Adams, David J..

Overview

David J. Adams is currently Distinguished Professor and Executive Director of the Illawarra Health & Medical Research Institute (IHMRI) at the University of Wollongong. He was previously Professor and Director of the Health Innovations Research Institute, RMIT University and an ARC Australian Professorial Fellow (2010-2015) and during the period 04/2013-02/2014 he was Acting Deputy Vice-Chancellor (Research & Innovation) and Vice-President, RMIT University. He was Professor and Chair of Physiology at the University of Queensland (UQ), Head of Department of Physiology & Pharmacology (1997-2000), Head of the School of Biomedical Sciences (2000-2007) and Professorial Research Fellow and Director of UQ Neuroscience Program, Queensland Brain Institute (2008-2009).

Top Publications

Year	Title
2008	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation Published in The Journal of Neuroscience
2017	α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA_B receptors Published in Gut
2012	Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels Published in British Journal of Pharmacology
2014	Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation Published in Journal of General Physiology
2016	Key structural determinants in the agonist binding loops of human β2 and β4 nicotinic acetylcholine receptor subunits contribute to α3β4 subtype selectivity of α-conotoxins Published in Journal of Biological Chemistry
2015	Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABAB receptor Published in Molecular Pharmacology
2013	Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor Published in Journal of Medicinal Chemistry
2013	Are nicotinic acetylcholine receptors coupled to G proteins? Published in BioEssays
2018	α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition Published in British Journal of Pharmacology
2006	μO-conotoxin MrVIB selectively blocks NaV1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits Published in Proceedings of the National Academy of Sciences of USA
2018	Structure-Activity Studies Reveal the Molecular Basis for GABA(B)-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1 Published in ACS Chemical Biology

Research Areas

Research Overview

Prof Adams' research focuses on membrane receptors and ion channels and is currently funded by an NHMRC Program Grant and ARC Discovery Grants (2015-2019). He is internationally recognised for his contributions to membrane physiology, in particular that of ion channel function and modulation using electrophysiological recording techniques. In the last 20 years, he has identified novel peptides (conotoxins) obtained from the venom of cone snails as probes for ion channel structure and function. This research has focused on investigating conotoxins that selectively target the voltage-gated sodium and calcium channels, nicotinic acetylcholine receptors, and G protein-coupled receptor modulation of calcium channels.

Available for Collaborative Projects

Head Of

Illawarra Health and Medical Research Institute (IHMRI) CEO and Executive Director 2016 -

Selected Publications

Journal Article

Year	Title
2020	Ketamine inhibits synaptic transmission and nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglia in situ Published In Neuropharmacology Volume 165 Altmetric
2020	Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom Published In Biochemical Pharmacology Volume 174 Altmetric
2019	Bombesin receptors as potential targets for anticancer drug delivery and imaging Published In The International Journal of Biochemistry and Cell Biology Volume 114 Pages 105567-1 - 105567-9 ISSN 1878-5875 Altmetric
2019	Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors Published In British Journal of Pharmacology Altmetric
2019	Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor Published In British Journal of Pharmacology Volume 176 Pages 2750 - 2763 ISSN 0007-1188 Altmetric
2019	Monoclonal antibody-conjugated dendritic nanostructures for siRNA delivery Published In Methods in Molecular Biology Volume 1974 Pages 195 - 201 ISSN 1064-3745 Altmetric
2019	On-Resin Strategy to Label α-Conotoxins: Cy5-RgIA, a Potent α9α10 Nicotinic Acetylcholine Receptor Imaging Probe Published In Australian Journal of Chemistry Altmetric
2019	α-Conotoxin Vc1.1 structure-activity relationship at the human α9α10 nicotinic acetylcholine receptor investigated by minimal side chain replacement Published In ACS Chemical Neuroscience Volume 10 Pages 4328 - 4336 ISSN 1948-7193 Altmetric
2018	A novel α-conopeptide Eu1.6 inhibits N-type (CaV2.2) calcium channels and exhibits potent analgesic activity Published In Scientific Reports Volume 8 Pages 1004-1 - 1004-13 ISSN 2045-2322 Altmetric
2018	Contribution of membrane receptor signalling to chronic visceral pain Published In The International Journal of Biochemistry and Cell Biology Volume 98 Pages 10 - 23 ISSN 1878-5875 Altmetric
2018	Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain Published In British Journal of Pharmacology Volume 175 Pages 2384 - 2398 ISSN 0007-1188 Altmetric
2018	Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1 Published In British Journal of Pharmacology Volume 175 Pages 2284 - 2295 ISSN 0007-1188 Altmetric
2018	Molecular Determinants Conferring the Stoichiometric-Dependent Activity of alpha-Conotoxins at the Human alpha 9 alpha 10 Nicotinic Acetylcholine Receptor Subtype Published In Journal of Medicinal Chemistry Volume 61 Pages 4628 - 4634 ISSN 0022-2623 Altmetric
2018	NMR structure of µ-conotoxin GIIIC: Leucine 18 induces local repacking of the N-terminus resulting in reduced Nav channel potency Published In Molecules Volume 23 Pages 2715-1 - 2715-12 ISSN 1420-3049 Altmetric
2018	Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides Published In Scientific Reports Volume 8 Pages 13397-1 - 13397-15 ISSN 2045-2322 Altmetric
2018	Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB Published In Biochemical Pharmacology Volume 155 Pages 288 - 297 ISSN 0006-2952 Altmetric
2018	Structure-Activity Studies Reveal the Molecular Basis for GABA(B)-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1 Published In ACS Chemical Biology Volume 13 Pages 1577 - 1587 ISSN 1554-8929 Altmetric
2018	Targeting of N-Type Calcium Channels via GABAB-Receptor Activation by α-Conotoxin Vc1.1 Variants Displaying Improved Analgesic Activity Published In Journal of Medicinal Chemistry Volume 61 Pages 10198 - 10205 ISSN 0022-2623 Altmetric
2018	α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition Published In British Journal of Pharmacology Volume 175 Pages 1855 - 1868 ISSN 0007-1188 Altmetric
2017	A novel lid-covering peptide inhibitor of nicotinic acetylcholine receptors derived from αd-conotoxin GeXXA Published In Marine Drugs Volume 15 ISSN 1660-3397 Altmetric
2017	Analgesic conopeptides targeting G protein-coupled receptors reduce excitability of sensory neurons Published In Neuropharmacology Volume 127 Pages 116 - 123 ISSN 0028-3908 Altmetric
2017	Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer Published In Journal of Biological Chemistry Volume 292 Pages 17101 - 17112 ISSN 0021-9258 Altmetric
2017	Identification of a novel O-conotoxin reveals an unusual and potent inhibitor of the human α9α10 nicotinic acetylcholine receptor Published In Marine Drugs Volume 15 Pages 170-1 - 170-13 ISSN 1660-3397 Altmetric
2017	In vivo and in vitro testing of native α-conotoxins from the injected venom of Conus purpurascens Published In Neuropharmacology Volume 127 Pages 253 - 259 ISSN 0028-3908 Altmetric
2017	Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors Published In Scientific Reports Volume 7 Pages 16606-1 - 16606-11 ISSN 2045-2322 Altmetric
2017	Neuropharmacology of venom peptides Published In Neuropharmacology Volume 127 Pages 1 - 3 ISSN 0028-3908 Altmetric
2017	Peptide grafted and self-assembled poly(γ-glutamic acid)-phenylalanine nanoparticles targeting camptothecin to glioma Published In Nanomedicine Volume 12 Pages 1661 - 1674 ISSN 1743-5889 Altmetric
2017	Role of Cys(I)-Cys(III) Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors Published In ACS Omega Volume 2 Pages 4621 - 4631 Altmetric
2017	The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity Published In Scientific Reports Volume 7 Pages 974-1 - 974-15 ISSN 2045-2322 Altmetric
2017	α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA_B receptors Published In Gut Volume 66 Pages 1083 - 1094 ISSN 0017-5749 Altmetric
2016	Effects of linker sequence modifications on the structure, stability, and biological activity of a cyclic α-conotoxin Published In Biopolymers Volume 106 Pages 864 - 875 Altmetric
2016	Improving efficacy, oral bioavailability, and delivery of paclitaxel using protein-grafted solid lipid nanoparticles Published In Molecular Pharmaceutics Volume 13 Pages 3903 - 3912 ISSN 1543-8384 Altmetric
2016	Key structural determinants in the agonist binding loops of human β2 and β4 nicotinic acetylcholine receptor subunits contribute to α3β4 subtype selectivity of α-conotoxins Published In Journal of Biological Chemistry Volume 291 Pages 23779 - 23792 ISSN 0021-9258 Altmetric
2016	Mechanism of direct Ca_v2.2 channel block by the κ-opioid receptor agonist U50488H Published In Neuropharmacology Volume 109 Pages 49 - 58 ISSN 0028-3908 Altmetric
2016	Modulation of human Na(v)1.7 channel gating by synthetic α-scorpion toxin OD1 and its analogs Published In Channels Volume 10 Pages 139 - 147 ISSN 1933-6950 Altmetric
2016	Structure-activity studies of cysteine-rich α-Conotoxins that inhibit high voltage-activated calcium channels via GABA_B receptor activation reveal a minimal functional motif Published In Angewandte Chemie International Edition Volume 55 Pages 4692 - 4696 ISSN 1521-3773 Altmetric
2016	Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer Published In Scientific Reports Volume 6 Pages 23179-1 - 23179-13 ISSN 2045-2322 Altmetric
2015	Alanine scan ofα-conotoxin regiia reveals a selective α3α4 nicotinic acetylcholine receptor antagonist Published In Journal of Biological Chemistry Volume 290 Pages 1039 - 1048 ISSN 0021-9258 Altmetric
2015	Biomedical applications of trastuzumab: as a therapeutic agent and a targeting ligand Published In Medicinal Research Reviews Volume 35 Pages 849 - 876 ISSN 0198-6325 Altmetric
2015	Bombesin-conjugated nanoparticles improve the cytotoxic efficacy of docetaxel against gastrin-releasing but androgen-independent prostate cancer Published In Nanomedicine Volume 10 Pages 2847 - 2859 ISSN 1743-5889 Altmetric
2015	Conotoxin αd-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors Published In Scientific Reports Volume 5 Pages 14261-1 - 14261-8 ISSN 2045-2322 Altmetric
2015	Cyclic-RGDfK peptide conjugated succinoyl-TPGS nanomicelles for targeted delivery of docetaxel to integrin receptor over-expressing angiogenic tumours Published In Nanomedicine: Nanotechnology, Biology and Medicine Volume 11 Pages 1511 - 1520 ISSN 1549-9634 Altmetric
2015	Distinct functional site in Ω-neurotoxins: novel antagonists of nicotinic acetylcholine receptors from snake venom Published In ACS Chemical Biology Volume 10 Pages 2805 - 2815 ISSN 1554-8929 Altmetric
2015	Inhibition of cholinergic pathways in Drosophila melanogaster by α-conotoxins Published In The FASEB Journal Volume 29 Pages 1011 - 1018 ISSN 0892-6638 Altmetric
2015	Less is more: design of a highly stable disulfide-deleted mutant of analgesic cyclic α-conotoxin Vc1.1 Published In Scientific Reports Volume 5 Pages 13264-1 - 13264-11 ISSN 2045-2322 Altmetric
2015	Molecular basis for differential sensitivity of α-conotoxin RegIIA at rat and human neuronal nicotinic acetylcholine receptors Published In Molecular Pharmacology Volume 88 Pages 993 - 1001 ISSN 0026-895X Altmetric
2015	Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABAB receptor Published In Molecular Pharmacology Volume 87 Pages 240 - 250 ISSN 0026-895X Altmetric
2015	α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors Published In Journal of the American Chemical Society Volume 137 Pages 3209 - 3212 ISSN 0002-7863 Altmetric
2014	Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets Published In Journal of Medicinal Chemistry Volume 57 Pages 9933 - 9944 ISSN 0022-2623 Altmetric
2014	Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation Published In Journal of General Physiology Volume 143 Pages 465 - 479 ISSN 0022-1295 Altmetric
2014	Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels Published In British Journal of Pharmacology Volume 171 Pages 3313 - 3327 ISSN 0007-1188 Altmetric
2014	Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors Published In Biochemical Pharmacology Volume 91 Pages 534 - 542 ISSN 0006-2952 Altmetric
2014	Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels Published In Biochemical Pharmacology Volume 89 Pages 276 - 286 ISSN 0006-2952 Altmetric
2013	Are nicotinic acetylcholine receptors coupled to G proteins? Published In BioEssays Volume 35 Pages 1025 - 1034 ISSN 0265-9247 Altmetric
2013	Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1 Published In ACS Chemical Biology Volume 8 Pages 1215 - 1222 ISSN 1554-8929 Altmetric
2013	Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor Published In Journal of Medicinal Chemistry Volume 56 Pages 3557 - 3567 ISSN 0022-2623 Altmetric
2013	Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors Published In ACS Chemical Biology Volume 8 Pages 1815 - 1821 ISSN 1554-8929 Altmetric
2013	Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors Published In Journal of Biological Chemistry Volume 288 Pages 34428 - 34442 Altmetric
2013	Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors Published In Biochemical Pharmacology Volume 86 Pages 791 - 799 Altmetric
2013	Kv3.1 channels stimulate adult neural precursor cell proliferation and neuronal differentiation Published In The Journal of Physiology Volume 591 Pages 2579 - 2591 ISSN 0022-3751 Altmetric
2013	Mechanisms of conotoxin inhibition of N-type (Cav2.2) calcium channels Published In BBA: Biomembranes Volume 1828 Pages 1619 - 1628 ISSN 0005-2736 Altmetric
2012	Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels Published In British Journal of Pharmacology Volume 166 Pages 486 - 500 ISSN 0007-1188 Altmetric
2012	Biophysical properties of Nav1.8/Nav1.2 chimeras and inhibition by μo-conotoxin MrVIB Published In British Journal of Pharmacology Volume 166 Pages 2148 - 2160 ISSN 0007-1188 Altmetric
2012	Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics? Published In Toxins Volume 4 Pages 1236 - 1260 ISSN 2072-6651 Altmetric
2012	Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain Published In Neuropharmacology Volume 62 Pages 2202 - 2207 ISSN 0028-3908 Altmetric
2012	Isolation, characterization and total regioselective synthesis of the novel μo-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels Published In Biochemical Pharmacology Volume 84 Pages 540 - 548 ISSN 0006-2952 Altmetric
2012	Localization of Nav 1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function Published In Channels Volume 6 Pages 103 - 110 ISSN 1933-6950 Altmetric
2012	RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs Published In Biochemical Pharmacology Volume 83 Pages 419 - 426 ISSN 0006-2952 Altmetric
2012	γ-Aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic α-conotoxins Published In Journal of Biological Chemistry Volume 287 Pages 23948 - 23957 ISSN 0021-9258 Altmetric
2011	A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain Published In Pain Volume 152 Pages 259 - 266 ISSN 0304-3959 Altmetric
2011	Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABAB receptor Published In Journal of Medicinal Chemistry Volume 54 Pages 6984 - 6992 ISSN 0022-2623 Altmetric
2011	Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function? Published In Journal of Biological Chemistry Volume 286 Pages 22546 - 22557 ISSN 0021-9258 Altmetric
2011	Purification of immature neuronal cells from neural stem cell progeny Published In PLoS One Volume 6 Pages e20941-1 - e20941-16 ISSN 1932-6203 Altmetric
2011	Regulation of voltage-gated ion channels in excitable cells by the ubiquitin ligases Nedd4 and Nedd4-2 Published In Channels Volume 5 Pages 79 - 88 ISSN 1933-6950 Altmetric
2011	Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization Published In Antioxidants and Redox Signaling Volume 14 Pages 87 - 95 ISSN 1523-0864 Altmetric
2011	Structure and activity of α-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABAB receptor-coupled N-type calcium channels Published In Journal of Biological Chemistry Volume 286 Pages 10233 - 10237 ISSN 0021-9258 Altmetric
2011	Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding Published In Angewandte Chemie International Edition Volume 50 Pages 6527 - 6529 ISSN 1521-3773 Altmetric
2010	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout mice Published In Channels Volume 4 Pages 51 - 54 ISSN 1933-6950 Altmetric
2010	Analgesic ω-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels Published In Molecular Pharmacology Volume 77 Pages 139 - 148 ISSN 0026-895X Altmetric
2010	Physiological roles of ion channels in adult neural stem cells and their progeny Published In Journal of Neurochemistry Volume 114 Pages 946 - 959 ISSN 0022-3042 Altmetric
2010	Solving the α-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antaqonists Published In Journal of the American Chemical Society Volume 132 Pages 3514 - 3522 ISSN 0002-7863 Altmetric
2010	The engineering of an orally active conotoxin for the treatment of neuropathic pain Published In Angewandte Chemie International Edition Volume 49 Pages 6545 - 6548 ISSN 1521-3773 Altmetric
2010	α-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of α3β4 nicotinic acetylcholine receptors Published In Journal of Biological Chemistry Volume 285 Pages 22254 - 22263 ISSN 0021-9258 Altmetric
2009	Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3 Published In Toxicon Volume 54 Pages 56 - 61 ISSN 1879-3150 Altmetric
2009	Inhibition of neuronal nicotinic acetylcholine receptor subtypes by α-conotoxin GID and analogues Published In Journal of Biological Chemistry Volume 284 Pages 4944 - 4951 ISSN 0021-9258 Altmetric
2009	Reactive oxygen species modulate neuronal excitability in rat intrinsic cardiac ganglia Published In Autonomic Neuroscience: Basic and Clinical Volume 150 Pages 45 - 52 ISSN 1566-0702 Altmetric
2009	Scanning mutagenesis of α-conotoxin Vc1.1 reveals residues crucial for activity at the α9α10 nicotinic acetylcholine receptor Published In Journal of Biological Chemistry Volume 284 Pages 20275 - 20284 ISSN 0021-9258 Altmetric
2008	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation Published In The Journal of Neuroscience Volume 28 Pages 10943 - 10951 ISSN 1529-2401 Altmetric
2008	Conotoxin modulation of voltage-gated sodium channels Published In The International Journal of Biochemistry and Cell Biology Volume 40 Pages 2363 - 2368 ISSN 1878-5875 Altmetric
2008	Kir and Kv channels regulate electrical properties and proliferation of adult neural precursor cells Published In Molecular and Cellular Neuroscience Volume 37 Pages 284 - 297 ISSN 1044-7431 Altmetric
2008	Molecular engineering of conotoxins: The importance of loop size to α-conotoxin structure and function Published In Journal of Medicinal Chemistry Volume 51 Pages 5575 - 5584 ISSN 0022-2623 Altmetric
2008	Neuronally selective μ-conotoxins from Conus striatus utilize an α-helical motif to target mammalian sodium channels Published In Journal of Biological Chemistry Volume 283 Pages 21621 - 21628 ISSN 0021-9258 Altmetric
2008	Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1 Published In American Journal of Physiology: Cell Physiology Volume 295 Pages C73 - C80 ISSN 0363-6143 Altmetric
2008	The three-dimensional structure of the analgesic α-conotoxin, RgIA Published In FEBS Letters Volume 582 Pages 597 - 602 ISSN 0014-5793 Altmetric
2008	ω-Conotoxin inhibition of excitatory synaptic transmission evoked by dorsal root stimulation in rat superficial dorsal horn Published In Neuropharmacology Volume 55 Pages 860 - 864 ISSN 0028-3908 Altmetric
2007	Are α9α10 nicotinic acetylcholine receptors a pain target for α-conotoxins? Published In Molecular Pharmacology Volume 72 Pages 1406 - 1410 ISSN 0026-895X Altmetric
2007	Chemical modification of conotoxins to improve stability and activity Published In ACS Chemical Biology Volume 2 Pages 457 - 468 ISSN 1554-8929 Altmetric
2007	Distinct activities of novel neurotoxins from Australian venomous snakes for nicotinic acetylcholine receptors Published In Cellular and Molecular Life Sciences Volume 64 Pages 2829 - 2840 ISSN 1420-9071 Altmetric
2007	Isolation and structure-activity of μ-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels Published In Molecular Pharmacology Volume 71 Pages 676 - 685 ISSN 0026-895X Altmetric
2007	Liposome reconstitution and modulation of recombinant N-methyl-D-aspartate receptor channels by membrane stretch Published In Proceedings of the National Academy of Sciences of USA Volume 104 Pages 1540 - 1545 ISSN 0027-8424 Altmetric
2007	NEDD4-2 as a potential candidate susceptibility gene for epileptic photosensitivity Published In Genes, Brain and Behavior Volume 6 Pages 750 - 755 ISSN 1601-183X Altmetric
2007	Polymodal regulation of NMDA receptor channels Published In Channels Volume 1 Pages 334 - 343 ISSN 1933-6950 Altmetric
2007	Purinergic receptor activation inhibits mitogen-stimulated proliferation in primary neurospheres from the adult mouse subventricular zone Published In Molecular and Cellular Neuroscience Volume 35 Pages 535 - 548 ISSN 1044-7431 Altmetric
2007	Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by ubiquitination: novel role for Nedd4-2 Published In Journal of Biological Chemistry Volume 282 Pages 12135 - 12142 ISSN 0021-9258 Altmetric
2007	Structure of α-conotoxin BuIA: influences of disulfide connectivity on structural dynamics Published In BMC Structural Biology Volume 7 Page p. 28 ISSN 1472-6807 Altmetric
2007	The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells Published In The Journal of Neuroscience Volume 27 Pages 3734 - 3742 ISSN 1529-2401 Altmetric

Collection Or Series Editor For

The Journal of Physiology (Journal) 2015 -
Marine Drugs (Journal) 2014 -
The International Journal of Biochemistry and Cell Biology (Journal) 2013 -
Frontiers in Pharmacology (Journal) 2010 -
Channels (Journal) 2006 -
Neuropharmacology (Journal) 2016 - 2017
Pfluegers Archiv: European journal of physiology (Journal) 2008 - 2011
American Journal of Physiology: Heart and Circulatory Physiology (Journal) 1991 - 1996

Investigator On

Year	Title
2015 - 2020	Nicotinic receptor structure and function probed with conotoxinx Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2019	Inflammatory Pain - Control of Immune Cell Nicotinic Receptor Signaling by Conotoxins? Mechanisms and Screening Platforms Awarded by: Deutscher Akademischer Austausch Dienst (DAAD) Funding Scheme: Australia Germany Joint Cooperation Scheme
2018	Electrophysiology Facility for Cell Phenotyping and Drug Discovery Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2017	Identifying novel gene mutations for molecular diagnosis of Familial Hemiplegic Migraine Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2013 - 2016	Alpha-Conotoxin Inhibition of Chronic Visceral Pain Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2015	Ion channel modulators of pain pathways Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Program Grant

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Conotoxin modulation of voltage-gated calcium and potassium channels via GABA-B receptor activation	Bony, Anuja
Doctor of Philosophy	Nicotinic acetylcholine receptor structure and function probed with venom derived peptides.	Bye, Lydia

Professional Service Activities

NSW Office for Health and Medical Research Cardiovascular Disease Research Advisory Committee 2018 - 2022
Multiple Sclerosis Research Australia (MSRA) Member of the Research Management Council 2007 - 2015
National Health and Medical Research Council Assigners Academy 2012 - 2014
Australian Academy of Science National Committee for Biomedical Sciences 2003 - 2009
The University of Queensland Head of School of Biomedical Sciences 2000 - 2007
University of Queensland Head of Department of Physiology and Pharmacology 1998 - 2000

Education And Training

Marine Biological Laboratory, Woods Hole, MA, Grass Fellowship in Neurophysiology 1980 -
Ph.D. in Physiology, University of New South Wales, School of Physiology & Pharmacology, An Analysis of Ionic Channels in Aplysia Nerve Cell Membrane. 1974 - 1978
B Science (Hon) in Physiology, University of New South Wales 1970 - 1973
University College of London (UCL) , Department of Pharmacology, Beit Memorial Fellowship for Medical Research, UK 1981 - 1983
University of Washington School of Medicine, Department of Physiology & Biophysics, Muscular Dystrophy Association of America Postdoctoral Fellowship 1978 - 1980

Awards And Honors

NHMRC Ten of the Best Health & Medical Research Projects, conferred by NHMRC, 2011
Finalist, Australian Museum Eureka Prize People’s Choice Award, conferred by Australian Museum Eureka Prizes, 2005
Finalist, Royal Societies of Australia Eureka Prize for Interdisciplinary Scientific Research, conferred by Australian Museum Eureka Prizes, 2004
Australian Professorial Fellowship, conferred by Austrlian Research Council (ARC), 2010 - 2015

Keywords

Membrane physiology
Neuropharmacology
Cellular neuroscience
Electrophysiology
Ion channels
Membrane biophysics

Full Name

David John Adams

Mailing Address

Illawarra Health & Medical Research Institute (IHMRI)

University of Wollongong

Wollongong

NSW

2522

Australia

Located In Facility

Illawarra Health and Medical Research Institute

Orcid Id

http://orcid.org/0000-0002-7030-2288 (confirmed)

Top Publications

Year	Title
2008	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation Published in The Journal of Neuroscience
2017	α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA_B receptors Published in Gut
2012	Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels Published in British Journal of Pharmacology
2014	Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation Published in Journal of General Physiology
2016	Key structural determinants in the agonist binding loops of human β2 and β4 nicotinic acetylcholine receptor subunits contribute to α3β4 subtype selectivity of α-conotoxins Published in Journal of Biological Chemistry
2015	Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABAB receptor Published in Molecular Pharmacology
2013	Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor Published in Journal of Medicinal Chemistry
2013	Are nicotinic acetylcholine receptors coupled to G proteins? Published in BioEssays
2018	α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition Published in British Journal of Pharmacology
2006	μO-conotoxin MrVIB selectively blocks NaV1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits Published in Proceedings of the National Academy of Sciences of USA
2018	Structure-Activity Studies Reveal the Molecular Basis for GABA(B)-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1 Published in ACS Chemical Biology

Research Areas

Research Overview

Prof Adams' research focuses on membrane receptors and ion channels and is currently funded by an NHMRC Program Grant and ARC Discovery Grants (2015-2019). He is internationally recognised for his contributions to membrane physiology, in particular that of ion channel function and modulation using electrophysiological recording techniques. In the last 20 years, he has identified novel peptides (conotoxins) obtained from the venom of cone snails as probes for ion channel structure and function. This research has focused on investigating conotoxins that selectively target the voltage-gated sodium and calcium channels, nicotinic acetylcholine receptors, and G protein-coupled receptor modulation of calcium channels.

Head Of

Illawarra Health and Medical Research Institute (IHMRI) CEO and Executive Director 2016 -

Selected Publications

Journal Article

Year	Title
2020	Ketamine inhibits synaptic transmission and nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglia in situ Published In Neuropharmacology Volume 165 Altmetric
2020	Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom Published In Biochemical Pharmacology Volume 174 Altmetric
2019	Bombesin receptors as potential targets for anticancer drug delivery and imaging Published In The International Journal of Biochemistry and Cell Biology Volume 114 Pages 105567-1 - 105567-9 ISSN 1878-5875 Altmetric
2019	Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors Published In British Journal of Pharmacology Altmetric
2019	Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor Published In British Journal of Pharmacology Volume 176 Pages 2750 - 2763 ISSN 0007-1188 Altmetric
2019	Monoclonal antibody-conjugated dendritic nanostructures for siRNA delivery Published In Methods in Molecular Biology Volume 1974 Pages 195 - 201 ISSN 1064-3745 Altmetric
2019	On-Resin Strategy to Label α-Conotoxins: Cy5-RgIA, a Potent α9α10 Nicotinic Acetylcholine Receptor Imaging Probe Published In Australian Journal of Chemistry Altmetric
2019	α-Conotoxin Vc1.1 structure-activity relationship at the human α9α10 nicotinic acetylcholine receptor investigated by minimal side chain replacement Published In ACS Chemical Neuroscience Volume 10 Pages 4328 - 4336 ISSN 1948-7193 Altmetric
2018	A novel α-conopeptide Eu1.6 inhibits N-type (CaV2.2) calcium channels and exhibits potent analgesic activity Published In Scientific Reports Volume 8 Pages 1004-1 - 1004-13 ISSN 2045-2322 Altmetric
2018	Contribution of membrane receptor signalling to chronic visceral pain Published In The International Journal of Biochemistry and Cell Biology Volume 98 Pages 10 - 23 ISSN 1878-5875 Altmetric
2018	Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain Published In British Journal of Pharmacology Volume 175 Pages 2384 - 2398 ISSN 0007-1188 Altmetric
2018	Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1 Published In British Journal of Pharmacology Volume 175 Pages 2284 - 2295 ISSN 0007-1188 Altmetric
2018	Molecular Determinants Conferring the Stoichiometric-Dependent Activity of alpha-Conotoxins at the Human alpha 9 alpha 10 Nicotinic Acetylcholine Receptor Subtype Published In Journal of Medicinal Chemistry Volume 61 Pages 4628 - 4634 ISSN 0022-2623 Altmetric
2018	NMR structure of µ-conotoxin GIIIC: Leucine 18 induces local repacking of the N-terminus resulting in reduced Nav channel potency Published In Molecules Volume 23 Pages 2715-1 - 2715-12 ISSN 1420-3049 Altmetric
2018	Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides Published In Scientific Reports Volume 8 Pages 13397-1 - 13397-15 ISSN 2045-2322 Altmetric
2018	Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB Published In Biochemical Pharmacology Volume 155 Pages 288 - 297 ISSN 0006-2952 Altmetric
2018	Structure-Activity Studies Reveal the Molecular Basis for GABA(B)-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1 Published In ACS Chemical Biology Volume 13 Pages 1577 - 1587 ISSN 1554-8929 Altmetric
2018	Targeting of N-Type Calcium Channels via GABAB-Receptor Activation by α-Conotoxin Vc1.1 Variants Displaying Improved Analgesic Activity Published In Journal of Medicinal Chemistry Volume 61 Pages 10198 - 10205 ISSN 0022-2623 Altmetric
2018	α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition Published In British Journal of Pharmacology Volume 175 Pages 1855 - 1868 ISSN 0007-1188 Altmetric
2017	A novel lid-covering peptide inhibitor of nicotinic acetylcholine receptors derived from αd-conotoxin GeXXA Published In Marine Drugs Volume 15 ISSN 1660-3397 Altmetric
2017	Analgesic conopeptides targeting G protein-coupled receptors reduce excitability of sensory neurons Published In Neuropharmacology Volume 127 Pages 116 - 123 ISSN 0028-3908 Altmetric
2017	Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer Published In Journal of Biological Chemistry Volume 292 Pages 17101 - 17112 ISSN 0021-9258 Altmetric
2017	Identification of a novel O-conotoxin reveals an unusual and potent inhibitor of the human α9α10 nicotinic acetylcholine receptor Published In Marine Drugs Volume 15 Pages 170-1 - 170-13 ISSN 1660-3397 Altmetric
2017	In vivo and in vitro testing of native α-conotoxins from the injected venom of Conus purpurascens Published In Neuropharmacology Volume 127 Pages 253 - 259 ISSN 0028-3908 Altmetric
2017	Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors Published In Scientific Reports Volume 7 Pages 16606-1 - 16606-11 ISSN 2045-2322 Altmetric
2017	Neuropharmacology of venom peptides Published In Neuropharmacology Volume 127 Pages 1 - 3 ISSN 0028-3908 Altmetric
2017	Peptide grafted and self-assembled poly(γ-glutamic acid)-phenylalanine nanoparticles targeting camptothecin to glioma Published In Nanomedicine Volume 12 Pages 1661 - 1674 ISSN 1743-5889 Altmetric
2017	Role of Cys(I)-Cys(III) Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors Published In ACS Omega Volume 2 Pages 4621 - 4631 Altmetric
2017	The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity Published In Scientific Reports Volume 7 Pages 974-1 - 974-15 ISSN 2045-2322 Altmetric
2017	α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA_B receptors Published In Gut Volume 66 Pages 1083 - 1094 ISSN 0017-5749 Altmetric
2016	Effects of linker sequence modifications on the structure, stability, and biological activity of a cyclic α-conotoxin Published In Biopolymers Volume 106 Pages 864 - 875 Altmetric
2016	Improving efficacy, oral bioavailability, and delivery of paclitaxel using protein-grafted solid lipid nanoparticles Published In Molecular Pharmaceutics Volume 13 Pages 3903 - 3912 ISSN 1543-8384 Altmetric
2016	Key structural determinants in the agonist binding loops of human β2 and β4 nicotinic acetylcholine receptor subunits contribute to α3β4 subtype selectivity of α-conotoxins Published In Journal of Biological Chemistry Volume 291 Pages 23779 - 23792 ISSN 0021-9258 Altmetric
2016	Mechanism of direct Ca_v2.2 channel block by the κ-opioid receptor agonist U50488H Published In Neuropharmacology Volume 109 Pages 49 - 58 ISSN 0028-3908 Altmetric
2016	Modulation of human Na(v)1.7 channel gating by synthetic α-scorpion toxin OD1 and its analogs Published In Channels Volume 10 Pages 139 - 147 ISSN 1933-6950 Altmetric
2016	Structure-activity studies of cysteine-rich α-Conotoxins that inhibit high voltage-activated calcium channels via GABA_B receptor activation reveal a minimal functional motif Published In Angewandte Chemie International Edition Volume 55 Pages 4692 - 4696 ISSN 1521-3773 Altmetric
2016	Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer Published In Scientific Reports Volume 6 Pages 23179-1 - 23179-13 ISSN 2045-2322 Altmetric
2015	Alanine scan ofα-conotoxin regiia reveals a selective α3α4 nicotinic acetylcholine receptor antagonist Published In Journal of Biological Chemistry Volume 290 Pages 1039 - 1048 ISSN 0021-9258 Altmetric
2015	Biomedical applications of trastuzumab: as a therapeutic agent and a targeting ligand Published In Medicinal Research Reviews Volume 35 Pages 849 - 876 ISSN 0198-6325 Altmetric
2015	Bombesin-conjugated nanoparticles improve the cytotoxic efficacy of docetaxel against gastrin-releasing but androgen-independent prostate cancer Published In Nanomedicine Volume 10 Pages 2847 - 2859 ISSN 1743-5889 Altmetric
2015	Conotoxin αd-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors Published In Scientific Reports Volume 5 Pages 14261-1 - 14261-8 ISSN 2045-2322 Altmetric
2015	Cyclic-RGDfK peptide conjugated succinoyl-TPGS nanomicelles for targeted delivery of docetaxel to integrin receptor over-expressing angiogenic tumours Published In Nanomedicine: Nanotechnology, Biology and Medicine Volume 11 Pages 1511 - 1520 ISSN 1549-9634 Altmetric
2015	Distinct functional site in Ω-neurotoxins: novel antagonists of nicotinic acetylcholine receptors from snake venom Published In ACS Chemical Biology Volume 10 Pages 2805 - 2815 ISSN 1554-8929 Altmetric
2015	Inhibition of cholinergic pathways in Drosophila melanogaster by α-conotoxins Published In The FASEB Journal Volume 29 Pages 1011 - 1018 ISSN 0892-6638 Altmetric
2015	Less is more: design of a highly stable disulfide-deleted mutant of analgesic cyclic α-conotoxin Vc1.1 Published In Scientific Reports Volume 5 Pages 13264-1 - 13264-11 ISSN 2045-2322 Altmetric
2015	Molecular basis for differential sensitivity of α-conotoxin RegIIA at rat and human neuronal nicotinic acetylcholine receptors Published In Molecular Pharmacology Volume 88 Pages 993 - 1001 ISSN 0026-895X Altmetric
2015	Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABAB receptor Published In Molecular Pharmacology Volume 87 Pages 240 - 250 ISSN 0026-895X Altmetric
2015	α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors Published In Journal of the American Chemical Society Volume 137 Pages 3209 - 3212 ISSN 0002-7863 Altmetric
2014	Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets Published In Journal of Medicinal Chemistry Volume 57 Pages 9933 - 9944 ISSN 0022-2623 Altmetric
2014	Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation Published In Journal of General Physiology Volume 143 Pages 465 - 479 ISSN 0022-1295 Altmetric
2014	Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels Published In British Journal of Pharmacology Volume 171 Pages 3313 - 3327 ISSN 0007-1188 Altmetric
2014	Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors Published In Biochemical Pharmacology Volume 91 Pages 534 - 542 ISSN 0006-2952 Altmetric
2014	Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels Published In Biochemical Pharmacology Volume 89 Pages 276 - 286 ISSN 0006-2952 Altmetric
2013	Are nicotinic acetylcholine receptors coupled to G proteins? Published In BioEssays Volume 35 Pages 1025 - 1034 ISSN 0265-9247 Altmetric
2013	Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1 Published In ACS Chemical Biology Volume 8 Pages 1215 - 1222 ISSN 1554-8929 Altmetric
2013	Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor Published In Journal of Medicinal Chemistry Volume 56 Pages 3557 - 3567 ISSN 0022-2623 Altmetric
2013	Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors Published In ACS Chemical Biology Volume 8 Pages 1815 - 1821 ISSN 1554-8929 Altmetric
2013	Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors Published In Journal of Biological Chemistry Volume 288 Pages 34428 - 34442 Altmetric
2013	Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors Published In Biochemical Pharmacology Volume 86 Pages 791 - 799 Altmetric
2013	Kv3.1 channels stimulate adult neural precursor cell proliferation and neuronal differentiation Published In The Journal of Physiology Volume 591 Pages 2579 - 2591 ISSN 0022-3751 Altmetric
2013	Mechanisms of conotoxin inhibition of N-type (Cav2.2) calcium channels Published In BBA: Biomembranes Volume 1828 Pages 1619 - 1628 ISSN 0005-2736 Altmetric
2012	Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels Published In British Journal of Pharmacology Volume 166 Pages 486 - 500 ISSN 0007-1188 Altmetric
2012	Biophysical properties of Nav1.8/Nav1.2 chimeras and inhibition by μo-conotoxin MrVIB Published In British Journal of Pharmacology Volume 166 Pages 2148 - 2160 ISSN 0007-1188 Altmetric
2012	Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics? Published In Toxins Volume 4 Pages 1236 - 1260 ISSN 2072-6651 Altmetric
2012	Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain Published In Neuropharmacology Volume 62 Pages 2202 - 2207 ISSN 0028-3908 Altmetric
2012	Isolation, characterization and total regioselective synthesis of the novel μo-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels Published In Biochemical Pharmacology Volume 84 Pages 540 - 548 ISSN 0006-2952 Altmetric
2012	Localization of Nav 1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function Published In Channels Volume 6 Pages 103 - 110 ISSN 1933-6950 Altmetric
2012	RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs Published In Biochemical Pharmacology Volume 83 Pages 419 - 426 ISSN 0006-2952 Altmetric
2012	γ-Aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic α-conotoxins Published In Journal of Biological Chemistry Volume 287 Pages 23948 - 23957 ISSN 0021-9258 Altmetric
2011	A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain Published In Pain Volume 152 Pages 259 - 266 ISSN 0304-3959 Altmetric
2011	Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABAB receptor Published In Journal of Medicinal Chemistry Volume 54 Pages 6984 - 6992 ISSN 0022-2623 Altmetric
2011	Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function? Published In Journal of Biological Chemistry Volume 286 Pages 22546 - 22557 ISSN 0021-9258 Altmetric
2011	Purification of immature neuronal cells from neural stem cell progeny Published In PLoS One Volume 6 Pages e20941-1 - e20941-16 ISSN 1932-6203 Altmetric
2011	Regulation of voltage-gated ion channels in excitable cells by the ubiquitin ligases Nedd4 and Nedd4-2 Published In Channels Volume 5 Pages 79 - 88 ISSN 1933-6950 Altmetric
2011	Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization Published In Antioxidants and Redox Signaling Volume 14 Pages 87 - 95 ISSN 1523-0864 Altmetric
2011	Structure and activity of α-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABAB receptor-coupled N-type calcium channels Published In Journal of Biological Chemistry Volume 286 Pages 10233 - 10237 ISSN 0021-9258 Altmetric
2011	Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding Published In Angewandte Chemie International Edition Volume 50 Pages 6527 - 6529 ISSN 1521-3773 Altmetric
2010	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout mice Published In Channels Volume 4 Pages 51 - 54 ISSN 1933-6950 Altmetric
2010	Analgesic ω-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels Published In Molecular Pharmacology Volume 77 Pages 139 - 148 ISSN 0026-895X Altmetric
2010	Physiological roles of ion channels in adult neural stem cells and their progeny Published In Journal of Neurochemistry Volume 114 Pages 946 - 959 ISSN 0022-3042 Altmetric
2010	Solving the α-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antaqonists Published In Journal of the American Chemical Society Volume 132 Pages 3514 - 3522 ISSN 0002-7863 Altmetric
2010	The engineering of an orally active conotoxin for the treatment of neuropathic pain Published In Angewandte Chemie International Edition Volume 49 Pages 6545 - 6548 ISSN 1521-3773 Altmetric
2010	α-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of α3β4 nicotinic acetylcholine receptors Published In Journal of Biological Chemistry Volume 285 Pages 22254 - 22263 ISSN 0021-9258 Altmetric
2009	Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3 Published In Toxicon Volume 54 Pages 56 - 61 ISSN 1879-3150 Altmetric
2009	Inhibition of neuronal nicotinic acetylcholine receptor subtypes by α-conotoxin GID and analogues Published In Journal of Biological Chemistry Volume 284 Pages 4944 - 4951 ISSN 0021-9258 Altmetric
2009	Reactive oxygen species modulate neuronal excitability in rat intrinsic cardiac ganglia Published In Autonomic Neuroscience: Basic and Clinical Volume 150 Pages 45 - 52 ISSN 1566-0702 Altmetric
2009	Scanning mutagenesis of α-conotoxin Vc1.1 reveals residues crucial for activity at the α9α10 nicotinic acetylcholine receptor Published In Journal of Biological Chemistry Volume 284 Pages 20275 - 20284 ISSN 0021-9258 Altmetric
2008	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation Published In The Journal of Neuroscience Volume 28 Pages 10943 - 10951 ISSN 1529-2401 Altmetric
2008	Conotoxin modulation of voltage-gated sodium channels Published In The International Journal of Biochemistry and Cell Biology Volume 40 Pages 2363 - 2368 ISSN 1878-5875 Altmetric
2008	Kir and Kv channels regulate electrical properties and proliferation of adult neural precursor cells Published In Molecular and Cellular Neuroscience Volume 37 Pages 284 - 297 ISSN 1044-7431 Altmetric
2008	Molecular engineering of conotoxins: The importance of loop size to α-conotoxin structure and function Published In Journal of Medicinal Chemistry Volume 51 Pages 5575 - 5584 ISSN 0022-2623 Altmetric
2008	Neuronally selective μ-conotoxins from Conus striatus utilize an α-helical motif to target mammalian sodium channels Published In Journal of Biological Chemistry Volume 283 Pages 21621 - 21628 ISSN 0021-9258 Altmetric
2008	Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1 Published In American Journal of Physiology: Cell Physiology Volume 295 Pages C73 - C80 ISSN 0363-6143 Altmetric
2008	The three-dimensional structure of the analgesic α-conotoxin, RgIA Published In FEBS Letters Volume 582 Pages 597 - 602 ISSN 0014-5793 Altmetric
2008	ω-Conotoxin inhibition of excitatory synaptic transmission evoked by dorsal root stimulation in rat superficial dorsal horn Published In Neuropharmacology Volume 55 Pages 860 - 864 ISSN 0028-3908 Altmetric
2007	Are α9α10 nicotinic acetylcholine receptors a pain target for α-conotoxins? Published In Molecular Pharmacology Volume 72 Pages 1406 - 1410 ISSN 0026-895X Altmetric
2007	Chemical modification of conotoxins to improve stability and activity Published In ACS Chemical Biology Volume 2 Pages 457 - 468 ISSN 1554-8929 Altmetric
2007	Distinct activities of novel neurotoxins from Australian venomous snakes for nicotinic acetylcholine receptors Published In Cellular and Molecular Life Sciences Volume 64 Pages 2829 - 2840 ISSN 1420-9071 Altmetric
2007	Isolation and structure-activity of μ-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels Published In Molecular Pharmacology Volume 71 Pages 676 - 685 ISSN 0026-895X Altmetric
2007	Liposome reconstitution and modulation of recombinant N-methyl-D-aspartate receptor channels by membrane stretch Published In Proceedings of the National Academy of Sciences of USA Volume 104 Pages 1540 - 1545 ISSN 0027-8424 Altmetric
2007	NEDD4-2 as a potential candidate susceptibility gene for epileptic photosensitivity Published In Genes, Brain and Behavior Volume 6 Pages 750 - 755 ISSN 1601-183X Altmetric
2007	Polymodal regulation of NMDA receptor channels Published In Channels Volume 1 Pages 334 - 343 ISSN 1933-6950 Altmetric
2007	Purinergic receptor activation inhibits mitogen-stimulated proliferation in primary neurospheres from the adult mouse subventricular zone Published In Molecular and Cellular Neuroscience Volume 35 Pages 535 - 548 ISSN 1044-7431 Altmetric
2007	Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by ubiquitination: novel role for Nedd4-2 Published In Journal of Biological Chemistry Volume 282 Pages 12135 - 12142 ISSN 0021-9258 Altmetric
2007	Structure of α-conotoxin BuIA: influences of disulfide connectivity on structural dynamics Published In BMC Structural Biology Volume 7 Page p. 28 ISSN 1472-6807 Altmetric
2007	The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells Published In The Journal of Neuroscience Volume 27 Pages 3734 - 3742 ISSN 1529-2401 Altmetric

Collection Or Series Editor For

The Journal of Physiology (Journal) 2015 -
Marine Drugs (Journal) 2014 -
The International Journal of Biochemistry and Cell Biology (Journal) 2013 -
Frontiers in Pharmacology (Journal) 2010 -
Channels (Journal) 2006 -
Neuropharmacology (Journal) 2016 - 2017
Pfluegers Archiv: European journal of physiology (Journal) 2008 - 2011
American Journal of Physiology: Heart and Circulatory Physiology (Journal) 1991 - 1996

Investigator On

Year	Title
2015 - 2020	Nicotinic receptor structure and function probed with conotoxinx Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2019	Inflammatory Pain - Control of Immune Cell Nicotinic Receptor Signaling by Conotoxins? Mechanisms and Screening Platforms Awarded by: Deutscher Akademischer Austausch Dienst (DAAD) Funding Scheme: Australia Germany Joint Cooperation Scheme
2018	Electrophysiology Facility for Cell Phenotyping and Drug Discovery Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2017	Identifying novel gene mutations for molecular diagnosis of Familial Hemiplegic Migraine Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2013 - 2016	Alpha-Conotoxin Inhibition of Chronic Visceral Pain Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2015	Ion channel modulators of pain pathways Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Program Grant

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Conotoxin modulation of voltage-gated calcium and potassium channels via GABA-B receptor activation	Bony, Anuja
Doctor of Philosophy	Nicotinic acetylcholine receptor structure and function probed with venom derived peptides.	Bye, Lydia

Professional Service Activities

NSW Office for Health and Medical Research Cardiovascular Disease Research Advisory Committee 2018 - 2022
Multiple Sclerosis Research Australia (MSRA) Member of the Research Management Council 2007 - 2015
National Health and Medical Research Council Assigners Academy 2012 - 2014
Australian Academy of Science National Committee for Biomedical Sciences 2003 - 2009
The University of Queensland Head of School of Biomedical Sciences 2000 - 2007
University of Queensland Head of Department of Physiology and Pharmacology 1998 - 2000

Education And Training

Marine Biological Laboratory, Woods Hole, MA, Grass Fellowship in Neurophysiology 1980 -
Ph.D. in Physiology, University of New South Wales, School of Physiology & Pharmacology, An Analysis of Ionic Channels in Aplysia Nerve Cell Membrane. 1974 - 1978
B Science (Hon) in Physiology, University of New South Wales 1970 - 1973
University College of London (UCL) , Department of Pharmacology, Beit Memorial Fellowship for Medical Research, UK 1981 - 1983
University of Washington School of Medicine, Department of Physiology & Biophysics, Muscular Dystrophy Association of America Postdoctoral Fellowship 1978 - 1980

Awards And Honors

NHMRC Ten of the Best Health & Medical Research Projects, conferred by NHMRC, 2011
Finalist, Australian Museum Eureka Prize People’s Choice Award, conferred by Australian Museum Eureka Prizes, 2005
Finalist, Royal Societies of Australia Eureka Prize for Interdisciplinary Scientific Research, conferred by Australian Museum Eureka Prizes, 2004
Australian Professorial Fellowship, conferred by Austrlian Research Council (ARC), 2010 - 2015

Keywords

Membrane physiology
Neuropharmacology
Cellular neuroscience
Electrophysiology
Ion channels
Membrane biophysics

Full Name

David John Adams

Mailing Address

Illawarra Health & Medical Research Institute (IHMRI)

University of Wollongong

Wollongong

NSW

2522

Australia

Located In Facility

Illawarra Health and Medical Research Institute

Orcid Id

http://orcid.org/0000-0002-7030-2288 (confirmed)

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Overview

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Research Overview

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Publications

Selected Publications

Journal Article

Collection Or Series Editor For

Funding

Investigator On

Supervision

Advisees

Graduate Advising Relationship

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Education And Training

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Keywords

Contact

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