Adams, David J..

Overview

David J. Adams is currently Distinguished Professor and Executive Director of the Illawarra Health & Medical Research Institute (IHMRI) at the University of Wollongong. He was previously Professor and Director of the Health Innovations Research Institute, RMIT University and an ARC Australian Professorial Fellow (2010-2015) and during the period 04/2013-02/2014 he was Acting Deputy Vice-Chancellor (Research & Innovation) and Vice-President, RMIT University. He was Professor and Chair of Physiology at the University of Queensland (UQ), Head of Department of Physiology & Pharmacology (1997-2000), Head of the School of Biomedical Sciences (2000-2007) and Professorial Research Fellow and Director of UQ Neuroscience Program, Queensland Brain Institute (2008-2009).

Top Publications

Year	Title
2008	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation Published in The Journal of Neuroscience
2012	Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels Published in British Journal of Pharmacology
2014	Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation Published in Journal of General Physiology
2016	Key structural determinants in the agonist binding loops of human β2 and β4 nicotinic acetylcholine receptor subunits contribute to α3β4 subtype selectivity of α-conotoxins Published in Journal of Biological Chemistry
2017	α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA_B receptors Published in Gut
2015	Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABAB receptor Published in Molecular Pharmacology
2013	Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor Published in Journal of Medicinal Chemistry
2013	Are nicotinic acetylcholine receptors coupled to G proteins? Published in BioEssays
2018	α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition Published in British Journal of Pharmacology
2006	μO-conotoxin MrVIB selectively blocks NaV1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits Published in Proceedings of the National Academy of Sciences of USA

Research Areas

Research Overview

Prof Adams' research focuses on membrane receptors and ion channels and is currently funded by an NHMRC Program Grant and ARC Discovery Grants (2015-2019). He is internationally recognised for his contributions to membrane physiology, in particular that of ion channel function and modulation using electrophysiological recording techniques. In the last 20 years, he has identified novel peptides (conotoxins) obtained from the venom of cone snails as probes for ion channel structure and function. This research has focused on investigating conotoxins that selectively target the voltage-gated sodium and calcium channels, nicotinic acetylcholine receptors, and G protein-coupled receptor modulation of calcium channels.

Selected Publications

Journal Article

Year	Title
2018	A novel α-conopeptide Eu1.6 inhibits N-type (CaV2.2) calcium channels and exhibits potent analgesic activity Published In Scientific Reports Volume 8 Pages 1004-1 - 1004-13 ISSN 2045-2322 Altmetric
2018	Contribution of membrane receptor signalling to chronic visceral pain Published In The International Journal of Biochemistry and Cell Biology Volume 98 Pages 10 - 23 ISSN 1357-2725 Altmetric
2018	Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain Published In British Journal of Pharmacology Volume Online First Pages 1 - 15 ISSN 0007-1188 Altmetric
2018	Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1 Published In British Journal of Pharmacology Volume 175 Pages 2284 - 2295 ISSN 0007-1188 Altmetric
2018	Molecular Determinants Conferring the Stoichiometric-Dependent Activity of alpha-Conotoxins at the Human alpha 9 alpha 10 Nicotinic Acetylcholine Receptor Subtype Published In Journal of Medicinal Chemistry Volume 61 Pages 4628 - 4634 ISSN 0022-2623 Altmetric
2018	NMR structure of µ-conotoxin GIIIC: Leucine 18 induces local repacking of the N-terminus resulting in reduced Nav channel potency Published In Molecules Volume 23 Pages 2715-1 - 2715-12 ISSN 1420-3049 Altmetric
2018	Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides Published In Scientific Reports Volume 8 Pages 13397-1 - 13397-15 ISSN 2045-2322 Altmetric
2018	Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB Published In Biochemical Pharmacology Volume 155 Pages 288 - 297 ISSN 0006-2952 Altmetric
2018	Structure-Activity Studies Reveal the Molecular Basis for GABA(B)-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1 Published In ACS Chemical Biology Volume 13 Pages 1577 - 1587 ISSN 1554-8929 Altmetric
2018	Targeting of N-Type Calcium Channels via GABAB-Receptor Activation by α-Conotoxin Vc1.1 Variants Displaying Improved Analgesic Activity Published In Journal of Medicinal Chemistry Volume 61 Pages 10198 - 10205 ISSN 0022-2623 Altmetric
2018	α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition Published In British Journal of Pharmacology Volume 175 Pages 1855 - 1868 ISSN 0007-1188 Altmetric
2017	A novel lid-covering peptide inhibitor of nicotinic acetylcholine receptors derived from αd-conotoxin GeXXA Published In Marine Drugs Volume 15 ISSN 1660-3397 Altmetric
2017	Analgesic conopeptides targeting G protein-coupled receptors reduce excitability of sensory neurons Published In Neuropharmacology Volume 127 Pages 116 - 123 ISSN 0028-3908 Altmetric
2017	Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer Published In Journal of Biological Chemistry Volume 292 Pages 17101 - 17112 ISSN 0021-9258 Altmetric
2017	Identification of a novel O-conotoxin reveals an unusual and potent inhibitor of the human α9α10 nicotinic acetylcholine receptor Published In Marine Drugs Volume 15 Pages 170-1 - 170-13 ISSN 1660-3397 Altmetric
2017	In vivo and in vitro testing of native α-conotoxins from the injected venom of Conus purpurascens Published In Neuropharmacology Volume 127 Pages 253 - 259 ISSN 0028-3908 Altmetric
2017	Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors Published In Scientific Reports Volume 7 Pages 16606-1 - 16606-11 ISSN 2045-2322 Altmetric
2017	Neuropharmacology of venom peptides Published In Neuropharmacology Volume 127 Pages 1 - 3 ISSN 0028-3908 Altmetric
2017	Peptide grafted and self-assembled poly(γ-glutamic acid)-phenylalanine nanoparticles targeting camptothecin to glioma Published In Nanomedicine Volume 12 Pages 1661 - 1674 ISSN 1743-5889 Altmetric
2017	Role of Cys(I)-Cys(III) Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors Published In ACS Omega Volume 2 Pages 4621 - 4631 Altmetric
2017	The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity Published In Scientific Reports Volume 7 Pages 974-1 - 974-15 ISSN 2045-2322 Altmetric
2017	α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA_B receptors Published In Gut Volume 66 Pages 1083 - 1094 ISSN 0017-5749 Altmetric
2016	Effects of linker sequence modifications on the structure, stability, and biological activity of a cyclic α-conotoxin Published In Biopolymers Volume 106 Pages 864 - 875 Altmetric
2016	Improving efficacy, oral bioavailability, and delivery of paclitaxel using protein-grafted solid lipid nanoparticles Published In Molecular Pharmaceutics Volume 13 Pages 3903 - 3912 ISSN 1543-8384 Altmetric
2016	Key structural determinants in the agonist binding loops of human β2 and β4 nicotinic acetylcholine receptor subunits contribute to α3β4 subtype selectivity of α-conotoxins Published In Journal of Biological Chemistry Volume 291 Pages 23779 - 23792 ISSN 0021-9258 Altmetric
2016	Mechanism of direct Ca_v2.2 channel block by the κ-opioid receptor agonist U50488H Published In Neuropharmacology Volume 109 Pages 49 - 58 ISSN 0028-3908 Altmetric
2016	Modulation of human Na(v)1.7 channel gating by synthetic α-scorpion toxin OD1 and its analogs Published In Channels Volume 10 Pages 139 - 147 ISSN 1933-6950 Altmetric
2016	Structure-activity studies of cysteine-rich α-Conotoxins that inhibit high voltage-activated calcium channels via GABA_B receptor activation reveal a minimal functional motif Published In Angewandte Chemie International Edition Volume 55 Pages 4692 - 4696 ISSN 1433-7851 Altmetric
2016	Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer Published In Scientific Reports Volume 6 Pages 23179-1 - 23179-13 ISSN 2045-2322 Altmetric
2015	Alanine scan ofα-conotoxin regiia reveals a selective α3α4 nicotinic acetylcholine receptor antagonist Published In Journal of Biological Chemistry Volume 290 Pages 1039 - 1048 ISSN 0021-9258 Altmetric
2015	Biomedical applications of trastuzumab: as a therapeutic agent and a targeting ligand Published In Medicinal Research Reviews Volume 35 Pages 849 - 876 ISSN 0198-6325 Altmetric
2015	Bombesin-conjugated nanoparticles improve the cytotoxic efficacy of docetaxel against gastrin-releasing but androgen-independent prostate cancer Published In Nanomedicine Volume 10 Pages 2847 - 2859 ISSN 1743-5889 Altmetric
2015	Conotoxin αd-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors Published In Scientific Reports Volume 5 Pages 14261-1 - 14261-8 ISSN 2045-2322 Altmetric
2015	Cyclic-RGDfK peptide conjugated succinoyl-TPGS nanomicelles for targeted delivery of docetaxel to integrin receptor over-expressing angiogenic tumours Published In Nanomedicine: Nanotechnology, Biology and Medicine Volume 11 Pages 1511 - 1520 ISSN 1549-9634 Altmetric
2015	Distinct functional site in Ω-neurotoxins: novel antagonists of nicotinic acetylcholine receptors from snake venom Published In ACS Chemical Biology Volume 10 Pages 2805 - 2815 ISSN 1554-8929 Altmetric
2015	Inhibition of cholinergic pathways in Drosophila melanogaster by α-conotoxins Published In The FASEB Journal Volume 29 Pages 1011 - 1018 ISSN 0892-6638 Altmetric
2015	Less is more: design of a highly stable disulfide-deleted mutant of analgesic cyclic α-conotoxin Vc1.1 Published In Scientific Reports Volume 5 Pages 13264-1 - 13264-11 ISSN 2045-2322 Altmetric
2015	Molecular basis for differential sensitivity of α-conotoxin RegIIA at rat and human neuronal nicotinic acetylcholine receptors Published In Molecular Pharmacology Volume 88 Pages 993 - 1001 ISSN 0026-895X Altmetric
2015	Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABAB receptor Published In Molecular Pharmacology Volume 87 Pages 240 - 250 ISSN 0026-895X Altmetric
2015	α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors Published In Journal of the American Chemical Society Volume 137 Pages 3209 - 3212 ISSN 0002-7863 Altmetric
2014	Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets Published In Journal of Medicinal Chemistry Volume 57 Pages 9933 - 9944 ISSN 0022-2623 Altmetric
2014	Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation Published In Journal of General Physiology Volume 143 Pages 465 - 479 ISSN 0022-1295 Altmetric
2014	Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels Published In British Journal of Pharmacology Volume 171 Pages 3313 - 3327 ISSN 0007-1188 Altmetric
2014	Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors Published In Biochemical Pharmacology Volume 91 Pages 534 - 542 ISSN 0006-2952 Altmetric
2014	Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels Published In Biochemical Pharmacology Volume 89 Pages 276 - 286 ISSN 0006-2952 Altmetric
2013	Are nicotinic acetylcholine receptors coupled to G proteins? Published In BioEssays Volume 35 Pages 1025 - 1034 ISSN 0265-9247 Altmetric
2013	Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1 Published In ACS Chemical Biology Volume 8 Pages 1215 - 1222 ISSN 1554-8929 Altmetric
2013	Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor Published In Journal of Medicinal Chemistry Volume 56 Pages 3557 - 3567 ISSN 0022-2623 Altmetric
2013	Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors Published In ACS Chemical Biology Volume 8 Pages 1815 - 1821 ISSN 1554-8929 Altmetric
2013	Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors Published In Journal of Biological Chemistry Volume 288 Pages 34428 - 34442 Altmetric
2013	Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors Published In Biochemical Pharmacology Volume 86 Pages 791 - 799 Altmetric
2013	Kv3.1 channels stimulate adult neural precursor cell proliferation and neuronal differentiation Published In The Journal of Physiology Volume 591 Pages 2579 - 2591 ISSN 0022-3751 Altmetric
2013	Mechanisms of conotoxin inhibition of N-type (Cav2.2) calcium channels Published In BBA: Biomembranes Volume 1828 Pages 1619 - 1628 ISSN 0005-2736 Altmetric
2012	Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels Published In British Journal of Pharmacology Volume 166 Pages 486 - 500 ISSN 0007-1188 Altmetric
2012	Biophysical properties of Nav1.8/Nav1.2 chimeras and inhibition by μo-conotoxin MrVIB Published In British Journal of Pharmacology Volume 166 Pages 2148 - 2160 ISSN 0007-1188 Altmetric
2012	Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics? Published In Toxins Volume 4 Pages 1236 - 1260 ISSN 2072-6651 Altmetric
2012	Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain Published In Neuropharmacology Volume 62 Pages 2202 - 2207 ISSN 0028-3908 Altmetric
2012	Isolation, characterization and total regioselective synthesis of the novel μo-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels Published In Biochemical Pharmacology Volume 84 Pages 540 - 548 ISSN 0006-2952 Altmetric
2012	Localization of Nav 1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function Published In Channels Volume 6 Pages 103 - 110 ISSN 1933-6950 Altmetric
2012	RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs Published In Biochemical Pharmacology Volume 83 Pages 419 - 426 ISSN 0006-2952 Altmetric
2012	γ-Aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic α-conotoxins Published In Journal of Biological Chemistry Volume 287 Pages 23948 - 23957 ISSN 0021-9258 Altmetric
2011	A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain Published In Pain Volume 152 Pages 259 - 266 ISSN 0304-3959 Altmetric
2011	Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABAB receptor Published In Journal of Medicinal Chemistry Volume 54 Pages 6984 - 6992 ISSN 0022-2623 Altmetric
2011	Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function? Published In Journal of Biological Chemistry Volume 286 Pages 22546 - 22557 ISSN 0021-9258 Altmetric
2011	Purification of immature neuronal cells from neural stem cell progeny Published In PLoS One Volume 6 Pages e20941-1 - e20941-16 ISSN 1932-6203 Altmetric
2011	Regulation of voltage-gated ion channels in excitable cells by the ubiquitin ligases Nedd4 and Nedd4-2 Published In Channels Volume 5 Pages 79 - 88 ISSN 1933-6950 Altmetric
2011	Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization Published In Antioxidants and Redox Signaling Volume 14 Pages 87 - 95 ISSN 1523-0864 Altmetric
2011	Structure and activity of α-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABAB receptor-coupled N-type calcium channels Published In Journal of Biological Chemistry Volume 286 Pages 10233 - 10237 ISSN 0021-9258 Altmetric
2011	Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding Published In Angewandte Chemie International Edition Volume 50 Pages 6527 - 6529 ISSN 1433-7851 Altmetric
2010	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout mice Published In Channels Volume 4 Pages 51 - 54 ISSN 1933-6950 Altmetric
2010	Analgesic ω-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels Published In Molecular Pharmacology Volume 77 Pages 139 - 148 ISSN 0026-895X Altmetric
2010	Physiological roles of ion channels in adult neural stem cells and their progeny Published In Journal of Neurochemistry Volume 114 Pages 946 - 959 ISSN 0022-3042 Altmetric
2010	Solving the α-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antaqonists Published In Journal of the American Chemical Society Volume 132 Pages 3514 - 3522 ISSN 0002-7863 Altmetric
2010	The engineering of an orally active conotoxin for the treatment of neuropathic pain Published In Angewandte Chemie International Edition Volume 49 Pages 6545 - 6548 ISSN 1433-7851 Altmetric
2010	α-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of α3β4 nicotinic acetylcholine receptors Published In Journal of Biological Chemistry Volume 285 Pages 22254 - 22263 ISSN 0021-9258 Altmetric
2009	Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3 Published In Toxicon Volume 54 Pages 56 - 61 ISSN 1879-3150 Altmetric
2009	Inhibition of neuronal nicotinic acetylcholine receptor subtypes by α-conotoxin GID and analogues Published In Journal of Biological Chemistry Volume 284 Pages 4944 - 4951 ISSN 0021-9258 Altmetric
2009	Reactive oxygen species modulate neuronal excitability in rat intrinsic cardiac ganglia Published In Autonomic Neuroscience: Basic and Clinical Volume 150 Pages 45 - 52 ISSN 1566-0702 Altmetric
2009	Scanning mutagenesis of α-conotoxin Vc1.1 reveals residues crucial for activity at the α9α10 nicotinic acetylcholine receptor Published In Journal of Biological Chemistry Volume 284 Pages 20275 - 20284 ISSN 0021-9258 Altmetric
2008	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation Published In The Journal of Neuroscience Volume 28 Pages 10943 - 10951 ISSN 0270-6474 Altmetric
2008	Conotoxin modulation of voltage-gated sodium channels Published In The International Journal of Biochemistry and Cell Biology Volume 40 Pages 2363 - 2368 ISSN 1357-2725 Altmetric
2008	Kir and Kv channels regulate electrical properties and proliferation of adult neural precursor cells Published In Molecular and Cellular Neuroscience Volume 37 Pages 284 - 297 ISSN 1044-7431 Altmetric
2008	Molecular engineering of conotoxins: The importance of loop size to α-conotoxin structure and function Published In Journal of Medicinal Chemistry Volume 51 Pages 5575 - 5584 ISSN 0022-2623 Altmetric
2008	Neuronally selective μ-conotoxins from Conus striatus utilize an α-helical motif to target mammalian sodium channels Published In Journal of Biological Chemistry Volume 283 Pages 21621 - 21628 ISSN 0021-9258 Altmetric
2008	Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1 Published In American Journal of Physiology: Cell Physiology Volume 295 Pages C73 - C80 ISSN 0363-6143 Altmetric
2008	The three-dimensional structure of the analgesic α-conotoxin, RgIA Published In FEBS Letters Volume 582 Pages 597 - 602 ISSN 0014-5793 Altmetric
2008	ω-Conotoxin inhibition of excitatory synaptic transmission evoked by dorsal root stimulation in rat superficial dorsal horn Published In Neuropharmacology Volume 55 Pages 860 - 864 ISSN 0028-3908 Altmetric
2007	Are α9α10 nicotinic acetylcholine receptors a pain target for α-conotoxins? Published In Molecular Pharmacology Volume 72 Pages 1406 - 1410 ISSN 0026-895X Altmetric
2007	Chemical modification of conotoxins to improve stability and activity Published In ACS Chemical Biology Volume 2 Pages 457 - 468 ISSN 1554-8929 Altmetric
2007	Distinct activities of novel neurotoxins from Australian venomous snakes for nicotinic acetylcholine receptors Published In Cellular and Molecular Life Sciences Volume 64 Pages 2829 - 2840 ISSN 1420-9071 Altmetric
2007	Isolation and structure-activity of μ-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels Published In Molecular Pharmacology Volume 71 Pages 676 - 685 ISSN 0026-895X Altmetric
2007	Liposome reconstitution and modulation of recombinant N-methyl-D-aspartate receptor channels by membrane stretch Published In Proceedings of the National Academy of Sciences of USA Volume 104 Pages 1540 - 1545 ISSN 0027-8424 Altmetric
2007	NEDD4-2 as a potential candidate susceptibility gene for epileptic photosensitivity Published In Genes, Brain and Behavior Volume 6 Pages 750 - 755 ISSN 1601-183X Altmetric
2007	Polymodal regulation of NMDA receptor channels Published In Channels Volume 1 Pages 334 - 343 ISSN 1933-6950 Altmetric
2007	Purinergic receptor activation inhibits mitogen-stimulated proliferation in primary neurospheres from the adult mouse subventricular zone Published In Molecular and Cellular Neuroscience Volume 35 Pages 535 - 548 ISSN 1044-7431 Altmetric
2007	Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by ubiquitination: novel role for Nedd4-2 Published In Journal of Biological Chemistry Volume 282 Pages 12135 - 12142 ISSN 0021-9258 Altmetric
2007	Structure of α-conotoxin BuIA: influences of disulfide connectivity on structural dynamics Published In BMC Structural Biology Volume 7 Page p. 28 ISSN 1472-6807 Altmetric
2007	The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells Published In The Journal of Neuroscience Volume 27 Pages 3734 - 3742 ISSN 0270-6474 Altmetric
2007	ω-Conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels Published In European Journal of Neuroscience Volume 25 Pages 435 - 444 ISSN 0953-816X Altmetric
2006	Identification of a novel class of nicotinic receptor antagonists: dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum Published In Journal of Biological Chemistry Volume 281 Pages 24745 - 24755 ISSN 0021-9258 Altmetric
2006	Mutations within the selectivity filter of the NMDA receptor-channel influence voltage dependent block by 5-hydroxytryptamine Published In British Journal of Pharmacology Volume 149 Pages 163 - 169 ISSN 0007-1188 Altmetric
2006	NMDA receptor subunit-dependent modulation by conantokin-G and Ala(7)-conantokin-G Published In Journal of Neurochemistry Volume 96 Pages 283 - 291 ISSN 0022-3042 Altmetric
2006	Neuronal voltage-gated sodium channel subtypes: key roles in inflammatory and neuropathic pain Published In The International Journal of Biochemistry and Cell Biology Volume 38 Pages 2005 - 2010 ISSN 1357-2725 Altmetric
2006	The synthesis, structural characterization, and receptor specificity of the α-conotoxin Vc1.1 Published In Journal of Biological Chemistry Volume 281 Pages 23254 - 23263 ISSN 0021-9258 Altmetric
2006	α-Selenoconotoxins, a new class of potent α7 neuronal nicotinic receptor antagonists Published In Journal of Biological Chemistry Volume 281 Pages 14136 - 14143 ISSN 0021-9258 Altmetric
2006	μO-conotoxin MrVIB selectively blocks NaV1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits Published In Proceedings of the National Academy of Sciences of USA Volume 103 Pages 17030 - 17035 ISSN 0027-8424 Altmetric
2005	Developmental changes in expression of GABAA receptor-channels in rat intrinsic cardiac ganglion neurones Published In The Journal of Physiology Volume 564 Pages 465 - 474 ISSN 0022-3751 Altmetric
2005	Engineering stable peptide toxins by means of backbone cyclization: stabilization of the α-conotoxin MII Published In Proceedings of the National Academy of Sciences of USA Volume 102 Pages 13767 - 13772 ISSN 0027-8424 Altmetric
2005	Intravenous anaesthetics inhibit nicotinic acetylcholine receptor-mediated currents and Ca²⁺ transients in rat intracardiac ganglion neurons Published In British Journal of Pharmacology Volume 144 Pages 98 - 107 ISSN 0007-1188 Altmetric
2005	Selective modulation of neuronal nicotinic acetylcholine receptor channel subunits by Go-protein subunits Published In The Journal of Neuroscience Volume 25 Pages 3571 - 3577 ISSN 0270-6474 Altmetric
2005	Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner Published In Journal of Pharmacology and Experimental Therapeutics Volume 314 Pages 1353 - 1361 ISSN 1521-0103 Altmetric
2005	Voltage-dependent inhibition of recombinant NMDA receptor-mediated currents by 5-hydroxytryptamine Published In British Journal of Pharmacology Volume 144 Pages 323 - 330 ISSN 0007-1188 Altmetric
2004	Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors Published In Molecular Pharmacology Volume 65 Pages 1386 - 1396 ISSN 0026-895X Altmetric
2004	Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells Published In European Journal of Neuroscience Volume 20 Pages 1 - 13 ISSN 0953-816X Altmetric
2004	Chemical and functional identification and characterization of novel sulfated α-conotoxins from the cone snail Conus anemone Published In Journal of Medicinal Chemistry Volume 47 Pages 1234 - 1241 ISSN 0022-2623 Altmetric
2004	Expression and function of neuronal nicotinic ACh receptors in rat microvascular endothelial cells Published In American Journal of Physiology: Heart and Circulatory Physiology Volume 286 Pages H486 - H491 ISSN 0363-6135 Altmetric
2004	Functional maturation of isolated neural progenitor cells from the adult rat hippocampus Published In European Journal of Neuroscience Volume 19 Pages 2410 - 2420 ISSN 0953-816X Altmetric
2004	Overexpressed Cavβ3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of "ultra-slow"^^ and "closed-state"^^ inactivation Published In Journal of General Physiology Volume 123 Pages 401 - 416 ISSN 0022-1295 Altmetric
2004	Potassium channels and membrane potential in the modulation of intracellular calcium in vascular endothelial cells Published In Journal of Cardiovascular Electrophysiology Volume 15 Pages 598 - 610 ISSN 1045-3873 Altmetric
2004	Regulation of neuronal voltage-gated sodium channels by the ubiquitin protein ligases Nedd4 and Nedd4-2 Published In Journal of Biological Chemistry Volume 279 Pages 28930 - 28935 ISSN 0021-9258 Altmetric
2004	Structures of μO-conotoxins from Conus marmoreus: Inhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons Published In Journal of Biological Chemistry Volume 279 Pages 25774 - 25782 ISSN 0021-9258 Altmetric
2004	The α₂δ auxiliary subunit reduces affinity of ω-conotoxins for recombinant N-type (Ca_v2.2) calcium channels Published In Journal of Biological Chemistry Volume 279 Pages 34705 - 34714 ISSN 0021-9258 Altmetric
2003	Allosteric α1-adrenoreceptor antagonism by the conopeptide ρ-TIA Published In Journal of Biological Chemistry Volume 278 Pages 34451 - 34457 ISSN 0021-9258 Altmetric
2003	Inhibition of the norepinephrine transporter by the venom peptide χ-MrIA: site of action, Na+ dependence, and structure-activity relationship Published In Journal of Biological Chemistry Volume 278 Pages 40317 - 40323 ISSN 0021-9258 Altmetric
2003	Isolation, structure, and activity of GID, a novel α4/7-conotoxin with an extended N-terminal sequence Published In Journal of Biological Chemistry Volume 278 Pages 3137 - 3144 ISSN 0021-9258 Altmetric
2003	Muscarinic and nicotinic ACh receptor activation differentially mobilize Ca2+ in rat intracardiac ganglion neurons Published In Journal of Neurophysiology Volume 90 Pages 1956 - 1964 ISSN 0022-3077 Altmetric
2003	Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of α-conotoxin MII Published In Journal of Medicinal Chemistry Volume 46 Pages 1266 - 1272 ISSN 0022-2623 Altmetric
2003	α-conotoxins PnIA and [A10L]PnIA stabilize different states of the α7-L247T nicotinic acetylcholine receptor Published In Journal of Biological Chemistry Volume 278 Pages 26908 - 26914 ISSN 0021-9258 Altmetric
2003	ω-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals Published In Journal of Biological Chemistry Volume 278 Pages 4057 - 4062 ISSN 0021-9258 Altmetric
2002	A new level of conotoxin diversity, a non-native disulfide bond connectivity in α-conotoxin AuIB reduces structural definition but increases biological activity Published In Journal of Biological Chemistry Volume 277 Pages 48849 - 48857 ISSN 0021-9258 Altmetric
2002	Basal nonselective cation permeability in rat cardiac microvascular endothelial cells Published In Microvascular Research Volume 64 Pages 187 - 197 ISSN 0026-2862 Altmetric
2002	Ciguatoxin-induced oscillations in membrane potential and action potential firing in rat parasympathetic neurons Published In European Journal of Neuroscience Volume 16 Pages 242 - 248 ISSN 0953-816X Altmetric
2002	Neural control of the heart: developmental changes in ionic conductances in mammalian intrinsic cardiac neurons Published In Autonomic Neuroscience: Basic and Clinical Volume 98 Pages 75 - 78 ISSN 1566-0702 Altmetric
2002	Solution structure of μ-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels Published In Journal of Biological Chemistry Volume 277 Pages 27247 - 27255 ISSN 0021-9258 Altmetric
2001	An ATP-sensitive K+ conductance in dissociated neurones from adult rat intracardiac ganglia Published In The Journal of Physiology Volume 534 Pages 713 - 720 ISSN 0022-3751 Altmetric
2001	Developmental changes in hyperpolarization-activated currents Ih and IK(IR) in isolated rat intracardiac neurons Published In Journal of Neurophysiology Volume 86 Pages 312 - 320 ISSN 0022-3077
2001	Ionic selectivity of native ATP-activated (P2X) receptor channels in dissociated neurones from rat parasympathetic ganglia Published In The Journal of Physiology Volume 534 Pages 423 - 435 ISSN 0022-3751 Altmetric
2001	Large-conductance calcium-activated potassium channels in neonatal rat intracardiac ganglion neurons Published In Pfluegers Archiv: European journal of physiology Volume 441 Pages 629 - 638 ISSN 0031-6768 Altmetric
2001	Pre- and postsynaptic actions of ATP on neurotransmission in rat submandibular ganglia Published In Neuroscience Volume 107 Pages 283 - 291 ISSN 0306-4522 Altmetric
2001	The synthesis and structure of an n-terminal dodecanoic acid conjugate of α-conotoxin MII Published In International Journal of Peptide Research and Therapeutics Volume 8 Pages 235 - 239 ISSN 0929-5666 Altmetric
2001	Two new classes of conopeptides inhibit the α1-adrenoceptor and noradrenaline transporter Published In Nature Neuroscience Volume 4 Pages 902 - 907 ISSN 1097-6256 Altmetric
2000	Novel ω-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes Published In Journal of Biological Chemistry Volume 275 Pages 35335 - 35344 ISSN 0021-9258 Altmetric
2000	P2Y purinoceptor activation mobilizes intracellular Ca2+ and induces a membrane current in rat intracardiac neurones Published In The Journal of Physiology Volume 526 Pages 287 - 298 ISSN 0022-3751 Altmetric
2000	Substance P preferentially inhibits large conductance nicotinic ACh receptor channels in rat intracardiac ganglion neurons Published In Journal of Neurophysiology Volume 84 Pages 1961 - 1970 ISSN 0022-3077 Altmetric
2000	VIP and PACAP potentiation of nicotinic ACh-evoked currents in rat parasympathetic neurons is mediated by G-protein activation Published In European Journal of Neuroscience Volume 12 Pages 2243 - 2251 ISSN 0953-816X Altmetric
1999	Calcium channels controlling acetylcholine release from preganglionic nerve terminals in rat autonomic ganglia Published In Neuroscience Volume 95 Pages 1121 - 1127 ISSN 0306-4522 Altmetric
1999	Conotoxins and their potential pharmaceutical applications Published In Drug Development Research Volume 46 Pages 219 - 234 ISSN 0272-4391 Altmetric
1999	Mechanisms of verapamil inhibition of action potential firing in rat intracardiac ganglion neurons Published In Journal of Pharmacology and Experimental Therapeutics Volume 289 Pages 1502 - 1508 ISSN 1521-0103
1999	Met-enkephalin-induced mobilization of intracellular Ca2+ in rat intracardiac ganglion neurones Published In Neuroscience Letters Volume 264 Pages 105 - 108 ISSN 0304-3940 Altmetric
1999	Single amino acid substitutions in α-conotoxin PnIA shift selectivity for subtypes of the mammalian neuronal nicotinic acetylcholine receptor Published In Journal of Biological Chemistry Volume 274 Pages 36559 - 36564 ISSN 0021-9258 Altmetric
1998	ACh- and caffeine-induced Ca2+ mobilization and current activation in rabbit arterial endothelial cells Published In American Journal of Physiology: Heart and Circulatory Physiology Volume 275 Pages H1748 - H1758 ISSN 0363-6135
1998	Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons Published In Journal of Pharmacology and Experimental Therapeutics Volume 284 Pages 516 - 525 ISSN 1521-0103
1998	Ciguatoxin (CTX-1) modulates single tetrodotoxin-sensitive sodium channels in rat parasympathetic neurones Published In Neuroscience Letters Volume 252 Pages 103 - 106 ISSN 0304-3940 Altmetric
1998	Opioid receptor-mediated inhibition of ω-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons Published In Journal of Neurophysiology Volume 79 Pages 753 - 762 ISSN 0022-3077
1998	α-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors Published In Journal of Biological Chemistry Volume 273 Pages 15667 - 15674 ISSN 0021-9258 Altmetric
1997	Characterization of ATP-sensitive potassium channels in freshly dissociated rabbit aortic endothelial cells Published In American Journal of Physiology: Heart and Circulatory Physiology Volume 272 Pages H2507 - H2511 ISSN 0363-6135
1997	Heterogeneity of nicotinic receptor class and subunit mRNA expression among individual parasympathetic neurons from rat intracardiac ganglia Published In The Journal of Neuroscience Volume 17 Pages 586 - 596 ISSN 0270-6474
1997	M4 muscarinic receptor activation modulates calcium channel currents in rat intracardiac neurons Published In Journal of Neurophysiology Volume 78 Pages 1903 - 1912 ISSN 0022-3077
1997	Passive and active membrane properties of isolated rat intracardiac neurons: Regulation by H- and M-currents Published In Journal of Neurophysiology Volume 78 Pages 1890 - 1902 ISSN 0022-3077
1996	Vasoactive intestinal polypeptide modulation of nicotinic ACh receptor channels in rat intracardiac neurones Published In The Journal of Physiology Volume 493 Pages 503 - 515 ISSN 0022-3751 Altmetric
1995	An ATP-sensitive potassium conductance in rabbit arterial endothelial cells Published In The Journal of Physiology Volume 485 Pages 595 - 606 ISSN 0022-3751 Altmetric
1995	Caffeine-evoked, calcium-sensitive membrane currents in rabbit aortic endothelial cells Published In British Journal of Pharmacology Volume 115 Pages 133 - 141 ISSN 0007-1188
1995	Monovalent and divalent cation permeability and block of neuronal nicotinic receptor channels in rat parasympathetic ganglia Published In Journal of General Physiology Volume 105 Pages 701 - 723 ISSN 0022-1295 Altmetric
1995	The relationship of brevetoxin 'length' and A-ring functionality to binding and activity in neuronal sodium channels Published In Chemistry and Biology Volume 2 Pages 533 - 541 ISSN 1074-5521 Altmetric
1994	Cytosolic [Ca2+] measurements in endothelium of rabbit cardiac valves using imaging fluorescence microscopy Published In American Journal of Physiology: Heart and Circulatory Physiology Volume 266 Pages H2130 - H2135 ISSN 0363-6135
1994	Ionic channels in vascular endothelial cells Published In Trends in Cardiovascular Medicine Volume 4 Pages 18 - 26 ISSN 1873-2615 Altmetric
1994	Is the A-ring lactone of brevetoxin PbTX-3 required for sodium channel orphan receptor binding and activity? Published In Natural Toxins Volume 2 Pages 212 - 221 Altmetric
1994	Local anaesthetic blockade of neuronal nicotinic ACh receptor-channels in rat parasympathetic ganglion cells Published In British Journal of Pharmacology Volume 111 Pages 663 - 672 ISSN 0007-1188
1994	TEA inhibits ACh-induced EDRF release: endothelial Ca2+-dependent K+ channels contribute to vascular tone Published In American Journal of Physiology: Heart and Circulatory Physiology Volume 267 Pages H1135 - H1141 ISSN 0363-6135
1993	Membrane properties and discharge characteristics of rat intracardiac neurones in vitro: the effect of temperature Published In The Journal of Physiology Volume 467 Page p. 356 ISSN 0022-3751 Altmetric
1993	α-Adrenergic modulation of ionic currents in cultured parasympathetic neurons from rat intracardiac ganglia Published In Journal of Neurophysiology Volume 69 Pages 1060 - 1070 ISSN 0022-3077
1992	Calcium entry-dependent oscillations of cytoplasmic calcium concentration in cultured endothelial cell monolayers Published In Proceedings of the National Academy of Sciences of USA Volume 89 Pages 1690 - 1694 ISSN 0027-8424
1992	Calcium permeability and modulation of nicotinic acetylcholine receptor-channels in rat parasympathetic neurons Published In Journal of Physiology: Paris Volume 86 Pages 67 - 76 ISSN 0928-4257 Altmetric
1992	Calcium-activated potassium channels in native endothelial cells from rabbit aorta: conductance, Ca2+ sensitivity and block Published In The Journal of Physiology Volume 455 Pages 601 - 621 ISSN 0022-3751 Altmetric
1992	Resting membrane potential and potassium currents in cultured parasympathetic neurones from rat intracardiac ganglia Published In The Journal of Physiology Volume 456 Pages 405 - 424 ISSN 0022-3751 Altmetric
1992	Voltage-dependent sodium and calcium currents in cultured parasympathetic neurones from rat intracardiac ganglia Published In The Journal of Physiology Volume 456 Pages 425 - 441 ISSN 0022-3751 Altmetric
1991	Acetylcholine-evoked currents in cultured neurones dissociated from rat parasympathetic cardiac ganglia Published In The Journal of Physiology Volume 434 Pages 215 - 237 ISSN 0022-3751 Altmetric
1991	Adenosine triphosphate-evoked currents in cultured neurones dissociated from rat parasympathetic cardiac ganglia Published In The Journal of Physiology Volume 434 Pages 239 - 256 ISSN 0022-3751 Altmetric
1991	Cytosolic calcium ion regulation in cultured endothelial cells Published In Advances in Experimental Medicine and Biology Volume 304 Pages 257 - 271 ISSN 0065-2598 Altmetric
1991	Modes of hexamethonium action on acetylcholine receptor channels in frog skeletal muscle Published In British Journal of Pharmacology Volume 102 Pages 135 - 145 ISSN 0007-1188
1990	Membrane potential and Na+-K+ pump activity modulate resting and bradykinin-stimulated changes in cytosolic free calcium in cultured endothelial cells from bovine atria Published In Journal of Biological Chemistry Volume 265 Pages 2613 - 2619 ISSN 0021-9258
1990	Neurotransmission in neonatal rat cardiac ganglion in situ Published In American Journal of Physiology: Heart and Circulatory Physiology Volume 259 Pages H997 - H1005 ISSN 0363-6135
1990	Synergistic hypotensive effect of vasoactive intestinal polypeptide and α-blockade with phentolamine: evidence for vasoactive intestinal peptide α-adrenoceptor coupling in the cardiovascular system of newborn dogs Published In Circulation Research Volume 67 Pages 986 - 992 ISSN 0009-7330
1989	Bradykinin and inositol 1,4,5-trisphosphate-stimulated calcium release from intracellular stores in cultured bovine endothelial cells Published In Pfluegers Archiv: European journal of physiology Volume 414 Pages 377 - 384 ISSN 0031-6768 Altmetric
1989	Inhibition of neurally-evoked transmitter release by calcium channel antagonists in rat parasympathetic ganglia Published In British Journal of Pharmacology Volume 97 Pages 1125 - 1136 ISSN 0007-1188
1989	Ion channels and regulation of intracellular calcium in vascular endothelial cells Published In The FASEB Journal Volume 3 Pages 2389 - 2400 ISSN 0892-6638
1989	Synchronized oscillations in cytoplasmic free calcium concentrations in confluent bradykinin-stimulated bovine pulmonary artery endothelial cell monolayers Published In Journal of Biological Chemistry Volume 264 Pages 6 - 9 ISSN 0021-9258
1988	Role of calcium in the activation of endothelial cells Published In Journal of Cardiovascular Pharmacology Volume 12 Pages S119 - S123 ISSN 0160-2446
1988	The actions of L-glutamate at the postsynaptic membrane of the squid giant synapse Published In The Journal of Experimental Biology Volume 140 Pages 535 - 548 ISSN 0022-0949
1987	Calcium entry through receptor-operated channels in bovine pulmonary artery endothelial cells Published In Tissue and Cell Volume 19 Pages 733 - 745 ISSN 1532-3072 Altmetric
1985	Inhibitors of calcium buffering depress evoked transmitter release at the squid giant synapse. Published In The Journal of Physiology Volume 369 Pages 145 - 159 ISSN 0022-3751 Altmetric
1985	Some properties of acetylcholine receptors in human cultured myotubes Published In Proceedings of the Royal Society B: Biological Sciences Volume 224 Pages 183 - 196 ISSN 0962-8452 Altmetric
1982	Inhibitory postsynaptic currents at Aplysia cholinergic synapses: effects of permeant anions and depressant drugs Published In Proceedings of the Royal Society B: Biological Sciences Volume 214 Pages 335 - 350 ISSN 0962-8452 Altmetric
1981	Block of endplate channels by permeant cations in frog skeletal muscle Published In Journal of General Physiology Volume 78 Pages 593 - 615 ISSN 0022-1295 Altmetric
1980	Divalent ion currents and the delayed potassium conductance in an Aplysia neurone Published In The Journal of Physiology Volume 304 Pages 297 - 313 ISSN 0022-3751 Altmetric
1980	Ionic currents in molluscan soma Published In Annual Review of Neuroscience Volume 3 Pages 141 - 167 ISSN 0147-006X Altmetric
1980	The permeability of endplate channels to monovalent and divalent metal cations Published In Journal of General Physiology Volume 75 Pages 493 - 510 ISSN 0022-1295
1980	The permeability of the endplate channel to organic cations in frog muscle Published In Journal of General Physiology Volume 75 Pages 469 - 492 ISSN 0022-1295 Altmetric
1979	Characteristics of sodium and calcium conductance changes produced by membrane depolarization in an Aplysia neurone Published In The Journal of Physiology Volume 289 Pages 143 - 161 ISSN 0022-3751 Altmetric
1979	Ionic currents in response to membrane depolarization in an aplysia neurone Published In The Journal of Physiology Volume 289 Pages 115 - 141 ISSN 0022-3751 Altmetric
1979	Sodium and calcium gating currents in an Aplysia neurone Published In The Journal of Physiology Volume 291 Pages 467 - 481 ISSN 0022-3751 Altmetric
1978	An effect of ethanol at a glutamate synapse Published In Clinical and Experimental Pharmacology and Physiology Volume 5 Pages 275 - 276 ISSN 0305-1870 Altmetric
1978	Asymmetrical displacement currents Published In Nature Volume 271 Pages 586 - 587 ISSN 0028-0836 Altmetric
1977	Ethanol reduces excitatory postsynaptic current duration at a crustacean neuromuscular junction Published In Nature Volume 266 Pages 739 - 741 ISSN 0028-0836 Altmetric
1977	Funnel web spider venom produces spontaneous action potentials in nerve Published In Life Sciences Volume 20 Pages 243 - 249 ISSN 0024-3205 Altmetric
1976	Gating currents associated with sodium and calcium currents in an Aplysia neuron Published In Science Volume 192 Pages 783 - 784 ISSN 0096-3771 Altmetric
1976	Voltage sensitivity of inhibitory postsynaptic currents in Aplysia buccal ganglia Published In Brain Research Volume 115 Pages 506 - 511 ISSN 0006-8993 Altmetric

Chapter

Year	Title
2015	Venoms-based drug discovery: bioassays, electrophysiology, high-throughput screens and target identincation Published In Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics Publisher http://pubs.rsc.org/en/Content/eBook/978-1-84973-663-3#!divbookcontent: Royal Society of Chemistry Pages 97 - 128 Altmetric

Collection Or Series Editor For

The Journal of Physiology (Journal) 2015 -
Marine Drugs (Journal) 2014 -
The International Journal of Biochemistry and Cell Biology (Journal) 2013 -
Frontiers in Pharmacology (Journal) 2010 -
Channels (Journal) 2006 -
Neuropharmacology (Journal) 2016 - 2017
Pfluegers Archiv: European journal of physiology (Journal) 2008 - 2011
American Journal of Physiology: Heart and Circulatory Physiology (Journal) 1991 - 1996

Investigator On

Year	Title
2015 - 2020	Nicotinic receptor structure and function probed with conotoxinx Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2018	Electrophysiology Facility for Cell Phenotyping and Drug Discovery Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2017	Identifying novel gene mutations for molecular diagnosis of Familial Hemiplegic Migraine Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2013 - 2016	Alpha-Conotoxin Inhibition of Chronic Visceral Pain Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2015	Ion channel modulators of pain pathways Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Program Grant
	Inflammatory Pain - Control of Immune Cell Nicotinic Receptor Signaling by Conotoxins? Mechanisms and Screening Platforms Awarded by: Deutscher Akademischer Austausch Dienst (DAAD) Funding Scheme: Australia Germany Joint Cooperation Scheme

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Conotoxin modulation of voltage-gated calcium and potassium channels via GABA-B receptor activation	Bony, Anuja
Doctor of Philosophy	Nicotinic acetylcholine receptor structure and function probed with venom derived peptides.	Bye, Lydia

Professional Service Activities

NSW Office for Health and Medical Research Cardiovascular Disease Research Advisory Committee 2018 - 2022
Multiple Sclerosis Research Australia (MSRA) Member of the Research Management Council 2007 - 2015
National Health and Medical Research Council Assigners Academy 2012 - 2014
Australian Academy of Science National Committee for Biomedical Sciences 2003 - 2009
The University of Queensland Head of School of Biomedical Sciences 2000 - 2007
University of Queensland Head of Department of Physiology and Pharmacology 1998 - 2000

Education And Training

Marine Biological Laboratory, Woods Hole, MA, Grass Fellowship in Neurophysiology 1980 -
Ph.D. in Physiology, University of New South Wales, School of Physiology & Pharmacology, An Analysis of Ionic Channels in Aplysia Nerve Cell Membrane. 1974 - 1978
B Science (Hon) in Physiology, University of New South Wales 1970 - 1973
University College of London (UCL) , Department of Pharmacology, Beit Memorial Fellowship for Medical Research, UK 1981 - 1983
University of Washington School of Medicine, Department of Physiology & Biophysics, Muscular Dystrophy Association of America Postdoctoral Fellowship 1978 - 1980

Awards And Honors

NHMRC Ten of the Best Health & Medical Research Projects, conferred by NHMRC, 2011
Finalist, Australian Museum Eureka Prize People’s Choice Award, conferred by Australian Museum Eureka Prizes, 2005
Finalist, Royal Societies of Australia Eureka Prize for Interdisciplinary Scientific Research, conferred by Australian Museum Eureka Prizes, 2004
Australian Professorial Fellowship, conferred by Austrlian Research Council (ARC), 2010 - 2015

Keywords

Membrane physiology
Neuropharmacology
Cellular neuroscience
Electrophysiology
Ion channels
Membrane biophysics

Full Name

David John Adams

Mailing Address

Illawarra Health & Medical Research Institute (IHMRI)

University of Wollongong

Wollongong

NSW

2522

Australia

Located In Facility

Illawarra Health and Medical Research Institute

Orcid Id

http://orcid.org/0000-0002-7030-2288 (confirmed)

Top Publications

Year	Title
2008	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation Published in The Journal of Neuroscience
2012	Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels Published in British Journal of Pharmacology
2014	Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation Published in Journal of General Physiology
2016	Key structural determinants in the agonist binding loops of human β2 and β4 nicotinic acetylcholine receptor subunits contribute to α3β4 subtype selectivity of α-conotoxins Published in Journal of Biological Chemistry
2017	α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA_B receptors Published in Gut
2015	Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABAB receptor Published in Molecular Pharmacology
2013	Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor Published in Journal of Medicinal Chemistry
2013	Are nicotinic acetylcholine receptors coupled to G proteins? Published in BioEssays
2018	α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition Published in British Journal of Pharmacology
2006	μO-conotoxin MrVIB selectively blocks NaV1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits Published in Proceedings of the National Academy of Sciences of USA

Research Areas

Research Overview

Prof Adams' research focuses on membrane receptors and ion channels and is currently funded by an NHMRC Program Grant and ARC Discovery Grants (2015-2019). He is internationally recognised for his contributions to membrane physiology, in particular that of ion channel function and modulation using electrophysiological recording techniques. In the last 20 years, he has identified novel peptides (conotoxins) obtained from the venom of cone snails as probes for ion channel structure and function. This research has focused on investigating conotoxins that selectively target the voltage-gated sodium and calcium channels, nicotinic acetylcholine receptors, and G protein-coupled receptor modulation of calcium channels.

Selected Publications

Journal Article

Year	Title
2018	A novel α-conopeptide Eu1.6 inhibits N-type (CaV2.2) calcium channels and exhibits potent analgesic activity Published In Scientific Reports Volume 8 Pages 1004-1 - 1004-13 ISSN 2045-2322 Altmetric
2018	Contribution of membrane receptor signalling to chronic visceral pain Published In The International Journal of Biochemistry and Cell Biology Volume 98 Pages 10 - 23 ISSN 1357-2725 Altmetric
2018	Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain Published In British Journal of Pharmacology Volume Online First Pages 1 - 15 ISSN 0007-1188 Altmetric
2018	Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1 Published In British Journal of Pharmacology Volume 175 Pages 2284 - 2295 ISSN 0007-1188 Altmetric
2018	Molecular Determinants Conferring the Stoichiometric-Dependent Activity of alpha-Conotoxins at the Human alpha 9 alpha 10 Nicotinic Acetylcholine Receptor Subtype Published In Journal of Medicinal Chemistry Volume 61 Pages 4628 - 4634 ISSN 0022-2623 Altmetric
2018	NMR structure of µ-conotoxin GIIIC: Leucine 18 induces local repacking of the N-terminus resulting in reduced Nav channel potency Published In Molecules Volume 23 Pages 2715-1 - 2715-12 ISSN 1420-3049 Altmetric
2018	Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides Published In Scientific Reports Volume 8 Pages 13397-1 - 13397-15 ISSN 2045-2322 Altmetric
2018	Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB Published In Biochemical Pharmacology Volume 155 Pages 288 - 297 ISSN 0006-2952 Altmetric
2018	Structure-Activity Studies Reveal the Molecular Basis for GABA(B)-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1 Published In ACS Chemical Biology Volume 13 Pages 1577 - 1587 ISSN 1554-8929 Altmetric
2018	Targeting of N-Type Calcium Channels via GABAB-Receptor Activation by α-Conotoxin Vc1.1 Variants Displaying Improved Analgesic Activity Published In Journal of Medicinal Chemistry Volume 61 Pages 10198 - 10205 ISSN 0022-2623 Altmetric
2018	α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition Published In British Journal of Pharmacology Volume 175 Pages 1855 - 1868 ISSN 0007-1188 Altmetric
2017	A novel lid-covering peptide inhibitor of nicotinic acetylcholine receptors derived from αd-conotoxin GeXXA Published In Marine Drugs Volume 15 ISSN 1660-3397 Altmetric
2017	Analgesic conopeptides targeting G protein-coupled receptors reduce excitability of sensory neurons Published In Neuropharmacology Volume 127 Pages 116 - 123 ISSN 0028-3908 Altmetric
2017	Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer Published In Journal of Biological Chemistry Volume 292 Pages 17101 - 17112 ISSN 0021-9258 Altmetric
2017	Identification of a novel O-conotoxin reveals an unusual and potent inhibitor of the human α9α10 nicotinic acetylcholine receptor Published In Marine Drugs Volume 15 Pages 170-1 - 170-13 ISSN 1660-3397 Altmetric
2017	In vivo and in vitro testing of native α-conotoxins from the injected venom of Conus purpurascens Published In Neuropharmacology Volume 127 Pages 253 - 259 ISSN 0028-3908 Altmetric
2017	Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors Published In Scientific Reports Volume 7 Pages 16606-1 - 16606-11 ISSN 2045-2322 Altmetric
2017	Neuropharmacology of venom peptides Published In Neuropharmacology Volume 127 Pages 1 - 3 ISSN 0028-3908 Altmetric
2017	Peptide grafted and self-assembled poly(γ-glutamic acid)-phenylalanine nanoparticles targeting camptothecin to glioma Published In Nanomedicine Volume 12 Pages 1661 - 1674 ISSN 1743-5889 Altmetric
2017	Role of Cys(I)-Cys(III) Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors Published In ACS Omega Volume 2 Pages 4621 - 4631 Altmetric
2017	The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity Published In Scientific Reports Volume 7 Pages 974-1 - 974-15 ISSN 2045-2322 Altmetric
2017	α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA_B receptors Published In Gut Volume 66 Pages 1083 - 1094 ISSN 0017-5749 Altmetric
2016	Effects of linker sequence modifications on the structure, stability, and biological activity of a cyclic α-conotoxin Published In Biopolymers Volume 106 Pages 864 - 875 Altmetric
2016	Improving efficacy, oral bioavailability, and delivery of paclitaxel using protein-grafted solid lipid nanoparticles Published In Molecular Pharmaceutics Volume 13 Pages 3903 - 3912 ISSN 1543-8384 Altmetric
2016	Key structural determinants in the agonist binding loops of human β2 and β4 nicotinic acetylcholine receptor subunits contribute to α3β4 subtype selectivity of α-conotoxins Published In Journal of Biological Chemistry Volume 291 Pages 23779 - 23792 ISSN 0021-9258 Altmetric
2016	Mechanism of direct Ca_v2.2 channel block by the κ-opioid receptor agonist U50488H Published In Neuropharmacology Volume 109 Pages 49 - 58 ISSN 0028-3908 Altmetric
2016	Modulation of human Na(v)1.7 channel gating by synthetic α-scorpion toxin OD1 and its analogs Published In Channels Volume 10 Pages 139 - 147 ISSN 1933-6950 Altmetric
2016	Structure-activity studies of cysteine-rich α-Conotoxins that inhibit high voltage-activated calcium channels via GABA_B receptor activation reveal a minimal functional motif Published In Angewandte Chemie International Edition Volume 55 Pages 4692 - 4696 ISSN 1433-7851 Altmetric
2016	Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer Published In Scientific Reports Volume 6 Pages 23179-1 - 23179-13 ISSN 2045-2322 Altmetric
2015	Alanine scan ofα-conotoxin regiia reveals a selective α3α4 nicotinic acetylcholine receptor antagonist Published In Journal of Biological Chemistry Volume 290 Pages 1039 - 1048 ISSN 0021-9258 Altmetric
2015	Biomedical applications of trastuzumab: as a therapeutic agent and a targeting ligand Published In Medicinal Research Reviews Volume 35 Pages 849 - 876 ISSN 0198-6325 Altmetric
2015	Bombesin-conjugated nanoparticles improve the cytotoxic efficacy of docetaxel against gastrin-releasing but androgen-independent prostate cancer Published In Nanomedicine Volume 10 Pages 2847 - 2859 ISSN 1743-5889 Altmetric
2015	Conotoxin αd-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors Published In Scientific Reports Volume 5 Pages 14261-1 - 14261-8 ISSN 2045-2322 Altmetric
2015	Cyclic-RGDfK peptide conjugated succinoyl-TPGS nanomicelles for targeted delivery of docetaxel to integrin receptor over-expressing angiogenic tumours Published In Nanomedicine: Nanotechnology, Biology and Medicine Volume 11 Pages 1511 - 1520 ISSN 1549-9634 Altmetric
2015	Distinct functional site in Ω-neurotoxins: novel antagonists of nicotinic acetylcholine receptors from snake venom Published In ACS Chemical Biology Volume 10 Pages 2805 - 2815 ISSN 1554-8929 Altmetric
2015	Inhibition of cholinergic pathways in Drosophila melanogaster by α-conotoxins Published In The FASEB Journal Volume 29 Pages 1011 - 1018 ISSN 0892-6638 Altmetric
2015	Less is more: design of a highly stable disulfide-deleted mutant of analgesic cyclic α-conotoxin Vc1.1 Published In Scientific Reports Volume 5 Pages 13264-1 - 13264-11 ISSN 2045-2322 Altmetric
2015	Molecular basis for differential sensitivity of α-conotoxin RegIIA at rat and human neuronal nicotinic acetylcholine receptors Published In Molecular Pharmacology Volume 88 Pages 993 - 1001 ISSN 0026-895X Altmetric
2015	Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABAB receptor Published In Molecular Pharmacology Volume 87 Pages 240 - 250 ISSN 0026-895X Altmetric
2015	α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors Published In Journal of the American Chemical Society Volume 137 Pages 3209 - 3212 ISSN 0002-7863 Altmetric
2014	Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets Published In Journal of Medicinal Chemistry Volume 57 Pages 9933 - 9944 ISSN 0022-2623 Altmetric
2014	Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation Published In Journal of General Physiology Volume 143 Pages 465 - 479 ISSN 0022-1295 Altmetric
2014	Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels Published In British Journal of Pharmacology Volume 171 Pages 3313 - 3327 ISSN 0007-1188 Altmetric
2014	Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors Published In Biochemical Pharmacology Volume 91 Pages 534 - 542 ISSN 0006-2952 Altmetric
2014	Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels Published In Biochemical Pharmacology Volume 89 Pages 276 - 286 ISSN 0006-2952 Altmetric
2013	Are nicotinic acetylcholine receptors coupled to G proteins? Published In BioEssays Volume 35 Pages 1025 - 1034 ISSN 0265-9247 Altmetric
2013	Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1 Published In ACS Chemical Biology Volume 8 Pages 1215 - 1222 ISSN 1554-8929 Altmetric
2013	Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor Published In Journal of Medicinal Chemistry Volume 56 Pages 3557 - 3567 ISSN 0022-2623 Altmetric
2013	Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors Published In ACS Chemical Biology Volume 8 Pages 1815 - 1821 ISSN 1554-8929 Altmetric
2013	Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors Published In Journal of Biological Chemistry Volume 288 Pages 34428 - 34442 Altmetric
2013	Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors Published In Biochemical Pharmacology Volume 86 Pages 791 - 799 Altmetric
2013	Kv3.1 channels stimulate adult neural precursor cell proliferation and neuronal differentiation Published In The Journal of Physiology Volume 591 Pages 2579 - 2591 ISSN 0022-3751 Altmetric
2013	Mechanisms of conotoxin inhibition of N-type (Cav2.2) calcium channels Published In BBA: Biomembranes Volume 1828 Pages 1619 - 1628 ISSN 0005-2736 Altmetric
2012	Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels Published In British Journal of Pharmacology Volume 166 Pages 486 - 500 ISSN 0007-1188 Altmetric
2012	Biophysical properties of Nav1.8/Nav1.2 chimeras and inhibition by μo-conotoxin MrVIB Published In British Journal of Pharmacology Volume 166 Pages 2148 - 2160 ISSN 0007-1188 Altmetric
2012	Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics? Published In Toxins Volume 4 Pages 1236 - 1260 ISSN 2072-6651 Altmetric
2012	Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain Published In Neuropharmacology Volume 62 Pages 2202 - 2207 ISSN 0028-3908 Altmetric
2012	Isolation, characterization and total regioselective synthesis of the novel μo-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels Published In Biochemical Pharmacology Volume 84 Pages 540 - 548 ISSN 0006-2952 Altmetric
2012	Localization of Nav 1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function Published In Channels Volume 6 Pages 103 - 110 ISSN 1933-6950 Altmetric
2012	RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs Published In Biochemical Pharmacology Volume 83 Pages 419 - 426 ISSN 0006-2952 Altmetric
2012	γ-Aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic α-conotoxins Published In Journal of Biological Chemistry Volume 287 Pages 23948 - 23957 ISSN 0021-9258 Altmetric
2011	A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain Published In Pain Volume 152 Pages 259 - 266 ISSN 0304-3959 Altmetric
2011	Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABAB receptor Published In Journal of Medicinal Chemistry Volume 54 Pages 6984 - 6992 ISSN 0022-2623 Altmetric
2011	Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function? Published In Journal of Biological Chemistry Volume 286 Pages 22546 - 22557 ISSN 0021-9258 Altmetric
2011	Purification of immature neuronal cells from neural stem cell progeny Published In PLoS One Volume 6 Pages e20941-1 - e20941-16 ISSN 1932-6203 Altmetric
2011	Regulation of voltage-gated ion channels in excitable cells by the ubiquitin ligases Nedd4 and Nedd4-2 Published In Channels Volume 5 Pages 79 - 88 ISSN 1933-6950 Altmetric
2011	Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization Published In Antioxidants and Redox Signaling Volume 14 Pages 87 - 95 ISSN 1523-0864 Altmetric
2011	Structure and activity of α-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABAB receptor-coupled N-type calcium channels Published In Journal of Biological Chemistry Volume 286 Pages 10233 - 10237 ISSN 0021-9258 Altmetric
2011	Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding Published In Angewandte Chemie International Edition Volume 50 Pages 6527 - 6529 ISSN 1433-7851 Altmetric
2010	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout mice Published In Channels Volume 4 Pages 51 - 54 ISSN 1933-6950 Altmetric
2010	Analgesic ω-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels Published In Molecular Pharmacology Volume 77 Pages 139 - 148 ISSN 0026-895X Altmetric
2010	Physiological roles of ion channels in adult neural stem cells and their progeny Published In Journal of Neurochemistry Volume 114 Pages 946 - 959 ISSN 0022-3042 Altmetric
2010	Solving the α-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antaqonists Published In Journal of the American Chemical Society Volume 132 Pages 3514 - 3522 ISSN 0002-7863 Altmetric
2010	The engineering of an orally active conotoxin for the treatment of neuropathic pain Published In Angewandte Chemie International Edition Volume 49 Pages 6545 - 6548 ISSN 1433-7851 Altmetric
2010	α-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of α3β4 nicotinic acetylcholine receptors Published In Journal of Biological Chemistry Volume 285 Pages 22254 - 22263 ISSN 0021-9258 Altmetric
2009	Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3 Published In Toxicon Volume 54 Pages 56 - 61 ISSN 1879-3150 Altmetric
2009	Inhibition of neuronal nicotinic acetylcholine receptor subtypes by α-conotoxin GID and analogues Published In Journal of Biological Chemistry Volume 284 Pages 4944 - 4951 ISSN 0021-9258 Altmetric
2009	Reactive oxygen species modulate neuronal excitability in rat intrinsic cardiac ganglia Published In Autonomic Neuroscience: Basic and Clinical Volume 150 Pages 45 - 52 ISSN 1566-0702 Altmetric
2009	Scanning mutagenesis of α-conotoxin Vc1.1 reveals residues crucial for activity at the α9α10 nicotinic acetylcholine receptor Published In Journal of Biological Chemistry Volume 284 Pages 20275 - 20284 ISSN 0021-9258 Altmetric
2008	Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation Published In The Journal of Neuroscience Volume 28 Pages 10943 - 10951 ISSN 0270-6474 Altmetric
2008	Conotoxin modulation of voltage-gated sodium channels Published In The International Journal of Biochemistry and Cell Biology Volume 40 Pages 2363 - 2368 ISSN 1357-2725 Altmetric
2008	Kir and Kv channels regulate electrical properties and proliferation of adult neural precursor cells Published In Molecular and Cellular Neuroscience Volume 37 Pages 284 - 297 ISSN 1044-7431 Altmetric
2008	Molecular engineering of conotoxins: The importance of loop size to α-conotoxin structure and function Published In Journal of Medicinal Chemistry Volume 51 Pages 5575 - 5584 ISSN 0022-2623 Altmetric
2008	Neuronally selective μ-conotoxins from Conus striatus utilize an α-helical motif to target mammalian sodium channels Published In Journal of Biological Chemistry Volume 283 Pages 21621 - 21628 ISSN 0021-9258 Altmetric
2008	Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1 Published In American Journal of Physiology: Cell Physiology Volume 295 Pages C73 - C80 ISSN 0363-6143 Altmetric
2008	The three-dimensional structure of the analgesic α-conotoxin, RgIA Published In FEBS Letters Volume 582 Pages 597 - 602 ISSN 0014-5793 Altmetric
2008	ω-Conotoxin inhibition of excitatory synaptic transmission evoked by dorsal root stimulation in rat superficial dorsal horn Published In Neuropharmacology Volume 55 Pages 860 - 864 ISSN 0028-3908 Altmetric
2007	Are α9α10 nicotinic acetylcholine receptors a pain target for α-conotoxins? Published In Molecular Pharmacology Volume 72 Pages 1406 - 1410 ISSN 0026-895X Altmetric
2007	Chemical modification of conotoxins to improve stability and activity Published In ACS Chemical Biology Volume 2 Pages 457 - 468 ISSN 1554-8929 Altmetric
2007	Distinct activities of novel neurotoxins from Australian venomous snakes for nicotinic acetylcholine receptors Published In Cellular and Molecular Life Sciences Volume 64 Pages 2829 - 2840 ISSN 1420-9071 Altmetric
2007	Isolation and structure-activity of μ-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels Published In Molecular Pharmacology Volume 71 Pages 676 - 685 ISSN 0026-895X Altmetric
2007	Liposome reconstitution and modulation of recombinant N-methyl-D-aspartate receptor channels by membrane stretch Published In Proceedings of the National Academy of Sciences of USA Volume 104 Pages 1540 - 1545 ISSN 0027-8424 Altmetric
2007	NEDD4-2 as a potential candidate susceptibility gene for epileptic photosensitivity Published In Genes, Brain and Behavior Volume 6 Pages 750 - 755 ISSN 1601-183X Altmetric
2007	Polymodal regulation of NMDA receptor channels Published In Channels Volume 1 Pages 334 - 343 ISSN 1933-6950 Altmetric
2007	Purinergic receptor activation inhibits mitogen-stimulated proliferation in primary neurospheres from the adult mouse subventricular zone Published In Molecular and Cellular Neuroscience Volume 35 Pages 535 - 548 ISSN 1044-7431 Altmetric
2007	Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by ubiquitination: novel role for Nedd4-2 Published In Journal of Biological Chemistry Volume 282 Pages 12135 - 12142 ISSN 0021-9258 Altmetric
2007	Structure of α-conotoxin BuIA: influences of disulfide connectivity on structural dynamics Published In BMC Structural Biology Volume 7 Page p. 28 ISSN 1472-6807 Altmetric
2007	The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells Published In The Journal of Neuroscience Volume 27 Pages 3734 - 3742 ISSN 0270-6474 Altmetric
2007	ω-Conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels Published In European Journal of Neuroscience Volume 25 Pages 435 - 444 ISSN 0953-816X Altmetric
2006	Identification of a novel class of nicotinic receptor antagonists: dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum Published In Journal of Biological Chemistry Volume 281 Pages 24745 - 24755 ISSN 0021-9258 Altmetric
2006	Mutations within the selectivity filter of the NMDA receptor-channel influence voltage dependent block by 5-hydroxytryptamine Published In British Journal of Pharmacology Volume 149 Pages 163 - 169 ISSN 0007-1188 Altmetric
2006	NMDA receptor subunit-dependent modulation by conantokin-G and Ala(7)-conantokin-G Published In Journal of Neurochemistry Volume 96 Pages 283 - 291 ISSN 0022-3042 Altmetric
2006	Neuronal voltage-gated sodium channel subtypes: key roles in inflammatory and neuropathic pain Published In The International Journal of Biochemistry and Cell Biology Volume 38 Pages 2005 - 2010 ISSN 1357-2725 Altmetric
2006	The synthesis, structural characterization, and receptor specificity of the α-conotoxin Vc1.1 Published In Journal of Biological Chemistry Volume 281 Pages 23254 - 23263 ISSN 0021-9258 Altmetric
2006	α-Selenoconotoxins, a new class of potent α7 neuronal nicotinic receptor antagonists Published In Journal of Biological Chemistry Volume 281 Pages 14136 - 14143 ISSN 0021-9258 Altmetric
2006	μO-conotoxin MrVIB selectively blocks NaV1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits Published In Proceedings of the National Academy of Sciences of USA Volume 103 Pages 17030 - 17035 ISSN 0027-8424 Altmetric
2005	Developmental changes in expression of GABAA receptor-channels in rat intrinsic cardiac ganglion neurones Published In The Journal of Physiology Volume 564 Pages 465 - 474 ISSN 0022-3751 Altmetric
2005	Engineering stable peptide toxins by means of backbone cyclization: stabilization of the α-conotoxin MII Published In Proceedings of the National Academy of Sciences of USA Volume 102 Pages 13767 - 13772 ISSN 0027-8424 Altmetric
2005	Intravenous anaesthetics inhibit nicotinic acetylcholine receptor-mediated currents and Ca²⁺ transients in rat intracardiac ganglion neurons Published In British Journal of Pharmacology Volume 144 Pages 98 - 107 ISSN 0007-1188 Altmetric
2005	Selective modulation of neuronal nicotinic acetylcholine receptor channel subunits by Go-protein subunits Published In The Journal of Neuroscience Volume 25 Pages 3571 - 3577 ISSN 0270-6474 Altmetric
2005	Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner Published In Journal of Pharmacology and Experimental Therapeutics Volume 314 Pages 1353 - 1361 ISSN 1521-0103 Altmetric
2005	Voltage-dependent inhibition of recombinant NMDA receptor-mediated currents by 5-hydroxytryptamine Published In British Journal of Pharmacology Volume 144 Pages 323 - 330 ISSN 0007-1188 Altmetric
2004	Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors Published In Molecular Pharmacology Volume 65 Pages 1386 - 1396 ISSN 0026-895X Altmetric
2004	Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells Published In European Journal of Neuroscience Volume 20 Pages 1 - 13 ISSN 0953-816X Altmetric
2004	Chemical and functional identification and characterization of novel sulfated α-conotoxins from the cone snail Conus anemone Published In Journal of Medicinal Chemistry Volume 47 Pages 1234 - 1241 ISSN 0022-2623 Altmetric
2004	Expression and function of neuronal nicotinic ACh receptors in rat microvascular endothelial cells Published In American Journal of Physiology: Heart and Circulatory Physiology Volume 286 Pages H486 - H491 ISSN 0363-6135 Altmetric
2004	Functional maturation of isolated neural progenitor cells from the adult rat hippocampus Published In European Journal of Neuroscience Volume 19 Pages 2410 - 2420 ISSN 0953-816X Altmetric
2004	Overexpressed Cavβ3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of "ultra-slow"^^ and "closed-state"^^ inactivation Published In Journal of General Physiology Volume 123 Pages 401 - 416 ISSN 0022-1295 Altmetric
2004	Potassium channels and membrane potential in the modulation of intracellular calcium in vascular endothelial cells Published In Journal of Cardiovascular Electrophysiology Volume 15 Pages 598 - 610 ISSN 1045-3873 Altmetric
2004	Regulation of neuronal voltage-gated sodium channels by the ubiquitin protein ligases Nedd4 and Nedd4-2 Published In Journal of Biological Chemistry Volume 279 Pages 28930 - 28935 ISSN 0021-9258 Altmetric
2004	Structures of μO-conotoxins from Conus marmoreus: Inhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons Published In Journal of Biological Chemistry Volume 279 Pages 25774 - 25782 ISSN 0021-9258 Altmetric
2004	The α₂δ auxiliary subunit reduces affinity of ω-conotoxins for recombinant N-type (Ca_v2.2) calcium channels Published In Journal of Biological Chemistry Volume 279 Pages 34705 - 34714 ISSN 0021-9258 Altmetric
2003	Allosteric α1-adrenoreceptor antagonism by the conopeptide ρ-TIA Published In Journal of Biological Chemistry Volume 278 Pages 34451 - 34457 ISSN 0021-9258 Altmetric
2003	Inhibition of the norepinephrine transporter by the venom peptide χ-MrIA: site of action, Na+ dependence, and structure-activity relationship Published In Journal of Biological Chemistry Volume 278 Pages 40317 - 40323 ISSN 0021-9258 Altmetric
2003	Isolation, structure, and activity of GID, a novel α4/7-conotoxin with an extended N-terminal sequence Published In Journal of Biological Chemistry Volume 278 Pages 3137 - 3144 ISSN 0021-9258 Altmetric
2003	Muscarinic and nicotinic ACh receptor activation differentially mobilize Ca2+ in rat intracardiac ganglion neurons Published In Journal of Neurophysiology Volume 90 Pages 1956 - 1964 ISSN 0022-3077 Altmetric
2003	Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of α-conotoxin MII Published In Journal of Medicinal Chemistry Volume 46 Pages 1266 - 1272 ISSN 0022-2623 Altmetric
2003	α-conotoxins PnIA and [A10L]PnIA stabilize different states of the α7-L247T nicotinic acetylcholine receptor Published In Journal of Biological Chemistry Volume 278 Pages 26908 - 26914 ISSN 0021-9258 Altmetric
2003	ω-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals Published In Journal of Biological Chemistry Volume 278 Pages 4057 - 4062 ISSN 0021-9258 Altmetric
2002	A new level of conotoxin diversity, a non-native disulfide bond connectivity in α-conotoxin AuIB reduces structural definition but increases biological activity Published In Journal of Biological Chemistry Volume 277 Pages 48849 - 48857 ISSN 0021-9258 Altmetric
2002	Basal nonselective cation permeability in rat cardiac microvascular endothelial cells Published In Microvascular Research Volume 64 Pages 187 - 197 ISSN 0026-2862 Altmetric
2002	Ciguatoxin-induced oscillations in membrane potential and action potential firing in rat parasympathetic neurons Published In European Journal of Neuroscience Volume 16 Pages 242 - 248 ISSN 0953-816X Altmetric
2002	Neural control of the heart: developmental changes in ionic conductances in mammalian intrinsic cardiac neurons Published In Autonomic Neuroscience: Basic and Clinical Volume 98 Pages 75 - 78 ISSN 1566-0702 Altmetric
2002	Solution structure of μ-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels Published In Journal of Biological Chemistry Volume 277 Pages 27247 - 27255 ISSN 0021-9258 Altmetric
2001	An ATP-sensitive K+ conductance in dissociated neurones from adult rat intracardiac ganglia Published In The Journal of Physiology Volume 534 Pages 713 - 720 ISSN 0022-3751 Altmetric
2001	Developmental changes in hyperpolarization-activated currents Ih and IK(IR) in isolated rat intracardiac neurons Published In Journal of Neurophysiology Volume 86 Pages 312 - 320 ISSN 0022-3077
2001	Ionic selectivity of native ATP-activated (P2X) receptor channels in dissociated neurones from rat parasympathetic ganglia Published In The Journal of Physiology Volume 534 Pages 423 - 435 ISSN 0022-3751 Altmetric
2001	Large-conductance calcium-activated potassium channels in neonatal rat intracardiac ganglion neurons Published In Pfluegers Archiv: European journal of physiology Volume 441 Pages 629 - 638 ISSN 0031-6768 Altmetric
2001	Pre- and postsynaptic actions of ATP on neurotransmission in rat submandibular ganglia Published In Neuroscience Volume 107 Pages 283 - 291 ISSN 0306-4522 Altmetric
2001	The synthesis and structure of an n-terminal dodecanoic acid conjugate of α-conotoxin MII Published In International Journal of Peptide Research and Therapeutics Volume 8 Pages 235 - 239 ISSN 0929-5666 Altmetric
2001	Two new classes of conopeptides inhibit the α1-adrenoceptor and noradrenaline transporter Published In Nature Neuroscience Volume 4 Pages 902 - 907 ISSN 1097-6256 Altmetric
2000	Novel ω-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes Published In Journal of Biological Chemistry Volume 275 Pages 35335 - 35344 ISSN 0021-9258 Altmetric
2000	P2Y purinoceptor activation mobilizes intracellular Ca2+ and induces a membrane current in rat intracardiac neurones Published In The Journal of Physiology Volume 526 Pages 287 - 298 ISSN 0022-3751 Altmetric
2000	Substance P preferentially inhibits large conductance nicotinic ACh receptor channels in rat intracardiac ganglion neurons Published In Journal of Neurophysiology Volume 84 Pages 1961 - 1970 ISSN 0022-3077 Altmetric
2000	VIP and PACAP potentiation of nicotinic ACh-evoked currents in rat parasympathetic neurons is mediated by G-protein activation Published In European Journal of Neuroscience Volume 12 Pages 2243 - 2251 ISSN 0953-816X Altmetric
1999	Calcium channels controlling acetylcholine release from preganglionic nerve terminals in rat autonomic ganglia Published In Neuroscience Volume 95 Pages 1121 - 1127 ISSN 0306-4522 Altmetric
1999	Conotoxins and their potential pharmaceutical applications Published In Drug Development Research Volume 46 Pages 219 - 234 ISSN 0272-4391 Altmetric
1999	Mechanisms of verapamil inhibition of action potential firing in rat intracardiac ganglion neurons Published In Journal of Pharmacology and Experimental Therapeutics Volume 289 Pages 1502 - 1508 ISSN 1521-0103
1999	Met-enkephalin-induced mobilization of intracellular Ca2+ in rat intracardiac ganglion neurones Published In Neuroscience Letters Volume 264 Pages 105 - 108 ISSN 0304-3940 Altmetric
1999	Single amino acid substitutions in α-conotoxin PnIA shift selectivity for subtypes of the mammalian neuronal nicotinic acetylcholine receptor Published In Journal of Biological Chemistry Volume 274 Pages 36559 - 36564 ISSN 0021-9258 Altmetric
1998	ACh- and caffeine-induced Ca2+ mobilization and current activation in rabbit arterial endothelial cells Published In American Journal of Physiology: Heart and Circulatory Physiology Volume 275 Pages H1748 - H1758 ISSN 0363-6135
1998	Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons Published In Journal of Pharmacology and Experimental Therapeutics Volume 284 Pages 516 - 525 ISSN 1521-0103
1998	Ciguatoxin (CTX-1) modulates single tetrodotoxin-sensitive sodium channels in rat parasympathetic neurones Published In Neuroscience Letters Volume 252 Pages 103 - 106 ISSN 0304-3940 Altmetric
1998	Opioid receptor-mediated inhibition of ω-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons Published In Journal of Neurophysiology Volume 79 Pages 753 - 762 ISSN 0022-3077
1998	α-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors Published In Journal of Biological Chemistry Volume 273 Pages 15667 - 15674 ISSN 0021-9258 Altmetric
1997	Characterization of ATP-sensitive potassium channels in freshly dissociated rabbit aortic endothelial cells Published In American Journal of Physiology: Heart and Circulatory Physiology Volume 272 Pages H2507 - H2511 ISSN 0363-6135
1997	Heterogeneity of nicotinic receptor class and subunit mRNA expression among individual parasympathetic neurons from rat intracardiac ganglia Published In The Journal of Neuroscience Volume 17 Pages 586 - 596 ISSN 0270-6474
1997	M4 muscarinic receptor activation modulates calcium channel currents in rat intracardiac neurons Published In Journal of Neurophysiology Volume 78 Pages 1903 - 1912 ISSN 0022-3077
1997	Passive and active membrane properties of isolated rat intracardiac neurons: Regulation by H- and M-currents Published In Journal of Neurophysiology Volume 78 Pages 1890 - 1902 ISSN 0022-3077
1996	Vasoactive intestinal polypeptide modulation of nicotinic ACh receptor channels in rat intracardiac neurones Published In The Journal of Physiology Volume 493 Pages 503 - 515 ISSN 0022-3751 Altmetric
1995	An ATP-sensitive potassium conductance in rabbit arterial endothelial cells Published In The Journal of Physiology Volume 485 Pages 595 - 606 ISSN 0022-3751 Altmetric
1995	Caffeine-evoked, calcium-sensitive membrane currents in rabbit aortic endothelial cells Published In British Journal of Pharmacology Volume 115 Pages 133 - 141 ISSN 0007-1188
1995	Monovalent and divalent cation permeability and block of neuronal nicotinic receptor channels in rat parasympathetic ganglia Published In Journal of General Physiology Volume 105 Pages 701 - 723 ISSN 0022-1295 Altmetric
1995	The relationship of brevetoxin 'length' and A-ring functionality to binding and activity in neuronal sodium channels Published In Chemistry and Biology Volume 2 Pages 533 - 541 ISSN 1074-5521 Altmetric
1994	Cytosolic [Ca2+] measurements in endothelium of rabbit cardiac valves using imaging fluorescence microscopy Published In American Journal of Physiology: Heart and Circulatory Physiology Volume 266 Pages H2130 - H2135 ISSN 0363-6135
1994	Ionic channels in vascular endothelial cells Published In Trends in Cardiovascular Medicine Volume 4 Pages 18 - 26 ISSN 1873-2615 Altmetric
1994	Is the A-ring lactone of brevetoxin PbTX-3 required for sodium channel orphan receptor binding and activity? Published In Natural Toxins Volume 2 Pages 212 - 221 Altmetric
1994	Local anaesthetic blockade of neuronal nicotinic ACh receptor-channels in rat parasympathetic ganglion cells Published In British Journal of Pharmacology Volume 111 Pages 663 - 672 ISSN 0007-1188
1994	TEA inhibits ACh-induced EDRF release: endothelial Ca2+-dependent K+ channels contribute to vascular tone Published In American Journal of Physiology: Heart and Circulatory Physiology Volume 267 Pages H1135 - H1141 ISSN 0363-6135
1993	Membrane properties and discharge characteristics of rat intracardiac neurones in vitro: the effect of temperature Published In The Journal of Physiology Volume 467 Page p. 356 ISSN 0022-3751 Altmetric
1993	α-Adrenergic modulation of ionic currents in cultured parasympathetic neurons from rat intracardiac ganglia Published In Journal of Neurophysiology Volume 69 Pages 1060 - 1070 ISSN 0022-3077
1992	Calcium entry-dependent oscillations of cytoplasmic calcium concentration in cultured endothelial cell monolayers Published In Proceedings of the National Academy of Sciences of USA Volume 89 Pages 1690 - 1694 ISSN 0027-8424
1992	Calcium permeability and modulation of nicotinic acetylcholine receptor-channels in rat parasympathetic neurons Published In Journal of Physiology: Paris Volume 86 Pages 67 - 76 ISSN 0928-4257 Altmetric
1992	Calcium-activated potassium channels in native endothelial cells from rabbit aorta: conductance, Ca2+ sensitivity and block Published In The Journal of Physiology Volume 455 Pages 601 - 621 ISSN 0022-3751 Altmetric
1992	Resting membrane potential and potassium currents in cultured parasympathetic neurones from rat intracardiac ganglia Published In The Journal of Physiology Volume 456 Pages 405 - 424 ISSN 0022-3751 Altmetric
1992	Voltage-dependent sodium and calcium currents in cultured parasympathetic neurones from rat intracardiac ganglia Published In The Journal of Physiology Volume 456 Pages 425 - 441 ISSN 0022-3751 Altmetric
1991	Acetylcholine-evoked currents in cultured neurones dissociated from rat parasympathetic cardiac ganglia Published In The Journal of Physiology Volume 434 Pages 215 - 237 ISSN 0022-3751 Altmetric
1991	Adenosine triphosphate-evoked currents in cultured neurones dissociated from rat parasympathetic cardiac ganglia Published In The Journal of Physiology Volume 434 Pages 239 - 256 ISSN 0022-3751 Altmetric
1991	Cytosolic calcium ion regulation in cultured endothelial cells Published In Advances in Experimental Medicine and Biology Volume 304 Pages 257 - 271 ISSN 0065-2598 Altmetric
1991	Modes of hexamethonium action on acetylcholine receptor channels in frog skeletal muscle Published In British Journal of Pharmacology Volume 102 Pages 135 - 145 ISSN 0007-1188
1990	Membrane potential and Na+-K+ pump activity modulate resting and bradykinin-stimulated changes in cytosolic free calcium in cultured endothelial cells from bovine atria Published In Journal of Biological Chemistry Volume 265 Pages 2613 - 2619 ISSN 0021-9258
1990	Neurotransmission in neonatal rat cardiac ganglion in situ Published In American Journal of Physiology: Heart and Circulatory Physiology Volume 259 Pages H997 - H1005 ISSN 0363-6135
1990	Synergistic hypotensive effect of vasoactive intestinal polypeptide and α-blockade with phentolamine: evidence for vasoactive intestinal peptide α-adrenoceptor coupling in the cardiovascular system of newborn dogs Published In Circulation Research Volume 67 Pages 986 - 992 ISSN 0009-7330
1989	Bradykinin and inositol 1,4,5-trisphosphate-stimulated calcium release from intracellular stores in cultured bovine endothelial cells Published In Pfluegers Archiv: European journal of physiology Volume 414 Pages 377 - 384 ISSN 0031-6768 Altmetric
1989	Inhibition of neurally-evoked transmitter release by calcium channel antagonists in rat parasympathetic ganglia Published In British Journal of Pharmacology Volume 97 Pages 1125 - 1136 ISSN 0007-1188
1989	Ion channels and regulation of intracellular calcium in vascular endothelial cells Published In The FASEB Journal Volume 3 Pages 2389 - 2400 ISSN 0892-6638
1989	Synchronized oscillations in cytoplasmic free calcium concentrations in confluent bradykinin-stimulated bovine pulmonary artery endothelial cell monolayers Published In Journal of Biological Chemistry Volume 264 Pages 6 - 9 ISSN 0021-9258
1988	Role of calcium in the activation of endothelial cells Published In Journal of Cardiovascular Pharmacology Volume 12 Pages S119 - S123 ISSN 0160-2446
1988	The actions of L-glutamate at the postsynaptic membrane of the squid giant synapse Published In The Journal of Experimental Biology Volume 140 Pages 535 - 548 ISSN 0022-0949
1987	Calcium entry through receptor-operated channels in bovine pulmonary artery endothelial cells Published In Tissue and Cell Volume 19 Pages 733 - 745 ISSN 1532-3072 Altmetric
1985	Inhibitors of calcium buffering depress evoked transmitter release at the squid giant synapse. Published In The Journal of Physiology Volume 369 Pages 145 - 159 ISSN 0022-3751 Altmetric
1985	Some properties of acetylcholine receptors in human cultured myotubes Published In Proceedings of the Royal Society B: Biological Sciences Volume 224 Pages 183 - 196 ISSN 0962-8452 Altmetric
1982	Inhibitory postsynaptic currents at Aplysia cholinergic synapses: effects of permeant anions and depressant drugs Published In Proceedings of the Royal Society B: Biological Sciences Volume 214 Pages 335 - 350 ISSN 0962-8452 Altmetric
1981	Block of endplate channels by permeant cations in frog skeletal muscle Published In Journal of General Physiology Volume 78 Pages 593 - 615 ISSN 0022-1295 Altmetric
1980	Divalent ion currents and the delayed potassium conductance in an Aplysia neurone Published In The Journal of Physiology Volume 304 Pages 297 - 313 ISSN 0022-3751 Altmetric
1980	Ionic currents in molluscan soma Published In Annual Review of Neuroscience Volume 3 Pages 141 - 167 ISSN 0147-006X Altmetric
1980	The permeability of endplate channels to monovalent and divalent metal cations Published In Journal of General Physiology Volume 75 Pages 493 - 510 ISSN 0022-1295
1980	The permeability of the endplate channel to organic cations in frog muscle Published In Journal of General Physiology Volume 75 Pages 469 - 492 ISSN 0022-1295 Altmetric
1979	Characteristics of sodium and calcium conductance changes produced by membrane depolarization in an Aplysia neurone Published In The Journal of Physiology Volume 289 Pages 143 - 161 ISSN 0022-3751 Altmetric
1979	Ionic currents in response to membrane depolarization in an aplysia neurone Published In The Journal of Physiology Volume 289 Pages 115 - 141 ISSN 0022-3751 Altmetric
1979	Sodium and calcium gating currents in an Aplysia neurone Published In The Journal of Physiology Volume 291 Pages 467 - 481 ISSN 0022-3751 Altmetric
1978	An effect of ethanol at a glutamate synapse Published In Clinical and Experimental Pharmacology and Physiology Volume 5 Pages 275 - 276 ISSN 0305-1870 Altmetric
1978	Asymmetrical displacement currents Published In Nature Volume 271 Pages 586 - 587 ISSN 0028-0836 Altmetric
1977	Ethanol reduces excitatory postsynaptic current duration at a crustacean neuromuscular junction Published In Nature Volume 266 Pages 739 - 741 ISSN 0028-0836 Altmetric
1977	Funnel web spider venom produces spontaneous action potentials in nerve Published In Life Sciences Volume 20 Pages 243 - 249 ISSN 0024-3205 Altmetric
1976	Gating currents associated with sodium and calcium currents in an Aplysia neuron Published In Science Volume 192 Pages 783 - 784 ISSN 0096-3771 Altmetric
1976	Voltage sensitivity of inhibitory postsynaptic currents in Aplysia buccal ganglia Published In Brain Research Volume 115 Pages 506 - 511 ISSN 0006-8993 Altmetric

Chapter

Year	Title
2015	Venoms-based drug discovery: bioassays, electrophysiology, high-throughput screens and target identincation Published In Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics Publisher http://pubs.rsc.org/en/Content/eBook/978-1-84973-663-3#!divbookcontent: Royal Society of Chemistry Pages 97 - 128 Altmetric

Collection Or Series Editor For

The Journal of Physiology (Journal) 2015 -
Marine Drugs (Journal) 2014 -
The International Journal of Biochemistry and Cell Biology (Journal) 2013 -
Frontiers in Pharmacology (Journal) 2010 -
Channels (Journal) 2006 -
Neuropharmacology (Journal) 2016 - 2017
Pfluegers Archiv: European journal of physiology (Journal) 2008 - 2011
American Journal of Physiology: Heart and Circulatory Physiology (Journal) 1991 - 1996

Investigator On

Year	Title
2015 - 2020	Nicotinic receptor structure and function probed with conotoxinx Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2018	Electrophysiology Facility for Cell Phenotyping and Drug Discovery Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2017	Identifying novel gene mutations for molecular diagnosis of Familial Hemiplegic Migraine Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2013 - 2016	Alpha-Conotoxin Inhibition of Chronic Visceral Pain Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2015	Ion channel modulators of pain pathways Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Program Grant
	Inflammatory Pain - Control of Immune Cell Nicotinic Receptor Signaling by Conotoxins? Mechanisms and Screening Platforms Awarded by: Deutscher Akademischer Austausch Dienst (DAAD) Funding Scheme: Australia Germany Joint Cooperation Scheme

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Conotoxin modulation of voltage-gated calcium and potassium channels via GABA-B receptor activation	Bony, Anuja
Doctor of Philosophy	Nicotinic acetylcholine receptor structure and function probed with venom derived peptides.	Bye, Lydia

Professional Service Activities

NSW Office for Health and Medical Research Cardiovascular Disease Research Advisory Committee 2018 - 2022
Multiple Sclerosis Research Australia (MSRA) Member of the Research Management Council 2007 - 2015
National Health and Medical Research Council Assigners Academy 2012 - 2014
Australian Academy of Science National Committee for Biomedical Sciences 2003 - 2009
The University of Queensland Head of School of Biomedical Sciences 2000 - 2007
University of Queensland Head of Department of Physiology and Pharmacology 1998 - 2000

Education And Training

Marine Biological Laboratory, Woods Hole, MA, Grass Fellowship in Neurophysiology 1980 -
Ph.D. in Physiology, University of New South Wales, School of Physiology & Pharmacology, An Analysis of Ionic Channels in Aplysia Nerve Cell Membrane. 1974 - 1978
B Science (Hon) in Physiology, University of New South Wales 1970 - 1973
University College of London (UCL) , Department of Pharmacology, Beit Memorial Fellowship for Medical Research, UK 1981 - 1983
University of Washington School of Medicine, Department of Physiology & Biophysics, Muscular Dystrophy Association of America Postdoctoral Fellowship 1978 - 1980

Awards And Honors

NHMRC Ten of the Best Health & Medical Research Projects, conferred by NHMRC, 2011
Finalist, Australian Museum Eureka Prize People’s Choice Award, conferred by Australian Museum Eureka Prizes, 2005
Finalist, Royal Societies of Australia Eureka Prize for Interdisciplinary Scientific Research, conferred by Australian Museum Eureka Prizes, 2004
Australian Professorial Fellowship, conferred by Austrlian Research Council (ARC), 2010 - 2015

Keywords

Membrane physiology
Neuropharmacology
Cellular neuroscience
Electrophysiology
Ion channels
Membrane biophysics

Full Name

David John Adams

Mailing Address

Illawarra Health & Medical Research Institute (IHMRI)

University of Wollongong

Wollongong

NSW

2522

Australia

Located In Facility

Illawarra Health and Medical Research Institute

Orcid Id

http://orcid.org/0000-0002-7030-2288 (confirmed)

Overview

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Located In Facility

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Overview

Top Publications

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Research Overview

Publications

Selected Publications

Journal Article

Chapter

Collection Or Series Editor For

Funding

Investigator On

Supervision

Advisees

Graduate Advising Relationship

Service

Professional Service Activities

Background

Education And Training

Awards And Honors

Keywords

Contact

Full Name

Mailing Address

Located In Facility

Identity

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