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Lipidomics of vision

Grant


Scheme


  • Future Fellowships

Abstract


  • Our vision deteriorates with age. A main source of these changes is physical and chemical alterations to the lens. While considerable research effort has focussed upon lens proteins, little is known about the other main macromolecular constituent of the lens, membrane lipids. I hypothesise that there is a lack of lipid turnover in the human lens once synthesised, which results in age-related lipid degradation and modification leading to the development of cataract and presbyopia. The aim of this proposal is to test these hypotheses to provide the first comprehensive understanding of the human lens lipidome, its alteration during the ageing process and its role in the development of age-related disorders of the lens.

Date/time Interval


  • 2011 - 2016

Sponsor Award Id


  • FT110100249

Local Award Id


  • 101725

Scheme


  • Future Fellowships

Abstract


  • Our vision deteriorates with age. A main source of these changes is physical and chemical alterations to the lens. While considerable research effort has focussed upon lens proteins, little is known about the other main macromolecular constituent of the lens, membrane lipids. I hypothesise that there is a lack of lipid turnover in the human lens once synthesised, which results in age-related lipid degradation and modification leading to the development of cataract and presbyopia. The aim of this proposal is to test these hypotheses to provide the first comprehensive understanding of the human lens lipidome, its alteration during the ageing process and its role in the development of age-related disorders of the lens.

Date/time Interval


  • 2011 - 2016

Sponsor Award Id


  • FT110100249

Local Award Id


  • 101725