Watson, Debbie

Research Areas

Research Overview

Immunology, Genetics, Transplantation, Graft-versus-host disease

Geographic Focus

Wollongong Geographic Region

Available as Research Supervisor

Available for Collaborative Projects

Head Of

Genetics and Immunology Research Laboratory Group Leader 2019 -

Member Of

Molecular Horizons Member 2019 -
Illawarra Health and Medical Research Institute Member 2011 - 2019
Cancer Drug Discovery Group (CDDG) Member 2014 - 2017

Has Collaborator

Sluyter, Ronald Faculty Academic

Selected Publications

Journal Article

Year	Title
2019	Altered donor P2X7 activity in human leukocytes correlates with P2RX7 genotype but does not affect the development of graft-versus-host disease in humanised mice Published In Purinergic Signalling Volume Online First Pages 1 - 16 ISSN 1573-9538 Altmetric
2019	Increased splenic human CD4+:CD8+ T cell ratios, serum human interferon-γ and intestinal human interleukin-17 are associated with clinical graft-versus-host disease in humanized mice Published In Transplant Immunology Volume 54 Pages 38 - 46 ISSN 0966-3274 Altmetric
2019	Long-term treatment with the P2X7 receptor antagonist Brilliant Blue G reduces liver inflammation in a humanized mouse model of graft-versus-host disease Published In Cellular Immunology Volume 336 Pages 12 - 19 ISSN 0008-8749 Altmetric
2019	Pharmacological blockade of the CD39/CD73 pathway but not adenosine receptors augments disease in a humanized mouse model of graft-versus-host disease Published In Immunology and Cell Biology Volume Online First Pages 1 - 14 ISSN 0818-9641 Altmetric
2019	The A2A receptor agonist CGS 21680 has beneficial and adverse effects on disease development in a humanised mouse model of graft-versus-host disease Published In International Immunopharmacology Volume 72 Pages 479 - 486 ISSN 1567-5769 Altmetric
2018	Pro-inflammatory role of the ATP/P2X7 signalling axis in graft-versus-host disease in humanised mice Published In Purinergic Signalling Volume 14 Pages S57 - S58 ISSN 1573-9538 Altmetric
2017	P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1G93A amyotrophic lateral sclerosis mice Published In PeerJ Volume 5 Pages e3064-1 - e3064-29 Altmetric
2017	The P2X7 receptor antagonist Brilliant Blue G reduces serum human interferon-γ in a humanized mouse model of graft-versus-host disease Published In Clinical and Experimental Immunology Volume 190 Pages 79 - 95 ISSN 0009-9104 Altmetric
2017	The P2X7 receptor is not essential for development of imiquimod-induced psoriasis-like inflammation in mice Published In Purinergic Signalling Volume 13 Pages 405 - 415 ISSN 1573-9538 Altmetric
2016	P2X7 receptor in skin biology and diseases Published In World Journal of Dermatology Volume 5 Pages 72 - 83 Altmetric
2015	Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells Published In Immunology and Cell Biology Volume 93 Pages 77 - 85 ISSN 0818-9641 Altmetric
2015	Methyl-guanine-methyl-transferase transgenic bone marrow transplantation allows N, N-bis (2-chloroethyl)-nitrosourea driven donor mixed-chimerism without graft-versus-host disease, and with donor-specific allograft tolerance Published In Transplantation Volume 99 Pages 2476 - 2484 ISSN 0041-1337 Altmetric
2014	Investigating the effects of purinergic receptor (P2X7R) blockade on the development of graft-versus-host-disease (gvhd) in humanised mice Published In Immunology and Cell Biology Volume 92 Pages A5 - A5 ISSN 0818-9641 Altmetric
2014	T Cells continue to play on the ATP circuit Published In Journal of Immune Research Volume 1 Pages 1 - 2
2014	Transforming growth factor beta (TGFβ) plays a crucial role in prolonging allograft survival in an allodepletion ("pruning") skin transplant model Published In Transplant Immunology Volume 30 Pages 168 - 177 ISSN 0966-3274 Altmetric
2013	DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats Published In Kidney International Volume 83 Pages 223 - 232 ISSN 0085-2538 Altmetric
2013	Daedalic DNA vaccination against self antigens as a treatment for chronic kidney disease Published In International Journal of Clinical and Experimental Pathology Volume 6 Pages 326 - 333 ISSN 1936-2625
2013	Selective depletion of alloreactive T cells leads to long-term islet allograft survival across a major histocompatibility complex mismatch in diabetic mice Published In Cell Transplantation Volume 22 Pages 1929 - 1941 ISSN 0963-6897 Altmetric
2012	CD8+ regulatory T cells induced by T cell vaccination protect against autoimmune nephritis Published In Journal of the American Society of Nephrology Volume 23 Pages 1058 - 1067 ISSN 1046-6673 Altmetric
2009	CCL2 DNA vaccine to treat renal disease Published In The International Journal of Biochemistry and Cell Biology Volume 41 Pages 729 - 732 ISSN 1878-5875 Altmetric
2009	Tolerance induction by removal of alloreactive T cells: in-vivo and pruning strategies Published In Current Opinion in Organ Transplantation Volume 14 Pages 357 - 363 Altmetric
2008	Long-term cardiac allograft survival across an MHC mismatch after "pruning" of alloreactive CD4 T cells Published In Journal of Immunology Volume 180 Pages 6593 - 6603 ISSN 0022-1767
2007	Robust anti-tumor immunity and memory in Rag-1-deficient mice following adoptive transfer of cytokine-primed splenocytes and tumor CD80 expression Published In Cancer Immunology Immunotherapy Volume 56 Pages 1955 - 1965 ISSN 0340-7004 Altmetric

Presentations

Invited Talk

Investigator On

Year	Title
2019 - 2022	Immune Cell Depletion and P2X7 Receptor Blockade to Prevent Graft-versus-host Disease in Blood Cancer Treatment Awarded by: Cancer Council Funding Scheme: Project Grant
2011	Thermo REVCO Elite Plus Upright Freezer Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2009	Targeting the human immune response to bacterial superantigens Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Training Fellowships

Available as Research Supervisor

Potential Supervision Topics

Honours Project: Investigating ex vivo immune cell depletion strategies to prevent graft-versus-host disease
PhD project: Examining the effects of immune cell depletion and P2X7 blockade on graft-versus-leukaemia responses in humanised mice

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Therapeutics Strategies to Prevent Graft-versus-Host Disease	Adhikary, Sam
Doctor of Philosophy	The P2X7 Receptor in Inflammation and Disease	Cuthbertson, Peter

Education And Training

Ph.D. in Transplantation, University of Sydney, Faculty of Medicine, Novel Mechanisms of Tolerance Induction In the Mouse 2002 - 2006
Bachelor of Science (First Class) in Molecular Biology, Macquarie University, School of Biological Sciences 1992 - 1998

Full Name

Debbie Watson

Mailing Address

NorthFields Avenue

Wollongong

NSW

2522

Australia

Research Areas

Research Overview

Immunology, Genetics, Transplantation, Graft-versus-host disease

Geographic Focus

Wollongong Geographic Region

Head Of

Genetics and Immunology Research Laboratory Group Leader 2019 -

Member Of

Molecular Horizons Member 2019 -
Illawarra Health and Medical Research Institute Member 2011 - 2019
Cancer Drug Discovery Group (CDDG) Member 2014 - 2017

Has Collaborator

Sluyter, Ronald Faculty Academic

Selected Publications

Journal Article

Year	Title
2019	Altered donor P2X7 activity in human leukocytes correlates with P2RX7 genotype but does not affect the development of graft-versus-host disease in humanised mice Published In Purinergic Signalling Volume Online First Pages 1 - 16 ISSN 1573-9538 Altmetric
2019	Increased splenic human CD4+:CD8+ T cell ratios, serum human interferon-γ and intestinal human interleukin-17 are associated with clinical graft-versus-host disease in humanized mice Published In Transplant Immunology Volume 54 Pages 38 - 46 ISSN 0966-3274 Altmetric
2019	Long-term treatment with the P2X7 receptor antagonist Brilliant Blue G reduces liver inflammation in a humanized mouse model of graft-versus-host disease Published In Cellular Immunology Volume 336 Pages 12 - 19 ISSN 0008-8749 Altmetric
2019	Pharmacological blockade of the CD39/CD73 pathway but not adenosine receptors augments disease in a humanized mouse model of graft-versus-host disease Published In Immunology and Cell Biology Volume Online First Pages 1 - 14 ISSN 0818-9641 Altmetric
2019	The A2A receptor agonist CGS 21680 has beneficial and adverse effects on disease development in a humanised mouse model of graft-versus-host disease Published In International Immunopharmacology Volume 72 Pages 479 - 486 ISSN 1567-5769 Altmetric
2018	Pro-inflammatory role of the ATP/P2X7 signalling axis in graft-versus-host disease in humanised mice Published In Purinergic Signalling Volume 14 Pages S57 - S58 ISSN 1573-9538 Altmetric
2017	P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1G93A amyotrophic lateral sclerosis mice Published In PeerJ Volume 5 Pages e3064-1 - e3064-29 Altmetric
2017	The P2X7 receptor antagonist Brilliant Blue G reduces serum human interferon-γ in a humanized mouse model of graft-versus-host disease Published In Clinical and Experimental Immunology Volume 190 Pages 79 - 95 ISSN 0009-9104 Altmetric
2017	The P2X7 receptor is not essential for development of imiquimod-induced psoriasis-like inflammation in mice Published In Purinergic Signalling Volume 13 Pages 405 - 415 ISSN 1573-9538 Altmetric
2016	P2X7 receptor in skin biology and diseases Published In World Journal of Dermatology Volume 5 Pages 72 - 83 Altmetric
2015	Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells Published In Immunology and Cell Biology Volume 93 Pages 77 - 85 ISSN 0818-9641 Altmetric
2015	Methyl-guanine-methyl-transferase transgenic bone marrow transplantation allows N, N-bis (2-chloroethyl)-nitrosourea driven donor mixed-chimerism without graft-versus-host disease, and with donor-specific allograft tolerance Published In Transplantation Volume 99 Pages 2476 - 2484 ISSN 0041-1337 Altmetric
2014	Investigating the effects of purinergic receptor (P2X7R) blockade on the development of graft-versus-host-disease (gvhd) in humanised mice Published In Immunology and Cell Biology Volume 92 Pages A5 - A5 ISSN 0818-9641 Altmetric
2014	T Cells continue to play on the ATP circuit Published In Journal of Immune Research Volume 1 Pages 1 - 2
2014	Transforming growth factor beta (TGFβ) plays a crucial role in prolonging allograft survival in an allodepletion ("pruning") skin transplant model Published In Transplant Immunology Volume 30 Pages 168 - 177 ISSN 0966-3274 Altmetric
2013	DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats Published In Kidney International Volume 83 Pages 223 - 232 ISSN 0085-2538 Altmetric
2013	Daedalic DNA vaccination against self antigens as a treatment for chronic kidney disease Published In International Journal of Clinical and Experimental Pathology Volume 6 Pages 326 - 333 ISSN 1936-2625
2013	Selective depletion of alloreactive T cells leads to long-term islet allograft survival across a major histocompatibility complex mismatch in diabetic mice Published In Cell Transplantation Volume 22 Pages 1929 - 1941 ISSN 0963-6897 Altmetric
2012	CD8+ regulatory T cells induced by T cell vaccination protect against autoimmune nephritis Published In Journal of the American Society of Nephrology Volume 23 Pages 1058 - 1067 ISSN 1046-6673 Altmetric
2009	CCL2 DNA vaccine to treat renal disease Published In The International Journal of Biochemistry and Cell Biology Volume 41 Pages 729 - 732 ISSN 1878-5875 Altmetric
2009	Tolerance induction by removal of alloreactive T cells: in-vivo and pruning strategies Published In Current Opinion in Organ Transplantation Volume 14 Pages 357 - 363 Altmetric
2008	Long-term cardiac allograft survival across an MHC mismatch after "pruning" of alloreactive CD4 T cells Published In Journal of Immunology Volume 180 Pages 6593 - 6603 ISSN 0022-1767
2007	Robust anti-tumor immunity and memory in Rag-1-deficient mice following adoptive transfer of cytokine-primed splenocytes and tumor CD80 expression Published In Cancer Immunology Immunotherapy Volume 56 Pages 1955 - 1965 ISSN 0340-7004 Altmetric

Presentations

Invited Talk

Investigator On

Year	Title
2019 - 2022	Immune Cell Depletion and P2X7 Receptor Blockade to Prevent Graft-versus-host Disease in Blood Cancer Treatment Awarded by: Cancer Council Funding Scheme: Project Grant
2011	Thermo REVCO Elite Plus Upright Freezer Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2009	Targeting the human immune response to bacterial superantigens Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Training Fellowships

Potential Supervision Topics

Honours Project: Investigating ex vivo immune cell depletion strategies to prevent graft-versus-host disease
PhD project: Examining the effects of immune cell depletion and P2X7 blockade on graft-versus-leukaemia responses in humanised mice

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Therapeutics Strategies to Prevent Graft-versus-Host Disease	Adhikary, Sam
Doctor of Philosophy	The P2X7 Receptor in Inflammation and Disease	Cuthbertson, Peter

Education And Training

Ph.D. in Transplantation, University of Sydney, Faculty of Medicine, Novel Mechanisms of Tolerance Induction In the Mouse 2002 - 2006
Bachelor of Science (First Class) in Molecular Biology, Macquarie University, School of Biological Sciences 1992 - 1998

Full Name

Debbie Watson

Mailing Address

NorthFields Avenue

Wollongong

NSW

2522

Australia

Geographic Location

University of Wollongong

Located In Facility

Genetics and Immunology Research Laboratory

Orcid Id

http://orcid.org/0000-0002-6242-3944 (confirmed)

Scopus Id

55821923900

Overview

Research Areas

Research Overview

Geographic Focus

Available as Research Supervisor

Affiliation

Available for Collaborative Projects

Head Of

Member Of

Has Collaborator

Publications

Selected Publications

Journal Article

Presentations

Invited Talk

Funding

Investigator On

Supervision

Available as Research Supervisor

Potential Supervision Topics

Advisees

Graduate Advising Relationship

Background

Education And Training

Contact

Full Name

Mailing Address

Geographic Location

Located In Facility

Identity

Orcid Id

Scopus Id

Overview

Research Areas

Research Overview

Geographic Focus

Affiliation

Head Of

Member Of

Has Collaborator

Publications

Selected Publications

Journal Article

Presentations

Invited Talk

Funding

Investigator On

Supervision

Potential Supervision Topics

Advisees

Graduate Advising Relationship

Background

Education And Training

Contact

Full Name

Mailing Address

Geographic Location

Located In Facility

Identity

Orcid Id

Scopus Id

Visualisations

Research Areas

Geographic Focus