Scheme
- Project Grant
Targeting lagging strand DNA replication in model and pathogenic bacteria
GrantOverview
Abstract
- In this project, we will begin to target two essential protein interaction sites from each of several different bacterial species that we think fulfill the first criterion, then use two alternate methods to identify significant numbers of binding ligands with known affinities and bound structures. The methods for ligand discovery include molecular fragment-based screening by NMR and crystallography, and a novel in vivo selection system to identify tightly-binding peptides.
Date/time Interval
- 2011
Research Areas
Awarded By
Contributor
- Dixon, Nicholas E. - Chief Investigator
- Oakley, Aaron J. - Chief Investigator
Sponsor Award Id
- APP1007947
Local Award Id
- 11886
Affiliation
Contributor
- Dixon, Nicholas E. - Chief Investigator
- Oakley, Aaron J. - Chief Investigator
Other
Assigned By
- National Health and Medical Research Council (NHMRC) Funding Organization
Overview
Scheme
- Project Grant
Abstract
- In this project, we will begin to target two essential protein interaction sites from each of several different bacterial species that we think fulfill the first criterion, then use two alternate methods to identify significant numbers of binding ligands with known affinities and bound structures. The methods for ligand discovery include molecular fragment-based screening by NMR and crystallography, and a novel in vivo selection system to identify tightly-binding peptides.
Date/time Interval
- 2011
Research Areas
Awarded By
Contributor
- Dixon, Nicholas E. - Chief Investigator
- Oakley, Aaron J. - Chief Investigator
Sponsor Award Id
- APP1007947
Local Award Id
- 11886
Affiliation
Contributor
- Dixon, Nicholas E. - Chief Investigator
- Oakley, Aaron J. - Chief Investigator
Other
Assigned By
- National Health and Medical Research Council (NHMRC) Funding Organization