Skropeta, Danielle

Top Publications

Year	Title
2008	Deep-sea Natural Products Published in Natural Product Reports: a journal of current development in bioorganic chemistry
2007	N-glycolisation regulates endothelial lipase-mediated phospholipid hydrolysis in apoE- and apoA-I-containing high density lipoproteins Published in Journal of Lipid Research

Research Areas

Research Overview

Carbohydrate-based drug discovery and Nature-inspired medicinal chemistry.

Design, synthesis and biological evaluation of natural and carbohydrate-based anticancer agents. Glycopeptides for radioimaging. Natural product chemistry ranging from rare deep-sea invertebrates to abundant, local macroalage.

Available as Research Supervisor

Available for Collaborative Projects

Member Of

Royal Australian Chemical Institute (RACI) Chair of the Wollongong Section 1994 -

Selected Publications

Journal Article

Year	Title
2018	Acetylcholinesterase-inhibitory activity of Iranian plants: Combined HPLC/bioassay-guided fractionation, molecular networking and docking strategies for the dereplication of active compounds Published In Journal of Pharmaceutical and Biomedical Analysis Volume 158 Pages 471 - 479 ISSN 0731-7085 Altmetric
2018	Computer‐aided design of human sialyltransferase inhibitors of hST8Sia III Published In Journal of Molecular Recognition Volume 31 Pages e2684-1 - e2684-11 ISSN 1099-1352 Altmetric
2018	Effects of nutrients and processing on the nutritionally important metabolites of Ulva sp. (Chlorophyta) Published In Algal Research Volume 35 Pages 586 - 594 Altmetric
2018	Eyes in the sea: Unlocking the mysteries of the ocean using industrial, remotely operated vehicles (ROVs) Published In Science of the Total Environment Volume 634 Pages 1077 - 1091 ISSN 0048-9697 Altmetric
2017	Advancement of sialyltransferase inhibitors: therapeutic challenges and opportunities Published In Medicinal Research Reviews Volume 37 Pages 219 - 270 ISSN 0198-6325 Altmetric
2017	Computational Glycobiology: Mechanistic Studies of Carbohydrate-Active Enzymes and Implication for Inhibitor Design Published In Advances in Protein Chemistry and Structural Biology Volume 109 Pages 25 - 76 Altmetric
2017	Deep-sea observations at hydrocarbon drilling locations: contributions from the SERPENT Project after 120 field visits Published In Deep-Sea Research Part 2: Topical Studies in Oceanography Volume 137 Pages 463 - 479 ISSN 0967-0645 Altmetric
2017	Transition state-based ST6Gal I inhibitors: Mimicking the phosphodiester linkage with a triazole or carbamate through an enthalpy-entropy compensation Published In Scientific Reports Volume 7 Pages 14428-1 - 14428-11 ISSN 2045-2322 Altmetric
2016	Computational characterisation of the interactions between human ST6Gal I and transition-state analogue inhibitors: insights for inhibitor design Published In Journal of Molecular Recognition Volume 29 Pages 210 - 222 ISSN 1099-1352 Altmetric
2016	Parameters affecting the analytical profile of fatty acids in the macroalgal genus Ulva Published In Food Chemistry Volume 209 Pages 332 - 340 ISSN 0308-8146 Altmetric
2015	(Chemotaxonomic) implications of postharvest/storage-induced changes in plant volatile profiles - the case of Artemisia absinthium L. essential oil Published In Chemistry and Biodiversity Volume 12 Pages 1237 - 1255 ISSN 1612-1872 Altmetric
2015	Glycosylation and functionalization of native amino acids with azido uronic acids Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 71 Pages 9357 - 9365 ISSN 0040-4020 Altmetric
2015	Selecting Australian marine macroalgae based on the fatty acid composition and anti-inflammatory activity Published In Journal of Applied Phycology Volume 27 Pages 2111 - 2121 ISSN 0921-8971 Altmetric
2014	Recent advances in deep-sea natural products Published In Natural Product Reports: a journal of current development in bioorganic chemistry Volume 31 Pages 999 - 1025 ISSN 0265-0568 Altmetric
2013	Bioassays for anticancer activities Published In Methods in Molecular Biology Volume 1055 Pages 191 - 205 ISSN 1064-3745
2012	Anti-cancer activity of an acid-labile N-alkylisatin conjugate targeting the transferrin receptor Published In Cancer Letters Volume 316 Pages 151 - 156 ISSN 0304-3835 Altmetric
2012	Comparison of polar metabolites in Australian deep-sea sponges using HPLC-ESI-HRMS in combination with multivariate analysis Published In Planta Medica: natural products and medicinal plant research Volume 78 Pages 1149 - 1149 ISSN 0032-0943 Altmetric
2012	Fatty and volatile oils of the gypsywort lycopus europaeus L. and the gaussian-like distribution of its wax alkanes Published In JAOCS Volume 89 Pages 2165 - 2185 ISSN 0003-021X Altmetric
2012	Synthesis and anti-leukaemic activity of pyrrolo[3,2,1-hi]indole-1,2- diones, pyrrolo[3,2,1-ij]quinoline-1,2-diones and other polycyclic isatin derivatives Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 68 Pages 6810 - 6819 ISSN 0040-4020 Altmetric
2012	Targeting urokinase and the transferrin receptor with novel, anti-mitotic N-Alkylisatin cytotoxin conjugates causes selective cancer cell death and reduces tumor growth Published In Current Cancer Drug Targets Volume 12 Pages 64 - 73 ISSN 1568-0096 Altmetric
2012	c-AMP dependent protein kinase A inhibitory activity of six algal extracts from South Eastern Australia and their fatty acid composition Published In Natural Product Communications: an international journal for communications and reviews Volume 7 Pages 923 - 926 ISSN 1555-9475
2011	Kinase inhibitors from marine sponges Published In Marine Drugs Volume 9 Pages 2131 - 2154 ISSN 1660-3397 Altmetric
2011	Kinase inhibitory, haemolytic and cytotoxic activity of three deep-water sponges from North Western Australia and their fatty acid composition Published In Natural Product Communications: an international journal for communications and reviews Volume 6 Pages 1921 - 1924 ISSN 1555-9475
2011	Synthesis and hydrolytic evaluation of acid-labile imine-linked cytoxic isatin model systems Published In Bioorganic and Medicinal Chemistry Volume 19 Pages 1771 - 1778 ISSN 1464-3391 Altmetric
2010	Average mass scan of the total ion chromatogram versus percentage chemical composition in multivariate statistical comparison of complex volatile mixtures Published In Journal of the Brazilian Chemical Society Volume 21 Pages 2319 - 2326 ISSN 1678-4790 Altmetric
2010	Complete assignment of the 1H and 13C NMR spectra of antimicrobial 4-arylamino- 3-nitrocoumarin derivatives Published In Magnetic Resonance in Chemistry Volume 48 Pages 896 - 902 ISSN 1097-458X Altmetric
2010	Misidentification of tansy, tanacetum macrophyllum, as yarrow, achillea grandifolia: a health risk or benefit? Published In Natural Product Communications Volume 5 Pages 121 - 127
2010	Structures, biological activities and phylogenetic relationships of Terpenoids from marine ciliates of the Genus Euplotes Published In Marine Drugs Volume 8 Pages 2080 - 2116 ISSN 1660-3397 Altmetric
2009	Cytotoxic and anticancer activities of Isatin and its derivatives: a comprehensive review from 2000-2008 Published In Anti-Cancer Agents in Medicinal Chemistry Volume 9 Pages 397 - 414 ISSN 1568-0118
2009	PH-triggered release of potent isatin-derived cytotoxins conjugated to the tumour targeting protein PAI-2 Published In Annals of Oncology Volume 20 Pages iii34 - iii34 ISSN 0923-7534 Altmetric
2009	Solid-state and solution-phase conformations of pseudoproline-containing dipeptides Published In Australian Journal of Chemistry: an international journal for chemical science Volume 62 Pages 711 - 719 ISSN 0004-9425 Altmetric
2009	The effect of individual N-glycans on enzyme activity Published In Bioorganic and Medicinal Chemistry Volume 17 Pages 2645 - 2653 ISSN 1464-3391 Altmetric
2008	Chemotaxonomy of the peppergrass Lepidium coronopus (L.) Al-Shehbaz (syn. Coronopus squamatus) based on its volatile glucosinolate autolysis products Published In Biochemical Systematics and Ecology Volume 36 Pages 807 - 811 ISSN 0305-1978 Altmetric
2008	Deep-sea Natural Products Published In Natural Product Reports: a journal of current development in bioorganic chemistry Volume 25 Pages 1131 - 1166 ISSN 0265-0568 Altmetric
2008	N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents Published In Bioorganic and Medicinal Chemistry Volume 16 Pages 3118 - 3124 ISSN 1464-3391 Altmetric
2007	Domino pericyclic reactions of acyclic conjugated (E,Z,E,E)-tetraenes Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 48 Pages 3281 - 3284 ISSN 0040-4039 Altmetric
2007	N-glycolisation regulates endothelial lipase-mediated phospholipid hydrolysis in apoE- and apoA-I-containing high density lipoproteins Published In Journal of Lipid Research Volume 48 Pages 2047 - 2057 ISSN 0022-2275 Altmetric

Chapter

Year	Title
2013	Recent highlights in the development of isatin-based anticancer agents Published In Advances in Anticancer Agents in Medicinal Chemistry Publisher Bentham Science Publishers Pages 254 - 312 Altmetric
2010	Learning how to be an academic - the story of a new academic in the sciences Published In An Academic Life: A Handbook for New Academics Publisher ACER Press Pages 6 - 9

Conference Paper

Year	Title
2018	Understanding the Global Scientific Value of Industry ROV Data to Quantify Marine Ecology and Guide Offshore Decommissioning Strategies Published In Offshore Technology Conference Asia, 20-23 March, Kuala Lumpur, Malaysia Pages 1 - 10 Altmetric
2011	Selective Release of Potent N-Alkylisatin Based Cytotoxins via Hydrolysis of pH Sensitive Imine Linkers Published In 27th International Symposium on the Chemistry of Natural Products and the 7th International Conference on Biodiversity (ISCNP-27 & ICOB-7) Pages CT-19 - CT-19
2011	Synthesis of novel sugar diamino acids Published In GLYCO 21: 21st International Symposiumon on Glycoconjugates Pages 349 - 349
2010	Synthesis of novel sugar diamino acids Published In Pacifichem 2010, International Chemical Congress of Pacific Basin Societies Pages 291 - 291
2010	Selective release of potent N-alkylisatin based cytotoxins via hydrolysis of pH sensitive imine linkers Published In 2010 International Chemical Congress of Pacific Basin Societies Pages 938 - 938

Investigator On

Year	Title
2010	Cultivating Australian seaweeds for health and nutrition markets: Ulva and Cladosiphon sp. Awarded by: Rural Industries Research and Development Corporation Funding Scheme: Research Grant
2009	Synthesis, Radiolabelling and Biodistribution Studies of Selective Untegrin Antagonists as New PPET Cancer Imaging Agents Awarded by: Australian Institute of Nuclear Science and Engineering (AINSE) Funding Scheme: Research Award
2008	Understanding the tolerance of Antarctic mosses to climate change Awarded by: Australian Antarctic Division Funding Scheme: Grant
2007	Effect of deep-sea drilling on sustainability of deep-sea ecosystems Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects

Impact Story

Partnering in our region and beyond
Summary
Each of my research projects is the result of an interdisciplinary collaboration with either an academic, industry or community partner, ranging from local and regional partners to major international institutes and companies. 

Detail View

Detail View Summary View
Detail of Impact
In the Illawarra region I have a major partnership with <a href="https://www.venusshellsystems.com.au/" target="_blank" rel="noopener">Venus Shell Systems</a>, <a href="https://www.nowchem.com.au/" target="_blank" rel="noopener">NowChem</a> and <a href="http://www.bluebiotech.com.au/" target="_blank" rel="noopener">BlueBiotech</a>, with funding on two distinct research projects. Our work together spans the spectrum from marine biology to medicinal chemistry and from academia to industry, providing potential health benefits through the therapeutic formulations we are developing and employment opportunities for the region. <a href="https://youtu.be/Oje7Y1BEbHQ" target="_blank" rel="noopener">NowChem Video</a>. I also have strong relationship with the <a href="http://illawarracancercarers.org.au/" target="_blank" rel="noopener">Illawarra Cancer Carers</a> who have provided significant seed funding to our research on pancreatic cancer including the provision of student PhD scholarships. I am part of the Centre for Oncology Education and Research Translation (<a href="https://www.cancerinstitute.org.au/Data-research/Translating-research-into-practice/funded-centres/Centre-for-Oncology-Education-and-Research-Transla" target="_blank" rel="noopener">CONCERT</a>), a multidisciplinary cancer research hub for South West Sydney, Illawarra and Shoalhaven regions. CONCERT draws together around 200 professional members spanning all aspects of cancer research, diagnosis, treatment and care, and has provided unparalleled collaboration opportunities, access to cutting-edge biological assays, various cell lines and animal models of disease.I play a key role in an innovative interdisciplinary global deep-sea collaboration known as <a href="http://www.serpentproject.com/" target="_blank" rel="noopener">SERPENT</a> (Scientific Environmental ROV Partnership Using Existing Industrial Technology). The SERPENT project involves senior researchers from across Australia ranging from marine biologists (Prof. Dave Booth, UTS) to world-leading robotic engineers (Prof. Stefan Wiliams, ARC Future Fellow, USyd) from several Australian Universities collaborating with major Australian Oil and Gas companies including Chevron, Woodside, Santos, Apache, Inpex and ENI Pty Ltd. The deep-sea research program has featured broadly in the media including on the <a href="http://www.abc.net.au/7.30/new-project-uncovers-more-of-the-deep-sea/2785068" target="_blank" rel="noopener">ABC 7:30 Report</a>, as the subject of international documentary by award-winning film-maker Charles de Rouvre.
Field of Research
Countries / Regions
Beneficiaries

Beneficiary Quantification Description
External Partners
Evidence of Impact

Evidence Description
UOW Centres / Programs
UOW Researchers / Collaborators

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Development of Glycosyltransferase Inhibitors as a Novel Antimetastatic Strategy for Cancer Treatment	Dobie, Chris
Doctor of Philosophy	3D Printed Skin Grafts for Coverage of Partial or Full Thickness Burns	Daikuara, Luciana
Doctor of Philosophy	Synthesis and Evaluation of Amiloride Analogues as New Agents for Drug Resistant Tuberculosis	Bujaroski, Richard

Education And Training

Doctor of Philosophy in Organic Chemistry, Australian National University, Research School of Chemistry 1994 - 1999
B Science (Hon) in Organic Chemistry, Monash University 1990 - 1993

Awards And Honors

Athel Beckwith Lectureship, conferred by RACI Organic Chemistry Division, 2009

Keywords

Medicinal Chemistry
Organic Chemistry
Natural Products Chemistry
Carbohydrate Chemistry
Peptide Chemistry
Anticancer Agents

Full Name

Danielle Skropeta

Mailing Address

Northfields Ave

University of Wollongong

Wollongong

NSW

2522

Australia

Geographic Location

Wollongong Campus

Located In Facility

Building 18 (Chemistry)

Fax

+61-2-42214287

Orcid Id

http://orcid.org/0000-0002-2293-7916 (confirmed)

Web Of Science Researcher Id

G-3761-2015

Top Publications

Year	Title
2008	Deep-sea Natural Products Published in Natural Product Reports: a journal of current development in bioorganic chemistry
2007	N-glycolisation regulates endothelial lipase-mediated phospholipid hydrolysis in apoE- and apoA-I-containing high density lipoproteins Published in Journal of Lipid Research

Research Areas

Research Overview

Carbohydrate-based drug discovery and Nature-inspired medicinal chemistry.

Design, synthesis and biological evaluation of natural and carbohydrate-based anticancer agents. Glycopeptides for radioimaging. Natural product chemistry ranging from rare deep-sea invertebrates to abundant, local macroalage.

Member Of

Royal Australian Chemical Institute (RACI) Chair of the Wollongong Section 1994 -

Selected Publications

Journal Article

Year	Title
2018	Acetylcholinesterase-inhibitory activity of Iranian plants: Combined HPLC/bioassay-guided fractionation, molecular networking and docking strategies for the dereplication of active compounds Published In Journal of Pharmaceutical and Biomedical Analysis Volume 158 Pages 471 - 479 ISSN 0731-7085 Altmetric
2018	Computer‐aided design of human sialyltransferase inhibitors of hST8Sia III Published In Journal of Molecular Recognition Volume 31 Pages e2684-1 - e2684-11 ISSN 1099-1352 Altmetric
2018	Effects of nutrients and processing on the nutritionally important metabolites of Ulva sp. (Chlorophyta) Published In Algal Research Volume 35 Pages 586 - 594 Altmetric
2018	Eyes in the sea: Unlocking the mysteries of the ocean using industrial, remotely operated vehicles (ROVs) Published In Science of the Total Environment Volume 634 Pages 1077 - 1091 ISSN 0048-9697 Altmetric
2017	Advancement of sialyltransferase inhibitors: therapeutic challenges and opportunities Published In Medicinal Research Reviews Volume 37 Pages 219 - 270 ISSN 0198-6325 Altmetric
2017	Computational Glycobiology: Mechanistic Studies of Carbohydrate-Active Enzymes and Implication for Inhibitor Design Published In Advances in Protein Chemistry and Structural Biology Volume 109 Pages 25 - 76 Altmetric
2017	Deep-sea observations at hydrocarbon drilling locations: contributions from the SERPENT Project after 120 field visits Published In Deep-Sea Research Part 2: Topical Studies in Oceanography Volume 137 Pages 463 - 479 ISSN 0967-0645 Altmetric
2017	Transition state-based ST6Gal I inhibitors: Mimicking the phosphodiester linkage with a triazole or carbamate through an enthalpy-entropy compensation Published In Scientific Reports Volume 7 Pages 14428-1 - 14428-11 ISSN 2045-2322 Altmetric
2016	Computational characterisation of the interactions between human ST6Gal I and transition-state analogue inhibitors: insights for inhibitor design Published In Journal of Molecular Recognition Volume 29 Pages 210 - 222 ISSN 1099-1352 Altmetric
2016	Parameters affecting the analytical profile of fatty acids in the macroalgal genus Ulva Published In Food Chemistry Volume 209 Pages 332 - 340 ISSN 0308-8146 Altmetric
2015	(Chemotaxonomic) implications of postharvest/storage-induced changes in plant volatile profiles - the case of Artemisia absinthium L. essential oil Published In Chemistry and Biodiversity Volume 12 Pages 1237 - 1255 ISSN 1612-1872 Altmetric
2015	Glycosylation and functionalization of native amino acids with azido uronic acids Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 71 Pages 9357 - 9365 ISSN 0040-4020 Altmetric
2015	Selecting Australian marine macroalgae based on the fatty acid composition and anti-inflammatory activity Published In Journal of Applied Phycology Volume 27 Pages 2111 - 2121 ISSN 0921-8971 Altmetric
2014	Recent advances in deep-sea natural products Published In Natural Product Reports: a journal of current development in bioorganic chemistry Volume 31 Pages 999 - 1025 ISSN 0265-0568 Altmetric
2013	Bioassays for anticancer activities Published In Methods in Molecular Biology Volume 1055 Pages 191 - 205 ISSN 1064-3745
2012	Anti-cancer activity of an acid-labile N-alkylisatin conjugate targeting the transferrin receptor Published In Cancer Letters Volume 316 Pages 151 - 156 ISSN 0304-3835 Altmetric
2012	Comparison of polar metabolites in Australian deep-sea sponges using HPLC-ESI-HRMS in combination with multivariate analysis Published In Planta Medica: natural products and medicinal plant research Volume 78 Pages 1149 - 1149 ISSN 0032-0943 Altmetric
2012	Fatty and volatile oils of the gypsywort lycopus europaeus L. and the gaussian-like distribution of its wax alkanes Published In JAOCS Volume 89 Pages 2165 - 2185 ISSN 0003-021X Altmetric
2012	Synthesis and anti-leukaemic activity of pyrrolo[3,2,1-hi]indole-1,2- diones, pyrrolo[3,2,1-ij]quinoline-1,2-diones and other polycyclic isatin derivatives Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 68 Pages 6810 - 6819 ISSN 0040-4020 Altmetric
2012	Targeting urokinase and the transferrin receptor with novel, anti-mitotic N-Alkylisatin cytotoxin conjugates causes selective cancer cell death and reduces tumor growth Published In Current Cancer Drug Targets Volume 12 Pages 64 - 73 ISSN 1568-0096 Altmetric
2012	c-AMP dependent protein kinase A inhibitory activity of six algal extracts from South Eastern Australia and their fatty acid composition Published In Natural Product Communications: an international journal for communications and reviews Volume 7 Pages 923 - 926 ISSN 1555-9475
2011	Kinase inhibitors from marine sponges Published In Marine Drugs Volume 9 Pages 2131 - 2154 ISSN 1660-3397 Altmetric
2011	Kinase inhibitory, haemolytic and cytotoxic activity of three deep-water sponges from North Western Australia and their fatty acid composition Published In Natural Product Communications: an international journal for communications and reviews Volume 6 Pages 1921 - 1924 ISSN 1555-9475
2011	Synthesis and hydrolytic evaluation of acid-labile imine-linked cytoxic isatin model systems Published In Bioorganic and Medicinal Chemistry Volume 19 Pages 1771 - 1778 ISSN 1464-3391 Altmetric
2010	Average mass scan of the total ion chromatogram versus percentage chemical composition in multivariate statistical comparison of complex volatile mixtures Published In Journal of the Brazilian Chemical Society Volume 21 Pages 2319 - 2326 ISSN 1678-4790 Altmetric
2010	Complete assignment of the 1H and 13C NMR spectra of antimicrobial 4-arylamino- 3-nitrocoumarin derivatives Published In Magnetic Resonance in Chemistry Volume 48 Pages 896 - 902 ISSN 1097-458X Altmetric
2010	Misidentification of tansy, tanacetum macrophyllum, as yarrow, achillea grandifolia: a health risk or benefit? Published In Natural Product Communications Volume 5 Pages 121 - 127
2010	Structures, biological activities and phylogenetic relationships of Terpenoids from marine ciliates of the Genus Euplotes Published In Marine Drugs Volume 8 Pages 2080 - 2116 ISSN 1660-3397 Altmetric
2009	Cytotoxic and anticancer activities of Isatin and its derivatives: a comprehensive review from 2000-2008 Published In Anti-Cancer Agents in Medicinal Chemistry Volume 9 Pages 397 - 414 ISSN 1568-0118
2009	PH-triggered release of potent isatin-derived cytotoxins conjugated to the tumour targeting protein PAI-2 Published In Annals of Oncology Volume 20 Pages iii34 - iii34 ISSN 0923-7534 Altmetric
2009	Solid-state and solution-phase conformations of pseudoproline-containing dipeptides Published In Australian Journal of Chemistry: an international journal for chemical science Volume 62 Pages 711 - 719 ISSN 0004-9425 Altmetric
2009	The effect of individual N-glycans on enzyme activity Published In Bioorganic and Medicinal Chemistry Volume 17 Pages 2645 - 2653 ISSN 1464-3391 Altmetric
2008	Chemotaxonomy of the peppergrass Lepidium coronopus (L.) Al-Shehbaz (syn. Coronopus squamatus) based on its volatile glucosinolate autolysis products Published In Biochemical Systematics and Ecology Volume 36 Pages 807 - 811 ISSN 0305-1978 Altmetric
2008	Deep-sea Natural Products Published In Natural Product Reports: a journal of current development in bioorganic chemistry Volume 25 Pages 1131 - 1166 ISSN 0265-0568 Altmetric
2008	N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents Published In Bioorganic and Medicinal Chemistry Volume 16 Pages 3118 - 3124 ISSN 1464-3391 Altmetric
2007	Domino pericyclic reactions of acyclic conjugated (E,Z,E,E)-tetraenes Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 48 Pages 3281 - 3284 ISSN 0040-4039 Altmetric
2007	N-glycolisation regulates endothelial lipase-mediated phospholipid hydrolysis in apoE- and apoA-I-containing high density lipoproteins Published In Journal of Lipid Research Volume 48 Pages 2047 - 2057 ISSN 0022-2275 Altmetric

Chapter

Year	Title
2013	Recent highlights in the development of isatin-based anticancer agents Published In Advances in Anticancer Agents in Medicinal Chemistry Publisher Bentham Science Publishers Pages 254 - 312 Altmetric
2010	Learning how to be an academic - the story of a new academic in the sciences Published In An Academic Life: A Handbook for New Academics Publisher ACER Press Pages 6 - 9

Conference Paper

Year	Title
2018	Understanding the Global Scientific Value of Industry ROV Data to Quantify Marine Ecology and Guide Offshore Decommissioning Strategies Published In Offshore Technology Conference Asia, 20-23 March, Kuala Lumpur, Malaysia Pages 1 - 10 Altmetric
2011	Selective Release of Potent N-Alkylisatin Based Cytotoxins via Hydrolysis of pH Sensitive Imine Linkers Published In 27th International Symposium on the Chemistry of Natural Products and the 7th International Conference on Biodiversity (ISCNP-27 & ICOB-7) Pages CT-19 - CT-19
2011	Synthesis of novel sugar diamino acids Published In GLYCO 21: 21st International Symposiumon on Glycoconjugates Pages 349 - 349
2010	Synthesis of novel sugar diamino acids Published In Pacifichem 2010, International Chemical Congress of Pacific Basin Societies Pages 291 - 291
2010	Selective release of potent N-alkylisatin based cytotoxins via hydrolysis of pH sensitive imine linkers Published In 2010 International Chemical Congress of Pacific Basin Societies Pages 938 - 938

Investigator On

Year	Title
2010	Cultivating Australian seaweeds for health and nutrition markets: Ulva and Cladosiphon sp. Awarded by: Rural Industries Research and Development Corporation Funding Scheme: Research Grant
2009	Synthesis, Radiolabelling and Biodistribution Studies of Selective Untegrin Antagonists as New PPET Cancer Imaging Agents Awarded by: Australian Institute of Nuclear Science and Engineering (AINSE) Funding Scheme: Research Award
2008	Understanding the tolerance of Antarctic mosses to climate change Awarded by: Australian Antarctic Division Funding Scheme: Grant
2007	Effect of deep-sea drilling on sustainability of deep-sea ecosystems Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects

Impact Story

Partnering in our region and beyond
Summary
Each of my research projects is the result of an interdisciplinary collaboration with either an academic, industry or community partner, ranging from local and regional partners to major international institutes and companies. 

Detail View

Detail View Summary View
Detail of Impact
In the Illawarra region I have a major partnership with <a href="https://www.venusshellsystems.com.au/" target="_blank" rel="noopener">Venus Shell Systems</a>, <a href="https://www.nowchem.com.au/" target="_blank" rel="noopener">NowChem</a> and <a href="http://www.bluebiotech.com.au/" target="_blank" rel="noopener">BlueBiotech</a>, with funding on two distinct research projects. Our work together spans the spectrum from marine biology to medicinal chemistry and from academia to industry, providing potential health benefits through the therapeutic formulations we are developing and employment opportunities for the region. <a href="https://youtu.be/Oje7Y1BEbHQ" target="_blank" rel="noopener">NowChem Video</a>. I also have strong relationship with the <a href="http://illawarracancercarers.org.au/" target="_blank" rel="noopener">Illawarra Cancer Carers</a> who have provided significant seed funding to our research on pancreatic cancer including the provision of student PhD scholarships. I am part of the Centre for Oncology Education and Research Translation (<a href="https://www.cancerinstitute.org.au/Data-research/Translating-research-into-practice/funded-centres/Centre-for-Oncology-Education-and-Research-Transla" target="_blank" rel="noopener">CONCERT</a>), a multidisciplinary cancer research hub for South West Sydney, Illawarra and Shoalhaven regions. CONCERT draws together around 200 professional members spanning all aspects of cancer research, diagnosis, treatment and care, and has provided unparalleled collaboration opportunities, access to cutting-edge biological assays, various cell lines and animal models of disease.I play a key role in an innovative interdisciplinary global deep-sea collaboration known as <a href="http://www.serpentproject.com/" target="_blank" rel="noopener">SERPENT</a> (Scientific Environmental ROV Partnership Using Existing Industrial Technology). The SERPENT project involves senior researchers from across Australia ranging from marine biologists (Prof. Dave Booth, UTS) to world-leading robotic engineers (Prof. Stefan Wiliams, ARC Future Fellow, USyd) from several Australian Universities collaborating with major Australian Oil and Gas companies including Chevron, Woodside, Santos, Apache, Inpex and ENI Pty Ltd. The deep-sea research program has featured broadly in the media including on the <a href="http://www.abc.net.au/7.30/new-project-uncovers-more-of-the-deep-sea/2785068" target="_blank" rel="noopener">ABC 7:30 Report</a>, as the subject of international documentary by award-winning film-maker Charles de Rouvre.
Field of Research
Countries / Regions
Beneficiaries

Beneficiary Quantification Description
External Partners
Evidence of Impact

Evidence Description
UOW Centres / Programs
UOW Researchers / Collaborators

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Development of Glycosyltransferase Inhibitors as a Novel Antimetastatic Strategy for Cancer Treatment	Dobie, Chris
Doctor of Philosophy	3D Printed Skin Grafts for Coverage of Partial or Full Thickness Burns	Daikuara, Luciana
Doctor of Philosophy	Synthesis and Evaluation of Amiloride Analogues as New Agents for Drug Resistant Tuberculosis	Bujaroski, Richard

Education And Training

Doctor of Philosophy in Organic Chemistry, Australian National University, Research School of Chemistry 1994 - 1999
B Science (Hon) in Organic Chemistry, Monash University 1990 - 1993

Awards And Honors

Athel Beckwith Lectureship, conferred by RACI Organic Chemistry Division, 2009

Keywords

Medicinal Chemistry
Organic Chemistry
Natural Products Chemistry
Carbohydrate Chemistry
Peptide Chemistry
Anticancer Agents

Full Name

Danielle Skropeta

Mailing Address

Northfields Ave

University of Wollongong

Wollongong

NSW

2522

Australia

Geographic Location

Wollongong Campus

Located In Facility

Building 18 (Chemistry)

Fax

+61-2-42214287

Orcid Id

http://orcid.org/0000-0002-2293-7916 (confirmed)

Web Of Science Researcher Id

G-3761-2015

Overview

Top Publications

Research Areas

Research Overview

Available as Research Supervisor

Affiliation

Available for Collaborative Projects

Member Of

Publications

Selected Publications

Journal Article

Chapter

Conference Paper

Funding

Investigator On

Impact

Impact Story

Partnering in our region and beyond

Supervision

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Background

Education And Training

Awards And Honors

Keywords

Contact

Full Name

Mailing Address

Geographic Location

Located In Facility

Fax

Identity

Orcid Id

Web Of Science Researcher Id

Overview

Top Publications

Research Areas

Research Overview

Affiliation

Member Of

Publications

Selected Publications

Journal Article

Chapter

Conference Paper

Funding

Investigator On

Impact

Impact Story

Partnering in our region and beyond

Supervision

Advisees

Graduate Advising Relationship

Background

Education And Training

Awards And Honors

Keywords

Contact

Full Name

Mailing Address

Geographic Location

Located In Facility

Fax

Identity

Orcid Id

Web Of Science Researcher Id

Visualisations

Research Areas