Fragment-Based Screening Approaches for New Antibiotics Directed Against the Bacterial Sliding Clamp

Scheme

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• Discovery Projects

Abstract

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• The emergence of resistance to antibiotics in bacterial pathogens, and a lack of new antibiotics are of deep concern globally. Traditional paths to discovery have generally failed to deliver a new generation of antibacterial agents. Fragment-based screening offers a promising alternative. We will exploit a unique opportunity to combine innovative, complementary approaches to develop new lead compounds targeted against key bacterial pathogens: fragment based screening by crystallography and electrospray ionization mass spectrometry, followed by medicinal chemistry to develop these hits into leads. The target will be the beta-clamp, an essential part of the bacterial DNA replication machinery.

Date/time Interval

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• 2011 - 2014

Research Areas

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• 030499 - MEDICINAL AND BIOMOLECULAR CHEMISTRY NOT ELSEWHERE CLASSIFIED
• 060112 - STRUCTURAL BIOLOGY (INCL. MACROMOLECULAR MODELLING)

Awarded By

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• Australian Research Council (ARC) 

Contributor

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• Beck, Jennifer L. - Chief Investigator
• Kelso, Michael J. - Chief Investigator
• Oakley, Aaron J. - Chief Investigator

Sponsor Award Id

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• DP110100660

Local Award Id

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• 11830