Ashford, Bruce G.

Ashford, Bruce G. Dr

A/Prof Surgery (Research)

bruceash@uow.edu.au

Top Publications

Year	Title
2019	Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma Published in Journal of Investigative Dermatology
2018	Supraclavicular flap repair in the free flap era Published in ANZ Journal of Surgery

Research Overview

My primary area of research interest is in high risk and metastatic skin cancers. We are interested in understanding the genomic and transcriptomic events that predispose to recurrence, perineurial invasion and metastasis in cutaneous SCC My research activity stems directly from my clinical role as a Head & Neck Surgeon.

Head Of

Illawarra Shoalhaven Local Health District Executive Director of Research 2020 -

Member Of

Cancer Cell and Molecular Biology Investigator 2019 -

Clinical Activities

Illawarra Shoalhaven Local Health District Senior Staff Specialist Surgeon 2008 -

Selected Publications

Journal Article

Year	Title
2019	Chimeric Vastus Lateralis and Anterolateral Thigh Flap for Restoring Facial Defects and Dynamic Function following Radical Parotidectomy Published In Plastic and Reconstructive Surgery
2019	Is high-risk cutaneous squamous cell carcinoma of the head and neck a suitable candidate for current targeted therapies? Published In Journal of Clinical Pathology
2019	Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma Published In Journal of Investigative Dermatology
2019	Sentinel Node Biopsy in 105 High-Risk Cutaneous SCCs of the Head and Neck: Results of a Multicenter Prospective Study Published In Annals of Surgical Oncology
2018	Analysis and Comparison of the 8th Edition American Joint Committee on Cancer (AJCC) Nodal Staging System in Cutaneous and Oral Squamous Cell Cancer of the Head and Neck Published In Annals of Surgical Oncology
2018	Analysis of clinically relevant somatic mutations in high-risk head and neck cutaneous squamous cell carcinoma Published In Modern Pathology
2018	Lymph node ratio as a prognostic factor in metastatic cutaneous head and neck squamous cell carcinoma Published In Head and Neck: journal for the sciences and specialities of the head and neck
2018	Predictive value of the 8th edition American Joint Commission Cancer (AJCC) nodal staging system for patients with cutaneous squamous cell carcinoma of the head and neck Published In Journal of Surgical Oncology
2018	Prognostic implications of the 8th edition American Joint Committee on Cancer (AJCC) staging system in oral cavity squamous cell carcinoma Published In Oral Oncology
2018	Supraclavicular flap repair in the free flap era Published In ANZ Journal of Surgery
2017	PD-L1 expression predicts longer disease free survival in high risk head and neck cutaneous squamous cell carcinoma Published In Pathology
2017	p16 expression in cutaneous squamous cell carcinoma of the head and neck is not associated with integration of high risk HPV DNA or prognosis Published In Pathology
2016	Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma: a pilot study Published In Oncotarget
2016	Oropharyngeal cancer and human papilloma virus: evolving diagnostic and management paradigms Published In ANZ Journal of Surgery

Presentations

Invited Talk
- Mutational landscape of metastatic cSCC, University of Toronto Otolaryngology Grand Rounds 2020

Investigator On

Year	Title
2020 - 2023	Cutaneous Squamous Cell Carcinoma: defining prognostic markers of metastasis Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Ideas Grant
2020 - 2021	Establishing a molecular signature of risk of metastasis and progression in primary cutaneou s squamous cell carcinoma Awarded by: Tour de Cure Research Funding Scheme: Early Career Research Grant
2020	Reducing the Morbidity of Head and Neck Cancer Treatment Awarded by: Cancer Institute NSW Funding Scheme: Translational Program Grant (TPG)
2016	Unravelling genetic markers of progression and metastases in head and neck cutaneous squamous cell carcinoma Awarded by: Australian and New Zealand Head and Neck Cancer Society Research Foundation Funding Scheme: Research Grant
2015	Use of Smart Polymers in a 3D printed upper airway model of obstructive sleep apnoea Awarded by: The Garnett Passe and Rodney Williams Memorial Foundation Funding Scheme: Conjoint Grant

Other Research Activities

Tour de Cure Early Career Researcher 2020 - 2021

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Master of Philosophy -SMAH	The Role of Phenotyping in the Personalised Management of OSA	Lam, Matt
Doctor of Philosophy	A band aid over a gaping wound: An exploration of wellbeing in Australian surgical trainees	Balhatchet, Belinda
Doctor of Philosophy	Metastatic cutaneous squamous cell carcinoma (cSCC): development of 3- dimensional patient-derived cultures for functional genomics and drug response profiling.	Genenger, Benjamin

Education And Training

Ph.D. in Mutational profile of metastatic cutaneous SCC, Chemistry and Molecular Biosciences, Prof Marie Ranson 2014 - 2019
University of Queensland, Medicine 1999
University of Queensland, Dentistry 1991

Orcid Id

http://orcid.org/0000-0003-4547-6611 (confirmed)

Top Publications

Year	Title
2019	Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma Published in Journal of Investigative Dermatology
2018	Supraclavicular flap repair in the free flap era Published in ANZ Journal of Surgery

Research Overview

My primary area of research interest is in high risk and metastatic skin cancers. We are interested in understanding the genomic and transcriptomic events that predispose to recurrence, perineurial invasion and metastasis in cutaneous SCC My research activity stems directly from my clinical role as a Head & Neck Surgeon.

Head Of

Illawarra Shoalhaven Local Health District Executive Director of Research 2020 -

Member Of

Cancer Cell and Molecular Biology Investigator 2019 -

Clinical Activities

Illawarra Shoalhaven Local Health District Senior Staff Specialist Surgeon 2008 -

Selected Publications

Journal Article

Year	Title
2019	Chimeric Vastus Lateralis and Anterolateral Thigh Flap for Restoring Facial Defects and Dynamic Function following Radical Parotidectomy Published In Plastic and Reconstructive Surgery
2019	Is high-risk cutaneous squamous cell carcinoma of the head and neck a suitable candidate for current targeted therapies? Published In Journal of Clinical Pathology
2019	Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma Published In Journal of Investigative Dermatology
2019	Sentinel Node Biopsy in 105 High-Risk Cutaneous SCCs of the Head and Neck: Results of a Multicenter Prospective Study Published In Annals of Surgical Oncology
2018	Analysis and Comparison of the 8th Edition American Joint Committee on Cancer (AJCC) Nodal Staging System in Cutaneous and Oral Squamous Cell Cancer of the Head and Neck Published In Annals of Surgical Oncology
2018	Analysis of clinically relevant somatic mutations in high-risk head and neck cutaneous squamous cell carcinoma Published In Modern Pathology
2018	Lymph node ratio as a prognostic factor in metastatic cutaneous head and neck squamous cell carcinoma Published In Head and Neck: journal for the sciences and specialities of the head and neck
2018	Predictive value of the 8th edition American Joint Commission Cancer (AJCC) nodal staging system for patients with cutaneous squamous cell carcinoma of the head and neck Published In Journal of Surgical Oncology
2018	Prognostic implications of the 8th edition American Joint Committee on Cancer (AJCC) staging system in oral cavity squamous cell carcinoma Published In Oral Oncology
2018	Supraclavicular flap repair in the free flap era Published In ANZ Journal of Surgery
2017	PD-L1 expression predicts longer disease free survival in high risk head and neck cutaneous squamous cell carcinoma Published In Pathology
2017	p16 expression in cutaneous squamous cell carcinoma of the head and neck is not associated with integration of high risk HPV DNA or prognosis Published In Pathology
2016	Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma: a pilot study Published In Oncotarget
2016	Oropharyngeal cancer and human papilloma virus: evolving diagnostic and management paradigms Published In ANZ Journal of Surgery

Presentations

Invited Talk
- Mutational landscape of metastatic cSCC, University of Toronto Otolaryngology Grand Rounds 2020

Investigator On

Year	Title
2020 - 2023	Cutaneous Squamous Cell Carcinoma: defining prognostic markers of metastasis Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Ideas Grant
2020 - 2021	Establishing a molecular signature of risk of metastasis and progression in primary cutaneou s squamous cell carcinoma Awarded by: Tour de Cure Research Funding Scheme: Early Career Research Grant
2020	Reducing the Morbidity of Head and Neck Cancer Treatment Awarded by: Cancer Institute NSW Funding Scheme: Translational Program Grant (TPG)
2016	Unravelling genetic markers of progression and metastases in head and neck cutaneous squamous cell carcinoma Awarded by: Australian and New Zealand Head and Neck Cancer Society Research Foundation Funding Scheme: Research Grant
2015	Use of Smart Polymers in a 3D printed upper airway model of obstructive sleep apnoea Awarded by: The Garnett Passe and Rodney Williams Memorial Foundation Funding Scheme: Conjoint Grant

Other Research Activities

Tour de Cure Early Career Researcher 2020 - 2021

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Master of Philosophy -SMAH	The Role of Phenotyping in the Personalised Management of OSA	Lam, Matt
Doctor of Philosophy	A band aid over a gaping wound: An exploration of wellbeing in Australian surgical trainees	Balhatchet, Belinda
Doctor of Philosophy	Metastatic cutaneous squamous cell carcinoma (cSCC): development of 3- dimensional patient-derived cultures for functional genomics and drug response profiling.	Genenger, Benjamin

Education And Training

Ph.D. in Mutational profile of metastatic cutaneous SCC, Chemistry and Molecular Biosciences, Prof Marie Ranson 2014 - 2019
University of Queensland, Medicine 1999
University of Queensland, Dentistry 1991

Orcid Id

http://orcid.org/0000-0003-4547-6611 (confirmed)

Visualisations

Publication History

Investigator Network

Collaborator Map