Deng, Chao

Research Areas

Available as Research Supervisor

Selected Publications

Journal Article

Year	Title
2020	Overeating and food addiction in Major Depressive Disorder: Links to peripheral dopamine Published In Appetite Volume 148 Pages 104586-1 - 104586-9 ISSN 0195-6663 Altmetric
2019	Early antipsychotic exposure affects NMDA and GABAA receptor binding in the brains of juvenile rats Published In Psychiatry Research Volume 273 Pages 739 - 745 ISSN 1872-7123 Altmetric
2019	Modulation by chronic antipsychotic administration of PKA- and GSK3β-mediated pathways and the NMDA receptor in rat ventral midbrain Published In Psychopharmacology Volume Online First Pages 1 - 11 ISSN 0033-3158 Altmetric
2019	Simvastatin improves olanzapine-induced dyslipidemia in rats through inhibiting hepatic mTOR signaling pathway Published In Acta Pharmacologica Sinica Volume Online First Pages 1 - 9 ISSN 1671-4083 Altmetric
2019	Weight gain in Major Depressive Disorder: Linking appetite and disordered eating to leptin and ghrelin. Published In Psychiatry Research Volume Online First Pages 1 - 8 ISSN 1872-7123 Altmetric
2018	BDNF as a pharmacogenetic target for antipsychotic treatment of schizophrenia Published In Neuroscience Letters Volume Online First Pages 1 - 5 ISSN 0304-3940 Altmetric
2018	Chronic antipsychotic treatment differentially modulates protein kinase A- and glycogen synthase kinase 3 beta-dependent signaling pathways, N-methyl-D-aspartate receptor and γ-aminobutyric acid A receptors in nucleus accumbens of juvenile rats Published In Journal of Psychopharmacology Volume 32 Pages 1252 - 1263 ISSN 0269-8811 Altmetric
2018	Early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors Published In Neuropsychiatric Disease and Treatment Volume 14 Pages 1569 - 1583 ISSN 1176-6328 Altmetric
2018	Effects of short- and long-term aripiprazole treatment on Group I mGluRs in the nucleus accumbens: Comparison with haloperidol Published In Psychiatry Research Volume 260 Pages 152 - 157 ISSN 1872-7123 Altmetric
2018	Problematic eating behaviours, changes in appetite, and weight gain in Major Depressive Disorder: The role of leptin Published In Journal of Affective Disorders Volume 240 Pages 137 - 145 ISSN 0165-0327 Altmetric
2018	The effects of antipsychotics on the density of cannabinoid receptors in selected brain regions of male and female adolescent juvenile rats Published In Psychiatry Research Volume 266 Pages 317 - 322 ISSN 1872-7123 Altmetric
2017	Molecular mechanisms of antipsychotic drug-induced diabetes Published In Frontiers in Neuroscience Volume 11 Pages 643-1 - 643-12 ISSN 1662-4548 Altmetric
2017	Time-dependent changes and potential mechanisms of glucose-lipid metabolic disorders associated with chronic clozapine or olanzapine treatment in rats Published In Scientific Reports Volume 7 Pages 2762-1 - 2762-13 ISSN 2045-2322 Altmetric
2017	Time-dependent effects of olanzapine treatment on the expression of histidine decarboxylase, H1 and H3 receptor in the rat brain: The roles in olanzapine-induced obesity Published In Psychoneuroendocrinology Volume 85 Pages 190 - 199 ISSN 0306-4530 Altmetric
2016	Ameliorating antipsychotic-induced weight gain by betahistine: mechanisms and clinical implications Published In Pharmacological Research Volume 106 Pages 51 - 63 ISSN 1043-6618 Altmetric
2016	Aripiprazole and haloperidol activate GSK3β-dependent signalling pathway differentially in various brain regions of rats Published In International Journal of Molecular Sciences Volume 17 Pages 459-1 - 459-11 ISSN 1422-0067 Altmetric
2016	Aripiprazole increases the PKA signalling and expression of the GABA_A receptor and CREB1 in the nucleus accumbens of rats Published In Journal of Molecular Neuroscience Volume 59 Pages 36 - 47 ISSN 0895-8696 Altmetric
2016	Berberine alleviates olanzapine-induced adipogenesis via the AMPKα-SREBP pathway in 3T3-L1 cells Published In International Journal of Molecular Sciences Volume 17 Pages 1865-1 - 1865-12 ISSN 1422-0067 Altmetric
2016	Chronic administration of aripiprazole activates GSK3β-dependent signalling pathways, and up-regulates GABA_A receptor expression and CREB1 activity in rats Published In Scientific Reports Volume 6 Pages 30040-1 - 30040-12 ISSN 2045-2322 Altmetric
2016	Early antipsychotic exposure affects serotonin and dopamine receptor binding density differently in selected brain loci of male and female juvenile rats Published In Pharmacological Reports Volume 68 Pages 1028 - 1035 ISSN 1734-1140 Altmetric
2016	Early antipsychotic treatment in childhood/adolescent period has long-term effects on depressive-like, anxiety-like and locomotor behaviours in adult rats Published In Journal of Psychopharmacology Volume 30 Pages 204 - 214 ISSN 0269-8811 Altmetric
2016	Early antipsychotic treatment in juvenile rats elicits long-term alterations to the dopamine neurotransmitter system Published In International Journal of Molecular Sciences Volume 17 Pages 1944-1 - 1944-20 ISSN 1422-0067 Altmetric
2016	Interaction of dopamine D₂ and 5-HT_1A receptor partial agonism on antipsychotic efficacy Published In Journal of Clinical Psychopharmacology Volume 36 Pages 192 - 193 ISSN 0271-0749 Altmetric
2016	Modelling complex relationships between physiological and psychosocial factors in depression Published In International Journal of Psychophysiology Volume 108 Page p. 357 ISSN 0167-8760 Altmetric
2016	Reversal effect of simvastatin on the decrease in cannabinoid receptor 1 density in 6-hydroxydopamine lesioned rat brains Published In Life Sciences Volume 155 Pages 123 - 132 ISSN 0024-3205 Altmetric
2016	The second-generation antipsychotic drugs induced dyslipidemia: a review of research and mechanisms Published In Zhongguo Yaoxue Zazhi Volume 51 Pages 172 - 176 Altmetric
2015	Acute effects of oral olanzapine treatment on the expression of fatty acid and cholesterol metabolism-related gene in rats Published In Life Sciences Volume 128 Pages 72 - 78 ISSN 0024-3205 Altmetric
2015	Betahistine co-treatment ameliorates dyslipidemia induced by chronic olanzapine treatment in rats through modulation of hepatic AMPKα-SREBP-1 and PPARα-dependent pathways Published In Pharmacological Research Volume 100 Pages 36 - 46 ISSN 1043-6618 Altmetric
2015	Chronic betahistine co-treatment reverses olanzapine's effects on dopamine D2 but not 5-HT2A/2C bindings in rat brains Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 56 Pages 75 - 80 ISSN 0364-7722 Altmetric
2015	Differential effects of short- and long-term antipsychotic treatment on the expression of neuregulin-1 and ErbB4 receptors in the rat brain Published In Psychiatry Research Volume 225 Pages 347 - 354 ISSN 1872-7123 Altmetric
2015	Implications of ghrelin and hexarelin in diabetes and diabetes-associated heart diseases Published In Endocrine Volume 49 Pages 307 - 323 ISSN 1355-008X Altmetric
2015	Risperidone-induced weight gain and reduced locomotor activity in juvenile female rats: the role of histaminergic and NPY pathways Published In Pharmacological Research Volume 95-96 Pages 20 - 26 ISSN 1043-6618 Altmetric
2015	Unique effects of acute aripiprazole treatment on the dopamine D2 receptor downstream cAMP-PKA and Akt-GSK3β signalling pathways in rats Published In PLoS One Volume 10 Pages e0132722-1 - e0132722-20 ISSN 1932-6203 Altmetric
2014	Alterations of NMDA receptor binding in various brain regions among 6-hydroxydopamine-induced Parkinsonian rats Published In International Journal of Neuroscience Volume 124 Pages 457 - 465 ISSN 0020-7454 Altmetric
2014	Betahistine ameliorates olanzapine-induced weight gain through modulation of histaminergic, NPY and AMPK pathways Published In Psychoneuroendocrinology Volume 48 Pages 77 - 86 ISSN 0306-4530 Altmetric
2014	Different effects of Bifeprunox, Aripiprazole, and Haloperidol on body weight gain, food and water intake, and locomotor activity in rats Published In Pharmacology, Biochemistry and Behavior Volume 124 Pages 167 - 173 ISSN 1873-5177 Altmetric
2014	Effects of olanzapine on the elevation of macrophage infiltration and pro-inflammatory cytokine expression in female rats Published In Journal of Psychopharmacology Volume 28 Pages 1161 - 1169 ISSN 0269-8811 Altmetric
2014	Hypothalamic ghrelin signalling mediates olanzapine-induced hyperphagia and weight gain in female rats Published In International Journal of Neuropsychopharmacology Volume 17 Pages 807 - 818 ISSN 1461-1457 Altmetric
2014	Hypothalamic histamine H1 receptor-AMPK signaling time-dependently mediates olanzapine-induced hyperphagia and weight gain in female rats Published In Psychoneuroendocrinology Volume 42 Pages 153 - 164 ISSN 0306-4530 Altmetric
2014	Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics Published In Journal of Psychiatry and Neuroscience Volume 39 Pages 407 - 416 ISSN 0702-8466 Altmetric
2014	Olanzapine reduced brown adipose tissue thermogenesis and locomotor activity in female rats Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 51 Pages 172 - 180 ISSN 0364-7722 Altmetric
2014	Olanzapine-activated AMPK signaling in the dorsal vagal complex is attenuated by histamine H1 receptor agonist in female rats Published In Endocrinology Volume 155 Pages 4895 - 4904 ISSN 0013-7227 Altmetric
2014	Preventing olanzapine-induced weight gain using betahistine: a study in a rat model with chronic olanzapine treatment Published In PLoS One Volume 9 Pages e104160-1 - e104160-11 ISSN 1932-6203 Altmetric
2014	Simvastatin reverses the downregulation of M1/4 receptor binding in 6-hydroxydopamine-induced parkinsonian rats: the association with improvements in long-term memory Published In Neuroscience Volume 267 Pages 57 - 66 ISSN 0306-4522 Altmetric
2013	Effects of antipsychotic medications on appetite, weight, and insulin resistance Published In Endocrinology and Metabolism Clinics of North America Volume 42 Pages 545 - 563 ISSN 0889-8529 Altmetric
2013	Effects of olanzapine and betahistine co-treatment on serotonin transporter, 5-HT2A and dopamine D2 receptor binding density Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 47 Pages 62 - 68 ISSN 0364-7722 Altmetric
2013	Mapping the pathophysiology of schizophrenia: interactions between multiple cellular pathways Published In Frontiers in Cellular Neuroscience Volume 7 Pages 238-1 - 238-2 ISSN 1662-5102 Altmetric
2013	Metabotropic glutamate receptor 5 binding and protein expression in schizophrenia and following antipsychotic drug treatment Published In Schizophrenia Research Volume 146 Pages 170 - 176 ISSN 0920-9964 Altmetric
2013	Neuregulin-1 signalling and antipsychotic treatment: potential therapeutic targets in a schizophrenia candidate signalling pathway Published In Psychopharmacology Volume 226 Pages 201 - 215 ISSN 0033-3158 Altmetric
2013	Second generation antipsychotic-induced type 2 diabetes: a role for the muscarinic M3 receptor Published In CNS Drugs Volume 27 Pages 1069 - 1080 ISSN 1172-7047 Altmetric
2013	The association of antidepressant medication and body weight gain Published In Online Journal of Health and Allied Sciences Volume 12 Pages 1 - 9
2013	The role of ghrelin signalling in second-generation antipsychotic-induced weight gain Published In Psychoneuroendocrinology Volume 38 Pages 2423 - 2438 ISSN 0306-4530 Altmetric
2013	The role of hypothalamic H1 receptor antagonism in antipsychotic-induced weight gain Published In CNS Drugs Volume 27 Pages 423 - 434 ISSN 1172-7047 Altmetric
2012	Alterations to melanocortinergic, GABAergic and cannabinoid neurotransmission associated with olanzapine-induced weight gain Published In PLoS One Volume 7 Pages e33548 - 1 - e33548 - 12 ISSN 1932-6203 Altmetric
2012	Are there different neural mechanisms responsible for three stages of weight gain development in anti-psychotic therapy: Temporally based hypothesis Published In Asian Journal of Psychiatry Volume 5 Pages 315 - 318 ISSN 1876-2018 Altmetric
2012	Developmental vitamin D deficiency alters MK-801-induced behaviours in adult offspring Published In Psychopharmacology Volume 220 Pages 455 - 463 ISSN 0033-3158 Altmetric
2012	Effects of olanzapine on muscarinic M3 receptor binding density in the brain relates to weight gain, plasma insulin and metabolic hormone levels Published In European Neuropsychopharmacology Volume 22 Pages 364 - 373 ISSN 0924-977X Altmetric
2012	Reducing olanzapine-induced weight gain side-effect by using betahistine: a study in the rat model Published In Journal of Psychopharmacology Volume 26 Pages 1271 - 1279 ISSN 0269-8811 Altmetric
2011	Antipsychotic treatment and neuregulin 1 -ErbB4 signalling in schizophrenia Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 35 Pages 924 - 930 ISSN 0364-7722 Altmetric
2011	Olanzapine treatment and metabolic dysfunction: a dose response study in female Sprague Dawley rats Published In Behavioural Brain Research Volume 217 Pages 337 - 346 ISSN 0166-4328 Altmetric
2011	Potential control of risperidone-related cognitive deficits by adjunctive aripiprazole treatment Published In Journal of Clinical Psychopharmacology Volume 31 Pages 135 - 136 ISSN 0271-0749 Altmetric
2011	Simvastatin prevents dopaminergic neurodegeneration in experimental parkinsonian models: the association with anti-inflammatory responses Published In PLoS One Volume 6 Pages e20945 - e20945 ISSN 1932-6203 Altmetric
2011	Statins: multiple neuroprotective mechanisms in neurodegenerative diseases Published In Experimental Neurology Volume 230 Pages 27 - 34 ISSN 0014-4886 Altmetric
2010	Alterations in 5-HT2A receptor binding in various brain regions among 6-hydroxydopamine-induced Parkinsonian rats Published In Synapse (New York) Volume 64 Pages 224 - 230 ISSN 0887-4476 Altmetric
2010	Effects of antipsychotic drugs on muscarinic M1 receptors in the rat brain Published In Australian and New Zealand Journal of Psychiatry Volume 44 Page p. A51 ISSN 1440-1614
2010	Effects of simvastatin and 6-hydroxydopamine on histaminergic H1 receptor binding density in rat brains Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 34 Pages 1419 - 1425 ISSN 0364-7722 Altmetric
2010	Effects of typical and atypical antipsychotics on the expressions of neuregulin 1 and ERBB4 receptors Published In Australian and New Zealand Journal of Psychiatry Volume 44 Pages A49 - A50 ISSN 1440-1614
2010	Molecular cloning and characterization of the global regulator LaeA in Penicillium citrinum Published In Biotechnology Letters Volume 32 Pages 1733 - 1737 ISSN 0141-5492 Altmetric
2010	Olanzapine decreases POMC MRNA expression and M3 receptors binding density in the hypothalamus and brainstem: pathway for weight gain side-effect? Published In Australian and New Zealand Journal of Psychiatry Volume 44 Page p. A55 ISSN 1440-1614
2010	Olanzapine decreases cannabinoid CB1 receptors in the hypothalamus and brainstem, possibly through muscarinic M3 receptor antagonism Published In International Journal of Neuropsychopharmacology Volume 13 Pages 111 - 112 ISSN 1461-1457 Altmetric
2010	Potential control of antipsychotic-induced hyperprolactinemia and obesity in children and adolescents by aripiprazole Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 34 Pages 1157 - 1158 ISSN 0364-7722 Altmetric
2010	Reduce the olanzapine-induced body weight gain with histamine H1 receptor agonist betahistine in rats Published In International Journal of Neuropsychopharmacology Volume 13 Page p. 99 ISSN 1461-1457 Altmetric
2010	Sensitivity of the female rat to olanzapine-induced weight gain - far from the clinic? Published In Schizophrenia Research Volume 116 Pages 299 - 300 ISSN 0920-9964 Altmetric
2010	The role of histaminergic H1 and H3 receptors in food intake:-A mechanism fo atypical antipsychotic-induced weight gain? Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 34 Pages 1 - 4 ISSN 0364-7722 Altmetric
2010	What is the mechanism for aripiprazole's effect on reducing olanzapine-associated obesity? Published In Journal of Clinical Psychopharmacology Volume 30 Pages 480 - 481 ISSN 0271-0749 Altmetric
2009	Aripiprazole differentially affects mesolimbic and nigrostriatal dopaminergic transmission: implications for long-term drug efficacy and low extrapyramidal side-effects Published In International Journal of Neuropsychopharmacology Volume 12 Pages 941 - 952 ISSN 1461-1457 Altmetric
2009	Decreased density of serotonin 2A receptors in the superior temporal gyrus in schizophrenia - a postmortem study Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 33 Pages 867 - 871 ISSN 0364-7722 Altmetric
2009	Excitatory and inhibitory neurotransmission is chronically altered following perinatal NMDA receptor blockade Published In European Neuropsychopharmacology Volume 19 Pages 256 - 265 ISSN 0924-977X Altmetric
2009	High dose of simvastatin induces hyperlocomotive and anxiolytic-like activities: the association with the up-regulation of NMDA receptor binding in the rat brain Published In Experimental Neurology Volume 216 Pages 132 - 138 ISSN 0014-4886 Altmetric
2009	Obese reversal by a chronic energy restricted diet leaves an increased Arc NPY/AgRP, but no alteration in POMC/CART, mRNA expression in diet-induced obese mice Published In Behavioural Brain Research Volume 205 Pages 50 - 56 ISSN 0166-4328 Altmetric
2009	Perinatal PCP treatment alters the developmental expression of prefrontal and hippocampal muscarinic receptors Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 33 Pages 37 - 40 ISSN 0364-7722 Altmetric

Editor Of

Book
- Mapping the Pathophysiology of Schizophrenia: Interactions Between Multiple Cellular Pathways. Switzerland. 2014

Investigator On

Year	Title
2020 - 2025	Exposures of mobile phone radiofrequency electromagnetic energy in juveniles: effects on brain development and behaviours Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Ideas Grant
2019	GoBlot machines and Leica Objective Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2019	Rat activity wheel and living chamber system Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016 - 2019	Understanding the mechanisms for ameliorating/preventing antipsychotic-induced obesity in early life Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2018	Forced exercise/walking wheel system for rats Model 80805A Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2017	Lumenera Infinity 2-5 microscope colour camera Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2014 - 2017	Application of intelligent conducting polymers for treating schizophrenia and allied disorders focusing on neuronal outgrowth, myelination and synaptogenesis Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2012 - 2016	Schizophrenia: reversal of antipsychotic drug-induced obesity and its related metabolic disorders Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2014	SR-LAB ABS System Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2013	Roles of muscarinic M3 receptors in antipsychotic-induced metabolic side-effects: prevention and treatment of anti-psychotic insulin dysregulation Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2012	SU 105 Stirling Underbench Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2011	Understanding the mechanisms of functionally selective drugs: implication for new generation antipsychotic drugs Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2010	Precellys 24 tissue homogenizer and digital microplate shaker Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2010	Schizophrenia: prevention and treatment of atypical antipsychotic drug-induced obesity Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2008	The Development vitam D model (DVD) as an animal model for schizophrenia Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
	Small animal stereotaxic instrument and microinjection unit Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Master of Philosophy	Effects of Antipsychotic Drug Treatment on the Brain Development of Young Rats	Leite, Joshua
Doctor of Philosophy	Biological and Psychological Correlates of major Depressive Disorder	Mills, Jessica
Master of Philosophy	Antipsychotic-induced Metabolic Side-Effects in Juvenile Poly (I:C) Rats	Hodgson, James
Doctor of Philosophy	An Ontology to represent dementia and dementia care knowledge in computer readable format	Zhang, Zhenyu
Doctor of Philosophy	A Systematic Study of Currently Used CDSS (Clinical Decision Support System) for Future Development of CDSS	Zheng-Long, Tsai

Research Areas

Selected Publications

Journal Article

Year	Title
2020	Overeating and food addiction in Major Depressive Disorder: Links to peripheral dopamine Published In Appetite Volume 148 Pages 104586-1 - 104586-9 ISSN 0195-6663 Altmetric
2019	Early antipsychotic exposure affects NMDA and GABAA receptor binding in the brains of juvenile rats Published In Psychiatry Research Volume 273 Pages 739 - 745 ISSN 1872-7123 Altmetric
2019	Modulation by chronic antipsychotic administration of PKA- and GSK3β-mediated pathways and the NMDA receptor in rat ventral midbrain Published In Psychopharmacology Volume Online First Pages 1 - 11 ISSN 0033-3158 Altmetric
2019	Simvastatin improves olanzapine-induced dyslipidemia in rats through inhibiting hepatic mTOR signaling pathway Published In Acta Pharmacologica Sinica Volume Online First Pages 1 - 9 ISSN 1671-4083 Altmetric
2019	Weight gain in Major Depressive Disorder: Linking appetite and disordered eating to leptin and ghrelin. Published In Psychiatry Research Volume Online First Pages 1 - 8 ISSN 1872-7123 Altmetric
2018	BDNF as a pharmacogenetic target for antipsychotic treatment of schizophrenia Published In Neuroscience Letters Volume Online First Pages 1 - 5 ISSN 0304-3940 Altmetric
2018	Chronic antipsychotic treatment differentially modulates protein kinase A- and glycogen synthase kinase 3 beta-dependent signaling pathways, N-methyl-D-aspartate receptor and γ-aminobutyric acid A receptors in nucleus accumbens of juvenile rats Published In Journal of Psychopharmacology Volume 32 Pages 1252 - 1263 ISSN 0269-8811 Altmetric
2018	Early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors Published In Neuropsychiatric Disease and Treatment Volume 14 Pages 1569 - 1583 ISSN 1176-6328 Altmetric
2018	Effects of short- and long-term aripiprazole treatment on Group I mGluRs in the nucleus accumbens: Comparison with haloperidol Published In Psychiatry Research Volume 260 Pages 152 - 157 ISSN 1872-7123 Altmetric
2018	Problematic eating behaviours, changes in appetite, and weight gain in Major Depressive Disorder: The role of leptin Published In Journal of Affective Disorders Volume 240 Pages 137 - 145 ISSN 0165-0327 Altmetric
2018	The effects of antipsychotics on the density of cannabinoid receptors in selected brain regions of male and female adolescent juvenile rats Published In Psychiatry Research Volume 266 Pages 317 - 322 ISSN 1872-7123 Altmetric
2017	Molecular mechanisms of antipsychotic drug-induced diabetes Published In Frontiers in Neuroscience Volume 11 Pages 643-1 - 643-12 ISSN 1662-4548 Altmetric
2017	Time-dependent changes and potential mechanisms of glucose-lipid metabolic disorders associated with chronic clozapine or olanzapine treatment in rats Published In Scientific Reports Volume 7 Pages 2762-1 - 2762-13 ISSN 2045-2322 Altmetric
2017	Time-dependent effects of olanzapine treatment on the expression of histidine decarboxylase, H1 and H3 receptor in the rat brain: The roles in olanzapine-induced obesity Published In Psychoneuroendocrinology Volume 85 Pages 190 - 199 ISSN 0306-4530 Altmetric
2016	Ameliorating antipsychotic-induced weight gain by betahistine: mechanisms and clinical implications Published In Pharmacological Research Volume 106 Pages 51 - 63 ISSN 1043-6618 Altmetric
2016	Aripiprazole and haloperidol activate GSK3β-dependent signalling pathway differentially in various brain regions of rats Published In International Journal of Molecular Sciences Volume 17 Pages 459-1 - 459-11 ISSN 1422-0067 Altmetric
2016	Aripiprazole increases the PKA signalling and expression of the GABA_A receptor and CREB1 in the nucleus accumbens of rats Published In Journal of Molecular Neuroscience Volume 59 Pages 36 - 47 ISSN 0895-8696 Altmetric
2016	Berberine alleviates olanzapine-induced adipogenesis via the AMPKα-SREBP pathway in 3T3-L1 cells Published In International Journal of Molecular Sciences Volume 17 Pages 1865-1 - 1865-12 ISSN 1422-0067 Altmetric
2016	Chronic administration of aripiprazole activates GSK3β-dependent signalling pathways, and up-regulates GABA_A receptor expression and CREB1 activity in rats Published In Scientific Reports Volume 6 Pages 30040-1 - 30040-12 ISSN 2045-2322 Altmetric
2016	Early antipsychotic exposure affects serotonin and dopamine receptor binding density differently in selected brain loci of male and female juvenile rats Published In Pharmacological Reports Volume 68 Pages 1028 - 1035 ISSN 1734-1140 Altmetric
2016	Early antipsychotic treatment in childhood/adolescent period has long-term effects on depressive-like, anxiety-like and locomotor behaviours in adult rats Published In Journal of Psychopharmacology Volume 30 Pages 204 - 214 ISSN 0269-8811 Altmetric
2016	Early antipsychotic treatment in juvenile rats elicits long-term alterations to the dopamine neurotransmitter system Published In International Journal of Molecular Sciences Volume 17 Pages 1944-1 - 1944-20 ISSN 1422-0067 Altmetric
2016	Interaction of dopamine D₂ and 5-HT_1A receptor partial agonism on antipsychotic efficacy Published In Journal of Clinical Psychopharmacology Volume 36 Pages 192 - 193 ISSN 0271-0749 Altmetric
2016	Modelling complex relationships between physiological and psychosocial factors in depression Published In International Journal of Psychophysiology Volume 108 Page p. 357 ISSN 0167-8760 Altmetric
2016	Reversal effect of simvastatin on the decrease in cannabinoid receptor 1 density in 6-hydroxydopamine lesioned rat brains Published In Life Sciences Volume 155 Pages 123 - 132 ISSN 0024-3205 Altmetric
2016	The second-generation antipsychotic drugs induced dyslipidemia: a review of research and mechanisms Published In Zhongguo Yaoxue Zazhi Volume 51 Pages 172 - 176 Altmetric
2015	Acute effects of oral olanzapine treatment on the expression of fatty acid and cholesterol metabolism-related gene in rats Published In Life Sciences Volume 128 Pages 72 - 78 ISSN 0024-3205 Altmetric
2015	Betahistine co-treatment ameliorates dyslipidemia induced by chronic olanzapine treatment in rats through modulation of hepatic AMPKα-SREBP-1 and PPARα-dependent pathways Published In Pharmacological Research Volume 100 Pages 36 - 46 ISSN 1043-6618 Altmetric
2015	Chronic betahistine co-treatment reverses olanzapine's effects on dopamine D2 but not 5-HT2A/2C bindings in rat brains Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 56 Pages 75 - 80 ISSN 0364-7722 Altmetric
2015	Differential effects of short- and long-term antipsychotic treatment on the expression of neuregulin-1 and ErbB4 receptors in the rat brain Published In Psychiatry Research Volume 225 Pages 347 - 354 ISSN 1872-7123 Altmetric
2015	Implications of ghrelin and hexarelin in diabetes and diabetes-associated heart diseases Published In Endocrine Volume 49 Pages 307 - 323 ISSN 1355-008X Altmetric
2015	Risperidone-induced weight gain and reduced locomotor activity in juvenile female rats: the role of histaminergic and NPY pathways Published In Pharmacological Research Volume 95-96 Pages 20 - 26 ISSN 1043-6618 Altmetric
2015	Unique effects of acute aripiprazole treatment on the dopamine D2 receptor downstream cAMP-PKA and Akt-GSK3β signalling pathways in rats Published In PLoS One Volume 10 Pages e0132722-1 - e0132722-20 ISSN 1932-6203 Altmetric
2014	Alterations of NMDA receptor binding in various brain regions among 6-hydroxydopamine-induced Parkinsonian rats Published In International Journal of Neuroscience Volume 124 Pages 457 - 465 ISSN 0020-7454 Altmetric
2014	Betahistine ameliorates olanzapine-induced weight gain through modulation of histaminergic, NPY and AMPK pathways Published In Psychoneuroendocrinology Volume 48 Pages 77 - 86 ISSN 0306-4530 Altmetric
2014	Different effects of Bifeprunox, Aripiprazole, and Haloperidol on body weight gain, food and water intake, and locomotor activity in rats Published In Pharmacology, Biochemistry and Behavior Volume 124 Pages 167 - 173 ISSN 1873-5177 Altmetric
2014	Effects of olanzapine on the elevation of macrophage infiltration and pro-inflammatory cytokine expression in female rats Published In Journal of Psychopharmacology Volume 28 Pages 1161 - 1169 ISSN 0269-8811 Altmetric
2014	Hypothalamic ghrelin signalling mediates olanzapine-induced hyperphagia and weight gain in female rats Published In International Journal of Neuropsychopharmacology Volume 17 Pages 807 - 818 ISSN 1461-1457 Altmetric
2014	Hypothalamic histamine H1 receptor-AMPK signaling time-dependently mediates olanzapine-induced hyperphagia and weight gain in female rats Published In Psychoneuroendocrinology Volume 42 Pages 153 - 164 ISSN 0306-4530 Altmetric
2014	Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics Published In Journal of Psychiatry and Neuroscience Volume 39 Pages 407 - 416 ISSN 0702-8466 Altmetric
2014	Olanzapine reduced brown adipose tissue thermogenesis and locomotor activity in female rats Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 51 Pages 172 - 180 ISSN 0364-7722 Altmetric
2014	Olanzapine-activated AMPK signaling in the dorsal vagal complex is attenuated by histamine H1 receptor agonist in female rats Published In Endocrinology Volume 155 Pages 4895 - 4904 ISSN 0013-7227 Altmetric
2014	Preventing olanzapine-induced weight gain using betahistine: a study in a rat model with chronic olanzapine treatment Published In PLoS One Volume 9 Pages e104160-1 - e104160-11 ISSN 1932-6203 Altmetric
2014	Simvastatin reverses the downregulation of M1/4 receptor binding in 6-hydroxydopamine-induced parkinsonian rats: the association with improvements in long-term memory Published In Neuroscience Volume 267 Pages 57 - 66 ISSN 0306-4522 Altmetric
2013	Effects of antipsychotic medications on appetite, weight, and insulin resistance Published In Endocrinology and Metabolism Clinics of North America Volume 42 Pages 545 - 563 ISSN 0889-8529 Altmetric
2013	Effects of olanzapine and betahistine co-treatment on serotonin transporter, 5-HT2A and dopamine D2 receptor binding density Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 47 Pages 62 - 68 ISSN 0364-7722 Altmetric
2013	Mapping the pathophysiology of schizophrenia: interactions between multiple cellular pathways Published In Frontiers in Cellular Neuroscience Volume 7 Pages 238-1 - 238-2 ISSN 1662-5102 Altmetric
2013	Metabotropic glutamate receptor 5 binding and protein expression in schizophrenia and following antipsychotic drug treatment Published In Schizophrenia Research Volume 146 Pages 170 - 176 ISSN 0920-9964 Altmetric
2013	Neuregulin-1 signalling and antipsychotic treatment: potential therapeutic targets in a schizophrenia candidate signalling pathway Published In Psychopharmacology Volume 226 Pages 201 - 215 ISSN 0033-3158 Altmetric
2013	Second generation antipsychotic-induced type 2 diabetes: a role for the muscarinic M3 receptor Published In CNS Drugs Volume 27 Pages 1069 - 1080 ISSN 1172-7047 Altmetric
2013	The association of antidepressant medication and body weight gain Published In Online Journal of Health and Allied Sciences Volume 12 Pages 1 - 9
2013	The role of ghrelin signalling in second-generation antipsychotic-induced weight gain Published In Psychoneuroendocrinology Volume 38 Pages 2423 - 2438 ISSN 0306-4530 Altmetric
2013	The role of hypothalamic H1 receptor antagonism in antipsychotic-induced weight gain Published In CNS Drugs Volume 27 Pages 423 - 434 ISSN 1172-7047 Altmetric
2012	Alterations to melanocortinergic, GABAergic and cannabinoid neurotransmission associated with olanzapine-induced weight gain Published In PLoS One Volume 7 Pages e33548 - 1 - e33548 - 12 ISSN 1932-6203 Altmetric
2012	Are there different neural mechanisms responsible for three stages of weight gain development in anti-psychotic therapy: Temporally based hypothesis Published In Asian Journal of Psychiatry Volume 5 Pages 315 - 318 ISSN 1876-2018 Altmetric
2012	Developmental vitamin D deficiency alters MK-801-induced behaviours in adult offspring Published In Psychopharmacology Volume 220 Pages 455 - 463 ISSN 0033-3158 Altmetric
2012	Effects of olanzapine on muscarinic M3 receptor binding density in the brain relates to weight gain, plasma insulin and metabolic hormone levels Published In European Neuropsychopharmacology Volume 22 Pages 364 - 373 ISSN 0924-977X Altmetric
2012	Reducing olanzapine-induced weight gain side-effect by using betahistine: a study in the rat model Published In Journal of Psychopharmacology Volume 26 Pages 1271 - 1279 ISSN 0269-8811 Altmetric
2011	Antipsychotic treatment and neuregulin 1 -ErbB4 signalling in schizophrenia Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 35 Pages 924 - 930 ISSN 0364-7722 Altmetric
2011	Olanzapine treatment and metabolic dysfunction: a dose response study in female Sprague Dawley rats Published In Behavioural Brain Research Volume 217 Pages 337 - 346 ISSN 0166-4328 Altmetric
2011	Potential control of risperidone-related cognitive deficits by adjunctive aripiprazole treatment Published In Journal of Clinical Psychopharmacology Volume 31 Pages 135 - 136 ISSN 0271-0749 Altmetric
2011	Simvastatin prevents dopaminergic neurodegeneration in experimental parkinsonian models: the association with anti-inflammatory responses Published In PLoS One Volume 6 Pages e20945 - e20945 ISSN 1932-6203 Altmetric
2011	Statins: multiple neuroprotective mechanisms in neurodegenerative diseases Published In Experimental Neurology Volume 230 Pages 27 - 34 ISSN 0014-4886 Altmetric
2010	Alterations in 5-HT2A receptor binding in various brain regions among 6-hydroxydopamine-induced Parkinsonian rats Published In Synapse (New York) Volume 64 Pages 224 - 230 ISSN 0887-4476 Altmetric
2010	Effects of antipsychotic drugs on muscarinic M1 receptors in the rat brain Published In Australian and New Zealand Journal of Psychiatry Volume 44 Page p. A51 ISSN 1440-1614
2010	Effects of simvastatin and 6-hydroxydopamine on histaminergic H1 receptor binding density in rat brains Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 34 Pages 1419 - 1425 ISSN 0364-7722 Altmetric
2010	Effects of typical and atypical antipsychotics on the expressions of neuregulin 1 and ERBB4 receptors Published In Australian and New Zealand Journal of Psychiatry Volume 44 Pages A49 - A50 ISSN 1440-1614
2010	Molecular cloning and characterization of the global regulator LaeA in Penicillium citrinum Published In Biotechnology Letters Volume 32 Pages 1733 - 1737 ISSN 0141-5492 Altmetric
2010	Olanzapine decreases POMC MRNA expression and M3 receptors binding density in the hypothalamus and brainstem: pathway for weight gain side-effect? Published In Australian and New Zealand Journal of Psychiatry Volume 44 Page p. A55 ISSN 1440-1614
2010	Olanzapine decreases cannabinoid CB1 receptors in the hypothalamus and brainstem, possibly through muscarinic M3 receptor antagonism Published In International Journal of Neuropsychopharmacology Volume 13 Pages 111 - 112 ISSN 1461-1457 Altmetric
2010	Potential control of antipsychotic-induced hyperprolactinemia and obesity in children and adolescents by aripiprazole Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 34 Pages 1157 - 1158 ISSN 0364-7722 Altmetric
2010	Reduce the olanzapine-induced body weight gain with histamine H1 receptor agonist betahistine in rats Published In International Journal of Neuropsychopharmacology Volume 13 Page p. 99 ISSN 1461-1457 Altmetric
2010	Sensitivity of the female rat to olanzapine-induced weight gain - far from the clinic? Published In Schizophrenia Research Volume 116 Pages 299 - 300 ISSN 0920-9964 Altmetric
2010	The role of histaminergic H1 and H3 receptors in food intake:-A mechanism fo atypical antipsychotic-induced weight gain? Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 34 Pages 1 - 4 ISSN 0364-7722 Altmetric
2010	What is the mechanism for aripiprazole's effect on reducing olanzapine-associated obesity? Published In Journal of Clinical Psychopharmacology Volume 30 Pages 480 - 481 ISSN 0271-0749 Altmetric
2009	Aripiprazole differentially affects mesolimbic and nigrostriatal dopaminergic transmission: implications for long-term drug efficacy and low extrapyramidal side-effects Published In International Journal of Neuropsychopharmacology Volume 12 Pages 941 - 952 ISSN 1461-1457 Altmetric
2009	Decreased density of serotonin 2A receptors in the superior temporal gyrus in schizophrenia - a postmortem study Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 33 Pages 867 - 871 ISSN 0364-7722 Altmetric
2009	Excitatory and inhibitory neurotransmission is chronically altered following perinatal NMDA receptor blockade Published In European Neuropsychopharmacology Volume 19 Pages 256 - 265 ISSN 0924-977X Altmetric
2009	High dose of simvastatin induces hyperlocomotive and anxiolytic-like activities: the association with the up-regulation of NMDA receptor binding in the rat brain Published In Experimental Neurology Volume 216 Pages 132 - 138 ISSN 0014-4886 Altmetric
2009	Obese reversal by a chronic energy restricted diet leaves an increased Arc NPY/AgRP, but no alteration in POMC/CART, mRNA expression in diet-induced obese mice Published In Behavioural Brain Research Volume 205 Pages 50 - 56 ISSN 0166-4328 Altmetric
2009	Perinatal PCP treatment alters the developmental expression of prefrontal and hippocampal muscarinic receptors Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 33 Pages 37 - 40 ISSN 0364-7722 Altmetric

Editor Of

Book
- Mapping the Pathophysiology of Schizophrenia: Interactions Between Multiple Cellular Pathways. Switzerland. 2014

Investigator On

Year	Title
2020 - 2025	Exposures of mobile phone radiofrequency electromagnetic energy in juveniles: effects on brain development and behaviours Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Ideas Grant
2019	GoBlot machines and Leica Objective Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2019	Rat activity wheel and living chamber system Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016 - 2019	Understanding the mechanisms for ameliorating/preventing antipsychotic-induced obesity in early life Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2018	Forced exercise/walking wheel system for rats Model 80805A Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2017	Lumenera Infinity 2-5 microscope colour camera Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2014 - 2017	Application of intelligent conducting polymers for treating schizophrenia and allied disorders focusing on neuronal outgrowth, myelination and synaptogenesis Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2012 - 2016	Schizophrenia: reversal of antipsychotic drug-induced obesity and its related metabolic disorders Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2014	SR-LAB ABS System Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2013	Roles of muscarinic M3 receptors in antipsychotic-induced metabolic side-effects: prevention and treatment of anti-psychotic insulin dysregulation Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2012	SU 105 Stirling Underbench Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2011	Understanding the mechanisms of functionally selective drugs: implication for new generation antipsychotic drugs Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2010	Precellys 24 tissue homogenizer and digital microplate shaker Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2010	Schizophrenia: prevention and treatment of atypical antipsychotic drug-induced obesity Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2008	The Development vitam D model (DVD) as an animal model for schizophrenia Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
	Small animal stereotaxic instrument and microinjection unit Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Master of Philosophy	Effects of Antipsychotic Drug Treatment on the Brain Development of Young Rats	Leite, Joshua
Doctor of Philosophy	Biological and Psychological Correlates of major Depressive Disorder	Mills, Jessica
Master of Philosophy	Antipsychotic-induced Metabolic Side-Effects in Juvenile Poly (I:C) Rats	Hodgson, James
Doctor of Philosophy	An Ontology to represent dementia and dementia care knowledge in computer readable format	Zhang, Zhenyu
Doctor of Philosophy	A Systematic Study of Currently Used CDSS (Clinical Decision Support System) for Future Development of CDSS	Zheng-Long, Tsai

Orcid Id

http://orcid.org/0000-0003-1147-5741 (confirmed)

Web Of Science Researcher Id

F-4417-2016

Scopus Id

26424514600

Deng, Chao Prof

Professor, Head of Antipsychotic Research Laboratory

Overview

Research Areas

Available as Research Supervisor

Publications

Selected Publications

Journal Article

Editor Of

Book

Funding

Investigator On

Supervision

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Identity

Orcid Id

Web Of Science Researcher Id

Scopus Id

Overview

Research Areas

Publications

Selected Publications

Journal Article

Editor Of

Book

Funding

Investigator On

Supervision

Advisees

Graduate Advising Relationship

Identity

Orcid Id

Web Of Science Researcher Id

Scopus Id

Visualisations

Research Areas