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Targetting brain lipid homeostasis to treat Alzheimer's disease

Grant


Scheme


  • Future Fellowships

Abstract


  • The research program to be undertaken will focus on the development of novel therapeutic strategies to modulate cerebral lipid homeostasis with the aim of reducing accumulation of the Alzheimer's disease-causing amyloid-beta peptide in the brain. The proposal builds on very exciting recent work by A/Pr Garner that indicates lipid homeostasis potently regulates neuronal amyloid-beta production. The major objectives are to fully elucidate the mechanism of action of several novel lipid targeting compounds that have already been developed by A/Pr Garner, to determine the therapeutic efficacy of these compounds in animal models, and to optimise the anti-amyloidogenic actions of these compounds using rational drug design approaches.

Date/time Interval


  • 2009

Sponsor Award Id


  • FT0991986

Local Award Id


  • 10856

Scheme


  • Future Fellowships

Abstract


  • The research program to be undertaken will focus on the development of novel therapeutic strategies to modulate cerebral lipid homeostasis with the aim of reducing accumulation of the Alzheimer's disease-causing amyloid-beta peptide in the brain. The proposal builds on very exciting recent work by A/Pr Garner that indicates lipid homeostasis potently regulates neuronal amyloid-beta production. The major objectives are to fully elucidate the mechanism of action of several novel lipid targeting compounds that have already been developed by A/Pr Garner, to determine the therapeutic efficacy of these compounds in animal models, and to optimise the anti-amyloidogenic actions of these compounds using rational drug design approaches.

Date/time Interval


  • 2009

Sponsor Award Id


  • FT0991986

Local Award Id


  • 10856