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Investigating the propagation of protein aggregation in amyotrophic lateral sclerosis

Grant


Scheme


  • Project Grant

Abstract


  • Amyotrophic lateral sclerosis (ALS; also known as Motor Neurone Disease) is a rapidly progressive disease that attacks neurones responsible for controlling voluntary muscles, consequently leading to muscular paralysis and invariably death. Recent work in humans suggests that degeneration beginsfocally and spreads contiguously through the three dimensional anatomy of the nervous system1. The prevalence of ALS internationally is estimated to be between 3 ⬠7 people per 100,0002; in 2006 there were on average 10 deaths attributed to ALS each week in Australia3. Currently there is no effective treatment for ALS.

Date/time Interval


  • 2011

Sponsor Award Id


  • APP1003032

Local Award Id


  • 11883

Scheme


  • Project Grant

Abstract


  • Amyotrophic lateral sclerosis (ALS; also known as Motor Neurone Disease) is a rapidly progressive disease that attacks neurones responsible for controlling voluntary muscles, consequently leading to muscular paralysis and invariably death. Recent work in humans suggests that degeneration beginsfocally and spreads contiguously through the three dimensional anatomy of the nervous system1. The prevalence of ALS internationally is estimated to be between 3 ⬠7 people per 100,0002; in 2006 there were on average 10 deaths attributed to ALS each week in Australia3. Currently there is no effective treatment for ALS.

Date/time Interval


  • 2011

Sponsor Award Id


  • APP1003032

Local Award Id


  • 11883