Skip to main content
placeholder image

Microprobe XFM and XAS of gold anti-arthritic agents in macrophages

Grant


Scheme


  • Travel Grant

Abstract


  • Rheumatoid arthritis is a painful and debilitating disease that affects more that 500,000 Australians. One of the treatments of the disease involves the administration of gold drugs. While these have been in clinical use for more than 50 years, it is unclear how they exert their therapeutic effects. Recently, it was shown that gold nanoparticles also relieve the symptoms of rheumatoid arthritis. Consequently, the aim of this project is to use microprobe XFM and XAS to elucidate the targets of established gold therapeutics and gold nanoparticles in macrophages, and determine whether they act by similar mechanisms.

Date/time Interval


  • 2011

Sponsor Award Id


  • AS113/XFM4086

Local Award Id


  • 102694

Scheme


  • Travel Grant

Abstract


  • Rheumatoid arthritis is a painful and debilitating disease that affects more that 500,000 Australians. One of the treatments of the disease involves the administration of gold drugs. While these have been in clinical use for more than 50 years, it is unclear how they exert their therapeutic effects. Recently, it was shown that gold nanoparticles also relieve the symptoms of rheumatoid arthritis. Consequently, the aim of this project is to use microprobe XFM and XAS to elucidate the targets of established gold therapeutics and gold nanoparticles in macrophages, and determine whether they act by similar mechanisms.

Date/time Interval


  • 2011

Sponsor Award Id


  • AS113/XFM4086

Local Award Id


  • 102694