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The Design and Development of the Next Generation Anti-HIV Drugs

Grant


Collaborating Organisation


Scheme


  • Linkage Projects

Abstract


  • Computer-aided modelling is important at all stages of the drug design and development process. However, there is a lack of suitable methodologies that can take into account the high degree of flexibility of enzymes. This proposal intends to develop such methodologies, using the HIV-1 reverse transcriptase (RT) as the target enzyme. RT is a well validated drug target for anti-HIV drugs, but resistance is a problem with current drugs. Our methodologies and their integration into the whole iterative process of drug design, synthesis and testing should yield new lead compounds for therapeutics designed specifically to overcome drug resistant HIV strains.

Date/time Interval


  • 2008

Sponsor Award Id


  • LP0884061

Local Award Id


  • 10192

Collaborating Organisation


Scheme


  • Linkage Projects

Abstract


  • Computer-aided modelling is important at all stages of the drug design and development process. However, there is a lack of suitable methodologies that can take into account the high degree of flexibility of enzymes. This proposal intends to develop such methodologies, using the HIV-1 reverse transcriptase (RT) as the target enzyme. RT is a well validated drug target for anti-HIV drugs, but resistance is a problem with current drugs. Our methodologies and their integration into the whole iterative process of drug design, synthesis and testing should yield new lead compounds for therapeutics designed specifically to overcome drug resistant HIV strains.

Date/time Interval


  • 2008

Sponsor Award Id


  • LP0884061

Local Award Id


  • 10192