essential protein interaction sites from each of several different bacterial species that we think fulfill the first criterion, then use two alternate methods to identify significant numbers of binding ligands with known affinities and bound structures. The methods for ligand discovery include molecular fragment-based screening by NMR and crystallography, and a novel in vivo selection system to identify tightly-binding peptides.

Date/time Interval


  • 2011

Sponsor Award Id


  • APP1007947

Local Award Id


  • 11886

Scheme


  • Project Grant

Abstract


  • In this project, we will begin to target two essential protein interaction sites from each of several different bacterial species that we think fulfill the first criterion, then use two alternate methods to identify significant numbers of binding ligands with known affinities and bound structures. The methods for ligand discovery include molecular fragment-based screening by NMR and crystallography, and a novel in vivo selection system to identify tightly-binding peptides.

Date/time Interval


  • 2011

Sponsor Award Id


  • APP1007947

Local Award Id


  • 11886