Deng, Chao Prof

Selected Publications

• Journal Article

  Year	Title
  2023	Causal effect of gut microbiota-derived metabolite trimethylamine N-oxide on Parkinson's disease: A Mendelian randomisation study. Published In Eur J Neurol
  2023	Olanzapine-induced decreases of FGF21 in brown adipose tissue via histone modulations drive UCP1-dependent thermogenetic impairment Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2022	A review of the application of machine learning in adult obesity studies Published In Applied Computing and Intelligence
  2022	Agitation Prevalence in People With Dementia in Australian Residential Aged Care Facilities: Findings From Machine Learning of Electronic Health Records Published In Journal of gerontological nursing
  2022	Cevimeline co-treatment attenuates olanzapine-induced metabolic disorders via modulating hepatic M3 muscarinic receptor: AMPK�� signalling pathway in female rats Published In Journal of Psychopharmacology
  2022	Developing an Intuitive Graph Representation of Knowledge for Nonpharmacological Treatment of Psychotic Symptoms in Dementia Published In Journal of gerontological nursing
  2022	Effects of Risperidone and Prenatal Poly I:C Exposure on GABAA Receptors and AKT-GSK3�� Pathway in the Ventral Tegmental Area of Female Juvenile Rats Published In Biomolecules
  2022	Emergency department presentations of patients with alcohol use disorders in an Australian regional health district Published In Substance Abuse
  2022	Epigenetic histone acetylation modulating prenatal Poly I:C induced neuroinflammation in the prefrontal cortex of rats: a study in a maternal immune activation model Published In Frontiers in Cellular Neuroscience
  2022	Gold nanoclusters eliminate obesity induced by antipsychotics Published In Scientific Reports
  2022	Predicting Readmission Following Hospital Treatment for Patients with Alcohol Related Diagnoses in an Australian Regional Health District Published In Studies in Health Technology and Informatics
  2022	Prenatal Poly I:C Challenge Affects Behaviors and Neurotransmission via Elevated Neuroinflammation Responses in Female Juvenile Rats Published In International Journal of Neuropsychopharmacology
  2022	The long-lasting effects of early antipsychotic exposure during juvenile period on adult behaviours - A study in a poly I:C rat model. Published In Pharmacology, biochemistry, and behavior
  2021	Cortisol in relation to problematic eating behaviours, adiposity and symptom profiles in Major Depressive Disorder Published In Comprehensive Psychoneuroendocrinology
  2021	Kidney plays an important role in ketogenesis induced by risperidone and voluntary exercise in juvenile female rats Published In Psychiatry Research
  2021	Olanzapine Induces Inflammation and Immune Response via Activating ER Stress in the Rat Prefrontal Cortex Published In Current Medical Science
  2021	Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain Published In Frontiers in Neuroscience
  2020	Brown adipose tissue activity is modulated in olanzapine-treated young rats by simvastatin Published In BMC Pharmacology and Toxicology
  2020	Developing an ontology for representing the domain knowledge specific to non-pharmacological treatment for agitation in dementia Published In Alzheimer's and Dementia
  2020	Editorial: Metabolic Disturbances in Mental Illness: Neuropathogenetic Mechanisms and Therapeutic Implications Published In Frontiers in Neuroscience
  2020	Epigenetic histone modulations of PPAR�� and related pathways contribute to olanzapine-induced metabolic disorders Published In Pharmacological Research
  2020	Exercise intervention for preventing risperidone-induced dyslipidemia and gluco-metabolic disorders in female juvenile rats Published In Pharmacology Biochemistry and Behavior
  2020	Overeating and food addiction in Major Depressive Disorder: Links to peripheral dopamine Published In Appetite
  2020	The correlation between metabolic syndrome and neurocognitive and social cognitive performance of patients with schizophrenia Published In Psychiatry Research
  2020	The dosage-dependent effects of cevimeline in preventing olanzapine-induced metabolic side-effects in female rats Published In Pharmacology Biochemistry and Behavior
  2020	Understanding interactions between caregivers and care recipients in person-centered dementia care: A rapid review Published In Clinical Interventions in Aging
  2019	Early antipsychotic exposure affects NMDA and GABAA receptor binding in the brains of juvenile rats Published In Psychiatry Research
  2019	Modulation by chronic antipsychotic administration of PKA- and GSK3β-mediated pathways and the NMDA receptor in rat ventral midbrain Published In Psychopharmacology
  2019	Simvastatin improves olanzapine-induced dyslipidemia in rats through inhibiting hepatic mTOR signaling pathway Published In Acta Pharmacologica Sinica
  2019	Weight gain in Major Depressive Disorder: Linking appetite and disordered eating to leptin and ghrelin. Published In Psychiatry Research
  2018	Atypical Antipsychotics Regulate NMDA Receptor expression via GSK3beta/beta-catenin and GSK3beta/CREB1 Pathways in the Striatum of Young Rats Published In Proceedings for Annual Meeting of The Japanese Pharmacological Society
  2018	BDNF as a pharmacogenetic target for antipsychotic treatment of schizophrenia Published In Neuroscience Letters
  2018	Chronic antipsychotic treatment differentially modulates protein kinase A- and glycogen synthase kinase 3 beta-dependent signaling pathways, N-methyl-D-aspartate receptor and γ-aminobutyric acid A receptors in nucleus accumbens of juvenile rats Published In Journal of Psychopharmacology
  2018	Early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors Published In Neuropsychiatric Disease and Treatment
  2018	Effects of short- and long-term aripiprazole treatment on Group I mGluRs in the nucleus accumbens: Comparison with haloperidol Published In Psychiatry Research
  2018	Problematic eating behaviours, changes in appetite, and weight gain in Major Depressive Disorder: The role of leptin Published In Journal of Affective Disorders
  2018	The effects of antipsychotics on the density of cannabinoid receptors in selected brain regions of male and female adolescent juvenile rats Published In Psychiatry Research
  2017	Molecular mechanisms of antipsychotic drug-induced diabetes Published In Frontiers in Neuroscience
  2017	Time-dependent changes and potential mechanisms of glucose-lipid metabolic disorders associated with chronic clozapine or olanzapine treatment in rats Published In Scientific Reports
  2017	Time-dependent effects of olanzapine treatment on the expression of histidine decarboxylase, H1 and H3 receptor in the rat brain: The roles in olanzapine-induced obesity Published In Psychoneuroendocrinology
  2016	Ameliorating antipsychotic-induced weight gain by betahistine: mechanisms and clinical implications Published In Pharmacological Research
  2016	Aripiprazole and haloperidol activate GSK3β-dependent signalling pathway differentially in various brain regions of rats Published In International Journal of Molecular Sciences
  2016	Aripiprazole increases the PKA signalling and expression of the GABAA receptor and CREB1 in the nucleus accumbens of rats Published In Journal of Molecular Neuroscience
  2016	Berberine alleviates olanzapine-induced adipogenesis via the AMPKα-SREBP pathway in 3T3-L1 cells Published In International Journal of Molecular Sciences
  2016	Chronic administration of aripiprazole activates GSK3β-dependent signalling pathways, and up-regulates GABAA receptor expression and CREB1 activity in rats Published In Scientific Reports
  2016	Early antipsychotic exposure affects serotonin and dopamine receptor binding density differently in selected brain loci of male and female juvenile rats Published In Pharmacological Reports
  2016	Early antipsychotic treatment in childhood/adolescent period has long-term effects on depressive-like, anxiety-like and locomotor behaviours in adult rats Published In Journal of Psychopharmacology
  2016	Early antipsychotic treatment in juvenile rats elicits long-term alterations to the dopamine neurotransmitter system Published In International Journal of Molecular Sciences
  2016	Interaction of dopamine D2 and 5-HT1A receptor partial agonism on antipsychotic efficacy Published In Journal of Clinical Psychopharmacology
  2016	Modelling complex relationships between physiological and psychosocial factors in depression Published In International Journal of Psychophysiology
  2016	PM336. Early Antipsychotic Treatment in Childhood/Adolescent Period has Long-term Effects on Dopamine Receptors of Adult Rat Brains Published In The International Journal of Neuropsychopharmacology
  2016	PM364. Early risperidone exposure affects serotonin, dopamine and cannabinoid receptors binding density differently in male and female juvenile rats Published In The International Journal of Neuropsychopharmacology
  2016	PM439. Chronic effects of aripiprazole on the GSK3��-dependent pathways, NMDA receptor and CREB1 in the rat brain Published In The International Journal of Neuropsychopharmacology
  2016	Reversal effect of simvastatin on the decrease in cannabinoid receptor 1 density in 6-hydroxydopamine lesioned rat brains Published In Life Sciences
  2016	The second-generation antipsychotic drugs induced dyslipidemia: a review of research and mechanisms Published In Zhongguo Yaoxue Zazhi
  2015	Acute effects of oral olanzapine treatment on the expression of fatty acid and cholesterol metabolism-related gene in rats Published In Life Sciences
  2015	Betahistine co-treatment ameliorates dyslipidemia induced by chronic olanzapine treatment in rats through modulation of hepatic AMPKα-SREBP-1 and PPARα-dependent pathways Published In Pharmacological Research
  2015	Chronic betahistine co-treatment reverses olanzapine's effects on dopamine D2 but not 5-HT2A/2C bindings in rat brains Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2015	Differential effects of short- and long-term antipsychotic treatment on the expression of neuregulin-1 and ErbB4 receptors in the rat brain Published In Psychiatry Research
  2015	Implications of ghrelin and hexarelin in diabetes and diabetes-associated heart diseases Published In Endocrine
  2015	Risperidone-induced weight gain and reduced locomotor activity in juvenile female rats: the role of histaminergic and NPY pathways Published In Pharmacological Research
  2015	Unique effects of acute aripiprazole treatment on the dopamine D2 receptor downstream cAMP-PKA and Akt-GSK3β signalling pathways in rats Published In PLoS One
  2014	Alterations of NMDA receptor binding in various brain regions among 6-hydroxydopamine-induced Parkinsonian rats Published In International Journal of Neuroscience
  2014	Betahistine ameliorates olanzapine-induced weight gain through modulation of histaminergic, NPY and AMPK pathways Published In Psychoneuroendocrinology
  2014	Different effects of Bifeprunox, Aripiprazole, and Haloperidol on body weight gain, food and water intake, and locomotor activity in rats Published In Pharmacology, Biochemistry and Behavior
  2014	Effects of olanzapine on the elevation of macrophage infiltration and pro-inflammatory cytokine expression in female rats Published In Journal of Psychopharmacology
  2014	Hypothalamic ghrelin signalling mediates olanzapine-induced hyperphagia and weight gain in female rats Published In International Journal of Neuropsychopharmacology
  2014	Hypothalamic histamine H1 receptor-AMPK signaling time-dependently mediates olanzapine-induced hyperphagia and weight gain in female rats Published In Psychoneuroendocrinology
  2014	Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics Published In Journal of Psychiatry and Neuroscience
  2014	Olanzapine reduced brown adipose tissue thermogenesis and locomotor activity in female rats Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2014	Olanzapine-activated AMPK signaling in the dorsal vagal complex is attenuated by histamine H1 receptor agonist in female rats Published In Endocrinology
  2014	Preventing olanzapine-induced weight gain using betahistine: a study in a rat model with chronic olanzapine treatment Published In PLoS One
  2014	Simvastatin reverses the downregulation of M1/4 receptor binding in 6-hydroxydopamine-induced parkinsonian rats: the association with improvements in long-term memory Published In Neuroscience
  2013	Effects of antipsychotic medications on appetite, weight, and insulin resistance Published In Endocrinology and Metabolism Clinics of North America
  2013	Effects of olanzapine and betahistine co-treatment on serotonin transporter, 5-HT2A and dopamine D2 receptor binding density Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2013	Mapping the pathophysiology of schizophrenia: interactions between multiple cellular pathways Published In Frontiers in Cellular Neuroscience
  2013	Metabotropic glutamate receptor 5 binding and protein expression in schizophrenia and following antipsychotic drug treatment Published In Schizophrenia Research
  2013	Neuregulin-1 signalling and antipsychotic treatment: potential therapeutic targets in a schizophrenia candidate signalling pathway Published In Psychopharmacology
  2013	Second generation antipsychotic-induced type 2 diabetes: a role for the muscarinic M3 receptor Published In CNS Drugs
  2013	The association of antidepressant medication and body weight gain Published In Online Journal of Health and Allied Sciences
  2013	The role of ghrelin signalling in second-generation antipsychotic-induced weight gain Published In Psychoneuroendocrinology
  2013	The role of hypothalamic H1 receptor antagonism in antipsychotic-induced weight gain Published In CNS Drugs
  2012	Alterations to melanocortinergic, GABAergic and cannabinoid neurotransmission associated with olanzapine-induced weight gain Published In PLoS One
  2012	Are there different neural mechanisms responsible for three stages of weight gain development in anti-psychotic therapy: Temporally based hypothesis Published In Asian Journal of Psychiatry
  2012	Developmental vitamin D deficiency alters MK-801-induced behaviours in adult offspring Published In Psychopharmacology
  2012	Effects of olanzapine on muscarinic M3 receptor binding density in the brain relates to weight gain, plasma insulin and metabolic hormone levels Published In European Neuropsychopharmacology
  2012	Reducing olanzapine-induced weight gain side-effect by using betahistine: a study in the rat model Published In Journal of Psychopharmacology
  2011	Antipsychotic treatment and neuregulin 1 -ErbB4 signalling in schizophrenia Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2011	Olanzapine treatment and metabolic dysfunction: a dose response study in female Sprague Dawley rats Published In Behavioural Brain Research
  2011	Potential control of risperidone-related cognitive deficits by adjunctive aripiprazole treatment Published In Journal of Clinical Psychopharmacology
  2011	Simvastatin prevents dopaminergic neurodegeneration in experimental parkinsonian models: the association with anti-inflammatory responses Published In PLoS One
  2011	Statins: multiple neuroprotective mechanisms in neurodegenerative diseases Published In Experimental Neurology
  2010	Alterations in 5-HT2A receptor binding in various brain regions among 6-hydroxydopamine-induced Parkinsonian rats Published In Synapse (New York)
  2010	Effects of antipsychotic drugs on muscarinic M1 receptors in the rat brain Published In Australian and New Zealand Journal of Psychiatry
  2010	Effects of simvastatin and 6-hydroxydopamine on histaminergic H1 receptor binding density in rat brains Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2010	Effects of typical and atypical antipsychotics on the expressions of neuregulin 1 and ERBB4 receptors Published In Australian and New Zealand Journal of Psychiatry
  2010	Molecular cloning and characterization of the global regulator LaeA in Penicillium citrinum Published In Biotechnology Letters
  2010	Olanzapine decreases POMC MRNA expression and M3 receptors binding density in the hypothalamus and brainstem: pathway for weight gain side-effect? Published In Australian and New Zealand Journal of Psychiatry
  2010	Olanzapine decreases cannabinoid CB1 receptors in the hypothalamus and brainstem, possibly through muscarinic M3 receptor antagonism Published In International Journal of Neuropsychopharmacology
  2010	Potential control of antipsychotic-induced hyperprolactinemia and obesity in children and adolescents by aripiprazole Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2010	Reduce the olanzapine-induced body weight gain with histamine H1 receptor agonist betahistine in rats Published In International Journal of Neuropsychopharmacology
  2010	Sensitivity of the female rat to olanzapine-induced weight gain - far from the clinic? Published In Schizophrenia Research
  2010	The role of histaminergic H1 and H3 receptors in food intake:-A mechanism fo atypical antipsychotic-induced weight gain? Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2010	What is the mechanism for aripiprazole's effect on reducing olanzapine-associated obesity? Published In Journal of Clinical Psychopharmacology
  2009	Aripiprazole differentially affects mesolimbic and nigrostriatal dopaminergic transmission: implications for long-term drug efficacy and low extrapyramidal side-effects Published In International Journal of Neuropsychopharmacology
  2009	Decreased density of serotonin 2A receptors in the superior temporal gyrus in schizophrenia - a postmortem study Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2009	Excitatory and inhibitory neurotransmission is chronically altered following perinatal NMDA receptor blockade Published In European Neuropsychopharmacology
  2009	High dose of simvastatin induces hyperlocomotive and anxiolytic-like activities: the association with the up-regulation of NMDA receptor binding in the rat brain Published In Experimental Neurology
  2009	Obese reversal by a chronic energy restricted diet leaves an increased Arc NPY/AgRP, but no alteration in POMC/CART, mRNA expression in diet-induced obese mice Published In Behavioural Brain Research
  2009	Perinatal PCP treatment alters the developmental expression of prefrontal and hippocampal muscarinic receptors Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2009	Serotonin 2A receptor and its association with the pathology of schizophrenia Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2009	The effects of antipsychotic drugs administration on 5-HT1A receptor expression in the limbic system of the rat brain Published In Neuroscience
  2008	Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade Published In Neurochemical Research
  2008	Effects of antipsychotic medication on muscarinic M1 receptor mRNA expression in the rat brain Published In Journal of Neuroscience Research
  2008	Perinatal NMDA receptor blockade alters D2, NMDA and M1/M4 receptors in later life: implications for pathological processes of schizophrenia Published In Schizophrenia Research
  2008	Perinatal administration of PCP alters adult behaviour in female Sprague-Dawley rats Published In Behavioural Brain Research
  2008	Short- and long-term effects of antipsychotic drug treatment on weight gain and H1 receptor expression Published In Psychoneuroendocrinology
  2008	The effects of antipsychotics on the density of cannabinoid receptors in the dorsal vagal complex of rats: Implications for olanzapine-induced weight gain Published In International Journal of Neuropsychopharmacology
  2008	Ventromedial hypothalamic NPY Y2 receptor in the maintenance of body weight in diet-induced obesity in mice Published In Neurochemical Research
  2007	A rodent model of NMDA receptor hypofunction for the study of schizophrenia Published In Neuroscience Bulletin
  2007	A static handgrip method for distal quantitative sweat measurements Published In Neuroscience Letters
  2007	AM 251 and beta-Funaltrexamine reduce fat intake in a fat-preferring strain of mouse Published In Behavioural Brain Research
  2007	Decreased plasma peptide YY accompanied by elevated peptide YY and Y2 receptor binding densities in the medulla oblongata of diet-induced obese mice Published In Endocrinology
  2007	Dose-dependent effects of atypical antipsychotic drug olanzapine on weight gain and cholecystokinin levels in rats Published In Neuroscience Bulletin
  2007	Histamine H1 mRNA expression is decreased in the rat hypothalamus following olanzapine treatment Published In Schizophrenia Bulletin
  2007	NMDA receptor hypofunction during early brain development: relevance to schizophrenia Published In Schizophrenia Bulletin
  2007	No changes in cannabinoid CB1 receptor binding density in the superior temporal gyrus in schizophrenia Published In Schizophrenia Bulletin
  2007	No changes in densities of cannabinoid receptors in the superior temporal gyrus in schizophrenia Published In Neuroscience Bulletin
  2007	Olanzapine treatment decreases the density of muscarinic M2 receptors in the dorsal vagal complex of rats Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2000	Organization of intratelencephalic projections to the visual Wulst of the chick Published In Brain Research
  1999	Differential sensitivities of the two visual pathways of the chick to labelling by fluorescent retrograde tracers Published In Journal of Neuroscience Methods
  1998	Bilaterally projecting neurons in the two visual pathways of chicks Published In Brain Research
  1998	Organisation of the tectorotundal and SP/IPS-rotundal projections in the chick Published In Journal of Comparative Neurology
  1997	Differential contributions of the two visual pathways to functional lateralization in chicks Published In Behavioural Brain Research
  1993	Convergence of somatic and visual afferent impulses in the Wulst of pigeon Published In Experimental Brain Research
  1992	Overlap of somatic and visual response areas in the Wulst of pigeon Published In Brain Research
  1989	Projection of afferent impulses from the brachial plexus and sciatic nerve to the corpus striatum in pigeons Published In Acta Physiologica Sinica

• Chapter

  Year	Title
  2021	Health 3.0 Published In Encyclopedia of Gerontology and Population Aging Publisher : Springer
  2019	Health 3.0 Published In Encyclopedia of Gerontology and Population Aging Publisher Cham, Switzerland

• Conference Paper

  Year	Title
  2017	Relationships of hormone levels with hunger, weight gain and problematic eating behaviours in Major Depressive Disorder Published In Frontiers in Human Neuroscience Abstract: ASP2017 27th Annual Meeting for the Australasian Society for Psychophysiology
  2015	Risperidone-induced weight gain in juvenile female rats through modulating hypothalamic histaminergic/NPY pathways and activity Published In JOURNAL OF NEUROCHEMISTRY
  2013	An analysis of metabotropic glutamate receptors 2/3 and 5 in schizophrenia, major depression and bipolar disorder from the stanley neuropathology consortium Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
  2013	Binding affinity of aripiprazole to the dopamine D2 receptor in different regions of the rat brain Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
  2013	Central administration of histamine H1 receptor agonist, fMPH, blocks olanzapineinduced activation of ampk-cpt1 signaling in the dorsal vagal complex in rats Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
  2013	Effects of chronic antipsychotic treatment on dopamine synthesis Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
  2013	Long term effects of olanzapine and betahistine on serotonin 5-HT2A receptor binding in the rat brain Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
  2013	Time-dependent ghrelinergic signaling and hyperphagia induced by olanzapine Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
  2012	Differential effects of aripiprazole and haloperidol on dopamine markers in the arcuate nucleus and prolactin levels in male rats Published In The International Journal of Neuropsychopharmacology: Abstracts from the 28th CINP World Congress of Neuropsychopharmacology
  2012	Effects of dopamine D2 receptor partial agonist bifeprunox on body weight gain, food and water intake in male rats Published In Australian Neuroscience Society 32nd Annual meeting
  2012	Effects of olanzapine and betahistine on serotonin 5-HT2A receptor binding in the rat brain Published In ANS 2012: Australian Neuroscience Society 32nd Annual meeting
  2012	MGluR5 and NMDA receptor density are reduced in the dorsolateral prefrontal cortex of schizoaffective but not schizophrenia patients Published In Society of Biological Psychiatry 67th Annual Meeting
  2012	Metabotropic glutamate receptor subtype 5 is reduced in schizophrenia subjects with comorbid major depression and unchanged following antipsychotic drug treatment Published In Australian Neuroscience Society 32nd Annual meeting
  2012	Neuregulin1 and ErbB4 Protein Expression in Schizophrenia and their Relationship with NMDA Receptor Binding Published In BIOLOGICAL PSYCHIATRY
  2012	Olanzapine treatment and time-dependent changes of hypothalamic AMPK-ACC-CPT1 signalling, food intake and body weight in rats Published In ANS 2012: Australian Neuroscience Society 32nd Annual meeting
  2012	Preventing and treating olanzapine-induced obesity with betahistine: a chronic animal model study Published In The International Journal of Neuropsychopharmacology: Abstracts from the 28th CINP World Congress of Neuropsychopharmacology
  2012	Time-dependant alterations of hypothalamic energy regulatory network by olanzapine in rats Published In Australian Neuroscience Society 32nd Annual meeting
  2011	Aripiprazole selectively affects AKT/GSK protein expression in the nucleus accumbens and caudate putamen Published In 31st Annual Meeting of the Australian Neuroscience Society
  2011	Histamine H1 receptor agonist and control of olanzapine-induced obesity Published In 31st Annual Meeting of the Australian Neuroscience Society
  2011	Neuroendocrinological regulation of insulin dysfunction induced by olanzapine Published In 31st Annual Meeting of the Australian Neuroscience Society
  2010	An age difference in mu opioid receptor binding density in the human putamen but no changes in schizophrenia Published In Australian Neuroscience Society Annual Meeting, Sydney 2010
  2010	Effects of simvastatin and 6-hydroxydopamine lesion on histaminergic H1 receptor binding in rat brains Published In ANS/AuPS 2010 - the 30th Annual Meeting of the Australian Neuroscience Society, in conjunction with the 50th Anniversary Meeting of the Australian Physiological Society
  2010	Olanzapine decreases [3H]SR141716A binding to cannabinoid CB1 receptors in the rat hippocampus and auditory cortex: a dosage-dependent response Published In Australian Neuroscience Society Annual Meeting, Sydney 2010
  2010	Olanzapine-induced metabolic dysfunction: a role for central muscarinic M3 receptors Published In Australian Neuroscience Society Annual Meeting, Sydney 2010
  2010	The dosage response to the side-effect of metabolic dysfunction in female rats following olanzapine treatment Published In Australian Neuroscience Society Annual Meeting, Sydney 2010
  2009	Developmental vitamin D (DVD) deficiency alters MK-801 induced locomotion and glutamatergic rceptor binding Published In Australian Neuroscience Society Inc 29th Annual Meeting
  2009	Related pathological changes of serotonin 2A, muscarinic M1 and GABA A receptors in the superior temporal gyrus in schizophrenia Published In Australian Neuroscience Society Annual Meeting
  2008	Cholecystokinin mRNA expression in the arcuate hypothalamic nuclei in diet-induced obese and obese resistant mice Published In 6th Forum of European Neuroscience Abstract Volume 4
  2008	Neonatal interruption of NMDA receptors causes abnormal brain development and behavioural changes in adult rats Published In 35th Annual Australasian Society for the Study of Animal Behaviour Conference, Symposium on Brain and Behaviour
  2007	A negative association between the CB1 receptor mRNA expression and high fat intake during the course of diet-induced obesity in mice Published In 17th Neuropharmacology Conference: Cannabinoid Signalling in the Nervous System
  2007	Antipsychotic drugs increase food intake and cannabinoid CB1 receptor mRNA expression in the brain of rats Published In 17th Neuropharmacology Conference: Cannabinoid Signalling in the Nervous System
  2007	Effects of antipsychotic drugs on weight gain and CB1 receptors in the dorsal vagal complex of rats Published In 7th IBRO World Congress of Neuroscience
  2007	Effects of antipsychotics on muscarinic M1 receptor mRNA expression in the rat brain Published In 7th IBRO World Congress of Neuroscience
  2007	Effects of perinatal NMDA receptor antagonist treatment on dopaminergic system development and behaviour Published In 7th IBRO World Congress of Neuroscience
  2007	Long-term consequences of early brain development disruption on neurochemical balance and behaviour Published In 7th IBRO World Congress of Neuroscience
  2007	Phencyclidine induces apoptosis in the brain of neonatal but not adolescent and adult rats Published In 7th IBRO World Congress of Neuroscience
  2007	The role of Pyy and H1 histamine receptor expression in chronic diet-induced obese and diet-resistant mice Published In 7th IBRO World Congress of Neuroscience
  2006	Brain development disruption from PCP causes behavioural deficits in the forced swim test in later life Published In AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
  1999	Light experience and lateralization of the two visual pathways in the chick Published In Behavioural Brain Research

Editor Of

• Book

  • Mapping the Pathophysiology of Schizophrenia: Interactions Between Multiple Cellular Pathways.  Switzerland. 2014

Investigator On

Year	Title
2021	Barnes Mazes for rats and mice Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016 - 2019	Understanding the mechanisms for ameliorating/preventing antipsychotic-induced obesity in early life Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2018	Forced exercise/walking wheel system for rats Model 80805A Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2014 - 2017	Application of intelligent conducting polymers for treating schizophrenia and allied disorders focusing on neuronal outgrowth, myelination and synaptogenesis Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2012 - 2016	Schizophrenia: reversal of antipsychotic drug-induced obesity and its related metabolic disorders Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2013	Roles of muscarinic M3 receptors in antipsychotic-induced metabolic side-effects: prevention and treatment of anti-psychotic insulin dysregulation Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2012	SU 105 Stirling Underbench Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2011	Understanding the mechanisms of functionally selective drugs: implication for new generation antipsychotic drugs Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2010	Precellys 24 tissue homogenizer and digital microplate shaker Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2010	Schizophrenia: prevention and treatment of atypical antipsychotic drug-induced obesity Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2008	The Development vitam D model (DVD) as an animal model for schizophrenia Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
	Exposures of mobile phone radiofrequency electromagnetic energy in juveniles: effects on brain development and behaviours Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Ideas Grant
	GoBlot machines and Leica Objective Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
	Lumenera Infinity 2-5 microscope colour camera Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
	Rat activity wheel and living chamber system Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
	SR-LAB ABS System Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
	Small animal stereotaxic instrument and microinjection unit Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant

Impact Story

Advisees

• Graduate Advising Relationship

  Degree	Research Title	Advisee
  Master of Philosophy	Antipsychotic-induced Metabolic Side-Effects in Juvenile Poly (I:C) Rats	Hodgson, James
  Doctor of Philosophy	An Ontology to represent dementia and dementia care knowledge in computer readable format	Zhang, Zhenyu
  Doctor of Philosophy (Integrated)	Applying Natural Language Processing on Unstructured Data to Understand and Predict Malnutrition in Residential Aged Care Facilities	Alkhalaf, Mohammad
  Doctor of Philosophy	Understanding journey of patients with alcohol use disorder in Illawarra & Shoalhaven Local Health District	Zhang, Jingxiang
  Doctor of Philosophy	Effects of Radiofrequency Energy on Cognitive Function in a Mouse Model of Alzheimer's Disease	Sylvester, Emma
  Doctor of Philosophy	Investigating the Effects of Epigallocatechin Gallate in Improving Cognitive Function in a Poly I:C Rat Model for Schizophrenia: Mechanisms Tthrough Upregulating Ketogenesis in Brains	Yi, Weijie
  Doctor of Philosophy	Machine Learning for to Predict Dementia Agitation for People Living in Residential Aged- Care Facilities	Vithanage, Dinithi
  Doctor of Philosophy	Impact of mobile radiofrequency electromagnetic waves on behaviour and neurotransmission during the childhood-adolescent period.	Bala, Nathan
  Doctor of Philosophy	Pharmacological mechanisms of antipsychotic-induced metabolic sideeffects, and potential interventions	Busharat, Mariam

Orcid Id

• http://orcid.org/0000-0003-1147-5741 (confirmed)

Web Of Science Researcher Id

• F-4417-2016

Scopus Id

• 26424514600

Research Areas

• 1109 - NEUROSCIENCES
• 1115 - PHARMACOLOGY AND PHARMACEUTICAL SCIENCES

Selected Publications

• Journal Article

  Year	Title
  2023	Causal effect of gut microbiota-derived metabolite trimethylamine N-oxide on Parkinson's disease: A Mendelian randomisation study. Published In Eur J Neurol
  2023	Olanzapine-induced decreases of FGF21 in brown adipose tissue via histone modulations drive UCP1-dependent thermogenetic impairment Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2022	A review of the application of machine learning in adult obesity studies Published In Applied Computing and Intelligence
  2022	Agitation Prevalence in People With Dementia in Australian Residential Aged Care Facilities: Findings From Machine Learning of Electronic Health Records Published In Journal of gerontological nursing
  2022	Cevimeline co-treatment attenuates olanzapine-induced metabolic disorders via modulating hepatic M3 muscarinic receptor: AMPK�� signalling pathway in female rats Published In Journal of Psychopharmacology
  2022	Developing an Intuitive Graph Representation of Knowledge for Nonpharmacological Treatment of Psychotic Symptoms in Dementia Published In Journal of gerontological nursing
  2022	Effects of Risperidone and Prenatal Poly I:C Exposure on GABAA Receptors and AKT-GSK3�� Pathway in the Ventral Tegmental Area of Female Juvenile Rats Published In Biomolecules
  2022	Emergency department presentations of patients with alcohol use disorders in an Australian regional health district Published In Substance Abuse
  2022	Epigenetic histone acetylation modulating prenatal Poly I:C induced neuroinflammation in the prefrontal cortex of rats: a study in a maternal immune activation model Published In Frontiers in Cellular Neuroscience
  2022	Gold nanoclusters eliminate obesity induced by antipsychotics Published In Scientific Reports
  2022	Predicting Readmission Following Hospital Treatment for Patients with Alcohol Related Diagnoses in an Australian Regional Health District Published In Studies in Health Technology and Informatics
  2022	Prenatal Poly I:C Challenge Affects Behaviors and Neurotransmission via Elevated Neuroinflammation Responses in Female Juvenile Rats Published In International Journal of Neuropsychopharmacology
  2022	The long-lasting effects of early antipsychotic exposure during juvenile period on adult behaviours - A study in a poly I:C rat model. Published In Pharmacology, biochemistry, and behavior
  2021	Cortisol in relation to problematic eating behaviours, adiposity and symptom profiles in Major Depressive Disorder Published In Comprehensive Psychoneuroendocrinology
  2021	Kidney plays an important role in ketogenesis induced by risperidone and voluntary exercise in juvenile female rats Published In Psychiatry Research
  2021	Olanzapine Induces Inflammation and Immune Response via Activating ER Stress in the Rat Prefrontal Cortex Published In Current Medical Science
  2021	Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain Published In Frontiers in Neuroscience
  2020	Brown adipose tissue activity is modulated in olanzapine-treated young rats by simvastatin Published In BMC Pharmacology and Toxicology
  2020	Developing an ontology for representing the domain knowledge specific to non-pharmacological treatment for agitation in dementia Published In Alzheimer's and Dementia
  2020	Editorial: Metabolic Disturbances in Mental Illness: Neuropathogenetic Mechanisms and Therapeutic Implications Published In Frontiers in Neuroscience
  2020	Epigenetic histone modulations of PPAR�� and related pathways contribute to olanzapine-induced metabolic disorders Published In Pharmacological Research
  2020	Exercise intervention for preventing risperidone-induced dyslipidemia and gluco-metabolic disorders in female juvenile rats Published In Pharmacology Biochemistry and Behavior
  2020	Overeating and food addiction in Major Depressive Disorder: Links to peripheral dopamine Published In Appetite
  2020	The correlation between metabolic syndrome and neurocognitive and social cognitive performance of patients with schizophrenia Published In Psychiatry Research
  2020	The dosage-dependent effects of cevimeline in preventing olanzapine-induced metabolic side-effects in female rats Published In Pharmacology Biochemistry and Behavior
  2020	Understanding interactions between caregivers and care recipients in person-centered dementia care: A rapid review Published In Clinical Interventions in Aging
  2019	Early antipsychotic exposure affects NMDA and GABAA receptor binding in the brains of juvenile rats Published In Psychiatry Research
  2019	Modulation by chronic antipsychotic administration of PKA- and GSK3β-mediated pathways and the NMDA receptor in rat ventral midbrain Published In Psychopharmacology
  2019	Simvastatin improves olanzapine-induced dyslipidemia in rats through inhibiting hepatic mTOR signaling pathway Published In Acta Pharmacologica Sinica
  2019	Weight gain in Major Depressive Disorder: Linking appetite and disordered eating to leptin and ghrelin. Published In Psychiatry Research
  2018	Atypical Antipsychotics Regulate NMDA Receptor expression via GSK3beta/beta-catenin and GSK3beta/CREB1 Pathways in the Striatum of Young Rats Published In Proceedings for Annual Meeting of The Japanese Pharmacological Society
  2018	BDNF as a pharmacogenetic target for antipsychotic treatment of schizophrenia Published In Neuroscience Letters
  2018	Chronic antipsychotic treatment differentially modulates protein kinase A- and glycogen synthase kinase 3 beta-dependent signaling pathways, N-methyl-D-aspartate receptor and γ-aminobutyric acid A receptors in nucleus accumbens of juvenile rats Published In Journal of Psychopharmacology
  2018	Early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors Published In Neuropsychiatric Disease and Treatment
  2018	Effects of short- and long-term aripiprazole treatment on Group I mGluRs in the nucleus accumbens: Comparison with haloperidol Published In Psychiatry Research
  2018	Problematic eating behaviours, changes in appetite, and weight gain in Major Depressive Disorder: The role of leptin Published In Journal of Affective Disorders
  2018	The effects of antipsychotics on the density of cannabinoid receptors in selected brain regions of male and female adolescent juvenile rats Published In Psychiatry Research
  2017	Molecular mechanisms of antipsychotic drug-induced diabetes Published In Frontiers in Neuroscience
  2017	Time-dependent changes and potential mechanisms of glucose-lipid metabolic disorders associated with chronic clozapine or olanzapine treatment in rats Published In Scientific Reports
  2017	Time-dependent effects of olanzapine treatment on the expression of histidine decarboxylase, H1 and H3 receptor in the rat brain: The roles in olanzapine-induced obesity Published In Psychoneuroendocrinology
  2016	Ameliorating antipsychotic-induced weight gain by betahistine: mechanisms and clinical implications Published In Pharmacological Research
  2016	Aripiprazole and haloperidol activate GSK3β-dependent signalling pathway differentially in various brain regions of rats Published In International Journal of Molecular Sciences
  2016	Aripiprazole increases the PKA signalling and expression of the GABAA receptor and CREB1 in the nucleus accumbens of rats Published In Journal of Molecular Neuroscience
  2016	Berberine alleviates olanzapine-induced adipogenesis via the AMPKα-SREBP pathway in 3T3-L1 cells Published In International Journal of Molecular Sciences
  2016	Chronic administration of aripiprazole activates GSK3β-dependent signalling pathways, and up-regulates GABAA receptor expression and CREB1 activity in rats Published In Scientific Reports
  2016	Early antipsychotic exposure affects serotonin and dopamine receptor binding density differently in selected brain loci of male and female juvenile rats Published In Pharmacological Reports
  2016	Early antipsychotic treatment in childhood/adolescent period has long-term effects on depressive-like, anxiety-like and locomotor behaviours in adult rats Published In Journal of Psychopharmacology
  2016	Early antipsychotic treatment in juvenile rats elicits long-term alterations to the dopamine neurotransmitter system Published In International Journal of Molecular Sciences
  2016	Interaction of dopamine D2 and 5-HT1A receptor partial agonism on antipsychotic efficacy Published In Journal of Clinical Psychopharmacology
  2016	Modelling complex relationships between physiological and psychosocial factors in depression Published In International Journal of Psychophysiology
  2016	PM336. Early Antipsychotic Treatment in Childhood/Adolescent Period has Long-term Effects on Dopamine Receptors of Adult Rat Brains Published In The International Journal of Neuropsychopharmacology
  2016	PM364. Early risperidone exposure affects serotonin, dopamine and cannabinoid receptors binding density differently in male and female juvenile rats Published In The International Journal of Neuropsychopharmacology
  2016	PM439. Chronic effects of aripiprazole on the GSK3��-dependent pathways, NMDA receptor and CREB1 in the rat brain Published In The International Journal of Neuropsychopharmacology
  2016	Reversal effect of simvastatin on the decrease in cannabinoid receptor 1 density in 6-hydroxydopamine lesioned rat brains Published In Life Sciences
  2016	The second-generation antipsychotic drugs induced dyslipidemia: a review of research and mechanisms Published In Zhongguo Yaoxue Zazhi
  2015	Acute effects of oral olanzapine treatment on the expression of fatty acid and cholesterol metabolism-related gene in rats Published In Life Sciences
  2015	Betahistine co-treatment ameliorates dyslipidemia induced by chronic olanzapine treatment in rats through modulation of hepatic AMPKα-SREBP-1 and PPARα-dependent pathways Published In Pharmacological Research
  2015	Chronic betahistine co-treatment reverses olanzapine's effects on dopamine D2 but not 5-HT2A/2C bindings in rat brains Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2015	Differential effects of short- and long-term antipsychotic treatment on the expression of neuregulin-1 and ErbB4 receptors in the rat brain Published In Psychiatry Research
  2015	Implications of ghrelin and hexarelin in diabetes and diabetes-associated heart diseases Published In Endocrine
  2015	Risperidone-induced weight gain and reduced locomotor activity in juvenile female rats: the role of histaminergic and NPY pathways Published In Pharmacological Research
  2015	Unique effects of acute aripiprazole treatment on the dopamine D2 receptor downstream cAMP-PKA and Akt-GSK3β signalling pathways in rats Published In PLoS One
  2014	Alterations of NMDA receptor binding in various brain regions among 6-hydroxydopamine-induced Parkinsonian rats Published In International Journal of Neuroscience
  2014	Betahistine ameliorates olanzapine-induced weight gain through modulation of histaminergic, NPY and AMPK pathways Published In Psychoneuroendocrinology
  2014	Different effects of Bifeprunox, Aripiprazole, and Haloperidol on body weight gain, food and water intake, and locomotor activity in rats Published In Pharmacology, Biochemistry and Behavior
  2014	Effects of olanzapine on the elevation of macrophage infiltration and pro-inflammatory cytokine expression in female rats Published In Journal of Psychopharmacology
  2014	Hypothalamic ghrelin signalling mediates olanzapine-induced hyperphagia and weight gain in female rats Published In International Journal of Neuropsychopharmacology
  2014	Hypothalamic histamine H1 receptor-AMPK signaling time-dependently mediates olanzapine-induced hyperphagia and weight gain in female rats Published In Psychoneuroendocrinology
  2014	Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics Published In Journal of Psychiatry and Neuroscience
  2014	Olanzapine reduced brown adipose tissue thermogenesis and locomotor activity in female rats Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2014	Olanzapine-activated AMPK signaling in the dorsal vagal complex is attenuated by histamine H1 receptor agonist in female rats Published In Endocrinology
  2014	Preventing olanzapine-induced weight gain using betahistine: a study in a rat model with chronic olanzapine treatment Published In PLoS One
  2014	Simvastatin reverses the downregulation of M1/4 receptor binding in 6-hydroxydopamine-induced parkinsonian rats: the association with improvements in long-term memory Published In Neuroscience
  2013	Effects of antipsychotic medications on appetite, weight, and insulin resistance Published In Endocrinology and Metabolism Clinics of North America
  2013	Effects of olanzapine and betahistine co-treatment on serotonin transporter, 5-HT2A and dopamine D2 receptor binding density Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2013	Mapping the pathophysiology of schizophrenia: interactions between multiple cellular pathways Published In Frontiers in Cellular Neuroscience
  2013	Metabotropic glutamate receptor 5 binding and protein expression in schizophrenia and following antipsychotic drug treatment Published In Schizophrenia Research
  2013	Neuregulin-1 signalling and antipsychotic treatment: potential therapeutic targets in a schizophrenia candidate signalling pathway Published In Psychopharmacology
  2013	Second generation antipsychotic-induced type 2 diabetes: a role for the muscarinic M3 receptor Published In CNS Drugs
  2013	The association of antidepressant medication and body weight gain Published In Online Journal of Health and Allied Sciences
  2013	The role of ghrelin signalling in second-generation antipsychotic-induced weight gain Published In Psychoneuroendocrinology
  2013	The role of hypothalamic H1 receptor antagonism in antipsychotic-induced weight gain Published In CNS Drugs
  2012	Alterations to melanocortinergic, GABAergic and cannabinoid neurotransmission associated with olanzapine-induced weight gain Published In PLoS One
  2012	Are there different neural mechanisms responsible for three stages of weight gain development in anti-psychotic therapy: Temporally based hypothesis Published In Asian Journal of Psychiatry
  2012	Developmental vitamin D deficiency alters MK-801-induced behaviours in adult offspring Published In Psychopharmacology
  2012	Effects of olanzapine on muscarinic M3 receptor binding density in the brain relates to weight gain, plasma insulin and metabolic hormone levels Published In European Neuropsychopharmacology
  2012	Reducing olanzapine-induced weight gain side-effect by using betahistine: a study in the rat model Published In Journal of Psychopharmacology
  2011	Antipsychotic treatment and neuregulin 1 -ErbB4 signalling in schizophrenia Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2011	Olanzapine treatment and metabolic dysfunction: a dose response study in female Sprague Dawley rats Published In Behavioural Brain Research
  2011	Potential control of risperidone-related cognitive deficits by adjunctive aripiprazole treatment Published In Journal of Clinical Psychopharmacology
  2011	Simvastatin prevents dopaminergic neurodegeneration in experimental parkinsonian models: the association with anti-inflammatory responses Published In PLoS One
  2011	Statins: multiple neuroprotective mechanisms in neurodegenerative diseases Published In Experimental Neurology
  2010	Alterations in 5-HT2A receptor binding in various brain regions among 6-hydroxydopamine-induced Parkinsonian rats Published In Synapse (New York)
  2010	Effects of antipsychotic drugs on muscarinic M1 receptors in the rat brain Published In Australian and New Zealand Journal of Psychiatry
  2010	Effects of simvastatin and 6-hydroxydopamine on histaminergic H1 receptor binding density in rat brains Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2010	Effects of typical and atypical antipsychotics on the expressions of neuregulin 1 and ERBB4 receptors Published In Australian and New Zealand Journal of Psychiatry
  2010	Molecular cloning and characterization of the global regulator LaeA in Penicillium citrinum Published In Biotechnology Letters
  2010	Olanzapine decreases POMC MRNA expression and M3 receptors binding density in the hypothalamus and brainstem: pathway for weight gain side-effect? Published In Australian and New Zealand Journal of Psychiatry
  2010	Olanzapine decreases cannabinoid CB1 receptors in the hypothalamus and brainstem, possibly through muscarinic M3 receptor antagonism Published In International Journal of Neuropsychopharmacology
  2010	Potential control of antipsychotic-induced hyperprolactinemia and obesity in children and adolescents by aripiprazole Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2010	Reduce the olanzapine-induced body weight gain with histamine H1 receptor agonist betahistine in rats Published In International Journal of Neuropsychopharmacology
  2010	Sensitivity of the female rat to olanzapine-induced weight gain - far from the clinic? Published In Schizophrenia Research
  2010	The role of histaminergic H1 and H3 receptors in food intake:-A mechanism fo atypical antipsychotic-induced weight gain? Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2010	What is the mechanism for aripiprazole's effect on reducing olanzapine-associated obesity? Published In Journal of Clinical Psychopharmacology
  2009	Aripiprazole differentially affects mesolimbic and nigrostriatal dopaminergic transmission: implications for long-term drug efficacy and low extrapyramidal side-effects Published In International Journal of Neuropsychopharmacology
  2009	Decreased density of serotonin 2A receptors in the superior temporal gyrus in schizophrenia - a postmortem study Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2009	Excitatory and inhibitory neurotransmission is chronically altered following perinatal NMDA receptor blockade Published In European Neuropsychopharmacology
  2009	High dose of simvastatin induces hyperlocomotive and anxiolytic-like activities: the association with the up-regulation of NMDA receptor binding in the rat brain Published In Experimental Neurology
  2009	Obese reversal by a chronic energy restricted diet leaves an increased Arc NPY/AgRP, but no alteration in POMC/CART, mRNA expression in diet-induced obese mice Published In Behavioural Brain Research
  2009	Perinatal PCP treatment alters the developmental expression of prefrontal and hippocampal muscarinic receptors Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2009	Serotonin 2A receptor and its association with the pathology of schizophrenia Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2009	The effects of antipsychotic drugs administration on 5-HT1A receptor expression in the limbic system of the rat brain Published In Neuroscience
  2008	Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade Published In Neurochemical Research
  2008	Effects of antipsychotic medication on muscarinic M1 receptor mRNA expression in the rat brain Published In Journal of Neuroscience Research
  2008	Perinatal NMDA receptor blockade alters D2, NMDA and M1/M4 receptors in later life: implications for pathological processes of schizophrenia Published In Schizophrenia Research
  2008	Perinatal administration of PCP alters adult behaviour in female Sprague-Dawley rats Published In Behavioural Brain Research
  2008	Short- and long-term effects of antipsychotic drug treatment on weight gain and H1 receptor expression Published In Psychoneuroendocrinology
  2008	The effects of antipsychotics on the density of cannabinoid receptors in the dorsal vagal complex of rats: Implications for olanzapine-induced weight gain Published In International Journal of Neuropsychopharmacology
  2008	Ventromedial hypothalamic NPY Y2 receptor in the maintenance of body weight in diet-induced obesity in mice Published In Neurochemical Research
  2007	A rodent model of NMDA receptor hypofunction for the study of schizophrenia Published In Neuroscience Bulletin
  2007	A static handgrip method for distal quantitative sweat measurements Published In Neuroscience Letters
  2007	AM 251 and beta-Funaltrexamine reduce fat intake in a fat-preferring strain of mouse Published In Behavioural Brain Research
  2007	Decreased plasma peptide YY accompanied by elevated peptide YY and Y2 receptor binding densities in the medulla oblongata of diet-induced obese mice Published In Endocrinology
  2007	Dose-dependent effects of atypical antipsychotic drug olanzapine on weight gain and cholecystokinin levels in rats Published In Neuroscience Bulletin
  2007	Histamine H1 mRNA expression is decreased in the rat hypothalamus following olanzapine treatment Published In Schizophrenia Bulletin
  2007	NMDA receptor hypofunction during early brain development: relevance to schizophrenia Published In Schizophrenia Bulletin
  2007	No changes in cannabinoid CB1 receptor binding density in the superior temporal gyrus in schizophrenia Published In Schizophrenia Bulletin
  2007	No changes in densities of cannabinoid receptors in the superior temporal gyrus in schizophrenia Published In Neuroscience Bulletin
  2007	Olanzapine treatment decreases the density of muscarinic M2 receptors in the dorsal vagal complex of rats Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry
  2000	Organization of intratelencephalic projections to the visual Wulst of the chick Published In Brain Research
  1999	Differential sensitivities of the two visual pathways of the chick to labelling by fluorescent retrograde tracers Published In Journal of Neuroscience Methods
  1998	Bilaterally projecting neurons in the two visual pathways of chicks Published In Brain Research
  1998	Organisation of the tectorotundal and SP/IPS-rotundal projections in the chick Published In Journal of Comparative Neurology
  1997	Differential contributions of the two visual pathways to functional lateralization in chicks Published In Behavioural Brain Research
  1993	Convergence of somatic and visual afferent impulses in the Wulst of pigeon Published In Experimental Brain Research
  1992	Overlap of somatic and visual response areas in the Wulst of pigeon Published In Brain Research
  1989	Projection of afferent impulses from the brachial plexus and sciatic nerve to the corpus striatum in pigeons Published In Acta Physiologica Sinica

• Chapter

  Year	Title
  2021	Health 3.0 Published In Encyclopedia of Gerontology and Population Aging Publisher : Springer
  2019	Health 3.0 Published In Encyclopedia of Gerontology and Population Aging Publisher Cham, Switzerland

• Conference Paper

  Year	Title
  2017	Relationships of hormone levels with hunger, weight gain and problematic eating behaviours in Major Depressive Disorder Published In Frontiers in Human Neuroscience Abstract: ASP2017 27th Annual Meeting for the Australasian Society for Psychophysiology
  2015	Risperidone-induced weight gain in juvenile female rats through modulating hypothalamic histaminergic/NPY pathways and activity Published In JOURNAL OF NEUROCHEMISTRY
  2013	An analysis of metabotropic glutamate receptors 2/3 and 5 in schizophrenia, major depression and bipolar disorder from the stanley neuropathology consortium Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
  2013	Binding affinity of aripiprazole to the dopamine D2 receptor in different regions of the rat brain Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
  2013	Central administration of histamine H1 receptor agonist, fMPH, blocks olanzapineinduced activation of ampk-cpt1 signaling in the dorsal vagal complex in rats Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
  2013	Effects of chronic antipsychotic treatment on dopamine synthesis Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
  2013	Long term effects of olanzapine and betahistine on serotonin 5-HT2A receptor binding in the rat brain Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
  2013	Time-dependent ghrelinergic signaling and hyperphagia induced by olanzapine Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
  2012	Differential effects of aripiprazole and haloperidol on dopamine markers in the arcuate nucleus and prolactin levels in male rats Published In The International Journal of Neuropsychopharmacology: Abstracts from the 28th CINP World Congress of Neuropsychopharmacology
  2012	Effects of dopamine D2 receptor partial agonist bifeprunox on body weight gain, food and water intake in male rats Published In Australian Neuroscience Society 32nd Annual meeting
  2012	Effects of olanzapine and betahistine on serotonin 5-HT2A receptor binding in the rat brain Published In ANS 2012: Australian Neuroscience Society 32nd Annual meeting
  2012	MGluR5 and NMDA receptor density are reduced in the dorsolateral prefrontal cortex of schizoaffective but not schizophrenia patients Published In Society of Biological Psychiatry 67th Annual Meeting
  2012	Metabotropic glutamate receptor subtype 5 is reduced in schizophrenia subjects with comorbid major depression and unchanged following antipsychotic drug treatment Published In Australian Neuroscience Society 32nd Annual meeting
  2012	Neuregulin1 and ErbB4 Protein Expression in Schizophrenia and their Relationship with NMDA Receptor Binding Published In BIOLOGICAL PSYCHIATRY
  2012	Olanzapine treatment and time-dependent changes of hypothalamic AMPK-ACC-CPT1 signalling, food intake and body weight in rats Published In ANS 2012: Australian Neuroscience Society 32nd Annual meeting
  2012	Preventing and treating olanzapine-induced obesity with betahistine: a chronic animal model study Published In The International Journal of Neuropsychopharmacology: Abstracts from the 28th CINP World Congress of Neuropsychopharmacology
  2012	Time-dependant alterations of hypothalamic energy regulatory network by olanzapine in rats Published In Australian Neuroscience Society 32nd Annual meeting
  2011	Aripiprazole selectively affects AKT/GSK protein expression in the nucleus accumbens and caudate putamen Published In 31st Annual Meeting of the Australian Neuroscience Society
  2011	Histamine H1 receptor agonist and control of olanzapine-induced obesity Published In 31st Annual Meeting of the Australian Neuroscience Society
  2011	Neuroendocrinological regulation of insulin dysfunction induced by olanzapine Published In 31st Annual Meeting of the Australian Neuroscience Society
  2010	An age difference in mu opioid receptor binding density in the human putamen but no changes in schizophrenia Published In Australian Neuroscience Society Annual Meeting, Sydney 2010
  2010	Effects of simvastatin and 6-hydroxydopamine lesion on histaminergic H1 receptor binding in rat brains Published In ANS/AuPS 2010 - the 30th Annual Meeting of the Australian Neuroscience Society, in conjunction with the 50th Anniversary Meeting of the Australian Physiological Society
  2010	Olanzapine decreases [3H]SR141716A binding to cannabinoid CB1 receptors in the rat hippocampus and auditory cortex: a dosage-dependent response Published In Australian Neuroscience Society Annual Meeting, Sydney 2010
  2010	Olanzapine-induced metabolic dysfunction: a role for central muscarinic M3 receptors Published In Australian Neuroscience Society Annual Meeting, Sydney 2010
  2010	The dosage response to the side-effect of metabolic dysfunction in female rats following olanzapine treatment Published In Australian Neuroscience Society Annual Meeting, Sydney 2010
  2009	Developmental vitamin D (DVD) deficiency alters MK-801 induced locomotion and glutamatergic rceptor binding Published In Australian Neuroscience Society Inc 29th Annual Meeting
  2009	Related pathological changes of serotonin 2A, muscarinic M1 and GABA A receptors in the superior temporal gyrus in schizophrenia Published In Australian Neuroscience Society Annual Meeting
  2008	Cholecystokinin mRNA expression in the arcuate hypothalamic nuclei in diet-induced obese and obese resistant mice Published In 6th Forum of European Neuroscience Abstract Volume 4
  2008	Neonatal interruption of NMDA receptors causes abnormal brain development and behavioural changes in adult rats Published In 35th Annual Australasian Society for the Study of Animal Behaviour Conference, Symposium on Brain and Behaviour
  2007	A negative association between the CB1 receptor mRNA expression and high fat intake during the course of diet-induced obesity in mice Published In 17th Neuropharmacology Conference: Cannabinoid Signalling in the Nervous System
  2007	Antipsychotic drugs increase food intake and cannabinoid CB1 receptor mRNA expression in the brain of rats Published In 17th Neuropharmacology Conference: Cannabinoid Signalling in the Nervous System
  2007	Effects of antipsychotic drugs on weight gain and CB1 receptors in the dorsal vagal complex of rats Published In 7th IBRO World Congress of Neuroscience
  2007	Effects of antipsychotics on muscarinic M1 receptor mRNA expression in the rat brain Published In 7th IBRO World Congress of Neuroscience
  2007	Effects of perinatal NMDA receptor antagonist treatment on dopaminergic system development and behaviour Published In 7th IBRO World Congress of Neuroscience
  2007	Long-term consequences of early brain development disruption on neurochemical balance and behaviour Published In 7th IBRO World Congress of Neuroscience
  2007	Phencyclidine induces apoptosis in the brain of neonatal but not adolescent and adult rats Published In 7th IBRO World Congress of Neuroscience
  2007	The role of Pyy and H1 histamine receptor expression in chronic diet-induced obese and diet-resistant mice Published In 7th IBRO World Congress of Neuroscience
  2006	Brain development disruption from PCP causes behavioural deficits in the forced swim test in later life Published In AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
  1999	Light experience and lateralization of the two visual pathways in the chick Published In Behavioural Brain Research

Editor Of

• Book

  • Mapping the Pathophysiology of Schizophrenia: Interactions Between Multiple Cellular Pathways.  Switzerland. 2014

Investigator On

Year	Title
2021	Barnes Mazes for rats and mice Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016 - 2019	Understanding the mechanisms for ameliorating/preventing antipsychotic-induced obesity in early life Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2018	Forced exercise/walking wheel system for rats Model 80805A Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2014 - 2017	Application of intelligent conducting polymers for treating schizophrenia and allied disorders focusing on neuronal outgrowth, myelination and synaptogenesis Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2012 - 2016	Schizophrenia: reversal of antipsychotic drug-induced obesity and its related metabolic disorders Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2013	Roles of muscarinic M3 receptors in antipsychotic-induced metabolic side-effects: prevention and treatment of anti-psychotic insulin dysregulation Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2012	SU 105 Stirling Underbench Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2011	Understanding the mechanisms of functionally selective drugs: implication for new generation antipsychotic drugs Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2010	Precellys 24 tissue homogenizer and digital microplate shaker Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2010	Schizophrenia: prevention and treatment of atypical antipsychotic drug-induced obesity Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2008	The Development vitam D model (DVD) as an animal model for schizophrenia Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
	Exposures of mobile phone radiofrequency electromagnetic energy in juveniles: effects on brain development and behaviours Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Ideas Grant
	GoBlot machines and Leica Objective Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
	Lumenera Infinity 2-5 microscope colour camera Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
	Rat activity wheel and living chamber system Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
	SR-LAB ABS System Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
	Small animal stereotaxic instrument and microinjection unit Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant

Impact Story

Advisees

• Graduate Advising Relationship

  Degree	Research Title	Advisee
  Master of Philosophy	Antipsychotic-induced Metabolic Side-Effects in Juvenile Poly (I:C) Rats	Hodgson, James
  Doctor of Philosophy	An Ontology to represent dementia and dementia care knowledge in computer readable format	Zhang, Zhenyu
  Doctor of Philosophy (Integrated)	Applying Natural Language Processing on Unstructured Data to Understand and Predict Malnutrition in Residential Aged Care Facilities	Alkhalaf, Mohammad
  Doctor of Philosophy	Understanding journey of patients with alcohol use disorder in Illawarra & Shoalhaven Local Health District	Zhang, Jingxiang
  Doctor of Philosophy	Effects of Radiofrequency Energy on Cognitive Function in a Mouse Model of Alzheimer's Disease	Sylvester, Emma
  Doctor of Philosophy	Investigating the Effects of Epigallocatechin Gallate in Improving Cognitive Function in a Poly I:C Rat Model for Schizophrenia: Mechanisms Tthrough Upregulating Ketogenesis in Brains	Yi, Weijie
  Doctor of Philosophy	Machine Learning for to Predict Dementia Agitation for People Living in Residential Aged- Care Facilities	Vithanage, Dinithi
  Doctor of Philosophy	Impact of mobile radiofrequency electromagnetic waves on behaviour and neurotransmission during the childhood-adolescent period.	Bala, Nathan
  Doctor of Philosophy	Pharmacological mechanisms of antipsychotic-induced metabolic sideeffects, and potential interventions	Busharat, Mariam

Orcid Id

• http://orcid.org/0000-0003-1147-5741 (confirmed)

Web Of Science Researcher Id

• F-4417-2016

Scopus Id

• 26424514600