Adams, David J..

Overview

David J. Adams is currently Distinguished Professor and Executive Director of the Illawarra Health & Medical Research Institute (IHMRI) at the University of Wollongong. He is a Fellow of the Australian Academy of Health and Medical Sciences (FAHMS), the American Physiological Society (FAPS) and The Physiological Society UK (FTPS). He was previously Professor and Director of the Health Innovations Research Institute, RMIT University and an ARC Australian Professorial Fellow (2010-2015) and during the period 04/2013-02/2014 he was Acting Deputy Vice-Chancellor (Research & Innovation) and Vice-President, RMIT University. He was Professor and Chair of Physiology at the University of Queensland (UQ), Head of Department of Physiology & Pharmacology (1997-2000), Head of the School of Biomedical Sciences (2000-2007) and Professorial Research Fellow and Director of UQ Neuroscience Program, Queensland Brain Institute (2008-2009).

Top Publications

Year	Title
2008	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation Published in The Journal of Neuroscience
2017	α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA_B receptors Published in Gut
2012	Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels Published in British Journal of Pharmacology
2014	Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation Published in Journal of General Physiology
2016	Key structural determinants in the agonist binding loops of human β2 and β4 nicotinic acetylcholine receptor subunits contribute to α3β4 subtype selectivity of α-conotoxins Published in Journal of Biological Chemistry
2015	Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABAB receptor Published in Molecular Pharmacology
2013	Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor Published in Journal of Medicinal Chemistry
2013	Are nicotinic acetylcholine receptors coupled to G proteins? Published in BioEssays
2018	α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition Published in British Journal of Pharmacology
2006	μO-conotoxin MrVIB selectively blocks NaV1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits Published in Proceedings of the National Academy of Sciences of USA
2018	Structure-Activity Studies Reveal the Molecular Basis for GABA(B)-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1 Published in ACS Chemical Biology
2020	Ketamine inhibits synaptic transmission and nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglia in situ Published in Neuropharmacology

Research Areas

Research Overview

Prof Adams' research focuses on membrane receptors and ion channels and is currently funded by an NHMRC Program Grant and ARC Discovery Grants (2015-2019). He is internationally recognised for his contributions to membrane physiology, in particular that of ion channel function and modulation using electrophysiological recording techniques. In the last 20 years, he has identified novel peptides (conotoxins) obtained from the venom of cone snails as probes for ion channel structure and function. This research has focused on investigating conotoxins that selectively target the voltage-gated sodium and calcium channels, nicotinic acetylcholine receptors, and G protein-coupled receptor modulation of calcium channels.

Available for Collaborative Projects

Head Of

Illawarra Health and Medical Research Institute (IHMRI) CEO and Executive Director 2016 -

Member Of

American Physiological Society Fellow (FAPS) 2020 -
The Physiological Society Fellow (FTPS) 2019 -
Australasian Neuroscience Society Member 1996 -
Society for Neuroscience (USA) Member 1990 -
Society for General Physiologists Member 1981 -
Biophysical Society Member 1979 -
The Australian Physiological Society Member 1977 -
American Physiological Society Member 1993 - 2020
The Physiological Society Member 1988 - 2019

Has Collaborator

Dottori, Mirella Associate Professor
Ooi, Lezanne Associate Professor
Yu, Haibo Associate Professor
van Oijen, Antoine M. Distinguished Professor

Selected Publications

Journal Article

Year	Title
2020	(E)-3-Furan-2-yl-N-p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation Published In ACS Chemical Neuroscience
2020	An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides Published In Green Chemistry
2020	Dimerization of α-Conotoxins as a strategy to enhance the inhibition of the human α7 and α9α10 nicotinic acetylcholine receptors Published In Journal of Medicinal Chemistry
2020	Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors Published In British Journal of Pharmacology
2020	Interactions of the α3β2 Nicotinic Acetylcholine Receptor Interfaces with α-Conotoxin LsIA and its Carboxylated C-terminus Analogue: Molecular Dynamics Simulations Published In Marine Drugs
2020	Ketamine inhibits synaptic transmission and nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglia in situ Published In Neuropharmacology
2020	N-acetyl-D-glucosamine-conjugated PAMAM dendrimers as dual receptor-targeting nanocarriers for anticancer drug delivery Published In European Journal of Pharmaceutics and Biopharmaceutics
2020	On-Resin Strategy to Label α-Conotoxins: Cy5-RgIA, a Potent α9α10 Nicotinic Acetylcholine Receptor Imaging Probe Published In Australian Journal of Chemistry
2020	Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom Published In Biochemical Pharmacology
2019	Bombesin receptors as potential targets for anticancer drug delivery and imaging Published In The International Journal of Biochemistry and Cell Biology
2019	Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor Published In British Journal of Pharmacology
2019	Monoclonal antibody-conjugated dendritic nanostructures for siRNA delivery Published In Methods in Molecular Biology
2019	α-Conotoxin Vc1.1 structure-activity relationship at the human α9α10 nicotinic acetylcholine receptor investigated by minimal side chain replacement Published In ACS Chemical Neuroscience
2018	A novel α-conopeptide Eu1.6 inhibits N-type (CaV2.2) calcium channels and exhibits potent analgesic activity Published In Scientific Reports
2018	Contribution of membrane receptor signalling to chronic visceral pain Published In The International Journal of Biochemistry and Cell Biology
2018	Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain Published In British Journal of Pharmacology
2018	Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1 Published In British Journal of Pharmacology
2018	Molecular Determinants Conferring the Stoichiometric-Dependent Activity of alpha-Conotoxins at the Human alpha 9 alpha 10 Nicotinic Acetylcholine Receptor Subtype Published In Journal of Medicinal Chemistry
2018	NMR structure of µ-conotoxin GIIIC: Leucine 18 induces local repacking of the N-terminus resulting in reduced Nav channel potency Published In Molecules
2018	Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides Published In Scientific Reports
2018	Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB Published In Biochemical Pharmacology
2018	Structure-Activity Studies Reveal the Molecular Basis for GABA(B)-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1 Published In ACS Chemical Biology
2018	Targeting of N-Type Calcium Channels via GABAB-Receptor Activation by α-Conotoxin Vc1.1 Variants Displaying Improved Analgesic Activity Published In Journal of Medicinal Chemistry
2018	α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition Published In British Journal of Pharmacology
2017	A novel lid-covering peptide inhibitor of nicotinic acetylcholine receptors derived from αd-conotoxin GeXXA Published In Marine Drugs
2017	Analgesic conopeptides targeting G protein-coupled receptors reduce excitability of sensory neurons Published In Neuropharmacology
2017	Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer Published In Journal of Biological Chemistry
2017	Identification of a novel O-conotoxin reveals an unusual and potent inhibitor of the human α9α10 nicotinic acetylcholine receptor Published In Marine Drugs
2017	In vivo and in vitro testing of native α-conotoxins from the injected venom of Conus purpurascens Published In Neuropharmacology
2017	Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors Published In Scientific Reports
2017	Neuropharmacology of venom peptides Published In Neuropharmacology
2017	Peptide grafted and self-assembled poly(γ-glutamic acid)-phenylalanine nanoparticles targeting camptothecin to glioma Published In Nanomedicine
2017	Role of Cys(I)-Cys(III) Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors Published In ACS Omega
2017	The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity Published In Scientific Reports
2017	α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA_B receptors Published In Gut
2016	Effects of linker sequence modifications on the structure, stability, and biological activity of a cyclic α-conotoxin Published In Biopolymers
2016	Improving efficacy, oral bioavailability, and delivery of paclitaxel using protein-grafted solid lipid nanoparticles Published In Molecular Pharmaceutics
2016	Key structural determinants in the agonist binding loops of human β2 and β4 nicotinic acetylcholine receptor subunits contribute to α3β4 subtype selectivity of α-conotoxins Published In Journal of Biological Chemistry
2016	Mechanism of direct Ca_v2.2 channel block by the κ-opioid receptor agonist U50488H Published In Neuropharmacology
2016	Modulation of human Na(v)1.7 channel gating by synthetic α-scorpion toxin OD1 and its analogs Published In Channels
2016	Structure-activity studies of cysteine-rich α-Conotoxins that inhibit high voltage-activated calcium channels via GABA_B receptor activation reveal a minimal functional motif Published In Angewandte Chemie International Edition
2016	Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer Published In Scientific Reports
2015	Alanine scan ofα-conotoxin regiia reveals a selective α3α4 nicotinic acetylcholine receptor antagonist Published In Journal of Biological Chemistry
2015	Biomedical applications of trastuzumab: as a therapeutic agent and a targeting ligand Published In Medicinal Research Reviews
2015	Bombesin-conjugated nanoparticles improve the cytotoxic efficacy of docetaxel against gastrin-releasing but androgen-independent prostate cancer Published In Nanomedicine
2015	Conotoxin αd-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors Published In Scientific Reports
2015	Cyclic-RGDfK peptide conjugated succinoyl-TPGS nanomicelles for targeted delivery of docetaxel to integrin receptor over-expressing angiogenic tumours Published In Nanomedicine: Nanotechnology, Biology and Medicine
2015	Distinct functional site in Ω-neurotoxins: novel antagonists of nicotinic acetylcholine receptors from snake venom Published In ACS Chemical Biology
2015	Inhibition of cholinergic pathways in Drosophila melanogaster by α-conotoxins Published In The FASEB Journal
2015	Less is more: design of a highly stable disulfide-deleted mutant of analgesic cyclic α-conotoxin Vc1.1 Published In Scientific Reports
2015	Molecular basis for differential sensitivity of α-conotoxin RegIIA at rat and human neuronal nicotinic acetylcholine receptors Published In Molecular Pharmacology
2015	Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABAB receptor Published In Molecular Pharmacology
2015	α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors Published In Journal of the American Chemical Society
2014	Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets Published In Journal of Medicinal Chemistry
2014	Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation Published In Journal of General Physiology
2014	Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels Published In British Journal of Pharmacology
2014	Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors Published In Biochemical Pharmacology
2014	Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels Published In Biochemical Pharmacology
2013	Are nicotinic acetylcholine receptors coupled to G proteins? Published In BioEssays
2013	Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1 Published In ACS Chemical Biology
2013	Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor Published In Journal of Medicinal Chemistry
2013	Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors Published In ACS Chemical Biology
2013	Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors Published In Journal of Biological Chemistry
2013	Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors Published In Biochemical Pharmacology
2013	Kv3.1 channels stimulate adult neural precursor cell proliferation and neuronal differentiation Published In The Journal of Physiology
2013	Mechanisms of conotoxin inhibition of N-type (Cav2.2) calcium channels Published In BBA: Biomembranes
2012	Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels Published In British Journal of Pharmacology
2012	Biophysical properties of Nav1.8/Nav1.2 chimeras and inhibition by μo-conotoxin MrVIB Published In British Journal of Pharmacology
2012	Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics? Published In Toxins
2012	Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain Published In Neuropharmacology
2012	Isolation, characterization and total regioselective synthesis of the novel μo-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels Published In Biochemical Pharmacology
2012	Localization of Nav 1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function Published In Channels
2012	RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs Published In Biochemical Pharmacology
2012	γ-Aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic α-conotoxins Published In Journal of Biological Chemistry
2011	A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain Published In Pain
2011	Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABAB receptor Published In Journal of Medicinal Chemistry
2011	Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function? Published In Journal of Biological Chemistry
2011	Purification of immature neuronal cells from neural stem cell progeny Published In PLoS One
2011	Regulation of voltage-gated ion channels in excitable cells by the ubiquitin ligases Nedd4 and Nedd4-2 Published In Channels
2011	Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization Published In Antioxidants and Redox Signaling
2011	Structure and activity of α-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABAB receptor-coupled N-type calcium channels Published In Journal of Biological Chemistry
2011	Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding Published In Angewandte Chemie International Edition
2010	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout mice Published In Channels
2010	Analgesic ω-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels Published In Molecular Pharmacology
2010	Physiological roles of ion channels in adult neural stem cells and their progeny Published In Journal of Neurochemistry
2010	Solving the α-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antaqonists Published In Journal of the American Chemical Society
2010	The engineering of an orally active conotoxin for the treatment of neuropathic pain Published In Angewandte Chemie International Edition
2010	α-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of α3β4 nicotinic acetylcholine receptors Published In Journal of Biological Chemistry
2009	Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3 Published In Toxicon
2009	Inhibition of neuronal nicotinic acetylcholine receptor subtypes by α-conotoxin GID and analogues Published In Journal of Biological Chemistry
2009	Reactive oxygen species modulate neuronal excitability in rat intrinsic cardiac ganglia Published In Autonomic Neuroscience: Basic and Clinical
2009	Scanning mutagenesis of α-conotoxin Vc1.1 reveals residues crucial for activity at the α9α10 nicotinic acetylcholine receptor Published In Journal of Biological Chemistry
2008	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation Published In The Journal of Neuroscience
2008	Conotoxin modulation of voltage-gated sodium channels Published In The International Journal of Biochemistry and Cell Biology
2008	Kir and Kv channels regulate electrical properties and proliferation of adult neural precursor cells Published In Molecular and Cellular Neuroscience
2008	Molecular engineering of conotoxins: The importance of loop size to α-conotoxin structure and function Published In Journal of Medicinal Chemistry
2008	Neuronally selective μ-conotoxins from Conus striatus utilize an α-helical motif to target mammalian sodium channels Published In Journal of Biological Chemistry
2008	Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1 Published In American Journal of Physiology: Cell Physiology
2008	The three-dimensional structure of the analgesic α-conotoxin, RgIA Published In FEBS Letters
2008	ω-Conotoxin inhibition of excitatory synaptic transmission evoked by dorsal root stimulation in rat superficial dorsal horn Published In Neuropharmacology
2007	Are α9α10 nicotinic acetylcholine receptors a pain target for α-conotoxins? Published In Molecular Pharmacology
2007	Chemical modification of conotoxins to improve stability and activity Published In ACS Chemical Biology
2007	Distinct activities of novel neurotoxins from Australian venomous snakes for nicotinic acetylcholine receptors Published In Cellular and Molecular Life Sciences
2007	Isolation and structure-activity of μ-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels Published In Molecular Pharmacology
2007	Liposome reconstitution and modulation of recombinant N-methyl-D-aspartate receptor channels by membrane stretch Published In Proceedings of the National Academy of Sciences of USA
2007	NEDD4-2 as a potential candidate susceptibility gene for epileptic photosensitivity Published In Genes, Brain and Behavior
2007	Polymodal regulation of NMDA receptor channels Published In Channels
2007	Purinergic receptor activation inhibits mitogen-stimulated proliferation in primary neurospheres from the adult mouse subventricular zone Published In Molecular and Cellular Neuroscience
2007	Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by ubiquitination: novel role for Nedd4-2 Published In Journal of Biological Chemistry
2007	Structure of α-conotoxin BuIA: influences of disulfide connectivity on structural dynamics Published In BMC Structural Biology
2007	The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells Published In The Journal of Neuroscience
2007	ω-Conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels Published In European Journal of Neuroscience
2006	Identification of a novel class of nicotinic receptor antagonists: dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum Published In Journal of Biological Chemistry
2006	Mutations within the selectivity filter of the NMDA receptor-channel influence voltage dependent block by 5-hydroxytryptamine Published In British Journal of Pharmacology
2006	NMDA receptor subunit-dependent modulation by conantokin-G and Ala(7)-conantokin-G Published In Journal of Neurochemistry
2006	Neuronal voltage-gated sodium channel subtypes: key roles in inflammatory and neuropathic pain Published In The International Journal of Biochemistry and Cell Biology
2006	The synthesis, structural characterization, and receptor specificity of the α-conotoxin Vc1.1 Published In Journal of Biological Chemistry
2006	α-Selenoconotoxins, a new class of potent α7 neuronal nicotinic receptor antagonists Published In Journal of Biological Chemistry
2006	μO-conotoxin MrVIB selectively blocks NaV1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits Published In Proceedings of the National Academy of Sciences of USA
2005	Developmental changes in expression of GABAA receptor-channels in rat intrinsic cardiac ganglion neurones Published In The Journal of Physiology
2005	Engineering stable peptide toxins by means of backbone cyclization: stabilization of the α-conotoxin MII Published In Proceedings of the National Academy of Sciences of USA
2005	Intravenous anaesthetics inhibit nicotinic acetylcholine receptor-mediated currents and Ca²⁺ transients in rat intracardiac ganglion neurons Published In British Journal of Pharmacology
2005	Selective modulation of neuronal nicotinic acetylcholine receptor channel subunits by Go-protein subunits Published In The Journal of Neuroscience
2005	Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner Published In Journal of Pharmacology and Experimental Therapeutics
2005	Voltage-dependent inhibition of recombinant NMDA receptor-mediated currents by 5-hydroxytryptamine Published In British Journal of Pharmacology
2004	Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors Published In Molecular Pharmacology
2004	Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells Published In European Journal of Neuroscience
2004	Chemical and functional identification and characterization of novel sulfated α-conotoxins from the cone snail Conus anemone Published In Journal of Medicinal Chemistry
2004	Expression and function of neuronal nicotinic ACh receptors in rat microvascular endothelial cells Published In American Journal of Physiology: Heart and Circulatory Physiology
2004	Functional maturation of isolated neural progenitor cells from the adult rat hippocampus Published In European Journal of Neuroscience
2004	Overexpressed Cavβ3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of "ultra-slow"^^ and "closed-state"^^ inactivation Published In Journal of General Physiology
2004	Potassium channels and membrane potential in the modulation of intracellular calcium in vascular endothelial cells Published In Journal of Cardiovascular Electrophysiology
2004	Regulation of neuronal voltage-gated sodium channels by the ubiquitin protein ligases Nedd4 and Nedd4-2 Published In Journal of Biological Chemistry
2004	Structures of μO-conotoxins from Conus marmoreus: Inhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons Published In Journal of Biological Chemistry
2004	The α₂δ auxiliary subunit reduces affinity of ω-conotoxins for recombinant N-type (Ca_v2.2) calcium channels Published In Journal of Biological Chemistry
2003	Allosteric α1-adrenoreceptor antagonism by the conopeptide ρ-TIA Published In Journal of Biological Chemistry
2003	Inhibition of the norepinephrine transporter by the venom peptide χ-MrIA: site of action, Na+ dependence, and structure-activity relationship Published In Journal of Biological Chemistry
2003	Isolation, structure, and activity of GID, a novel α4/7-conotoxin with an extended N-terminal sequence Published In Journal of Biological Chemistry
2003	Muscarinic and nicotinic ACh receptor activation differentially mobilize Ca2+ in rat intracardiac ganglion neurons Published In Journal of Neurophysiology
2003	Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of α-conotoxin MII Published In Journal of Medicinal Chemistry
2003	α-conotoxins PnIA and [A10L]PnIA stabilize different states of the α7-L247T nicotinic acetylcholine receptor Published In Journal of Biological Chemistry
2003	ω-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals Published In Journal of Biological Chemistry
2002	A new level of conotoxin diversity, a non-native disulfide bond connectivity in α-conotoxin AuIB reduces structural definition but increases biological activity Published In Journal of Biological Chemistry
2002	Basal nonselective cation permeability in rat cardiac microvascular endothelial cells Published In Microvascular Research
2002	Ciguatoxin-induced oscillations in membrane potential and action potential firing in rat parasympathetic neurons Published In European Journal of Neuroscience
2002	Neural control of the heart: developmental changes in ionic conductances in mammalian intrinsic cardiac neurons Published In Autonomic Neuroscience: Basic and Clinical
2002	Solution structure of μ-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels Published In Journal of Biological Chemistry
2001	An ATP-sensitive K+ conductance in dissociated neurones from adult rat intracardiac ganglia Published In The Journal of Physiology
2001	Developmental changes in hyperpolarization-activated currents Ih and IK(IR) in isolated rat intracardiac neurons Published In Journal of Neurophysiology
2001	Ionic selectivity of native ATP-activated (P2X) receptor channels in dissociated neurones from rat parasympathetic ganglia Published In The Journal of Physiology
2001	Large-conductance calcium-activated potassium channels in neonatal rat intracardiac ganglion neurons Published In Pfluegers Archiv: European journal of physiology
2001	Pre- and postsynaptic actions of ATP on neurotransmission in rat submandibular ganglia Published In Neuroscience
2001	The synthesis and structure of an n-terminal dodecanoic acid conjugate of α-conotoxin MII Published In International Journal of Peptide Research and Therapeutics
2001	Two new classes of conopeptides inhibit the α1-adrenoceptor and noradrenaline transporter Published In Nature Neuroscience
2000	Novel ω-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes Published In Journal of Biological Chemistry
2000	P2Y purinoceptor activation mobilizes intracellular Ca2+ and induces a membrane current in rat intracardiac neurones Published In The Journal of Physiology
2000	Substance P preferentially inhibits large conductance nicotinic ACh receptor channels in rat intracardiac ganglion neurons Published In Journal of Neurophysiology
2000	VIP and PACAP potentiation of nicotinic ACh-evoked currents in rat parasympathetic neurons is mediated by G-protein activation Published In European Journal of Neuroscience
1999	Calcium channels controlling acetylcholine release from preganglionic nerve terminals in rat autonomic ganglia Published In Neuroscience
1999	Conotoxins and their potential pharmaceutical applications Published In Drug Development Research
1999	Mechanisms of verapamil inhibition of action potential firing in rat intracardiac ganglion neurons Published In Journal of Pharmacology and Experimental Therapeutics
1999	Met-enkephalin-induced mobilization of intracellular Ca2+ in rat intracardiac ganglion neurones Published In Neuroscience Letters
1999	Single amino acid substitutions in α-conotoxin PnIA shift selectivity for subtypes of the mammalian neuronal nicotinic acetylcholine receptor Published In Journal of Biological Chemistry
1998	ACh- and caffeine-induced Ca2+ mobilization and current activation in rabbit arterial endothelial cells Published In American Journal of Physiology: Heart and Circulatory Physiology
1998	Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons Published In Journal of Pharmacology and Experimental Therapeutics
1998	Ciguatoxin (CTX-1) modulates single tetrodotoxin-sensitive sodium channels in rat parasympathetic neurones Published In Neuroscience Letters
1998	Opioid receptor-mediated inhibition of ω-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons Published In Journal of Neurophysiology
1998	α-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors Published In Journal of Biological Chemistry
1997	Characterization of ATP-sensitive potassium channels in freshly dissociated rabbit aortic endothelial cells Published In American Journal of Physiology: Heart and Circulatory Physiology
1997	Heterogeneity of nicotinic receptor class and subunit mRNA expression among individual parasympathetic neurons from rat intracardiac ganglia Published In The Journal of Neuroscience
1997	M4 muscarinic receptor activation modulates calcium channel currents in rat intracardiac neurons Published In Journal of Neurophysiology
1997	Passive and active membrane properties of isolated rat intracardiac neurons: Regulation by H- and M-currents Published In Journal of Neurophysiology
1996	Vasoactive intestinal polypeptide modulation of nicotinic ACh receptor channels in rat intracardiac neurones Published In The Journal of Physiology
1995	An ATP-sensitive potassium conductance in rabbit arterial endothelial cells Published In The Journal of Physiology
1995	Caffeine-evoked, calcium-sensitive membrane currents in rabbit aortic endothelial cells Published In British Journal of Pharmacology
1995	Monovalent and divalent cation permeability and block of neuronal nicotinic receptor channels in rat parasympathetic ganglia Published In Journal of General Physiology
1995	The relationship of brevetoxin 'length' and A-ring functionality to binding and activity in neuronal sodium channels Published In Chemistry and Biology
1994	Cytosolic [Ca2+] measurements in endothelium of rabbit cardiac valves using imaging fluorescence microscopy Published In American Journal of Physiology: Heart and Circulatory Physiology
1994	Ionic channels in vascular endothelial cells Published In Trends in Cardiovascular Medicine
1994	Is the A-ring lactone of brevetoxin PbTX-3 required for sodium channel orphan receptor binding and activity? Published In Natural Toxins
1994	Local anaesthetic blockade of neuronal nicotinic ACh receptor-channels in rat parasympathetic ganglion cells Published In British Journal of Pharmacology
1994	TEA inhibits ACh-induced EDRF release: endothelial Ca2+-dependent K+ channels contribute to vascular tone Published In American Journal of Physiology: Heart and Circulatory Physiology
1993	Membrane properties and discharge characteristics of rat intracardiac neurones in vitro: the effect of temperature Published In The Journal of Physiology
1993	α-Adrenergic modulation of ionic currents in cultured parasympathetic neurons from rat intracardiac ganglia Published In Journal of Neurophysiology
1992	Calcium entry-dependent oscillations of cytoplasmic calcium concentration in cultured endothelial cell monolayers Published In Proceedings of the National Academy of Sciences of USA
1992	Calcium permeability and modulation of nicotinic acetylcholine receptor-channels in rat parasympathetic neurons Published In Journal of Physiology: Paris
1992	Calcium-activated potassium channels in native endothelial cells from rabbit aorta: conductance, Ca2+ sensitivity and block Published In The Journal of Physiology
1992	Resting membrane potential and potassium currents in cultured parasympathetic neurones from rat intracardiac ganglia Published In The Journal of Physiology
1992	Voltage-dependent sodium and calcium currents in cultured parasympathetic neurones from rat intracardiac ganglia Published In The Journal of Physiology
1991	Acetylcholine-evoked currents in cultured neurones dissociated from rat parasympathetic cardiac ganglia Published In The Journal of Physiology
1991	Adenosine triphosphate-evoked currents in cultured neurones dissociated from rat parasympathetic cardiac ganglia Published In The Journal of Physiology
1991	Cytosolic calcium ion regulation in cultured endothelial cells Published In Advances in Experimental Medicine and Biology
1991	Modes of hexamethonium action on acetylcholine receptor channels in frog skeletal muscle Published In British Journal of Pharmacology
1990	Membrane potential and Na+-K+ pump activity modulate resting and bradykinin-stimulated changes in cytosolic free calcium in cultured endothelial cells from bovine atria Published In Journal of Biological Chemistry
1990	Neurotransmission in neonatal rat cardiac ganglion in situ Published In American Journal of Physiology: Heart and Circulatory Physiology
1990	Synergistic hypotensive effect of vasoactive intestinal polypeptide and α-blockade with phentolamine: evidence for vasoactive intestinal peptide α-adrenoceptor coupling in the cardiovascular system of newborn dogs Published In Circulation Research
1989	Bradykinin and inositol 1,4,5-trisphosphate-stimulated calcium release from intracellular stores in cultured bovine endothelial cells Published In Pfluegers Archiv: European journal of physiology
1989	Inhibition of neurally-evoked transmitter release by calcium channel antagonists in rat parasympathetic ganglia Published In British Journal of Pharmacology
1989	Ion channels and regulation of intracellular calcium in vascular endothelial cells Published In The FASEB Journal
1989	Synchronized oscillations in cytoplasmic free calcium concentrations in confluent bradykinin-stimulated bovine pulmonary artery endothelial cell monolayers Published In Journal of Biological Chemistry
1988	Role of calcium in the activation of endothelial cells Published In Journal of Cardiovascular Pharmacology
1988	The actions of L-glutamate at the postsynaptic membrane of the squid giant synapse Published In The Journal of Experimental Biology
1987	Calcium entry through receptor-operated channels in bovine pulmonary artery endothelial cells Published In Tissue and Cell
1985	Inhibitors of calcium buffering depress evoked transmitter release at the squid giant synapse. Published In The Journal of Physiology
1985	Some properties of acetylcholine receptors in human cultured myotubes Published In Proceedings of the Royal Society B: Biological Sciences
1982	Inhibitory postsynaptic currents at Aplysia cholinergic synapses: effects of permeant anions and depressant drugs Published In Proceedings of the Royal Society B: Biological Sciences
1981	Block of endplate channels by permeant cations in frog skeletal muscle Published In Journal of General Physiology
1980	Divalent ion currents and the delayed potassium conductance in an Aplysia neurone Published In The Journal of Physiology
1980	Ionic currents in molluscan soma Published In Annual Review of Neuroscience
1980	The permeability of endplate channels to monovalent and divalent metal cations Published In Journal of General Physiology
1980	The permeability of the endplate channel to organic cations in frog muscle Published In Journal of General Physiology
1979	Characteristics of sodium and calcium conductance changes produced by membrane depolarization in an Aplysia neurone Published In The Journal of Physiology
1979	Ionic currents in response to membrane depolarization in an aplysia neurone Published In The Journal of Physiology
1979	Sodium and calcium gating currents in an Aplysia neurone Published In The Journal of Physiology
1978	An effect of ethanol at a glutamate synapse Published In Clinical and Experimental Pharmacology and Physiology
1978	Asymmetrical displacement currents Published In Nature
1977	Ethanol reduces excitatory postsynaptic current duration at a crustacean neuromuscular junction Published In Nature
1977	Funnel web spider venom produces spontaneous action potentials in nerve Published In Life Sciences
1976	Gating currents associated with sodium and calcium currents in an Aplysia neuron Published In Science
1976	Voltage sensitivity of inhibitory postsynaptic currents in Aplysia buccal ganglia Published In Brain Research

Chapter

Year	Title
2015	Venoms-based drug discovery: bioassays, electrophysiology, high-throughput screens and target identincation Published In Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics Publisher http://pubs.rsc.org/en/Content/eBook/978-1-84973-663-3#!divbookcontent

Collection Or Series Editor For

The Journal of Physiology (Journal) 2015 -
Marine Drugs (Journal) 2014 -
The International Journal of Biochemistry and Cell Biology (Journal) 2013 -
Frontiers in Pharmacology (Journal) 2010 -
Channels (Journal) 2006 -
Neuropharmacology (Journal) 2016 - 2017
Pfluegers Archiv: European journal of physiology (Journal) 2008 - 2011
American Journal of Physiology: Heart and Circulatory Physiology (Journal) 1991 - 1996

Investigator On

Year	Title
2021 - 2026	ARC Training Centre for Cryo-electron microscopy of membrane proteins for drug discovery - CCEMMP Awarded by: Australian Research Council (ARC) Funding Scheme: Industrial Transformation Training Centres
2020	Role of the intrinsic cardiac nervous system in myocardial ischaemia and arrhythmias Awarded by: NSW Health Funding Scheme: Cardiovascular Senior Researcher Grants
2015 - 2020	Nicotinic receptor structure and function probed with conotoxinx Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2019	Inflammatory Pain - Control of Immune Cell Nicotinic Receptor Signaling by Conotoxins? Mechanisms and Screening Platforms Awarded by: Deutscher Akademischer Austausch Dienst (DAAD) Funding Scheme: Australia Germany Joint Cooperation Scheme
2018	Electrophysiology Facility for Cell Phenotyping and Drug Discovery Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2017	Identifying novel gene mutations for molecular diagnosis of Familial Hemiplegic Migraine Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2013 - 2016	Alpha-Conotoxin Inhibition of Chronic Visceral Pain Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2015	Ion channel modulators of pain pathways Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Program Grant

Other Research Activities

NSW Cardiovascular Disease Senior Researcher Grant Chief Investigator 2020 - 2023
Grünenthal GmbH Pharmaceutical Company - Development of peptide therapeutics Chief Investigator 2019 - 2021
Australia (UA)-Germany (DAAD) Joint Research Cooperation Scheme Chief Investigator 2019 - 2020

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Nicotinic acetylcholine receptor structure and function probed with venom derived peptides.
Doctor of Philosophy	Conotoxin modulation of voltage-gated calcium and potassium channels via GABA-B receptor activation	Bony, Anuja
Doctor of Philosophy	Direct Piezoelectricity for 3D Cardiac Tissue Engineering and Remodelling	James, Emma

Professional Service Activities

NSW Office for Health and Medical Research Cardiovascular Disease Research Advisory Committee 2018 - 2022
Health Innovations Research Institute, RMIT University Director 2009 - 2015
Multiple Sclerosis Research Australia (MSRA) Member of the Research Management Council 2007 - 2015
National Health and Medical Research Council Assigners Academy 2012 - 2014
The Australian Physiological Society President 2004 - 2010
Queensland Brain Institute, University of Queensland Director, Neuroscience Program 2008 - 2009
Australian Academy of Science National Committee for Biomedical Sciences 2003 - 2009
The University of Queensland Head of School of Biomedical Sciences 2000 - 2007
University of Queensland Head of Department of Physiology and Pharmacology 1998 - 2000

Education And Training

Ph.D. in Physiology, University of New South Wales, School of Physiology & Pharmacology, An Analysis of Ionic Channels in Aplysia Nerve Cell Membrane. 1974 - 1978
B Science (Hon) in Physiology, University of New South Wales 1970 - 1973
University College of London (UCL) , Department of Pharmacology, Beit Memorial Fellowship for Medical Research, UK 1981 - 1983
Marine Biological Laboratory, Woods Hole, MA, Grass Fellowship in Neurophysiology 1980
University of Washington School of Medicine, Department of Physiology & Biophysics, Muscular Dystrophy Association of America Postdoctoral Fellowship 1978 - 1980

Awards And Honors

Fellow of the American Physiological Society (FAPS), conferred by American Physiological Society, 2020
Fellow (FAHMS), conferred by Australian Academy of Health and Medical Sciences, 2020
Fellow of The Physiological Society (FTPS), conferred by The Physiological Society, 2019
NHMRC Ten of the Best Health & Medical Research Projects, conferred by NHMRC, 2011
Finalist, Australian Museum Eureka Prize People’s Choice Award, conferred by Australian Museum Eureka Prizes, 2005
Finalist, Royal Societies of Australia Eureka Prize for Interdisciplinary Scientific Research, conferred by Australian Museum Eureka Prizes, 2004
Australian Professorial Fellowship, conferred by Austrlian Research Council (ARC), 2010 - 2015

Keywords

Membrane physiology
Neuropharmacology
Cellular neuroscience
Electrophysiology
Ion channels
Membrane biophysics

Full Name

David John Adams

Mailing Address

Illawarra Health & Medical Research Institute (IHMRI)

University of Wollongong

Wollongong

NSW

2522

Australia

Geographic Location

University of Wollongong

Located In Facility

Illawarra Health and Medical Research Institute

Orcid Id

http://orcid.org/0000-0002-7030-2288 (confirmed)

Web Of Science Researcher Id

K-3578-2019

Scopus Id

57211178067

Top Publications

Year	Title
2008	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation Published in The Journal of Neuroscience
2017	α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA_B receptors Published in Gut
2012	Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels Published in British Journal of Pharmacology
2014	Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation Published in Journal of General Physiology
2016	Key structural determinants in the agonist binding loops of human β2 and β4 nicotinic acetylcholine receptor subunits contribute to α3β4 subtype selectivity of α-conotoxins Published in Journal of Biological Chemistry
2015	Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABAB receptor Published in Molecular Pharmacology
2013	Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor Published in Journal of Medicinal Chemistry
2013	Are nicotinic acetylcholine receptors coupled to G proteins? Published in BioEssays
2018	α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition Published in British Journal of Pharmacology
2006	μO-conotoxin MrVIB selectively blocks NaV1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits Published in Proceedings of the National Academy of Sciences of USA
2018	Structure-Activity Studies Reveal the Molecular Basis for GABA(B)-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1 Published in ACS Chemical Biology
2020	Ketamine inhibits synaptic transmission and nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglia in situ Published in Neuropharmacology

Research Areas

Research Overview

Prof Adams' research focuses on membrane receptors and ion channels and is currently funded by an NHMRC Program Grant and ARC Discovery Grants (2015-2019). He is internationally recognised for his contributions to membrane physiology, in particular that of ion channel function and modulation using electrophysiological recording techniques. In the last 20 years, he has identified novel peptides (conotoxins) obtained from the venom of cone snails as probes for ion channel structure and function. This research has focused on investigating conotoxins that selectively target the voltage-gated sodium and calcium channels, nicotinic acetylcholine receptors, and G protein-coupled receptor modulation of calcium channels.

Head Of

Illawarra Health and Medical Research Institute (IHMRI) CEO and Executive Director 2016 -

Member Of

American Physiological Society Fellow (FAPS) 2020 -
The Physiological Society Fellow (FTPS) 2019 -
Australasian Neuroscience Society Member 1996 -
Society for Neuroscience (USA) Member 1990 -
Society for General Physiologists Member 1981 -
Biophysical Society Member 1979 -
The Australian Physiological Society Member 1977 -
American Physiological Society Member 1993 - 2020
The Physiological Society Member 1988 - 2019

Has Collaborator

Dottori, Mirella Associate Professor
Ooi, Lezanne Associate Professor
Yu, Haibo Associate Professor
van Oijen, Antoine M. Distinguished Professor

Selected Publications

Journal Article

Year	Title
2020	(E)-3-Furan-2-yl-N-p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation Published In ACS Chemical Neuroscience
2020	An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides Published In Green Chemistry
2020	Dimerization of α-Conotoxins as a strategy to enhance the inhibition of the human α7 and α9α10 nicotinic acetylcholine receptors Published In Journal of Medicinal Chemistry
2020	Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors Published In British Journal of Pharmacology
2020	Interactions of the α3β2 Nicotinic Acetylcholine Receptor Interfaces with α-Conotoxin LsIA and its Carboxylated C-terminus Analogue: Molecular Dynamics Simulations Published In Marine Drugs
2020	Ketamine inhibits synaptic transmission and nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglia in situ Published In Neuropharmacology
2020	N-acetyl-D-glucosamine-conjugated PAMAM dendrimers as dual receptor-targeting nanocarriers for anticancer drug delivery Published In European Journal of Pharmaceutics and Biopharmaceutics
2020	On-Resin Strategy to Label α-Conotoxins: Cy5-RgIA, a Potent α9α10 Nicotinic Acetylcholine Receptor Imaging Probe Published In Australian Journal of Chemistry
2020	Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom Published In Biochemical Pharmacology
2019	Bombesin receptors as potential targets for anticancer drug delivery and imaging Published In The International Journal of Biochemistry and Cell Biology
2019	Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor Published In British Journal of Pharmacology
2019	Monoclonal antibody-conjugated dendritic nanostructures for siRNA delivery Published In Methods in Molecular Biology
2019	α-Conotoxin Vc1.1 structure-activity relationship at the human α9α10 nicotinic acetylcholine receptor investigated by minimal side chain replacement Published In ACS Chemical Neuroscience
2018	A novel α-conopeptide Eu1.6 inhibits N-type (CaV2.2) calcium channels and exhibits potent analgesic activity Published In Scientific Reports
2018	Contribution of membrane receptor signalling to chronic visceral pain Published In The International Journal of Biochemistry and Cell Biology
2018	Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain Published In British Journal of Pharmacology
2018	Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1 Published In British Journal of Pharmacology
2018	Molecular Determinants Conferring the Stoichiometric-Dependent Activity of alpha-Conotoxins at the Human alpha 9 alpha 10 Nicotinic Acetylcholine Receptor Subtype Published In Journal of Medicinal Chemistry
2018	NMR structure of µ-conotoxin GIIIC: Leucine 18 induces local repacking of the N-terminus resulting in reduced Nav channel potency Published In Molecules
2018	Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides Published In Scientific Reports
2018	Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB Published In Biochemical Pharmacology
2018	Structure-Activity Studies Reveal the Molecular Basis for GABA(B)-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1 Published In ACS Chemical Biology
2018	Targeting of N-Type Calcium Channels via GABAB-Receptor Activation by α-Conotoxin Vc1.1 Variants Displaying Improved Analgesic Activity Published In Journal of Medicinal Chemistry
2018	α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition Published In British Journal of Pharmacology
2017	A novel lid-covering peptide inhibitor of nicotinic acetylcholine receptors derived from αd-conotoxin GeXXA Published In Marine Drugs
2017	Analgesic conopeptides targeting G protein-coupled receptors reduce excitability of sensory neurons Published In Neuropharmacology
2017	Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer Published In Journal of Biological Chemistry
2017	Identification of a novel O-conotoxin reveals an unusual and potent inhibitor of the human α9α10 nicotinic acetylcholine receptor Published In Marine Drugs
2017	In vivo and in vitro testing of native α-conotoxins from the injected venom of Conus purpurascens Published In Neuropharmacology
2017	Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors Published In Scientific Reports
2017	Neuropharmacology of venom peptides Published In Neuropharmacology
2017	Peptide grafted and self-assembled poly(γ-glutamic acid)-phenylalanine nanoparticles targeting camptothecin to glioma Published In Nanomedicine
2017	Role of Cys(I)-Cys(III) Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors Published In ACS Omega
2017	The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity Published In Scientific Reports
2017	α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA_B receptors Published In Gut
2016	Effects of linker sequence modifications on the structure, stability, and biological activity of a cyclic α-conotoxin Published In Biopolymers
2016	Improving efficacy, oral bioavailability, and delivery of paclitaxel using protein-grafted solid lipid nanoparticles Published In Molecular Pharmaceutics
2016	Key structural determinants in the agonist binding loops of human β2 and β4 nicotinic acetylcholine receptor subunits contribute to α3β4 subtype selectivity of α-conotoxins Published In Journal of Biological Chemistry
2016	Mechanism of direct Ca_v2.2 channel block by the κ-opioid receptor agonist U50488H Published In Neuropharmacology
2016	Modulation of human Na(v)1.7 channel gating by synthetic α-scorpion toxin OD1 and its analogs Published In Channels
2016	Structure-activity studies of cysteine-rich α-Conotoxins that inhibit high voltage-activated calcium channels via GABA_B receptor activation reveal a minimal functional motif Published In Angewandte Chemie International Edition
2016	Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer Published In Scientific Reports
2015	Alanine scan ofα-conotoxin regiia reveals a selective α3α4 nicotinic acetylcholine receptor antagonist Published In Journal of Biological Chemistry
2015	Biomedical applications of trastuzumab: as a therapeutic agent and a targeting ligand Published In Medicinal Research Reviews
2015	Bombesin-conjugated nanoparticles improve the cytotoxic efficacy of docetaxel against gastrin-releasing but androgen-independent prostate cancer Published In Nanomedicine
2015	Conotoxin αd-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors Published In Scientific Reports
2015	Cyclic-RGDfK peptide conjugated succinoyl-TPGS nanomicelles for targeted delivery of docetaxel to integrin receptor over-expressing angiogenic tumours Published In Nanomedicine: Nanotechnology, Biology and Medicine
2015	Distinct functional site in Ω-neurotoxins: novel antagonists of nicotinic acetylcholine receptors from snake venom Published In ACS Chemical Biology
2015	Inhibition of cholinergic pathways in Drosophila melanogaster by α-conotoxins Published In The FASEB Journal
2015	Less is more: design of a highly stable disulfide-deleted mutant of analgesic cyclic α-conotoxin Vc1.1 Published In Scientific Reports
2015	Molecular basis for differential sensitivity of α-conotoxin RegIIA at rat and human neuronal nicotinic acetylcholine receptors Published In Molecular Pharmacology
2015	Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABAB receptor Published In Molecular Pharmacology
2015	α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors Published In Journal of the American Chemical Society
2014	Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets Published In Journal of Medicinal Chemistry
2014	Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation Published In Journal of General Physiology
2014	Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels Published In British Journal of Pharmacology
2014	Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors Published In Biochemical Pharmacology
2014	Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels Published In Biochemical Pharmacology
2013	Are nicotinic acetylcholine receptors coupled to G proteins? Published In BioEssays
2013	Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1 Published In ACS Chemical Biology
2013	Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor Published In Journal of Medicinal Chemistry
2013	Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors Published In ACS Chemical Biology
2013	Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors Published In Journal of Biological Chemistry
2013	Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors Published In Biochemical Pharmacology
2013	Kv3.1 channels stimulate adult neural precursor cell proliferation and neuronal differentiation Published In The Journal of Physiology
2013	Mechanisms of conotoxin inhibition of N-type (Cav2.2) calcium channels Published In BBA: Biomembranes
2012	Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels Published In British Journal of Pharmacology
2012	Biophysical properties of Nav1.8/Nav1.2 chimeras and inhibition by μo-conotoxin MrVIB Published In British Journal of Pharmacology
2012	Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics? Published In Toxins
2012	Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain Published In Neuropharmacology
2012	Isolation, characterization and total regioselective synthesis of the novel μo-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels Published In Biochemical Pharmacology
2012	Localization of Nav 1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function Published In Channels
2012	RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs Published In Biochemical Pharmacology
2012	γ-Aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic α-conotoxins Published In Journal of Biological Chemistry
2011	A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain Published In Pain
2011	Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABAB receptor Published In Journal of Medicinal Chemistry
2011	Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function? Published In Journal of Biological Chemistry
2011	Purification of immature neuronal cells from neural stem cell progeny Published In PLoS One
2011	Regulation of voltage-gated ion channels in excitable cells by the ubiquitin ligases Nedd4 and Nedd4-2 Published In Channels
2011	Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization Published In Antioxidants and Redox Signaling
2011	Structure and activity of α-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABAB receptor-coupled N-type calcium channels Published In Journal of Biological Chemistry
2011	Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding Published In Angewandte Chemie International Edition
2010	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout mice Published In Channels
2010	Analgesic ω-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels Published In Molecular Pharmacology
2010	Physiological roles of ion channels in adult neural stem cells and their progeny Published In Journal of Neurochemistry
2010	Solving the α-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antaqonists Published In Journal of the American Chemical Society
2010	The engineering of an orally active conotoxin for the treatment of neuropathic pain Published In Angewandte Chemie International Edition
2010	α-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of α3β4 nicotinic acetylcholine receptors Published In Journal of Biological Chemistry
2009	Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3 Published In Toxicon
2009	Inhibition of neuronal nicotinic acetylcholine receptor subtypes by α-conotoxin GID and analogues Published In Journal of Biological Chemistry
2009	Reactive oxygen species modulate neuronal excitability in rat intrinsic cardiac ganglia Published In Autonomic Neuroscience: Basic and Clinical
2009	Scanning mutagenesis of α-conotoxin Vc1.1 reveals residues crucial for activity at the α9α10 nicotinic acetylcholine receptor Published In Journal of Biological Chemistry
2008	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation Published In The Journal of Neuroscience
2008	Conotoxin modulation of voltage-gated sodium channels Published In The International Journal of Biochemistry and Cell Biology
2008	Kir and Kv channels regulate electrical properties and proliferation of adult neural precursor cells Published In Molecular and Cellular Neuroscience
2008	Molecular engineering of conotoxins: The importance of loop size to α-conotoxin structure and function Published In Journal of Medicinal Chemistry
2008	Neuronally selective μ-conotoxins from Conus striatus utilize an α-helical motif to target mammalian sodium channels Published In Journal of Biological Chemistry
2008	Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1 Published In American Journal of Physiology: Cell Physiology
2008	The three-dimensional structure of the analgesic α-conotoxin, RgIA Published In FEBS Letters
2008	ω-Conotoxin inhibition of excitatory synaptic transmission evoked by dorsal root stimulation in rat superficial dorsal horn Published In Neuropharmacology
2007	Are α9α10 nicotinic acetylcholine receptors a pain target for α-conotoxins? Published In Molecular Pharmacology
2007	Chemical modification of conotoxins to improve stability and activity Published In ACS Chemical Biology
2007	Distinct activities of novel neurotoxins from Australian venomous snakes for nicotinic acetylcholine receptors Published In Cellular and Molecular Life Sciences
2007	Isolation and structure-activity of μ-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels Published In Molecular Pharmacology
2007	Liposome reconstitution and modulation of recombinant N-methyl-D-aspartate receptor channels by membrane stretch Published In Proceedings of the National Academy of Sciences of USA
2007	NEDD4-2 as a potential candidate susceptibility gene for epileptic photosensitivity Published In Genes, Brain and Behavior
2007	Polymodal regulation of NMDA receptor channels Published In Channels
2007	Purinergic receptor activation inhibits mitogen-stimulated proliferation in primary neurospheres from the adult mouse subventricular zone Published In Molecular and Cellular Neuroscience
2007	Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by ubiquitination: novel role for Nedd4-2 Published In Journal of Biological Chemistry
2007	Structure of α-conotoxin BuIA: influences of disulfide connectivity on structural dynamics Published In BMC Structural Biology
2007	The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells Published In The Journal of Neuroscience
2007	ω-Conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels Published In European Journal of Neuroscience
2006	Identification of a novel class of nicotinic receptor antagonists: dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum Published In Journal of Biological Chemistry
2006	Mutations within the selectivity filter of the NMDA receptor-channel influence voltage dependent block by 5-hydroxytryptamine Published In British Journal of Pharmacology
2006	NMDA receptor subunit-dependent modulation by conantokin-G and Ala(7)-conantokin-G Published In Journal of Neurochemistry
2006	Neuronal voltage-gated sodium channel subtypes: key roles in inflammatory and neuropathic pain Published In The International Journal of Biochemistry and Cell Biology
2006	The synthesis, structural characterization, and receptor specificity of the α-conotoxin Vc1.1 Published In Journal of Biological Chemistry
2006	α-Selenoconotoxins, a new class of potent α7 neuronal nicotinic receptor antagonists Published In Journal of Biological Chemistry
2006	μO-conotoxin MrVIB selectively blocks NaV1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits Published In Proceedings of the National Academy of Sciences of USA
2005	Developmental changes in expression of GABAA receptor-channels in rat intrinsic cardiac ganglion neurones Published In The Journal of Physiology
2005	Engineering stable peptide toxins by means of backbone cyclization: stabilization of the α-conotoxin MII Published In Proceedings of the National Academy of Sciences of USA
2005	Intravenous anaesthetics inhibit nicotinic acetylcholine receptor-mediated currents and Ca²⁺ transients in rat intracardiac ganglion neurons Published In British Journal of Pharmacology
2005	Selective modulation of neuronal nicotinic acetylcholine receptor channel subunits by Go-protein subunits Published In The Journal of Neuroscience
2005	Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner Published In Journal of Pharmacology and Experimental Therapeutics
2005	Voltage-dependent inhibition of recombinant NMDA receptor-mediated currents by 5-hydroxytryptamine Published In British Journal of Pharmacology
2004	Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors Published In Molecular Pharmacology
2004	Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells Published In European Journal of Neuroscience
2004	Chemical and functional identification and characterization of novel sulfated α-conotoxins from the cone snail Conus anemone Published In Journal of Medicinal Chemistry
2004	Expression and function of neuronal nicotinic ACh receptors in rat microvascular endothelial cells Published In American Journal of Physiology: Heart and Circulatory Physiology
2004	Functional maturation of isolated neural progenitor cells from the adult rat hippocampus Published In European Journal of Neuroscience
2004	Overexpressed Cavβ3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of "ultra-slow"^^ and "closed-state"^^ inactivation Published In Journal of General Physiology
2004	Potassium channels and membrane potential in the modulation of intracellular calcium in vascular endothelial cells Published In Journal of Cardiovascular Electrophysiology
2004	Regulation of neuronal voltage-gated sodium channels by the ubiquitin protein ligases Nedd4 and Nedd4-2 Published In Journal of Biological Chemistry
2004	Structures of μO-conotoxins from Conus marmoreus: Inhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons Published In Journal of Biological Chemistry
2004	The α₂δ auxiliary subunit reduces affinity of ω-conotoxins for recombinant N-type (Ca_v2.2) calcium channels Published In Journal of Biological Chemistry
2003	Allosteric α1-adrenoreceptor antagonism by the conopeptide ρ-TIA Published In Journal of Biological Chemistry
2003	Inhibition of the norepinephrine transporter by the venom peptide χ-MrIA: site of action, Na+ dependence, and structure-activity relationship Published In Journal of Biological Chemistry
2003	Isolation, structure, and activity of GID, a novel α4/7-conotoxin with an extended N-terminal sequence Published In Journal of Biological Chemistry
2003	Muscarinic and nicotinic ACh receptor activation differentially mobilize Ca2+ in rat intracardiac ganglion neurons Published In Journal of Neurophysiology
2003	Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of α-conotoxin MII Published In Journal of Medicinal Chemistry
2003	α-conotoxins PnIA and [A10L]PnIA stabilize different states of the α7-L247T nicotinic acetylcholine receptor Published In Journal of Biological Chemistry
2003	ω-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals Published In Journal of Biological Chemistry
2002	A new level of conotoxin diversity, a non-native disulfide bond connectivity in α-conotoxin AuIB reduces structural definition but increases biological activity Published In Journal of Biological Chemistry
2002	Basal nonselective cation permeability in rat cardiac microvascular endothelial cells Published In Microvascular Research
2002	Ciguatoxin-induced oscillations in membrane potential and action potential firing in rat parasympathetic neurons Published In European Journal of Neuroscience
2002	Neural control of the heart: developmental changes in ionic conductances in mammalian intrinsic cardiac neurons Published In Autonomic Neuroscience: Basic and Clinical
2002	Solution structure of μ-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels Published In Journal of Biological Chemistry
2001	An ATP-sensitive K+ conductance in dissociated neurones from adult rat intracardiac ganglia Published In The Journal of Physiology
2001	Developmental changes in hyperpolarization-activated currents Ih and IK(IR) in isolated rat intracardiac neurons Published In Journal of Neurophysiology
2001	Ionic selectivity of native ATP-activated (P2X) receptor channels in dissociated neurones from rat parasympathetic ganglia Published In The Journal of Physiology
2001	Large-conductance calcium-activated potassium channels in neonatal rat intracardiac ganglion neurons Published In Pfluegers Archiv: European journal of physiology
2001	Pre- and postsynaptic actions of ATP on neurotransmission in rat submandibular ganglia Published In Neuroscience
2001	The synthesis and structure of an n-terminal dodecanoic acid conjugate of α-conotoxin MII Published In International Journal of Peptide Research and Therapeutics
2001	Two new classes of conopeptides inhibit the α1-adrenoceptor and noradrenaline transporter Published In Nature Neuroscience
2000	Novel ω-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes Published In Journal of Biological Chemistry
2000	P2Y purinoceptor activation mobilizes intracellular Ca2+ and induces a membrane current in rat intracardiac neurones Published In The Journal of Physiology
2000	Substance P preferentially inhibits large conductance nicotinic ACh receptor channels in rat intracardiac ganglion neurons Published In Journal of Neurophysiology
2000	VIP and PACAP potentiation of nicotinic ACh-evoked currents in rat parasympathetic neurons is mediated by G-protein activation Published In European Journal of Neuroscience
1999	Calcium channels controlling acetylcholine release from preganglionic nerve terminals in rat autonomic ganglia Published In Neuroscience
1999	Conotoxins and their potential pharmaceutical applications Published In Drug Development Research
1999	Mechanisms of verapamil inhibition of action potential firing in rat intracardiac ganglion neurons Published In Journal of Pharmacology and Experimental Therapeutics
1999	Met-enkephalin-induced mobilization of intracellular Ca2+ in rat intracardiac ganglion neurones Published In Neuroscience Letters
1999	Single amino acid substitutions in α-conotoxin PnIA shift selectivity for subtypes of the mammalian neuronal nicotinic acetylcholine receptor Published In Journal of Biological Chemistry
1998	ACh- and caffeine-induced Ca2+ mobilization and current activation in rabbit arterial endothelial cells Published In American Journal of Physiology: Heart and Circulatory Physiology
1998	Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons Published In Journal of Pharmacology and Experimental Therapeutics
1998	Ciguatoxin (CTX-1) modulates single tetrodotoxin-sensitive sodium channels in rat parasympathetic neurones Published In Neuroscience Letters
1998	Opioid receptor-mediated inhibition of ω-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons Published In Journal of Neurophysiology
1998	α-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors Published In Journal of Biological Chemistry
1997	Characterization of ATP-sensitive potassium channels in freshly dissociated rabbit aortic endothelial cells Published In American Journal of Physiology: Heart and Circulatory Physiology
1997	Heterogeneity of nicotinic receptor class and subunit mRNA expression among individual parasympathetic neurons from rat intracardiac ganglia Published In The Journal of Neuroscience
1997	M4 muscarinic receptor activation modulates calcium channel currents in rat intracardiac neurons Published In Journal of Neurophysiology
1997	Passive and active membrane properties of isolated rat intracardiac neurons: Regulation by H- and M-currents Published In Journal of Neurophysiology
1996	Vasoactive intestinal polypeptide modulation of nicotinic ACh receptor channels in rat intracardiac neurones Published In The Journal of Physiology
1995	An ATP-sensitive potassium conductance in rabbit arterial endothelial cells Published In The Journal of Physiology
1995	Caffeine-evoked, calcium-sensitive membrane currents in rabbit aortic endothelial cells Published In British Journal of Pharmacology
1995	Monovalent and divalent cation permeability and block of neuronal nicotinic receptor channels in rat parasympathetic ganglia Published In Journal of General Physiology
1995	The relationship of brevetoxin 'length' and A-ring functionality to binding and activity in neuronal sodium channels Published In Chemistry and Biology
1994	Cytosolic [Ca2+] measurements in endothelium of rabbit cardiac valves using imaging fluorescence microscopy Published In American Journal of Physiology: Heart and Circulatory Physiology
1994	Ionic channels in vascular endothelial cells Published In Trends in Cardiovascular Medicine
1994	Is the A-ring lactone of brevetoxin PbTX-3 required for sodium channel orphan receptor binding and activity? Published In Natural Toxins
1994	Local anaesthetic blockade of neuronal nicotinic ACh receptor-channels in rat parasympathetic ganglion cells Published In British Journal of Pharmacology
1994	TEA inhibits ACh-induced EDRF release: endothelial Ca2+-dependent K+ channels contribute to vascular tone Published In American Journal of Physiology: Heart and Circulatory Physiology
1993	Membrane properties and discharge characteristics of rat intracardiac neurones in vitro: the effect of temperature Published In The Journal of Physiology
1993	α-Adrenergic modulation of ionic currents in cultured parasympathetic neurons from rat intracardiac ganglia Published In Journal of Neurophysiology
1992	Calcium entry-dependent oscillations of cytoplasmic calcium concentration in cultured endothelial cell monolayers Published In Proceedings of the National Academy of Sciences of USA
1992	Calcium permeability and modulation of nicotinic acetylcholine receptor-channels in rat parasympathetic neurons Published In Journal of Physiology: Paris
1992	Calcium-activated potassium channels in native endothelial cells from rabbit aorta: conductance, Ca2+ sensitivity and block Published In The Journal of Physiology
1992	Resting membrane potential and potassium currents in cultured parasympathetic neurones from rat intracardiac ganglia Published In The Journal of Physiology
1992	Voltage-dependent sodium and calcium currents in cultured parasympathetic neurones from rat intracardiac ganglia Published In The Journal of Physiology
1991	Acetylcholine-evoked currents in cultured neurones dissociated from rat parasympathetic cardiac ganglia Published In The Journal of Physiology
1991	Adenosine triphosphate-evoked currents in cultured neurones dissociated from rat parasympathetic cardiac ganglia Published In The Journal of Physiology
1991	Cytosolic calcium ion regulation in cultured endothelial cells Published In Advances in Experimental Medicine and Biology
1991	Modes of hexamethonium action on acetylcholine receptor channels in frog skeletal muscle Published In British Journal of Pharmacology
1990	Membrane potential and Na+-K+ pump activity modulate resting and bradykinin-stimulated changes in cytosolic free calcium in cultured endothelial cells from bovine atria Published In Journal of Biological Chemistry
1990	Neurotransmission in neonatal rat cardiac ganglion in situ Published In American Journal of Physiology: Heart and Circulatory Physiology
1990	Synergistic hypotensive effect of vasoactive intestinal polypeptide and α-blockade with phentolamine: evidence for vasoactive intestinal peptide α-adrenoceptor coupling in the cardiovascular system of newborn dogs Published In Circulation Research
1989	Bradykinin and inositol 1,4,5-trisphosphate-stimulated calcium release from intracellular stores in cultured bovine endothelial cells Published In Pfluegers Archiv: European journal of physiology
1989	Inhibition of neurally-evoked transmitter release by calcium channel antagonists in rat parasympathetic ganglia Published In British Journal of Pharmacology
1989	Ion channels and regulation of intracellular calcium in vascular endothelial cells Published In The FASEB Journal
1989	Synchronized oscillations in cytoplasmic free calcium concentrations in confluent bradykinin-stimulated bovine pulmonary artery endothelial cell monolayers Published In Journal of Biological Chemistry
1988	Role of calcium in the activation of endothelial cells Published In Journal of Cardiovascular Pharmacology
1988	The actions of L-glutamate at the postsynaptic membrane of the squid giant synapse Published In The Journal of Experimental Biology
1987	Calcium entry through receptor-operated channels in bovine pulmonary artery endothelial cells Published In Tissue and Cell
1985	Inhibitors of calcium buffering depress evoked transmitter release at the squid giant synapse. Published In The Journal of Physiology
1985	Some properties of acetylcholine receptors in human cultured myotubes Published In Proceedings of the Royal Society B: Biological Sciences
1982	Inhibitory postsynaptic currents at Aplysia cholinergic synapses: effects of permeant anions and depressant drugs Published In Proceedings of the Royal Society B: Biological Sciences
1981	Block of endplate channels by permeant cations in frog skeletal muscle Published In Journal of General Physiology
1980	Divalent ion currents and the delayed potassium conductance in an Aplysia neurone Published In The Journal of Physiology
1980	Ionic currents in molluscan soma Published In Annual Review of Neuroscience
1980	The permeability of endplate channels to monovalent and divalent metal cations Published In Journal of General Physiology
1980	The permeability of the endplate channel to organic cations in frog muscle Published In Journal of General Physiology
1979	Characteristics of sodium and calcium conductance changes produced by membrane depolarization in an Aplysia neurone Published In The Journal of Physiology
1979	Ionic currents in response to membrane depolarization in an aplysia neurone Published In The Journal of Physiology
1979	Sodium and calcium gating currents in an Aplysia neurone Published In The Journal of Physiology
1978	An effect of ethanol at a glutamate synapse Published In Clinical and Experimental Pharmacology and Physiology
1978	Asymmetrical displacement currents Published In Nature
1977	Ethanol reduces excitatory postsynaptic current duration at a crustacean neuromuscular junction Published In Nature
1977	Funnel web spider venom produces spontaneous action potentials in nerve Published In Life Sciences
1976	Gating currents associated with sodium and calcium currents in an Aplysia neuron Published In Science
1976	Voltage sensitivity of inhibitory postsynaptic currents in Aplysia buccal ganglia Published In Brain Research

Chapter

Year	Title
2015	Venoms-based drug discovery: bioassays, electrophysiology, high-throughput screens and target identincation Published In Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics Publisher http://pubs.rsc.org/en/Content/eBook/978-1-84973-663-3#!divbookcontent

Collection Or Series Editor For

The Journal of Physiology (Journal) 2015 -
Marine Drugs (Journal) 2014 -
The International Journal of Biochemistry and Cell Biology (Journal) 2013 -
Frontiers in Pharmacology (Journal) 2010 -
Channels (Journal) 2006 -
Neuropharmacology (Journal) 2016 - 2017
Pfluegers Archiv: European journal of physiology (Journal) 2008 - 2011
American Journal of Physiology: Heart and Circulatory Physiology (Journal) 1991 - 1996

Investigator On

Year	Title
2021 - 2026	ARC Training Centre for Cryo-electron microscopy of membrane proteins for drug discovery - CCEMMP Awarded by: Australian Research Council (ARC) Funding Scheme: Industrial Transformation Training Centres
2020	Role of the intrinsic cardiac nervous system in myocardial ischaemia and arrhythmias Awarded by: NSW Health Funding Scheme: Cardiovascular Senior Researcher Grants
2015 - 2020	Nicotinic receptor structure and function probed with conotoxinx Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2019	Inflammatory Pain - Control of Immune Cell Nicotinic Receptor Signaling by Conotoxins? Mechanisms and Screening Platforms Awarded by: Deutscher Akademischer Austausch Dienst (DAAD) Funding Scheme: Australia Germany Joint Cooperation Scheme
2018	Electrophysiology Facility for Cell Phenotyping and Drug Discovery Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2017	Identifying novel gene mutations for molecular diagnosis of Familial Hemiplegic Migraine Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2013 - 2016	Alpha-Conotoxin Inhibition of Chronic Visceral Pain Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2015	Ion channel modulators of pain pathways Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Program Grant

Other Research Activities

NSW Cardiovascular Disease Senior Researcher Grant Chief Investigator 2020 - 2023
Grünenthal GmbH Pharmaceutical Company - Development of peptide therapeutics Chief Investigator 2019 - 2021
Australia (UA)-Germany (DAAD) Joint Research Cooperation Scheme Chief Investigator 2019 - 2020

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Nicotinic acetylcholine receptor structure and function probed with venom derived peptides.
Doctor of Philosophy	Conotoxin modulation of voltage-gated calcium and potassium channels via GABA-B receptor activation	Bony, Anuja
Doctor of Philosophy	Direct Piezoelectricity for 3D Cardiac Tissue Engineering and Remodelling	James, Emma

Professional Service Activities

NSW Office for Health and Medical Research Cardiovascular Disease Research Advisory Committee 2018 - 2022
Health Innovations Research Institute, RMIT University Director 2009 - 2015
Multiple Sclerosis Research Australia (MSRA) Member of the Research Management Council 2007 - 2015
National Health and Medical Research Council Assigners Academy 2012 - 2014
The Australian Physiological Society President 2004 - 2010
Queensland Brain Institute, University of Queensland Director, Neuroscience Program 2008 - 2009
Australian Academy of Science National Committee for Biomedical Sciences 2003 - 2009
The University of Queensland Head of School of Biomedical Sciences 2000 - 2007
University of Queensland Head of Department of Physiology and Pharmacology 1998 - 2000

Education And Training

Ph.D. in Physiology, University of New South Wales, School of Physiology & Pharmacology, An Analysis of Ionic Channels in Aplysia Nerve Cell Membrane. 1974 - 1978
B Science (Hon) in Physiology, University of New South Wales 1970 - 1973
University College of London (UCL) , Department of Pharmacology, Beit Memorial Fellowship for Medical Research, UK 1981 - 1983
Marine Biological Laboratory, Woods Hole, MA, Grass Fellowship in Neurophysiology 1980
University of Washington School of Medicine, Department of Physiology & Biophysics, Muscular Dystrophy Association of America Postdoctoral Fellowship 1978 - 1980

Awards And Honors

Fellow of the American Physiological Society (FAPS), conferred by American Physiological Society, 2020
Fellow (FAHMS), conferred by Australian Academy of Health and Medical Sciences, 2020
Fellow of The Physiological Society (FTPS), conferred by The Physiological Society, 2019
NHMRC Ten of the Best Health & Medical Research Projects, conferred by NHMRC, 2011
Finalist, Australian Museum Eureka Prize People’s Choice Award, conferred by Australian Museum Eureka Prizes, 2005
Finalist, Royal Societies of Australia Eureka Prize for Interdisciplinary Scientific Research, conferred by Australian Museum Eureka Prizes, 2004
Australian Professorial Fellowship, conferred by Austrlian Research Council (ARC), 2010 - 2015

Keywords

Membrane physiology
Neuropharmacology
Cellular neuroscience
Electrophysiology
Ion channels
Membrane biophysics

Full Name

David John Adams

Mailing Address

Illawarra Health & Medical Research Institute (IHMRI)

University of Wollongong

Wollongong

NSW

2522

Australia

Geographic Location

University of Wollongong

Located In Facility

Illawarra Health and Medical Research Institute

Orcid Id

http://orcid.org/0000-0002-7030-2288 (confirmed)

Web Of Science Researcher Id

K-3578-2019

Scopus Id

57211178067

Overview

Overview

Top Publications

Research Areas

Research Overview

Affiliation

Available for Collaborative Projects

Head Of

Member Of

Has Collaborator

Publications

Selected Publications

Journal Article

Chapter

Collection Or Series Editor For

Funding

Investigator On

Other Research Activities

Supervision

Advisees

Graduate Advising Relationship

Service

Professional Service Activities

Background

Education And Training

Awards And Honors

Keywords

Contact

Full Name

Mailing Address

Geographic Location

Located In Facility

Identity

Orcid Id

Web Of Science Researcher Id

Scopus Id

Overview

Top Publications

Research Areas

Research Overview

Affiliation

Head Of

Member Of

Has Collaborator

Publications

Selected Publications

Journal Article

Chapter

Collection Or Series Editor For

Funding

Investigator On

Other Research Activities

Supervision

Advisees

Graduate Advising Relationship

Service

Professional Service Activities

Background

Education And Training

Awards And Honors

Keywords

Contact

Full Name

Mailing Address

Geographic Location

Located In Facility

Identity

Orcid Id

Web Of Science Researcher Id

Scopus Id

Visualisations

Research Areas