Adams, David Distinguished Professor

Head Of

• Illawarra Health and Medical Research Institute (IHMRI) CEO and Executive Director 2016 -

Member Of

• American Physiological Society Fellow (FAPS) 2020 -
• The Physiological Society Fellow (FTPS) 2019 -
• Australasian Neuroscience Society Member 1996 -
• Society for Neuroscience (USA) Member 1990 -
• Society for General Physiologists Member 1981 -
• Biophysical Society Member 1979 -
• The Australian Physiological Society Member 1977 -
• American Physiological Society Member 1993 - 2020
• The Physiological Society Member 1988 - 2019

Has Collaborator

• Dottori, Mirella  Associate Professor
• Ooi, Lezanne  Professor
• Yu, Haibo  Associate Professor
• van Oijen, Antoine M.  Distinguished Professor

Selected Publications

• Journal Article

  Year	Title
  2022	A 4/8 Subtype ��-Conotoxin Vt1.27 Inhibits N-Type Calcium Channels With Potent Anti-Allodynic Effect Published In Frontiers in Pharmacology
  2022	Analgesic ��-Conotoxin Binding Site on the Human GABAB Receptor Published In Molecular pharmacology
  2022	Analgesic ��-conotoxins modulate native and recombinant GIRK1/2 channels via activation of GABAB receptors and reduce neuroexcitability Published In British Journal of Pharmacology
  2022	Cysteine-Rich ��-Conotoxin SII Displays Novel Interactions at the Muscle Nicotinic Acetylcholine Receptor Published In ACS Chemical Neuroscience
  2022	Editorial: Sensory Abnormalities and Primary Sensory Neurons Published In Frontiers in Cellular Neuroscience
  2022	Glycinergic Modulation of Pain in Behavioral Animal Models Published In Frontiers in Pharmacology
  2022	Investigation of CACNA1I Cav3.3 Dysfunction in Hemiplegic Migraine Published In Frontiers in Molecular Neuroscience
  2022	Mechanism of Action and Structure-Activity Relationship of ��-Conotoxin Mr1.1 at the Human ��9��10 Nicotinic Acetylcholine Receptor Published In Journal of Medicinal Chemistry
  2022	Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider Published In Proceedings of the National Academy of Sciences of the United States of America
  2022	Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human ��3��4 Nicotinic Acetylcholine Receptor Published In Marine Drugs
  2022	µ-Theraphotoxin Pn3a inhibition of CaV3.3 channels reveals a novel isoform-selective drug binding site Published In eLife
  2022	��O-Conotoxin GeXIVA isomers modulate N-type calcium (CaV2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation Published In Journal of Neurochemistry
  2021	Alkyne-Bridged ��-Conotoxin Vc1.1 Potently Reverses Mechanical Allodynia in Neuropathic Pain Models Published In Journal of Medicinal Chemistry
  2021	Electrical properties and synaptic transmission in mouse intracardiac ganglion neurons in situ Published In Physiological Reports
  2021	Functional modulation of the human voltage-gated sodium channel NaV1.8 by auxiliary β subunits Published In Channels
  2021	Globular and ribbon isomers of Conus geographus α-conotoxins antagonize human nicotinic acetylcholine receptors Published In Biochemical Pharmacology
  2021	Medicinal chemistry, pharmacology, and therapeutic potential of ��-conotoxins antagonizing the ��9��10 nicotinic acetylcholine receptor Published In Pharmacology and Therapeutics
  2021	Spider Venom Peptide Pn3a Inhibition of Primary Afferent High Voltage-Activated Calcium Channels Published In Frontiers in Pharmacology
  2021	Trends in peptide drug discovery Published In Nature Reviews Drug Discovery
  2021	α-Conotoxin Bt1.8 from Conus betulinus selectively inhibits α6/α3β2β3 and α3β2 nicotinic acetylcholine receptor subtypes Published In Journal of Neurochemistry
  2020	(E)-3-Furan-2-yl- N- p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by ��7 Nicotinic Acetylcholine Receptor Potentiation Published In ACS Chemical Neuroscience
  2020	A method for high-content functional imaging of intracellular calcium responses in gelatin-immobilized non-adherent cells Published In Experimental Cell Research
  2020	An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides Published In Green Chemistry
  2020	Coronaridine congeners decrease neuropathic pain in mice and inhibit ��9��10 nicotinic acetylcholine receptors and CaV2.2 channels Published In Neuropharmacology
  2020	Dimerization of α-Conotoxins as a strategy to enhance the inhibition of the human α7 and α9α10 nicotinic acetylcholine receptors Published In Journal of Medicinal Chemistry
  2020	Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors Published In British Journal of Pharmacology
  2020	Interactions of the-3-2 Nicotinic Acetylcholine Receptor Interfaces with-Conotoxin LsIA and its Carboxylated C-terminus Analogue: Molecular Dynamics Simulations Published In Marine Drugs
  2020	Ketamine inhibits synaptic transmission and nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglia in situ Published In Neuropharmacology
  2020	Modulation of Native and Recombinant GIRK1/2 Channels by Analgesic alpha-conotoxins Published In BIOPHYSICAL JOURNAL
  2020	Molecular and Functional Characterization of Neurogenin-2 Induced Human Sensory Neurons Published In Frontiers in Cellular Neuroscience
  2020	N-acetyl-D-glucosamine-conjugated PAMAM dendrimers as dual receptor-targeting nanocarriers for anticancer drug delivery Published In European Journal of Pharmaceutics and Biopharmaceutics
  2020	On-resin strategy to label ��-Conotoxins: Cy5-RgIA, a Potent ��9��10 nicotinic acetylcholine receptor imaging probe Published In Australian Journal of Chemistry
  2020	Rational Design of α-Conotoxin RegIIA Analogues Selectively Inhibiting the Human α3β2 Nicotinic Acetylcholine Receptor through Computational Scanning Published In ACS Chemical Neuroscience
  2020	Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom Published In Biochemical Pharmacology
  2020	Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom Published In Biochemical Pharmacology
  2019	Analgesic transient receptor potential vanilloid-1-active compounds inhibit native and recombinant T-type calcium channels Published In British Journal of Pharmacology
  2019	BACKBONE CYCLIZATION OF ANALGESIC CONOTOXIN GEXIVA FACILITATES DIRECT FOLDING OF THE RIBBON ISOMER Published In TOXICON
  2019	Bombesin receptors as potential targets for anticancer drug delivery and imaging Published In The International Journal of Biochemistry and Cell Biology
  2019	DISSECTING THE NACHR-INHIBITING D-CONOTOXIN GEXXA Published In TOXICON
  2019	Drysdalin, an antagonist of nicotinic acetylcholine receptors highlights the importance of functional rather than structural conservation of amino acid residues Published In FASEB BioAdvances
  2019	High frequency repetitive transcranial magnetic stimulation for primary progressive apraxia of speech: A case series Published In Brain Stimulation
  2019	Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor Published In British Journal of Pharmacology
  2019	Monoclonal antibody-conjugated dendritic nanostructures for siRNA delivery Published In Methods in Molecular Biology
  2019	Opsoclonus-myoclonus-encephalopathy induced by cefepime Published In Journal of the Neurological Sciences
  2019	α-Conotoxin Vc1.1 structure-activity relationship at the human α9α10 nicotinic acetylcholine receptor investigated by minimal side chain replacement Published In ACS Chemical Neuroscience
  2018	A novel α-conopeptide Eu1.6 inhibits N-type (CaV2.2) calcium channels and exhibits potent analgesic activity Published In Scientific Reports
  2018	Contribution of membrane receptor signalling to chronic visceral pain Published In The International Journal of Biochemistry and Cell Biology
  2018	Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain Published In British Journal of Pharmacology
  2018	Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1 Published In British Journal of Pharmacology
  2018	Molecular Determinants Conferring the Stoichiometric-Dependent Activity of alpha-Conotoxins at the Human alpha 9 alpha 10 Nicotinic Acetylcholine Receptor Subtype Published In Journal of Medicinal Chemistry
  2018	NMR structure of µ-conotoxin GIIIC: Leucine 18 induces local repacking of the N-terminus resulting in reduced Nav channel potency Published In Molecules
  2018	Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides Published In Scientific Reports
  2018	Phase I Study of the Combination of Bendamustine, Rituximab, and Pixantrone in Patients With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma. Published In Clinical lymphoma, myeloma & leukemia
  2018	Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB Published In Biochemical Pharmacology
  2018	Structure-Activity Studies Reveal the Molecular Basis for GABA(B)-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1 Published In ACS Chemical Biology
  2018	Targeting of N-Type Calcium Channels via GABAB-Receptor Activation by α-Conotoxin Vc1.1 Variants Displaying Improved Analgesic Activity Published In Journal of Medicinal Chemistry
  2018	α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition Published In British Journal of Pharmacology
  2017	A novel lid-covering peptide inhibitor of nicotinic acetylcholine receptors derived from αd-conotoxin GeXXA Published In Marine Drugs
  2017	Analgesic conopeptides targeting G protein-coupled receptors reduce excitability of sensory neurons Published In Neuropharmacology
  2017	Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer Published In Journal of Biological Chemistry
  2017	Identification of a novel O-conotoxin reveals an unusual and potent inhibitor of the human α9α10 nicotinic acetylcholine receptor Published In Marine Drugs
  2017	In vivo and in vitro testing of native α-conotoxins from the injected venom of Conus purpurascens Published In Neuropharmacology
  2017	Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors Published In Scientific Reports
  2017	Intracranial hypotension: diagnosis by trial of Trendelenburg positioning and imaging Published In Internal and Emergency Medicine
  2017	Neuropharmacology of venom peptides Published In Neuropharmacology
  2017	Neurovascular uncoupling after rapid glycemic control as a trigger of the diabetic-uremic striatopallidal syndrome Published In Parkinsonism and Related Disorders
  2017	Peptide grafted and self-assembled poly(γ-glutamic acid)-phenylalanine nanoparticles targeting camptothecin to glioma Published In Nanomedicine
  2017	Role of Cys(I)-Cys(III) Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors Published In ACS Omega
  2017	The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity Published In Scientific Reports
  2017	α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors Published In Gut
  2016	Comments on Broca's 1861 case of aphasia Published In Annals of Neurology
  2016	Cyclic RGDfK Peptide Functionalized Polymeric Nanocarriers for Targeting Gemcitabine to Ovarian Cancer Cells Published In Molecular Pharmaceutics
  2016	Effects of linker sequence modifications on the structure, stability, and biological activity of a cyclic α-conotoxin Published In Biopolymers
  2016	Episodic Aphasia Associated With Cortical Spreading Depression After Subdural Hemorrhage Evacuation Published In The Neurohospitalist
  2016	Formulation and dosage of therapeutic nanosuspension for active targeting of docetaxel (WO 2014210485A1) Published In Expert Opinion on Therapeutic Patents
  2016	Improving efficacy, oral bioavailability, and delivery of paclitaxel using protein-grafted solid lipid nanoparticles Published In Molecular Pharmaceutics
  2016	Key structural determinants in the agonist binding loops of human β2 and β4 nicotinic acetylcholine receptor subunits contribute to α3β4 subtype selectivity of α-conotoxins Published In Journal of Biological Chemistry
  2016	Mechanism of direct Cav2.2 channel block by the κ-opioid receptor agonist U50488H Published In Neuropharmacology
  2016	Modulation of human Na(v)1.7 channel gating by synthetic α-scorpion toxin OD1 and its analogs Published In Channels
  2016	Store-operated Ca2+ entry (SOCE) and purinergic receptor-mediated Ca2+ homeostasis in murine bv2 microglia cells: Early cellular responses to ATP-mediated microglia activation Published In Frontiers in Molecular Neuroscience
  2016	Structure-activity studies of cysteine-rich α-Conotoxins that inhibit high voltage-activated calcium channels via GABAB receptor activation reveal a minimal functional motif Published In Angewandte Chemie International Edition
  2016	Structure–Activity Studies of Cysteine‐Rich α‐Conotoxins that Inhibit High‐Voltage‐Activated Calcium Channels via GABAB Receptor Activation Reveal a Minimal Functional Motif Published In Angewandte Chemie
  2016	Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer Published In Scientific Reports
  2016	Voltage-Gated R-Type Calcium Channel Inhibition via Human ��-, ��-, and ��-opioid Receptors Is Voltage-Independently Mediated by Gbg Protein Subunits Published In Molecular Pharmacology
  2015	Alanine scan ofα-conotoxin regiia reveals a selective α3α4 nicotinic acetylcholine receptor antagonist Published In Journal of Biological Chemistry
  2015	Biomedical applications of trastuzumab: as a therapeutic agent and a targeting ligand Published In Medicinal Research Reviews
  2015	Bombesin-conjugated nanoparticles improve the cytotoxic efficacy of docetaxel against gastrin-releasing but androgen-independent prostate cancer Published In Nanomedicine
  2015	Conotoxin αd-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors Published In Scientific Reports
  2015	Cyclic-RGDfK peptide conjugated succinoyl-TPGS nanomicelles for targeted delivery of docetaxel to integrin receptor over-expressing angiogenic tumours Published In Nanomedicine: Nanotechnology, Biology and Medicine
  2015	Distinct functional site in Ω-neurotoxins: novel antagonists of nicotinic acetylcholine receptors from snake venom Published In ACS Chemical Biology
  2015	Inhibition of cholinergic pathways in Drosophila melanogaster by α-conotoxins Published In The FASEB Journal
  2015	Less is more: design of a highly stable disulfide-deleted mutant of analgesic cyclic α-conotoxin Vc1.1 Published In Scientific Reports
  2015	Molecular basis for differential sensitivity of α-conotoxin RegIIA at rat and human neuronal nicotinic acetylcholine receptors Published In Molecular Pharmacology
  2015	Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABAB receptor Published In Molecular Pharmacology
  2015	Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins Published In Biopolymers
  2015	α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors Published In Journal of the American Chemical Society
  2014	888 α-Conotoxin Vc1.1 Targets GABAB Receptors Modulating CaV2.2 and CaV2.3 Calcium Channels in Sensory Pathways Mediating Chronic Visceral Pain Published In Gastroenterology
  2014	Dasatinib (BMS-35482) interacts synergistically with docetaxel, gemcitabine, topotecan, and doxorubicin in ovarian cancer cells with high SRC pathway activation and protein expression. Published In International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  2014	Dasatinib (BMS-35482) potentiates the activity of gemcitabine and docetaxel in uterine leiomyosarcoma cell lines. Published In Gynecologic oncology research and practice
  2014	Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets Published In Journal of Medicinal Chemistry
  2014	Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation Published In Journal of General Physiology
  2014	Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels Published In British Journal of Pharmacology
  2014	Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors Published In Biochemical Pharmacology
  2014	Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels Published In Biochemical Pharmacology
  2014	Low-dose acetazolamide reverses periventricular white matter hyperintensities in iNPH Published In Neurology
  2014	Use of SRC pathway activation in predicting dasatinib activity in ovarian cancer Published In Gynecologic Oncology
  2013	Abstract 4479: Preclinical toxicology and pharmacology for BACPTDP, a camptothecin that targets hypoxic/acidic tumors. Published In Cancer Research
  2013	Actions of ��-conotoxins on neuronal nicotinic acetylcholine receptors and synaptic transmission in rat parasympathetic ganglia Published In Autonomic Neuroscience
  2013	Are nicotinic acetylcholine receptors coupled to G proteins? Published In BioEssays
  2013	Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1 Published In ACS Chemical Biology
  2013	Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor Published In Journal of Medicinal Chemistry
  2013	Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors Published In ACS Chemical Biology
  2013	Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors Published In Journal of Biological Chemistry
  2013	Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors Published In Biochemical Pharmacology
  2013	Kv3.1 channels stimulate adult neural precursor cell proliferation and neuronal differentiation Published In The Journal of Physiology
  2013	MRI evidence of impaired CSF homeostasis in obesity-associated idiopathic intracranial hypertension Published In American Journal of Neuroradiology
  2013	Mechanisms of conotoxin inhibition of N-type (Cav2.2) calcium channels Published In BBA: Biomembranes
  2012	Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels Published In British Journal of Pharmacology
  2012	Biophysical properties of Nav1.8/Nav1.2 chimeras and inhibition by μo-conotoxin MrVIB Published In British Journal of Pharmacology
  2012	Clippers complicating multiple sclerosis causing concerns of CNS lymphoma Published In Neurology
  2012	Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics? Published In Toxins
  2012	Dasatinib (BMS-35482) potentiates the activity of gemcitabine and docetaxel in leiomyosarcoma cell lines Published In Gynecologic Oncology
  2012	Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain Published In Neuropharmacology
  2012	Isolation, characterization and total regioselective synthesis of the novel μo-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels Published In Biochemical Pharmacology
  2012	Localization of Nav 1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function Published In Channels
  2012	RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs Published In Biochemical Pharmacology
  2012	The Valley of Death in anticancer drug development: a reassessment. Published In Trends in pharmacological sciences
  2012	γ-Aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic α-conotoxins Published In Journal of Biological Chemistry
  2011	A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain Published In Pain
  2011	Analgesic ω-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels (Molecular Pharmacology (2010) 77, (139-148)) Published In Molecular Pharmacology
  2011	BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors. Published In Cancer chemotherapy and pharmacology
  2011	Dasatinib (BMS-35482) has synergistic activity with paclitaxel and carboplatin in ovarian cancer cells. Published In Gynecologic oncology
  2011	Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABAB receptor Published In Journal of Medicinal Chemistry
  2011	Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function? Published In Journal of Biological Chemistry
  2011	JC virus granule cell neuronopathy and hyper-IgE in HIV disease Published In Neurology
  2011	Purification of immature neuronal cells from neural stem cell progeny Published In PLoS One
  2011	Regulation of voltage-gated ion channels in excitable cells by the ubiquitin ligases Nedd4 and Nedd4-2 Published In Channels
  2011	Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization Published In Antioxidants and Redox Signaling
  2011	Structure and activity of α-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABAB receptor-coupled N-type calcium channels Published In Journal of Biological Chemistry
  2011	Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine���Assisted Folding Published In Angewandte Chemie
  2011	Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding Published In Angewandte Chemie International Edition
  2011	Tumor physiology and charge dynamics of anticancer drugs: implications for camptothecin-based drug development. Published In Current medicinal chemistry
  2010	Analgesic alpha-conotoxins Vc1.1 and RgIA inhibit N-type calcium channels in sensory neurons of alpha9 nicotinic receptor knockout mice. Published In Channels (Austin, Tex.)
  2010	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout mice Published In Channels
  2010	Analgesic ω-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels Published In Molecular Pharmacology
  2010	Dolichoectasia and multifocal simultaneous intracranial haemorrhages Published In BMJ Case Reports
  2010	Innentitelbild: The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain (Angew. Chem. 37/2010) Published In Angewandte Chemie
  2010	Inside Cover: The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain (Angew. Chem. Int. Ed. 37/2010) Published In Angewandte Chemie International Edition
  2010	Physiological roles of ion channels in adult neural stem cells and their progeny Published In Journal of Neurochemistry
  2010	Solving the α-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antaqonists Published In Journal of the American Chemical Society
  2010	The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain Published In Angewandte Chemie
  2010	The engineering of an orally active conotoxin for the treatment of neuropathic pain Published In Angewandte Chemie International Edition
  2010	α-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of α3β4 nicotinic acetylcholine receptors Published In Journal of Biological Chemistry
  2009	Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3 Published In Toxicon
  2009	Inhibition of neuronal nicotinic acetylcholine receptor subtypes by α-conotoxin GID and analogues Published In Journal of Biological Chemistry
  2009	P129 A pilot study of decitabine in combination with arsenic trioxide for patients with myelodysplastic syndromes Published In Leukemia Research
  2009	P134 A phase II pilot study of sorafenib in patients with myelodysplastic syndromes Published In Leukemia Research
  2009	Reactive oxygen species modulate neuronal excitability in rat intrinsic cardiac ganglia Published In Autonomic Neuroscience: Basic and Clinical
  2009	Scanning mutagenesis of α-conotoxin Vc1.1 reveals residues crucial for activity at the α9α10 nicotinic acetylcholine receptor Published In Journal of Biological Chemistry
  2008	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation Published In The Journal of Neuroscience
  2008	Anti proliferative activity of ELACY (CP-4055) in combination with cloretazine (VNP40101M), idarubicin, gemcitabine, irinotecan and topotecan in human leukemia and lymphoma cells. Published In Leukemia & lymphoma
  2008	Conotoxin modulation of voltage-gated sodium channels Published In The International Journal of Biochemistry and Cell Biology
  2008	Kir and Kv channels regulate electrical properties and proliferation of adult neural precursor cells Published In Molecular and Cellular Neuroscience
  2008	Molecular engineering of conotoxins: The importance of loop size to α-conotoxin structure and function Published In Journal of Medicinal Chemistry
  2008	Neuronally selective μ-conotoxins from Conus striatus utilize an α-helical motif to target mammalian sodium channels Published In Journal of Biological Chemistry
  2008	Phase I evaluation of gemcitabine, mitoxantrone, and their effect on plasma disposition of fludarabine in patients with relapsed or refractory acute myeloid leukemia. Published In Leukemia & lymphoma
  2008	Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1 Published In American Journal of Physiology: Cell Physiology
  2008	The three-dimensional structure of the analgesic α-conotoxin, RgIA Published In FEBS Letters
  2008	ω-Conotoxin inhibition of excitatory synaptic transmission evoked by dorsal root stimulation in rat superficial dorsal horn Published In Neuropharmacology
  2007	Are α9α10 nicotinic acetylcholine receptors a pain target for α-conotoxins? Published In Molecular Pharmacology
  2007	Chemical modification of conotoxins to improve stability and activity Published In ACS Chemical Biology
  2007	Distinct activities of novel neurotoxins from Australian venomous snakes for nicotinic acetylcholine receptors Published In Cellular and Molecular Life Sciences
  2007	Isolation and structure-activity of μ-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels Published In Molecular Pharmacology
  2007	Liposome reconstitution and modulation of recombinant N-methyl-D-aspartate receptor channels by membrane stretch Published In Proceedings of the National Academy of Sciences of USA
  2007	NEDD4-2 as a potential candidate susceptibility gene for epileptic photosensitivity Published In Genes, Brain and Behavior
  2007	Polymodal regulation of NMDA receptor channels Published In Channels
  2007	Purinergic receptor activation inhibits mitogen-stimulated proliferation in primary neurospheres from the adult mouse subventricular zone Published In Molecular and Cellular Neuroscience
  2007	Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by ubiquitination: novel role for Nedd4-2 Published In Journal of Biological Chemistry
  2007	Sarcoid meningitis with fulminant delirium and markedly abnormal cerebrospinal fluid Published In Archives of Neurology
  2007	Structure of α-conotoxin BuIA: influences of disulfide connectivity on structural dynamics Published In BMC Structural Biology
  2007	The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells Published In The Journal of Neuroscience
  2007	ω-Conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels Published In European Journal of Neuroscience
  2006	Antiproliferative Activity of ELACYT¿ (CP-4055) in Combination with Cloretazine (VNP40101M), Idarubicin or Gemcitabine in HL-60 Human Myeloid Leukemia Cells. Published In Blood
  2006	Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tumor pH gradient. Published In Cancer chemotherapy and pharmacology
  2006	Cortical reorganization following intradigital tendon transfer Published In NeuroReport
  2006	Identification of a novel class of nicotinic receptor antagonists: dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum Published In Journal of Biological Chemistry
  2006	Mutations within the selectivity filter of the NMDA receptor-channel influence voltage dependent block by 5-hydroxytryptamine Published In British Journal of Pharmacology
  2006	NMDA receptor subunit-dependent modulation by conantokin-G and Ala(7)-conantokin-G Published In Journal of Neurochemistry
  2006	Neuronal voltage-gated sodium channel subtypes: key roles in inflammatory and neuropathic pain Published In The International Journal of Biochemistry and Cell Biology
  2006	The synthesis, structural characterization, and receptor specificity of the α-conotoxin Vc1.1 Published In Journal of Biological Chemistry
  2006	WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo Published In Experimental Cell Research
  2006	α-Selenoconotoxins, a new class of potent α7 neuronal nicotinic receptor antagonists Published In Journal of Biological Chemistry
  2006	μO-conotoxin MrVIB selectively blocks NaV1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits Published In Proceedings of the National Academy of Sciences of USA
  2005	Camptothecin analogs with enhanced activity against human breast cancer cells. I. Correlation of potency with lipophilicity and persistence in the cleavage complex. Published In Cancer chemotherapy and pharmacology
  2005	Developmental changes in expression of GABAA receptor-channels in rat intrinsic cardiac ganglion neurones Published In The Journal of Physiology
  2005	Engineering stable peptide toxins by means of backbone cyclization: stabilization of the α-conotoxin MII Published In Proceedings of the National Academy of Sciences of USA
  2005	Erratum: Intravenous anaesthetics inhibit nicotinic acetylcholine receptor-mediated currents and Ca 2+ transients in rat intracardiac ganglion neurons (British Journal of Pharmacology (2005) 144 (98-107) doi:10.1038/sj.bjp.0705942) Published In British Journal of Pharmacology
  2005	Intravenous anaesthetics inhibit nicotinic acetylcholine receptor-mediated currents and Ca2+ transients in rat intracardiac ganglion neurons Published In British Journal of Pharmacology
  2005	Preclinical evaluation of gemcitabine combination regimens for application in acute myeloid leukemia. Published In Clinical cancer research : an official journal of the American Association for Cancer Research
  2005	Selective modulation of neuronal nicotinic acetylcholine receptor channel subunits by Go-protein subunits Published In The Journal of Neuroscience
  2005	Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner Published In Journal of Pharmacology and Experimental Therapeutics
  2005	Unusual findings in brain biopsies of two patients with acute magnetic resonance imaging lesions associated with focal seizures Published In Epilepsia
  2005	Voltage-dependent inhibition of recombinant NMDA receptor-mediated currents by 5-hydroxytryptamine Published In British Journal of Pharmacology
  2004	Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors Published In Molecular Pharmacology
  2004	Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells Published In European Journal of Neuroscience
  2004	Chemical and functional identification and characterization of novel sulfated α-conotoxins from the cone snail Conus anemone Published In Journal of Medicinal Chemistry
  2004	Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy Published In Neurology
  2004	Expression and function of neuronal nicotinic ACh receptors in rat microvascular endothelial cells Published In American Journal of Physiology: Heart and Circulatory Physiology
  2004	Functional maturation of isolated neural progenitor cells from the adult rat hippocampus Published In European Journal of Neuroscience
  2004	Overexpressed Cavβ3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of "ultra-slow"^^ and "closed-state"^^ inactivation Published In Journal of General Physiology
  2004	Potassium channels and membrane potential in the modulation of intracellular calcium in vascular endothelial cells Published In Journal of Cardiovascular Electrophysiology
  2004	Regulation of neuronal voltage-gated sodium channels by the ubiquitin protein ligases Nedd4 and Nedd4-2 Published In Journal of Biological Chemistry
  2004	Structures of μO-conotoxins from Conus marmoreus: Inhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons Published In Journal of Biological Chemistry
  2004	The α2δ auxiliary subunit reduces affinity of ω-conotoxins for recombinant N-type (Cav2.2) calcium channels Published In Journal of Biological Chemistry
  2003	4-Hydroperoxycyclophosphamide[ndash ]purged peripheral blood stem cells for autologous transplantation in patients with acute myeloid leukemia Published In Biology of Blood and Marrow Transplantation
  2003	4-hydroperoxycyclophosphamide--purged peripheral blood stem cells for autologous transplantation in patients with acute myeloid leukemia. Published In Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
  2003	Allosteric α1-adrenoreceptor antagonism by the conopeptide ρ-TIA Published In Journal of Biological Chemistry
  2003	Callosal neglect Published In Archives of Neurology
  2003	Clinicopathological review: Primary angiitis of the central nervous system in association with cerebral amyloid angiopathy Published In Neurosurgery
  2003	IL-4 and interferon gamma regulate expression of inducible nitric oxide synthase in chronic lymphocytic leukemia cells. Published In Leukemia
  2003	Inhibition of the norepinephrine transporter by the venom peptide χ-MrIA: site of action, Na+ dependence, and structure-activity relationship Published In Journal of Biological Chemistry
  2003	Isolation, structure, and activity of GID, a novel α4/7-conotoxin with an extended N-terminal sequence Published In Journal of Biological Chemistry
  2003	Muscarinic and nicotinic ACh receptor activation differentially mobilize Ca2+ in rat intracardiac ganglion neurons Published In Journal of Neurophysiology
  2003	Phase I evaluation of prolonged-infusion gemcitabine with fludarabine for relapsed or refractory acute myelogenous leukemia. Published In Clinical cancer research : an official journal of the American Association for Cancer Research
  2003	Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of α-conotoxin MII Published In Journal of Medicinal Chemistry
  2003	The activity of camptothecin analogues is enhanced in histocultures of human tumors and human tumor xenografts by modulation of extracellular pH. Published In Cancer chemotherapy and pharmacology
  2003	α-conotoxins PnIA and [A10L]PnIA stabilize different states of the α7-L247T nicotinic acetylcholine receptor Published In Journal of Biological Chemistry
  2003	ω-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals Published In Journal of Biological Chemistry
  2002	A new level of conotoxin diversity, a non-native disulfide bond connectivity in α-conotoxin AuIB reduces structural definition but increases biological activity Published In Journal of Biological Chemistry
  2002	Basal nonselective cation permeability in rat cardiac microvascular endothelial cells Published In Microvascular Research
  2002	Ciguatoxin-induced oscillations in membrane potential and action potential firing in rat parasympathetic neurons Published In European Journal of Neuroscience
  2002	Neural control of the heart: developmental changes in ionic conductances in mammalian intrinsic cardiac neurons Published In Autonomic Neuroscience: Basic and Clinical
  2002	Origins of skeletal pain: Sensory and sympathetic innervation of the mouse femur Published In NEUROSCIENCE
  2002	Phase I Evaluation of Prolonged-Infusion Gemcitabine With Mitoxantrone for Relapsed or Refractory Acute Leukemia Published In Journal of Clinical Oncology
  2002	Phase I evaluation of prolonged-infusion gemcitabine with irinotecan for relapsed or refractory leukemia or lymphoma. Published In Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  2002	Phase I evaluation of prolonged-infusion gemcitabine with mitoxantrone for relapsed or refractory acute leukemia. Published In Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  2002	Solution structure of μ-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels Published In Journal of Biological Chemistry
  2001	An ATP-sensitive K+ conductance in dissociated neurones from adult rat intracardiac ganglia Published In The Journal of Physiology
  2001	Developmental changes in hyperpolarization-activated currents Ih and IK(IR) in isolated rat intracardiac neurons Published In Journal of Neurophysiology
  2001	Dual role of glutathione in modulating camptothecin activity: depletion potentiates activity, but conjugation enhances the stability of the topoisomerase I-DNA cleavage complex. Published In Molecular cancer therapeutics
  2001	Ionic selectivity of native ATP-activated (P2X) receptor channels in dissociated neurones from rat parasympathetic ganglia Published In The Journal of Physiology
  2001	Large-conductance calcium-activated potassium channels in neonatal rat intracardiac ganglion neurons Published In Pfluegers Archiv: European journal of physiology
  2001	Pre- and postsynaptic actions of ATP on neurotransmission in rat submandibular ganglia Published In Neuroscience
  2001	The synthesis and structure of an n-terminal dodecanoic acid conjugate of α-conotoxin MII Published In International Journal of Peptide Research and Therapeutics
  2001	The synthesis and structure of an n-terminal dodecanoic acid conjugate of ��-conotoxin MII Published In International Journal of Peptide Research and Therapeutics
  2001	Two new classes of conopeptides inhibit the α1-adrenoceptor and noradrenaline transporter Published In Nature Neuroscience
  2001	ZNF265 - A novel spliceosomal protein able to induce alternative splicing Published In Journal of Cell Biology
  2000	Camptothecin analogues with enhanced antitumor activity at acidic pH. Published In Cancer chemotherapy and pharmacology
  2000	Evidence for a role of chloroethylaziridine in the cytotoxicity of cyclophosphamide. Published In Cancer chemotherapy and pharmacology
  2000	Novel ω-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes Published In Journal of Biological Chemistry
  2000	P2Y purinoceptor activation mobilizes intracellular Ca2+ and induces a membrane current in rat intracardiac neurones Published In The Journal of Physiology
  2000	Pharmacological characterisation of the P2Y(11) receptor in stably transfected haematological cell lines Published In MOLECULAR AND CELLULAR BIOCHEMISTRY
  2000	Substance P preferentially inhibits large conductance nicotinic ACh receptor channels in rat intracardiac ganglion neurons Published In Journal of Neurophysiology
  2000	VIP and PACAP potentiation of nicotinic ACh-evoked currents in rat parasympathetic neurons is mediated by G-protein activation Published In European Journal of Neuroscience
  1999	Calcium channels controlling acetylcholine release from preganglionic nerve terminals in rat autonomic ganglia Published In Neuroscience
  1999	Conotoxins and their potential pharmaceutical applications Published In Drug Development Research
  1999	Mechanisms of verapamil inhibition of action potential firing in rat intracardiac ganglion neurons Published In Journal of Pharmacology and Experimental Therapeutics
  1999	Met-enkephalin-induced mobilization of intracellular Ca2+ in rat intracardiac ganglion neurones Published In Neuroscience Letters
  1999	Pre-clinical evaluation of SN-38 and novel camptothecin analogs against human chronic B-cell lymphocytic leukemia lymphocytes. Published In Leukemia research
  1999	Single amino acid substitutions in α-conotoxin PnIA shift selectivity for subtypes of the mammalian neuronal nicotinic acetylcholine receptor Published In Journal of Biological Chemistry
  1998	ACh- and caffeine-induced Ca2+ mobilization and current activation in rabbit arterial endothelial cells Published In American Journal of Physiology: Heart and Circulatory Physiology
  1998	ACh- and caffeine-induced Ca2+ mobilization and current activation in rabbit arterial endothelial cells Published In American Journal of Physiology - Heart and Circulatory Physiology
  1998	Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons Published In Journal of Pharmacology and Experimental Therapeutics
  1998	Ciguatoxin (CTX-1) modulates single tetrodotoxin-sensitive sodium channels in rat parasympathetic neurones Published In Neuroscience Letters
  1998	Opioid receptor-mediated inhibition of ω-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons Published In Journal of Neurophysiology
  1998	Therapeutic efficacy of vinorelbine against pediatric and adult central nervous system tumors. Published In Cancer chemotherapy and pharmacology
  1998	α-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors Published In Journal of Biological Chemistry
  1997	Characterization of ATP-sensitive potassium channels in freshly dissociated rabbit aortic endothelial cells Published In American Journal of Physiology - Heart and Circulatory Physiology
  1997	Characterization of ATP-sensitive potassium channels in freshly dissociated rabbit aortic endothelial cells Published In American Journal of Physiology: Heart and Circulatory Physiology
  1997	Heterogeneity of nicotinic receptor class and subunit mRNA expression among individual parasympathetic neurons from rat intracardiac ganglia Published In The Journal of Neuroscience
  1997	M4 muscarinic receptor activation modulates calcium channel currents in rat intracardiac neurons Published In Journal of Neurophysiology
  1997	Passive and active membrane properties of isolated rat intracardiac neurons: Regulation by H- and M-currents Published In Journal of Neurophysiology
  1996	Vasoactive intestinal polypeptide modulation of nicotinic ACh receptor channels in rat intracardiac neurones Published In The Journal of Physiology
  1995	An ATP-sensitive potassium conductance in rabbit arterial endothelial cells Published In The Journal of Physiology
  1995	Caffeine-evoked, calcium-sensitive membrane currents in rabbit aortic endothelial cells Published In British Journal of Pharmacology
  1995	Monovalent and divalent cation permeability and block of neuronal nicotinic receptor channels in rat parasympathetic ganglia Published In Journal of General Physiology
  1995	The relationship of brevetoxin 'length' and A-ring functionality to binding and activity in neuronal sodium channels Published In Chemistry and Biology
  1994	Cytosolic [Ca2+] measurements in endothelium of rabbit cardiac valves using imaging fluorescence microscopy Published In American Journal of Physiology: Heart and Circulatory Physiology
  1994	Cytosolic [Ca2+] measurements in endothelium of rabbit cardiac valves using imaging fluorescence microscopy Published In American Journal of Physiology - Heart and Circulatory Physiology
  1994	Ionic channels in vascular endothelial cells Published In Trends in Cardiovascular Medicine
  1994	Is the A-ring lactone of brevetoxin PbTX-3 required for sodium channel orphan receptor binding and activity? Published In Natural Toxins
  1994	Local anaesthetic blockade of neuronal nicotinic ACh receptor-channels in rat parasympathetic ganglion cells Published In British Journal of Pharmacology
  1994	TEA inhibits ACh-induced EDRF release: Endothelial Ca2+-dependent K+ channels contribute to vascular tone Published In American Journal of Physiology - Heart and Circulatory Physiology
  1994	TEA inhibits ACh-induced EDRF release: Endothelial Ca2+-dependent K+ channels contribute to vascular tone Published In American Journal of Physiology - Heart and Circulatory Physiology
  1994	TEA inhibits ACh-induced EDRF release: endothelial Ca2+-dependent K+ channels contribute to vascular tone Published In American Journal of Physiology: Heart and Circulatory Physiology
  1993	Membrane properties and discharge characteristics of rat intracardiac neurones in vitro: the effect of temperature Published In The Journal of Physiology
  1993	α-Adrenergic modulation of ionic currents in cultured parasympathetic neurons from rat intracardiac ganglia Published In Journal of Neurophysiology
  1992	Calcium entry-dependent oscillations of cytoplasmic calcium concentration in cultured endothelial cell monolayers Published In Proceedings of the National Academy of Sciences of USA
  1992	Calcium permeability and modulation of nicotinic acetylcholine receptor-channels in rat parasympathetic neurons Published In Journal of Physiology: Paris
  1992	Calcium-activated potassium channels in native endothelial cells from rabbit aorta: conductance, Ca2+ sensitivity and block Published In The Journal of Physiology
  1992	Resting membrane potential and potassium currents in cultured parasympathetic neurones from rat intracardiac ganglia Published In The Journal of Physiology
  1992	Voltage-dependent sodium and calcium currents in cultured parasympathetic neurones from rat intracardiac ganglia Published In The Journal of Physiology
  1991	Acetylcholine-evoked currents in cultured neurones dissociated from rat parasympathetic cardiac ganglia Published In The Journal of Physiology
  1991	Adenosine triphosphate-evoked currents in cultured neurones dissociated from rat parasympathetic cardiac ganglia Published In The Journal of Physiology
  1991	Cytosolic calcium ion regulation in cultured endothelial cells Published In Advances in Experimental Medicine and Biology
  1991	Modes of hexamethonium action on acetylcholine receptor channels in frog skeletal muscle Published In British Journal of Pharmacology
  1990	Membrane potential and Na+-K+ pump activity modulate resting and bradykinin-stimulated changes in cytosolic free calcium in cultured endothelial cells from bovine atria Published In Journal of Biological Chemistry
  1990	Neurotransmission in neonatal rat cardiac ganglion in situ Published In American Journal of Physiology - Heart and Circulatory Physiology
  1990	Neurotransmission in neonatal rat cardiac ganglion in situ Published In American Journal of Physiology: Heart and Circulatory Physiology
  1990	Synergistic hypotensive effect of vasoactive intestinal polypeptide and α-blockade with phentolamine: evidence for vasoactive intestinal peptide α-adrenoceptor coupling in the cardiovascular system of newborn dogs Published In Circulation Research
  1989	Bradykinin and inositol 1,4,5-trisphosphate-stimulated calcium release from intracellular stores in cultured bovine endothelial cells Published In Pfluegers Archiv: European journal of physiology
  1989	Inhibition of neurally-evoked transmitter release by calcium channel antagonists in rat parasympathetic ganglia Published In British Journal of Pharmacology
  1989	Ion channels and regulation of intracellular calcium in vascular endothelial cells Published In The FASEB Journal
  1989	Synchronized oscillations in cytoplasmic free calcium concentrations in confluent bradykinin-stimulated bovine pulmonary artery endothelial cell monolayers Published In Journal of Biological Chemistry
  1988	Role of Calcium in the Activation of Endothelial Cells Published In Journal of Cardiovascular Pharmacology
  1988	Role of calcium in the activation of endothelial cells Published In Journal of Cardiovascular Pharmacology
  1988	Role of calcium in the activation of endothelial cells Published In Journal of Cardiovascular Pharmacology
  1988	The actions of L-glutamate at the postsynaptic membrane of the squid giant synapse Published In The Journal of Experimental Biology
  1987	Calcium entry through receptor-operated channels in bovine pulmonary artery endothelial cells Published In Tissue and Cell
  1985	Inhibitors of calcium buffering depress evoked transmitter release at the squid giant synapse. Published In The Journal of Physiology
  1985	Some properties of acetylcholine receptors in human cultured myotubes Published In Proceedings of the Royal Society B: Biological Sciences
  1983	INTERACTION OF INTERNAL ANIONS WITH POTASSIUM CHANNELS OF THE SQUID GIANT-AXON Published In JOURNAL OF GENERAL PHYSIOLOGY
  1982	Inhibitory postsynaptic currents at Aplysia cholinergic synapses: effects of permeant anions and depressant drugs Published In Proceedings of the Royal Society B: Biological Sciences
  1981	Block of endplate channels by permeant cations in frog skeletal muscle Published In Journal of General Physiology
  1981	Hyperventilation and 6-hour EEG recording in evaluation of absence seizures Published In Neurology
  1980	Divalent ion currents and the delayed potassium conductance in an Aplysia neurone Published In The Journal of Physiology
  1980	Ionic currents in molluscan soma Published In Annual Review of Neuroscience
  1980	The permeability of endplate channels to monovalent and divalent metal cations Published In Journal of General Physiology
  1980	The permeability of the endplate channel to organic cations in frog muscle Published In Journal of General Physiology
  1980	The permeability of the endplate channel to organic cations in frog muscle Published In Journal of General Physiology
  1979	Characteristics of sodium and calcium conductance changes produced by membrane depolarization in an Aplysia neurone Published In The Journal of Physiology
  1979	Ionic currents in response to membrane depolarization in an aplysia neurone Published In The Journal of Physiology
  1979	Sodium and calcium gating currents in an Aplysia neurone Published In The Journal of Physiology
  1978	An effect of ethanol at a glutamate synapse Published In Clinical and Experimental Pharmacology and Physiology
  1978	Asymmetrical displacement currents Published In Nature
  1978	Sodium valproate in the treatment of intractable seizure disorders: A clinical and electroencephalographic study Published In Neurology
  1977	Accessory nerve palsy Published In Journal of Neurology, Neurosurgery and Psychiatry
  1977	Ethanol reduces excitatory postsynaptic current duration at a crustacean neuromuscular junction Published In Nature
  1977	Funnel web spider venom produces spontaneous action potentials in nerve Published In Life Sciences
  1976	Gating currents associated with sodium and calcium currents in an Aplysia neuron Published In Science
  1976	Voltage sensitivity of inhibitory postsynaptic currents in Aplysia buccal ganglia Published In Brain Research

• Chapter

  Year	Title
  2022	Pharmacology and Structure-Function of Venom Peptide Inhibitors of N-Type (Cav2.2) Calcium Channels Published In Voltage-Gated Calcium Channels Publisher : Springer Nature
  2021	Venom-Derived Peptides Inhibiting Voltage-Gated Sodium and Calcium Channels in Mammalian Sensory Neurons Published In Advances in Experimental Medicine and Biology Publisher Springer Nature Singapore
  2021	Venom-Derived Peptides Inhibiting Voltage-Gated Sodium and Calcium Channels in Mammalian Sensory Neurons Published In Advances in Experimental Medicine and Biology Publisher Springer Singapore
  2018	Cyclic-RGDfK-Directed Docetaxel Loaded Nanomicelles for Angiogenic Tumor Targeting Published In Methods in Pharmacology and Toxicology Publisher : Springer New York
  2015	CHAPTER 4 Venoms-Based Drug Discovery: Bioassays, Electrophysiology, High-Throughput Screens and Target Identification Published In Venoms to Drugs Publisher Royal Society of Chemistry (RSC)
  2015	Venoms-based drug discovery: bioassays, electrophysiology, high-throughput screens and target identincation Published In Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics Publisher http://pubs.rsc.org/en/Content/eBook/978-1-84973-663-3#!divbookcontent
  2008	Voltage-Gated Calcium Channels in Nociception Published In Sensing with Ion Channels Publisher : Springer Berlin Heidelberg
  2008	Voltage-Gated Calcium Channels in Nociception Published In Sensing with Ion Channels Publisher : Springer Nature
  2005	Block of Voltage-Gated Calcium Channels by Peptide Toxins Published In Voltage-Gated Calcium Channels Publisher Springer Nature
  2005	Block of Voltage-Gated Calcium Channels by Peptide Toxins Published In Voltage-Gated Calcium Channels Publisher Springer US
  2001	Liposaccharides: Utilisation for Peptide Delivery and for Enhancing Synthetic Peptide Immunogenicity Published In Peptides: The Wave of the Future Publisher : Springer Nature
  2001	Liposaccharides: Utilisation for Peptide Delivery and for Enhancing Synthetic Peptide Immunogenicity Published In Peptides: The Wave of the Future Publisher : Springer Netherlands
  2001	Synthesis of N to C Terminal Cyclic Analogues of α-Conotoxin Iml by Chemoselective Ligation of Unprotected Linear Precursors Published In Peptides: The Wave of the Future Publisher Springer Nature
  2001	Synthesis of N to C Terminal Cyclic Analogues of α-Conotoxin Iml by Chemoselective Ligation of Unprotected Linear Precursors Published In Peptides: The Wave of the Future Publisher Springer Netherlands

• Conference Paper

  Year	Title
  2019	INTERACTION MECHANISM OF alpha-CONOTOXINS TO THE HUMAN alpha 9 alpha 10 NACHR SUBTYPE Published In TOXICON
  2019	INTERRELATIONSHIP BETWEEN NICOTINIC ACETYLCHOLINE RECEPTOR AND CYTOKINE PRODUCTION NOTED FOLLOWING T-CELL ANTIGEN RECOGNITION AND ACTIVATION Published In ANNALS OF THE RHEUMATIC DISEASES
  2019	STRUCTURES, FUNCTIONS OF TWO NOVEL alpha-CONOTOXINS FROM CONUS SNAILS IN SOUTH CHINA SEA Published In TOXICON
  2018	Inhibition of nicotinic acetylcholine receptor subtypes by the ribbon isomers of alpha-conotoxins. Published In JOURNAL OF PEPTIDE SCIENCE
  2016	MINIATURISED ALPHA-CONOTOXINS FOR THE TREATMENT OF PAIN Published In JOURNAL OF PEPTIDE SCIENCE
  2016	Modulation of colonic sensory signaling by novel alpha-conotoxin Vc1.1 analogues in mice Published In NEUROGASTROENTEROLOGY AND MOTILITY
  2015	"Store-operated" and P2X-induced Ca2+ entry are differentially modulated by the antibiotic minocycline in murine BV2 microglia cells Published In ACTA PHYSIOLOGICA
  2015	Inhibition of Human Ca(V)2.3 Channels via mu-, delta- and kappa- Opioid Receptor Activation Published In BIOPHYSICAL JOURNAL
  2014	A NEW TARGET FOR THE ALPHA-CONOTOXINS: THE GABA(B) RECEPTOR Published In JOURNAL OF PEPTIDE SCIENCE
  2014	Differential Ca(V)2.1 and Ca(V)2.3 Channel Inhibition by Baclofen and alpha-Conotoxin Vc1.1 via GABA(B) Receptor Activation Published In BIOPHYSICAL JOURNAL
  2014	alpha-Conotoxin Vc1.1 Targets GABAB Receptors Modulating CaV2.2 and CaV2.3 Calcium Channels in Sensory Pathways Mediating Chronic Visceral Pain Published In GASTROENTEROLOGY
  2013	A New Target for the Alpha-Conotoxins: The GABAB Receptor Published In BIOPOLYMERS
  2013	DEVELOPMENT OF ANALGESIC alpha-CONOTOXINS FOR TREATMENT OF CHRONIC PAIN Published In CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
  2013	Dicarba modification of alpha-conotoxin RgIA conferring selectivity towards alpha 9 alpha 10 nicotinic acetylcholine receptors Published In BIOCHEMICAL PHARMACOLOGY
  2013	Novel strategy of blocking nAChR revealed by dissecting a dimeric conotoxin alpha D-GeXXA Published In BIOCHEMICAL PHARMACOLOGY
  2013	Pn1.2, a New Alpha-conotoxin Targeting the GABAB Receptor Published In BIOPOLYMERS
  2013	alpha-Conotoxin Regiia Targeting Nicotinic Acetylcholine Receptors: Mutagenesis Studies Improving Selectivity and Potency Published In BIOPHYSICAL JOURNAL
  2012	Discovery, Characterization, and Functional Implications of Conotoxins from Cone Snails Species of the Americas Published In TOXICON
  2012	Modulation of Ca(v)2.2 Channels via Activation of Human GABA(B) Receptors Expressed in HEK293 Cells by Analgesic alpha-Conotoxins Published In BIOPHYSICAL JOURNAL
  2012	Spider-venom Peptides that Target the Human NaV1.7 channel: Potential Analgesics for the Treatment of Chronic Pain Published In TOXICON
  2011	Conotoxins - Blueprints for GPCR drug discovery? Published In BIOPOLYMERS
  2011	Scanning mutagenesis of alpha-conotoxin AuIB reveals a critical residue for activity at the alpha 3 beta 4 nicotinic acetylcholine receptor Published In BIOCHEMICAL PHARMACOLOGY
  2010	Stabilization of a-conotoxin AulB: influences of disulfide connectivity and backbone cyclization Published In JOURNAL OF PEPTIDE SCIENCE
  2010	The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain Published In JOURNAL OF PEPTIDE SCIENCE
  2009	ADULT NEURAL STEM/PRECURSOR CELL FUNCTIONS ARE CONTROLLED BY TWO DISTINCT POTASSIUM CHANNEL FAMILIES Published In JOURNAL OF PHYSIOLOGICAL SCIENCES
  2009	ANALGESIC omega-CONOTOXINS CVIE AND CVIF SELECTIVELY BLOCK N-TYPE CALCIUM CHANNELS IN A REVERSIBLE AND VOLTAGE-DEPENDENT MANNER Published In JOURNAL OF PHYSIOLOGICAL SCIENCES
  2009	Abstract C223: BACPTDP: A water¿soluble camptothecin pro¿drug that exploits the tumor pH gradient for enhanced activity in hypoxic/acidic tumors
  2009	MUTATIONAL STUDIES ON alpha-CONOTOXIN VCL1 Published In BIOPOLYMERS
  2005	Selective modulation of neuronal nicotinic acetylcholine receptor channel subunits by G(o)-protein subunits Published In BIOPHYSICAL JOURNAL
  2005	Sglk-1 and Nedd4/4-2 regulation of voltage-sensitive sodium channels Published In FASEB JOURNAL
  2004	Developmental regulation of GABA-ergic responses in intrinsic cardiac neurons of the rat heart Published In JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
  2004	INCREASING THE CONFORMATIONAL STABILITY OF ALPHA-CONOTOXIN IMI BY SUBSTITUTION OF DISULFIDE BONDS WITH ISOSTERIC DISELENIDE BONDS Published In JOURNAL OF PEPTIDE SCIENCE
  2004	NMDA receptor variant responses to conantokins Published In JOURNAL OF NEUROCHEMISTRY
  2002	A novel role of the beta 3 subunit in negative regulation of N-type calcium channels Published In BIOPHYSICAL JOURNAL
  2002	Affinity of omega-conotoxins and analogs for N-type calcium channels Published In BIOPHYSICAL JOURNAL
  2002	Developmental changes in the active membrane properties of rat intracardiac neurones in situ Published In JOURNAL OF PHYSIOLOGY-LONDON
  2002	Electrical properties of isolated neural stem cells from the adult rat hippocampus change upon differentiation Published In JOURNAL OF PHYSIOLOGY-LONDON
  2002	Isolation of a novel conotoxin that targets alpha 7 and alpha 3 beta 2 neuronal nicotinic acetylcholine receptors Published In BIOPHYSICAL JOURNAL
  2001	Muscarinic and nicotinic ACh receptor activation mobilize Ca2+ induces membrane currents in rat intracardiac neurons Published In BIOPHYSICAL JOURNAL
  2000	An ATP-sensitive K+ conductance in adult rat intrinsic cardiac neurones Published In JOURNAL OF PHYSIOLOGY-LONDON
  1998	Acetylcholine- and caffeine-induced global and local calcium mobilisation in freshly isolated rabbit aortic endothelial cells Published In PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
  1998	Properties of the hyperpolarization-activated cation current, I-h, in neonatal and adult rat intracardiac neurones in vitro Published In JOURNAL OF PHYSIOLOGY-LONDON
  1998	Verapamil modulates action potential firing in parasympathetic neurones of rat intracardiac ganglia Published In PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
  1997	Substance P preferentially inhibits the large conductance class of neuronal nicotinic ACh receptor channels expressed in parasympathetic neurones of rat intracardiac ganglia Published In JOURNAL OF PHYSIOLOGY-LONDON
  1995	Adenosine 5'-triphosphate receptor-mediated currents in rat intracardiac neurons Published In ADENOSINE AND ADENINE NUCLEOTIDES: FROM MOLECULAR BIOLOGY TO INTEGRATIVE PHYSIOLOGY
  1995	DISCHARGE CHARACTERISTICS OF NEONATAL RAT INTRACARDIAC NEURONS IN-VITRO - THE EFFECT OF POTASSIUM CHANNEL INHIBITORS Published In JOURNAL OF PHYSIOLOGY-LONDON
  1995	M(4) MUSCARINIC RECEPTOR ACTIVATION MODULATES VOLTAGE-DEPENDENT CALCIUM CONDUCTANCES IN ISOLATED RAT INTRACARDIAC NEURONS Published In JOURNAL OF PHYSIOLOGY-LONDON
  1994	AN ATP-SENSITIVE, SULFONYLUREA-INHIBITABLE K+ CONDUCTANCE IN NATIVE RABBIT ARTERIAL ENDOTHELIAL-CELLS Published In BIOPHYSICAL JOURNAL
  1994	BREVETOXIN-3 (PBTX-3) AND ITS DERIVATIVES MODULATE SINGLE SODIUM-CHANNELS IN RAT SENSORY NEURONS Published In BIOPHYSICAL JOURNAL
  1993	CAFFEINE-INDUCED CA-2+ RELEASE FROM INTRACELLULAR STORES IN FRESHLY DISSOCIATED ENDOTHELIAL-CELLS FROM RABBIT AORTA Published In JOURNAL OF PHYSIOLOGY-LONDON
  1993	CALCIUM SIGNALING IN VASCULAR ENDOTHELIAL-CELLS - CA2+ ENTRY AND RELEASE Published In ION FLUX IN PULMONARY VASCULAR CONTROL
  1992	K+ CURRENTS CONTRIBUTING TO THE RESTING MEMBRANE-POTENTIAL AND THE ACTION-POTENTIAL IN RAT PARASYMPATHETIC CARDIAC NEURONS Published In FASEB JOURNAL
  1990	NOREPINEPHRINE AND GTP-GAMMA-S ACTIVATE A TIME-INDEPENDENT BACKGROUND CURRENT IN RAT PARASYMPATHETIC CARDIAC NEURONS Published In BIOPHYSICAL JOURNAL
  1990	REGULATION OF [CA-2+]I IN ENDOCARDIAL CELLS BY MEMBRANE-POTENTIAL Published In ENDOTHELIUM-DERIVED RELAXING FACTORS
  1989	EFFECTS OF SODIUM-AZIDE AND CYTOSOLIC PH ON EVOKED TRANSMITTER RELEASE AT THE ISOLATED SQUID GIANT SYNAPSE Published In JOURNAL OF PHYSIOLOGY-LONDON
  1989	EFFECTS OF VASOACTIVE INTESTINAL PEPTIDE ON DEVELOPING CANINE CARDIOVASCULAR HEMODYNAMICS Published In PEDIATRIC RESEARCH
  1989	NA-CA EXCHANGE IN FURA-2-LOADED BOVINE PULMONARY-ARTERY ENDOTHELIAL-CELL MONOLAYERS Published In JOURNAL OF PHYSIOLOGY-LONDON
  1989	NOREPINEPHRINE AND GTP-GAMMA-S INHIBIT A CALCIUM CONDUCTANCE AND ACTIVATE A NONSELECTIVE CATION CONDUCTANCE IN RAT PARASYMPATHETIC CARDIAC NEURONS Published In JOURNAL OF GENERAL PHYSIOLOGY
  1989	SYNERGISTIC HYPOTENSIVE EFFECT OF VASOACTIVE INTESTINAL POLYPEPTIDE AND ALPHA BLOCKADE IN NEWBORN DOGS Published In PEDIATRIC RESEARCH
  1989	VIP-RECEPTOR BINDING-INHIBITION BLOCKS THE HYPOTENSIVE EFFECT OF PHENTOLAMINE IN NEWBORN PUPPIES - NEW EVIDENCE FOR ALPHA-RECEPTOR AND VIP-RECEPTOR COUPLING IN THE CARDIOVASCULAR-SYSTEM Published In AMERICAN JOURNAL OF CARDIOLOGY
  1988	BRADYKININ AND THROMBIN-ACTIVATED CATION CHANNELS IN CULTURED ENDOTHELIAL-CELLS FROM BOVINE PULMONARY-ARTERY Published In BIOPHYSICAL JOURNAL
  1987	INWARD RECTIFYING K+ CHANNELS AND THROMBIN-ACTIVATED CATION CHANNELS IN CULTURED ENDOTHELIAL-CELLS FROM BOVINE PULMONARY-ARTERY Published In JOURNAL OF PHYSIOLOGY-LONDON
  1987	NEUROTRANSMITTER ACTION AND MODULATION OF A CALCIUM CONDUCTANCE IN RAT CULTURED PARASYMPATHETIC CARDIAC NEURONS Published In JOURNAL OF PHYSIOLOGY-LONDON
  1986	AGONIST EFFICACY AT THE MOTOR END-PLATE - IS AGONIST POTENCY RELATED TO CHANNEL OPEN TIME Published In BIOPHYSICAL JOURNAL
  1985	WHOLE CELLS AND SINGLE CHANNEL RECORDING FROM GUINEA-PIG CULTURED MYENTERIC NEURONS Published In BIOPHYSICAL JOURNAL
  1984	INTRACELLULAR NH4+ AND H+ IONS ANTAGONIZE BLOCK OF SODIUM-CHANNELS BY SAXITOXIN AND TETRODOTOXIN Published In BIOPHYSICAL JOURNAL
  1983	ACETYLCHOLINE-RECEPTORS IN CULTURED HUMAN MYOTUBES - DISTRIBUTION AND SINGLE-CHANNEL PROPERTIES Published In JOURNAL OF PHYSIOLOGY-LONDON
  1983	CHEMICAL MODIFICATION OF ENDPLATE CHANNELS IN FROG SKELETAL-MUSCLE Published In JOURNAL OF PHYSIOLOGY-LONDON
  1983	CURRENT RELAXATIONS WITH HIGH AGONIST CONCENTRATIONS - DO ACETYLCHOLINE AND SUBERYLDICHOLINE BLOCK ION CHANNELS IN FROG-MUSCLE Published In JOURNAL OF PHYSIOLOGY-LONDON
  1983	METABOLIC-INHIBITORS AND LITHIUM DEPRESS SYNAPTIC TRANSMISSION AT THE SQUID GIANT SYNAPSE Published In JOURNAL OF PHYSIOLOGY-LONDON
  1981	INTERNAL ANIONS MODULATE POTASSIUM CHANNEL GATING IN SQUID AXONS Published In BIOPHYSICAL JOURNAL
  1981	PERMEANT CATIONS ALTER K CHANNEL KINETICS AND PERMEABILITY Published In BIOPHYSICAL JOURNAL
  1980	CONDUCTANCE FLUCTUATION MEASUREMENTS WITH PERMEANT ORGANIC CATIONS AT THE ENDPLATE CHANNEL Published In FEDERATION PROCEEDINGS
  1979	IONIC SELECTIVITY OF ENDPLATE CHANNELS Published In BIOPHYSICAL JOURNAL

Collection Or Series Editor For

• The Journal of Physiology  (Journal) 2015 -
• Marine Drugs  (Journal) 2014 -
• The International Journal of Biochemistry and Cell Biology  (Journal) 2013 -
• Frontiers in Pharmacology  (Journal) 2010 -
• Channels  (Journal) 2006 -
• Neuropharmacology  (Journal) 2016 - 2017
• Pfluegers Archiv: European journal of physiology  (Journal) 2008 - 2011
• American Journal of Physiology: Heart and Circulatory Physiology  (Journal) 1991 - 1996

Investigator On

Year	Title
2021 - 2026	ARC Training Centre for Cryo-electron microscopy of membrane proteins for drug discovery - CCEMMP Awarded by: Australian Research Council (ARC) Funding Scheme: Industrial Transformation Training Centres
2015 - 2020	Nicotinic receptor structure and function probed with conotoxinx Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2018	Electrophysiology Facility for Cell Phenotyping and Drug Discovery Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2013 - 2016	Alpha-Conotoxin Inhibition of Chronic Visceral Pain Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2015	Ion channel modulators of pain pathways Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Program Grant
	Identifying novel gene mutations for molecular diagnosis of Familial Hemiplegic Migraine Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
	Inflammatory Pain - Control of Immune Cell Nicotinic Receptor Signaling by Conotoxins? Mechanisms and Screening Platforms Awarded by: Deutscher Akademischer Austausch Dienst (DAAD) Funding Scheme: Australia Germany Joint Cooperation Scheme
	Role of the intrinsic cardiac nervous system in myocardial ischaemia and arrhythmias Awarded by: NSW Health Funding Scheme: Cardiovascular Senior Researcher Grants

Other Research Activities

• National Computational Merit Allocation Scheme 2022 CI 2022 -
• NSW Cardiovascular Disease Senior Researcher Grant Chief Investigator 2020 - 2023
• Grünenthal GmbH Pharmaceutical Company - Development of peptide therapeutics Chief Investigator 2019 - 2021
• Australia (UA)-Germany (DAAD) Joint Research Cooperation Scheme Chief Investigator 2019 - 2020

Impact Story

Advisees

• Graduate Advising Relationship

  Degree	Research Title	Advisee
  Doctor of Philosophy	Conquering chronic pain: an investigation into the structural and functional effects of the a-conotoxin Vc1.1 on GABA(B) receptor mediated G-protein signalling.
  Doctor of Philosophy	Nicotinic acetylcholine receptor structure and function probed with venom derived peptides.	Bye, Lydia
  Doctor of Philosophy	Direct Piezoelectricity for 3D Cardiac Tissue Engineering and Remodelling	James, Emma

Professional Service Activities

• NSW Office for Health and Medical Research Cardiovascular Disease Research Advisory Committee 2018 - 2022
• Health Innovations Research Institute, RMIT University Director 2009 - 2015
• Multiple Sclerosis Research Australia (MSRA) Member of the Research Management Council 2007 - 2015
• National Health and Medical Research Council Assigners Academy 2012 - 2014
• The Australian Physiological Society President 2004 - 2010
• Queensland Brain Institute, University of Queensland Director, Neuroscience Program 2008 - 2009
• Australian Academy of Science National Committee for Biomedical Sciences 2003 - 2009
• The University of Queensland Head of School of Biomedical Sciences 2000 - 2007
• University of Queensland Head of Department of Physiology and Pharmacology 1998 - 2000

Education And Training

• Ph.D. in Physiology, School of Physiology & Pharmacology, An Analysis of Ionic Channels in Aplysia Nerve Cell Membrane. 1974 - 1978
• B Science (Hon) in Physiology, University of New South Wales 1970 - 1973
• University College of London (UCL) , Department of Pharmacology, Beit Memorial Fellowship for Medical Research, UK 1981 - 1983
• Marine Biological Laboratory, Woods Hole, MA, Grass Fellowship in Neurophysiology 1980
• University of Washington School of Medicine, Department of Physiology & Biophysics, Muscular Dystrophy Association of America Postdoctoral Fellowship 1978 - 1980

Awards And Honors

• Fellow of the Royal Society of New South Wales, 2021
• Fellow of the American Physiological Society (FAPS), conferred by American Physiological Society, 2020
• Fellow (FAHMS), conferred by Australian Academy of Health and Medical Sciences, 2020
• Fellow of The Physiological Society (FTPS), conferred by The Physiological Society, 2019
• NHMRC Ten of the Best Health & Medical Research Projects, conferred by NHMRC, 2011
• Finalist, Australian Museum Eureka Prize People’s Choice Award, conferred by Australian Museum Eureka Prizes, 2005
• Finalist, Royal Societies of Australia Eureka Prize for Interdisciplinary Scientific Research, conferred by Australian Museum Eureka Prizes, 2004
• Australian Professorial Fellowship, conferred by Austrlian Research Council (ARC), 2010 - 2015

Keywords

• Membrane physiology
  Neuropharmacology
  Cellular neuroscience
  Electrophysiology
  Ion channels
  Membrane biophysics

Full Name

• David John Adams

Mailing Address

• Illawarra Health & Medical Research Institute (IHMRI)

  University of Wollongong

  Wollongong

  NSW

  2522

  Australia

Geographic Location

• University of Wollongong 

Located In Facility

• Illawarra Health and Medical Research Institute  

Orcid Id

• http://orcid.org/0000-0002-7030-2288 (confirmed)

Web Of Science Researcher Id

• K-3578-2019

Scopus Id

• 57211178067

Top Publications

Year	Title
2022	Analgesic ��-conotoxins modulate native and recombinant GIRK1/2 channels via activation of GABAB receptors and reduce neuroexcitability Published in   British Journal of Pharmacology
2021	Trends in peptide drug discovery Published in   Nature Reviews Drug Discovery
2018	α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition Published in   British Journal of Pharmacology
2018	Structure-Activity Studies Reveal the Molecular Basis for GABA(B)-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1 Published in   ACS Chemical Biology
2017	Analgesic conopeptides targeting G protein-coupled receptors reduce excitability of sensory neurons Published in   Neuropharmacology
2017	α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors Published in   Gut
2016	Key structural determinants in the agonist binding loops of human β2 and β4 nicotinic acetylcholine receptor subunits contribute to α3β4 subtype selectivity of α-conotoxins Published in   Journal of Biological Chemistry
2015	Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABAB receptor Published in   Molecular Pharmacology
2014	Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation Published in   Journal of General Physiology
2013	Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor Published in   Journal of Medicinal Chemistry

Research Areas

• 1109 - NEUROSCIENCES
• 1115 - PHARMACOLOGY AND PHARMACEUTICAL SCIENCES
• 1116 - MEDICAL PHYSIOLOGY
• 1199 - OTHER MEDICAL AND HEALTH SCIENCES

Research Overview

• Prof Adams' research focuses on membrane receptors and ion channels and is currently funded by an NHMRC Program Grant and ARC Discovery Grants (2015-2019).  He is internationally recognised for his contributions to membrane physiology, in particular that of ion channel function and modulation using electrophysiological recording techniques. In the last 20 years, he has identified novel peptides (conotoxins) obtained from the venom of cone snails as probes for ion channel structure and function. This research has focused on investigating conotoxins that selectively target the voltage-gated sodium and calcium channels, nicotinic acetylcholine receptors, and G protein-coupled receptor modulation of calcium channels.

Head Of

• Illawarra Health and Medical Research Institute (IHMRI) CEO and Executive Director 2016 -

Member Of

• American Physiological Society Fellow (FAPS) 2020 -
• The Physiological Society Fellow (FTPS) 2019 -
• Australasian Neuroscience Society Member 1996 -
• Society for Neuroscience (USA) Member 1990 -
• Society for General Physiologists Member 1981 -
• Biophysical Society Member 1979 -
• The Australian Physiological Society Member 1977 -
• American Physiological Society Member 1993 - 2020
• The Physiological Society Member 1988 - 2019

Has Collaborator

• Dottori, Mirella  Associate Professor
• Ooi, Lezanne  Professor
• Yu, Haibo  Associate Professor
• van Oijen, Antoine M.  Distinguished Professor

Selected Publications

• Journal Article

  Year	Title
  2022	A 4/8 Subtype ��-Conotoxin Vt1.27 Inhibits N-Type Calcium Channels With Potent Anti-Allodynic Effect Published In Frontiers in Pharmacology
  2022	Analgesic ��-Conotoxin Binding Site on the Human GABAB Receptor Published In Molecular pharmacology
  2022	Analgesic ��-conotoxins modulate native and recombinant GIRK1/2 channels via activation of GABAB receptors and reduce neuroexcitability Published In British Journal of Pharmacology
  2022	Cysteine-Rich ��-Conotoxin SII Displays Novel Interactions at the Muscle Nicotinic Acetylcholine Receptor Published In ACS Chemical Neuroscience
  2022	Editorial: Sensory Abnormalities and Primary Sensory Neurons Published In Frontiers in Cellular Neuroscience
  2022	Glycinergic Modulation of Pain in Behavioral Animal Models Published In Frontiers in Pharmacology
  2022	Investigation of CACNA1I Cav3.3 Dysfunction in Hemiplegic Migraine Published In Frontiers in Molecular Neuroscience
  2022	Mechanism of Action and Structure-Activity Relationship of ��-Conotoxin Mr1.1 at the Human ��9��10 Nicotinic Acetylcholine Receptor Published In Journal of Medicinal Chemistry
  2022	Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider Published In Proceedings of the National Academy of Sciences of the United States of America
  2022	Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human ��3��4 Nicotinic Acetylcholine Receptor Published In Marine Drugs
  2022	µ-Theraphotoxin Pn3a inhibition of CaV3.3 channels reveals a novel isoform-selective drug binding site Published In eLife
  2022	��O-Conotoxin GeXIVA isomers modulate N-type calcium (CaV2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation Published In Journal of Neurochemistry
  2021	Alkyne-Bridged ��-Conotoxin Vc1.1 Potently Reverses Mechanical Allodynia in Neuropathic Pain Models Published In Journal of Medicinal Chemistry
  2021	Electrical properties and synaptic transmission in mouse intracardiac ganglion neurons in situ Published In Physiological Reports
  2021	Functional modulation of the human voltage-gated sodium channel NaV1.8 by auxiliary β subunits Published In Channels
  2021	Globular and ribbon isomers of Conus geographus α-conotoxins antagonize human nicotinic acetylcholine receptors Published In Biochemical Pharmacology
  2021	Medicinal chemistry, pharmacology, and therapeutic potential of ��-conotoxins antagonizing the ��9��10 nicotinic acetylcholine receptor Published In Pharmacology and Therapeutics
  2021	Spider Venom Peptide Pn3a Inhibition of Primary Afferent High Voltage-Activated Calcium Channels Published In Frontiers in Pharmacology
  2021	Trends in peptide drug discovery Published In Nature Reviews Drug Discovery
  2021	α-Conotoxin Bt1.8 from Conus betulinus selectively inhibits α6/α3β2β3 and α3β2 nicotinic acetylcholine receptor subtypes Published In Journal of Neurochemistry
  2020	(E)-3-Furan-2-yl- N- p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by ��7 Nicotinic Acetylcholine Receptor Potentiation Published In ACS Chemical Neuroscience
  2020	A method for high-content functional imaging of intracellular calcium responses in gelatin-immobilized non-adherent cells Published In Experimental Cell Research
  2020	An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides Published In Green Chemistry
  2020	Coronaridine congeners decrease neuropathic pain in mice and inhibit ��9��10 nicotinic acetylcholine receptors and CaV2.2 channels Published In Neuropharmacology
  2020	Dimerization of α-Conotoxins as a strategy to enhance the inhibition of the human α7 and α9α10 nicotinic acetylcholine receptors Published In Journal of Medicinal Chemistry
  2020	Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors Published In British Journal of Pharmacology
  2020	Interactions of the-3-2 Nicotinic Acetylcholine Receptor Interfaces with-Conotoxin LsIA and its Carboxylated C-terminus Analogue: Molecular Dynamics Simulations Published In Marine Drugs
  2020	Ketamine inhibits synaptic transmission and nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglia in situ Published In Neuropharmacology
  2020	Modulation of Native and Recombinant GIRK1/2 Channels by Analgesic alpha-conotoxins Published In BIOPHYSICAL JOURNAL
  2020	Molecular and Functional Characterization of Neurogenin-2 Induced Human Sensory Neurons Published In Frontiers in Cellular Neuroscience
  2020	N-acetyl-D-glucosamine-conjugated PAMAM dendrimers as dual receptor-targeting nanocarriers for anticancer drug delivery Published In European Journal of Pharmaceutics and Biopharmaceutics
  2020	On-resin strategy to label ��-Conotoxins: Cy5-RgIA, a Potent ��9��10 nicotinic acetylcholine receptor imaging probe Published In Australian Journal of Chemistry
  2020	Rational Design of α-Conotoxin RegIIA Analogues Selectively Inhibiting the Human α3β2 Nicotinic Acetylcholine Receptor through Computational Scanning Published In ACS Chemical Neuroscience
  2020	Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom Published In Biochemical Pharmacology
  2020	Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom Published In Biochemical Pharmacology
  2019	Analgesic transient receptor potential vanilloid-1-active compounds inhibit native and recombinant T-type calcium channels Published In British Journal of Pharmacology
  2019	BACKBONE CYCLIZATION OF ANALGESIC CONOTOXIN GEXIVA FACILITATES DIRECT FOLDING OF THE RIBBON ISOMER Published In TOXICON
  2019	Bombesin receptors as potential targets for anticancer drug delivery and imaging Published In The International Journal of Biochemistry and Cell Biology
  2019	DISSECTING THE NACHR-INHIBITING D-CONOTOXIN GEXXA Published In TOXICON
  2019	Drysdalin, an antagonist of nicotinic acetylcholine receptors highlights the importance of functional rather than structural conservation of amino acid residues Published In FASEB BioAdvances
  2019	High frequency repetitive transcranial magnetic stimulation for primary progressive apraxia of speech: A case series Published In Brain Stimulation
  2019	Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor Published In British Journal of Pharmacology
  2019	Monoclonal antibody-conjugated dendritic nanostructures for siRNA delivery Published In Methods in Molecular Biology
  2019	Opsoclonus-myoclonus-encephalopathy induced by cefepime Published In Journal of the Neurological Sciences
  2019	α-Conotoxin Vc1.1 structure-activity relationship at the human α9α10 nicotinic acetylcholine receptor investigated by minimal side chain replacement Published In ACS Chemical Neuroscience
  2018	A novel α-conopeptide Eu1.6 inhibits N-type (CaV2.2) calcium channels and exhibits potent analgesic activity Published In Scientific Reports
  2018	Contribution of membrane receptor signalling to chronic visceral pain Published In The International Journal of Biochemistry and Cell Biology
  2018	Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain Published In British Journal of Pharmacology
  2018	Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1 Published In British Journal of Pharmacology
  2018	Molecular Determinants Conferring the Stoichiometric-Dependent Activity of alpha-Conotoxins at the Human alpha 9 alpha 10 Nicotinic Acetylcholine Receptor Subtype Published In Journal of Medicinal Chemistry
  2018	NMR structure of µ-conotoxin GIIIC: Leucine 18 induces local repacking of the N-terminus resulting in reduced Nav channel potency Published In Molecules
  2018	Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides Published In Scientific Reports
  2018	Phase I Study of the Combination of Bendamustine, Rituximab, and Pixantrone in Patients With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma. Published In Clinical lymphoma, myeloma & leukemia
  2018	Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB Published In Biochemical Pharmacology
  2018	Structure-Activity Studies Reveal the Molecular Basis for GABA(B)-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1 Published In ACS Chemical Biology
  2018	Targeting of N-Type Calcium Channels via GABAB-Receptor Activation by α-Conotoxin Vc1.1 Variants Displaying Improved Analgesic Activity Published In Journal of Medicinal Chemistry
  2018	α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition Published In British Journal of Pharmacology
  2017	A novel lid-covering peptide inhibitor of nicotinic acetylcholine receptors derived from αd-conotoxin GeXXA Published In Marine Drugs
  2017	Analgesic conopeptides targeting G protein-coupled receptors reduce excitability of sensory neurons Published In Neuropharmacology
  2017	Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer Published In Journal of Biological Chemistry
  2017	Identification of a novel O-conotoxin reveals an unusual and potent inhibitor of the human α9α10 nicotinic acetylcholine receptor Published In Marine Drugs
  2017	In vivo and in vitro testing of native α-conotoxins from the injected venom of Conus purpurascens Published In Neuropharmacology
  2017	Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors Published In Scientific Reports
  2017	Intracranial hypotension: diagnosis by trial of Trendelenburg positioning and imaging Published In Internal and Emergency Medicine
  2017	Neuropharmacology of venom peptides Published In Neuropharmacology
  2017	Neurovascular uncoupling after rapid glycemic control as a trigger of the diabetic-uremic striatopallidal syndrome Published In Parkinsonism and Related Disorders
  2017	Peptide grafted and self-assembled poly(γ-glutamic acid)-phenylalanine nanoparticles targeting camptothecin to glioma Published In Nanomedicine
  2017	Role of Cys(I)-Cys(III) Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors Published In ACS Omega
  2017	The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity Published In Scientific Reports
  2017	α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors Published In Gut
  2016	Comments on Broca's 1861 case of aphasia Published In Annals of Neurology
  2016	Cyclic RGDfK Peptide Functionalized Polymeric Nanocarriers for Targeting Gemcitabine to Ovarian Cancer Cells Published In Molecular Pharmaceutics
  2016	Effects of linker sequence modifications on the structure, stability, and biological activity of a cyclic α-conotoxin Published In Biopolymers
  2016	Episodic Aphasia Associated With Cortical Spreading Depression After Subdural Hemorrhage Evacuation Published In The Neurohospitalist
  2016	Formulation and dosage of therapeutic nanosuspension for active targeting of docetaxel (WO 2014210485A1) Published In Expert Opinion on Therapeutic Patents
  2016	Improving efficacy, oral bioavailability, and delivery of paclitaxel using protein-grafted solid lipid nanoparticles Published In Molecular Pharmaceutics
  2016	Key structural determinants in the agonist binding loops of human β2 and β4 nicotinic acetylcholine receptor subunits contribute to α3β4 subtype selectivity of α-conotoxins Published In Journal of Biological Chemistry
  2016	Mechanism of direct Cav2.2 channel block by the κ-opioid receptor agonist U50488H Published In Neuropharmacology
  2016	Modulation of human Na(v)1.7 channel gating by synthetic α-scorpion toxin OD1 and its analogs Published In Channels
  2016	Store-operated Ca2+ entry (SOCE) and purinergic receptor-mediated Ca2+ homeostasis in murine bv2 microglia cells: Early cellular responses to ATP-mediated microglia activation Published In Frontiers in Molecular Neuroscience
  2016	Structure-activity studies of cysteine-rich α-Conotoxins that inhibit high voltage-activated calcium channels via GABAB receptor activation reveal a minimal functional motif Published In Angewandte Chemie International Edition
  2016	Structure–Activity Studies of Cysteine‐Rich α‐Conotoxins that Inhibit High‐Voltage‐Activated Calcium Channels via GABAB Receptor Activation Reveal a Minimal Functional Motif Published In Angewandte Chemie
  2016	Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer Published In Scientific Reports
  2016	Voltage-Gated R-Type Calcium Channel Inhibition via Human ��-, ��-, and ��-opioid Receptors Is Voltage-Independently Mediated by Gbg Protein Subunits Published In Molecular Pharmacology
  2015	Alanine scan ofα-conotoxin regiia reveals a selective α3α4 nicotinic acetylcholine receptor antagonist Published In Journal of Biological Chemistry
  2015	Biomedical applications of trastuzumab: as a therapeutic agent and a targeting ligand Published In Medicinal Research Reviews
  2015	Bombesin-conjugated nanoparticles improve the cytotoxic efficacy of docetaxel against gastrin-releasing but androgen-independent prostate cancer Published In Nanomedicine
  2015	Conotoxin αd-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors Published In Scientific Reports
  2015	Cyclic-RGDfK peptide conjugated succinoyl-TPGS nanomicelles for targeted delivery of docetaxel to integrin receptor over-expressing angiogenic tumours Published In Nanomedicine: Nanotechnology, Biology and Medicine
  2015	Distinct functional site in Ω-neurotoxins: novel antagonists of nicotinic acetylcholine receptors from snake venom Published In ACS Chemical Biology
  2015	Inhibition of cholinergic pathways in Drosophila melanogaster by α-conotoxins Published In The FASEB Journal
  2015	Less is more: design of a highly stable disulfide-deleted mutant of analgesic cyclic α-conotoxin Vc1.1 Published In Scientific Reports
  2015	Molecular basis for differential sensitivity of α-conotoxin RegIIA at rat and human neuronal nicotinic acetylcholine receptors Published In Molecular Pharmacology
  2015	Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABAB receptor Published In Molecular Pharmacology
  2015	Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins Published In Biopolymers
  2015	α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors Published In Journal of the American Chemical Society
  2014	888 α-Conotoxin Vc1.1 Targets GABAB Receptors Modulating CaV2.2 and CaV2.3 Calcium Channels in Sensory Pathways Mediating Chronic Visceral Pain Published In Gastroenterology
  2014	Dasatinib (BMS-35482) interacts synergistically with docetaxel, gemcitabine, topotecan, and doxorubicin in ovarian cancer cells with high SRC pathway activation and protein expression. Published In International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  2014	Dasatinib (BMS-35482) potentiates the activity of gemcitabine and docetaxel in uterine leiomyosarcoma cell lines. Published In Gynecologic oncology research and practice
  2014	Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets Published In Journal of Medicinal Chemistry
  2014	Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation Published In Journal of General Physiology
  2014	Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels Published In British Journal of Pharmacology
  2014	Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors Published In Biochemical Pharmacology
  2014	Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels Published In Biochemical Pharmacology
  2014	Low-dose acetazolamide reverses periventricular white matter hyperintensities in iNPH Published In Neurology
  2014	Use of SRC pathway activation in predicting dasatinib activity in ovarian cancer Published In Gynecologic Oncology
  2013	Abstract 4479: Preclinical toxicology and pharmacology for BACPTDP, a camptothecin that targets hypoxic/acidic tumors. Published In Cancer Research
  2013	Actions of ��-conotoxins on neuronal nicotinic acetylcholine receptors and synaptic transmission in rat parasympathetic ganglia Published In Autonomic Neuroscience
  2013	Are nicotinic acetylcholine receptors coupled to G proteins? Published In BioEssays
  2013	Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1 Published In ACS Chemical Biology
  2013	Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor Published In Journal of Medicinal Chemistry
  2013	Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors Published In ACS Chemical Biology
  2013	Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors Published In Journal of Biological Chemistry
  2013	Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors Published In Biochemical Pharmacology
  2013	Kv3.1 channels stimulate adult neural precursor cell proliferation and neuronal differentiation Published In The Journal of Physiology
  2013	MRI evidence of impaired CSF homeostasis in obesity-associated idiopathic intracranial hypertension Published In American Journal of Neuroradiology
  2013	Mechanisms of conotoxin inhibition of N-type (Cav2.2) calcium channels Published In BBA: Biomembranes
  2012	Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels Published In British Journal of Pharmacology
  2012	Biophysical properties of Nav1.8/Nav1.2 chimeras and inhibition by μo-conotoxin MrVIB Published In British Journal of Pharmacology
  2012	Clippers complicating multiple sclerosis causing concerns of CNS lymphoma Published In Neurology
  2012	Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics? Published In Toxins
  2012	Dasatinib (BMS-35482) potentiates the activity of gemcitabine and docetaxel in leiomyosarcoma cell lines Published In Gynecologic Oncology
  2012	Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain Published In Neuropharmacology
  2012	Isolation, characterization and total regioselective synthesis of the novel μo-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels Published In Biochemical Pharmacology
  2012	Localization of Nav 1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function Published In Channels
  2012	RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs Published In Biochemical Pharmacology
  2012	The Valley of Death in anticancer drug development: a reassessment. Published In Trends in pharmacological sciences
  2012	γ-Aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic α-conotoxins Published In Journal of Biological Chemistry
  2011	A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain Published In Pain
  2011	Analgesic ω-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels (Molecular Pharmacology (2010) 77, (139-148)) Published In Molecular Pharmacology
  2011	BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors. Published In Cancer chemotherapy and pharmacology
  2011	Dasatinib (BMS-35482) has synergistic activity with paclitaxel and carboplatin in ovarian cancer cells. Published In Gynecologic oncology
  2011	Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABAB receptor Published In Journal of Medicinal Chemistry
  2011	Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function? Published In Journal of Biological Chemistry
  2011	JC virus granule cell neuronopathy and hyper-IgE in HIV disease Published In Neurology
  2011	Purification of immature neuronal cells from neural stem cell progeny Published In PLoS One
  2011	Regulation of voltage-gated ion channels in excitable cells by the ubiquitin ligases Nedd4 and Nedd4-2 Published In Channels
  2011	Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization Published In Antioxidants and Redox Signaling
  2011	Structure and activity of α-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABAB receptor-coupled N-type calcium channels Published In Journal of Biological Chemistry
  2011	Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine���Assisted Folding Published In Angewandte Chemie
  2011	Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding Published In Angewandte Chemie International Edition
  2011	Tumor physiology and charge dynamics of anticancer drugs: implications for camptothecin-based drug development. Published In Current medicinal chemistry
  2010	Analgesic alpha-conotoxins Vc1.1 and RgIA inhibit N-type calcium channels in sensory neurons of alpha9 nicotinic receptor knockout mice. Published In Channels (Austin, Tex.)
  2010	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout mice Published In Channels
  2010	Analgesic ω-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels Published In Molecular Pharmacology
  2010	Dolichoectasia and multifocal simultaneous intracranial haemorrhages Published In BMJ Case Reports
  2010	Innentitelbild: The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain (Angew. Chem. 37/2010) Published In Angewandte Chemie
  2010	Inside Cover: The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain (Angew. Chem. Int. Ed. 37/2010) Published In Angewandte Chemie International Edition
  2010	Physiological roles of ion channels in adult neural stem cells and their progeny Published In Journal of Neurochemistry
  2010	Solving the α-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antaqonists Published In Journal of the American Chemical Society
  2010	The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain Published In Angewandte Chemie
  2010	The engineering of an orally active conotoxin for the treatment of neuropathic pain Published In Angewandte Chemie International Edition
  2010	α-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of α3β4 nicotinic acetylcholine receptors Published In Journal of Biological Chemistry
  2009	Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3 Published In Toxicon
  2009	Inhibition of neuronal nicotinic acetylcholine receptor subtypes by α-conotoxin GID and analogues Published In Journal of Biological Chemistry
  2009	P129 A pilot study of decitabine in combination with arsenic trioxide for patients with myelodysplastic syndromes Published In Leukemia Research
  2009	P134 A phase II pilot study of sorafenib in patients with myelodysplastic syndromes Published In Leukemia Research
  2009	Reactive oxygen species modulate neuronal excitability in rat intrinsic cardiac ganglia Published In Autonomic Neuroscience: Basic and Clinical
  2009	Scanning mutagenesis of α-conotoxin Vc1.1 reveals residues crucial for activity at the α9α10 nicotinic acetylcholine receptor Published In Journal of Biological Chemistry
  2008	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation Published In The Journal of Neuroscience
  2008	Anti proliferative activity of ELACY (CP-4055) in combination with cloretazine (VNP40101M), idarubicin, gemcitabine, irinotecan and topotecan in human leukemia and lymphoma cells. Published In Leukemia & lymphoma
  2008	Conotoxin modulation of voltage-gated sodium channels Published In The International Journal of Biochemistry and Cell Biology
  2008	Kir and Kv channels regulate electrical properties and proliferation of adult neural precursor cells Published In Molecular and Cellular Neuroscience
  2008	Molecular engineering of conotoxins: The importance of loop size to α-conotoxin structure and function Published In Journal of Medicinal Chemistry
  2008	Neuronally selective μ-conotoxins from Conus striatus utilize an α-helical motif to target mammalian sodium channels Published In Journal of Biological Chemistry
  2008	Phase I evaluation of gemcitabine, mitoxantrone, and their effect on plasma disposition of fludarabine in patients with relapsed or refractory acute myeloid leukemia. Published In Leukemia & lymphoma
  2008	Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1 Published In American Journal of Physiology: Cell Physiology
  2008	The three-dimensional structure of the analgesic α-conotoxin, RgIA Published In FEBS Letters
  2008	ω-Conotoxin inhibition of excitatory synaptic transmission evoked by dorsal root stimulation in rat superficial dorsal horn Published In Neuropharmacology
  2007	Are α9α10 nicotinic acetylcholine receptors a pain target for α-conotoxins? Published In Molecular Pharmacology
  2007	Chemical modification of conotoxins to improve stability and activity Published In ACS Chemical Biology
  2007	Distinct activities of novel neurotoxins from Australian venomous snakes for nicotinic acetylcholine receptors Published In Cellular and Molecular Life Sciences
  2007	Isolation and structure-activity of μ-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels Published In Molecular Pharmacology
  2007	Liposome reconstitution and modulation of recombinant N-methyl-D-aspartate receptor channels by membrane stretch Published In Proceedings of the National Academy of Sciences of USA
  2007	NEDD4-2 as a potential candidate susceptibility gene for epileptic photosensitivity Published In Genes, Brain and Behavior
  2007	Polymodal regulation of NMDA receptor channels Published In Channels
  2007	Purinergic receptor activation inhibits mitogen-stimulated proliferation in primary neurospheres from the adult mouse subventricular zone Published In Molecular and Cellular Neuroscience
  2007	Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by ubiquitination: novel role for Nedd4-2 Published In Journal of Biological Chemistry
  2007	Sarcoid meningitis with fulminant delirium and markedly abnormal cerebrospinal fluid Published In Archives of Neurology
  2007	Structure of α-conotoxin BuIA: influences of disulfide connectivity on structural dynamics Published In BMC Structural Biology
  2007	The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells Published In The Journal of Neuroscience
  2007	ω-Conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels Published In European Journal of Neuroscience
  2006	Antiproliferative Activity of ELACYT¿ (CP-4055) in Combination with Cloretazine (VNP40101M), Idarubicin or Gemcitabine in HL-60 Human Myeloid Leukemia Cells. Published In Blood
  2006	Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tumor pH gradient. Published In Cancer chemotherapy and pharmacology