Ashford, Bruce G.

Ashford, Bruce G. Dr

A/Prof Surgery (Research)

bruceash@uow.edu.au

Top Publications

Year	Title
2019	Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma Published in Journal of Investigative Dermatology
2018	Supraclavicular flap repair in the free flap era Published in ANZ Journal of Surgery

Research Overview

My primary area of research interest is in high risk and metastatic skin cancers. We are interested in understanding the genomic and transcriptomic events that predispose to recurrence, perineurial invasion and metastasis in cutaneous SCC My research activity stems directly from my clinical role as a Head & Neck Surgeon.

Head Of

Illawarra Shoalhaven Local Health District Executive Director of Research 2020 -

Member Of

Cancer Cell and Molecular Biology Investigator 2019 -

Clinical Activities

Illawarra Shoalhaven Local Health District Senior Staff Specialist Surgeon 2008 -

Selected Publications

Journal Article

Year	Title
2019	Chimeric Vastus Lateralis and Anterolateral Thigh Flap for Restoring Facial Defects and Dynamic Function following Radical Parotidectomy Published In Plastic and Reconstructive Surgery Volume 144 Pages 853e - 863e ISSN 0032-1052 Altmetric
2019	Is high-risk cutaneous squamous cell carcinoma of the head and neck a suitable candidate for current targeted therapies? Published In Journal of Clinical Pathology Volume Online First Pages 1 - 6 ISSN 0021-9746 Altmetric
2019	Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma Published In Journal of Investigative Dermatology Volume 139 Pages 1449 - 1458.e1 ISSN 0022-202X Altmetric
2019	Sentinel Node Biopsy in 105 High-Risk Cutaneous SCCs of the Head and Neck: Results of a Multicenter Prospective Study Published In Annals of Surgical Oncology Volume 26 Pages 4481 - 4488 ISSN 1068-9265 Altmetric
2018	Analysis and Comparison of the 8th Edition American Joint Committee on Cancer (AJCC) Nodal Staging System in Cutaneous and Oral Squamous Cell Cancer of the Head and Neck Published In Annals of Surgical Oncology Volume 25 Pages 1730 - 1736 ISSN 1068-9265 Altmetric
2018	Analysis of clinically relevant somatic mutations in high-risk head and neck cutaneous squamous cell carcinoma Published In Modern Pathology Volume 31 Pages 275 - 287 ISSN 0893-3952 Altmetric
2018	Lymph node ratio as a prognostic factor in metastatic cutaneous head and neck squamous cell carcinoma Published In Head and Neck: journal for the sciences and specialities of the head and neck Volume 40 Pages 993 - 999 ISSN 1043-3074 Altmetric
2018	Predictive value of the 8th edition American Joint Commission Cancer (AJCC) nodal staging system for patients with cutaneous squamous cell carcinoma of the head and neck Published In Journal of Surgical Oncology Volume 117 Pages 765 - 772 ISSN 0022-4790 Altmetric
2018	Prognostic implications of the 8th edition American Joint Committee on Cancer (AJCC) staging system in oral cavity squamous cell carcinoma Published In Oral Oncology Volume 85 Pages 82 - 86 ISSN 1368-8375 Altmetric
2018	Supraclavicular flap repair in the free flap era Published In ANZ Journal of Surgery Volume 88 Pages 540 - 546 ISSN 0004-8682 Altmetric
2017	PD-L1 expression predicts longer disease free survival in high risk head and neck cutaneous squamous cell carcinoma Published In Pathology Volume 49 Pages 499 - 505 ISSN 0031-3025 Altmetric
2017	p16 expression in cutaneous squamous cell carcinoma of the head and neck is not associated with integration of high risk HPV DNA or prognosis Published In Pathology Volume 49 Pages 494 - 498 ISSN 0031-3025 Altmetric
2016	Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma: a pilot study Published In Oncotarget Volume 7 Pages 47111 - 47115 ISSN 1949-2553 Altmetric
2016	Oropharyngeal cancer and human papilloma virus: evolving diagnostic and management paradigms Published In ANZ Journal of Surgery Volume 86 Pages 442 - 447 ISSN 0004-8682 Altmetric

Presentations

Invited Talk
- Mutational landscape of metastatic cSCC, University of Toronto Otolaryngology Grand Rounds 2020

Investigator On

Year	Title
2020 - 2023	Cutaneous Squamous Cell Carcinoma: defining prognostic markers of metastasis Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Ideas Grant
2020	Establishing a molecular signature of risk of metastasis and progression in primary cutaneou s squamous cell carcinoma Awarded by: Tour de Cure Research Funding Scheme: Early Career Research Grant
2015	Use of Smart Polymers in a 3D printed upper airway model of obstructive sleep apnoea Awarded by: The Garnett Passe and Rodney Williams Memorial Foundation Funding Scheme: Conjoint Grant
	Unravelling genetic markers of progression and metastases in head and neck cutaneous squamous cell carcinoma Awarded by: Australian and New Zealand Head and Neck Cancer Society Research Foundation Funding Scheme: Research Grant

Other Research Activities

Tour de Cure Early Career Researcher 2020 - 2021

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Master of Philosophy -SMAH	Phenotypic Changes in Obstructive Sleep Apnoea.	Lam, Matt
Doctor of Philosophy	Evaluating the Current State of Wellbeing in Australian Surgical Trainees and the Short-Term Impact of Local Hospital Wellbeing Initiatives	Balhatchet, Belinda

Education And Training

Ph.D. in Mutational profile of metastatic cutaneous SCC, Chemistry and Molecular Biosciences, Prof Marie Ranson 2014 - 2019
University of Queensland, Medicine 1999
University of Queensland, Dentistry 1991

Top Publications

Year	Title
2019	Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma Published in Journal of Investigative Dermatology
2018	Supraclavicular flap repair in the free flap era Published in ANZ Journal of Surgery

Research Overview

My primary area of research interest is in high risk and metastatic skin cancers. We are interested in understanding the genomic and transcriptomic events that predispose to recurrence, perineurial invasion and metastasis in cutaneous SCC My research activity stems directly from my clinical role as a Head & Neck Surgeon.

Head Of

Illawarra Shoalhaven Local Health District Executive Director of Research 2020 -

Member Of

Cancer Cell and Molecular Biology Investigator 2019 -

Clinical Activities

Illawarra Shoalhaven Local Health District Senior Staff Specialist Surgeon 2008 -

Selected Publications

Journal Article

Year	Title
2019	Chimeric Vastus Lateralis and Anterolateral Thigh Flap for Restoring Facial Defects and Dynamic Function following Radical Parotidectomy Published In Plastic and Reconstructive Surgery Volume 144 Pages 853e - 863e ISSN 0032-1052 Altmetric
2019	Is high-risk cutaneous squamous cell carcinoma of the head and neck a suitable candidate for current targeted therapies? Published In Journal of Clinical Pathology Volume Online First Pages 1 - 6 ISSN 0021-9746 Altmetric
2019	Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma Published In Journal of Investigative Dermatology Volume 139 Pages 1449 - 1458.e1 ISSN 0022-202X Altmetric
2019	Sentinel Node Biopsy in 105 High-Risk Cutaneous SCCs of the Head and Neck: Results of a Multicenter Prospective Study Published In Annals of Surgical Oncology Volume 26 Pages 4481 - 4488 ISSN 1068-9265 Altmetric
2018	Analysis and Comparison of the 8th Edition American Joint Committee on Cancer (AJCC) Nodal Staging System in Cutaneous and Oral Squamous Cell Cancer of the Head and Neck Published In Annals of Surgical Oncology Volume 25 Pages 1730 - 1736 ISSN 1068-9265 Altmetric
2018	Analysis of clinically relevant somatic mutations in high-risk head and neck cutaneous squamous cell carcinoma Published In Modern Pathology Volume 31 Pages 275 - 287 ISSN 0893-3952 Altmetric
2018	Lymph node ratio as a prognostic factor in metastatic cutaneous head and neck squamous cell carcinoma Published In Head and Neck: journal for the sciences and specialities of the head and neck Volume 40 Pages 993 - 999 ISSN 1043-3074 Altmetric
2018	Predictive value of the 8th edition American Joint Commission Cancer (AJCC) nodal staging system for patients with cutaneous squamous cell carcinoma of the head and neck Published In Journal of Surgical Oncology Volume 117 Pages 765 - 772 ISSN 0022-4790 Altmetric
2018	Prognostic implications of the 8th edition American Joint Committee on Cancer (AJCC) staging system in oral cavity squamous cell carcinoma Published In Oral Oncology Volume 85 Pages 82 - 86 ISSN 1368-8375 Altmetric
2018	Supraclavicular flap repair in the free flap era Published In ANZ Journal of Surgery Volume 88 Pages 540 - 546 ISSN 0004-8682 Altmetric
2017	PD-L1 expression predicts longer disease free survival in high risk head and neck cutaneous squamous cell carcinoma Published In Pathology Volume 49 Pages 499 - 505 ISSN 0031-3025 Altmetric
2017	p16 expression in cutaneous squamous cell carcinoma of the head and neck is not associated with integration of high risk HPV DNA or prognosis Published In Pathology Volume 49 Pages 494 - 498 ISSN 0031-3025 Altmetric
2016	Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma: a pilot study Published In Oncotarget Volume 7 Pages 47111 - 47115 ISSN 1949-2553 Altmetric
2016	Oropharyngeal cancer and human papilloma virus: evolving diagnostic and management paradigms Published In ANZ Journal of Surgery Volume 86 Pages 442 - 447 ISSN 0004-8682 Altmetric

Presentations

Invited Talk
- Mutational landscape of metastatic cSCC, University of Toronto Otolaryngology Grand Rounds 2020

Investigator On

Year	Title
2020 - 2023	Cutaneous Squamous Cell Carcinoma: defining prognostic markers of metastasis Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Ideas Grant
2020	Establishing a molecular signature of risk of metastasis and progression in primary cutaneou s squamous cell carcinoma Awarded by: Tour de Cure Research Funding Scheme: Early Career Research Grant
2015	Use of Smart Polymers in a 3D printed upper airway model of obstructive sleep apnoea Awarded by: The Garnett Passe and Rodney Williams Memorial Foundation Funding Scheme: Conjoint Grant
	Unravelling genetic markers of progression and metastases in head and neck cutaneous squamous cell carcinoma Awarded by: Australian and New Zealand Head and Neck Cancer Society Research Foundation Funding Scheme: Research Grant

Other Research Activities

Tour de Cure Early Career Researcher 2020 - 2021

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Master of Philosophy -SMAH	Phenotypic Changes in Obstructive Sleep Apnoea.	Lam, Matt
Doctor of Philosophy	Evaluating the Current State of Wellbeing in Australian Surgical Trainees and the Short-Term Impact of Local Hospital Wellbeing Initiatives	Balhatchet, Belinda

Education And Training

Ph.D. in Mutational profile of metastatic cutaneous SCC, Chemistry and Molecular Biosciences, Prof Marie Ranson 2014 - 2019
University of Queensland, Medicine 1999
University of Queensland, Dentistry 1991

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