Ashford, Bruce

Top Publications

Year	Title
2019	Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma Published in Journal of Investigative Dermatology
2018	Supraclavicular flap repair in the free flap era Published in ANZ Journal of Surgery

Research Overview

My primary area of research interest is in high risk and metastatic skin cancers. We are interested in understanding the genomic and transcriptomic events that predispose to recurrence, perineurial invasion and metastasis in cutaneous SCC My research activity stems directly from my clinical role as a Head & Neck Surgeon.

Selected Publications

Journal Article

Year	Title
2021	Demystifying emerging bulk RNA-Seq applications: the application and utility of bioinformatic methodology. Published In Briefings in bioinformatics
2021	Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma Published In Scientific Reports
2021	P-115 The potential of panel-based gene expression analysis in the identification of head and neck cutaneous squamous cell carcinoma with high risk of lymph node metastasis Published In Oral Oncology
2021	Targeted ordering of investigations reduces costs of treatment for surgical inpatients Published In International Journal for Quality in Health Care
2021	The Vastus Lateralis Free Flap and Donor-Site Morbidity. A Systematic Review Published In Craniomaxillofacial Trauma & Reconstruction Open
2020	Comprehensive mutational and phenotypic characterization of new metastatic cutaneous squamous cell carcinoma cell lines reveal novel drug susceptibilities Published In International Journal of Molecular Sciences
2020	Gallstone Ileus Decades after Cholecystectomy and Pylorus-Preserving Whipples. Published In Case reports in surgery
2020	Thulium oxide nanoparticles as radioenhancers for the treatment of metastatic cutaneous squamous cell carcinoma Published In Physics in Medicine and Biology
2019	Chimeric Vastus Lateralis and Anterolateral Thigh Flap for Restoring Facial Defects and Dynamic Function following Radical Parotidectomy Published In Plastic and Reconstructive Surgery
2019	Is high-risk cutaneous squamous cell carcinoma of the head and neck a suitable candidate for current targeted therapies? Published In Journal of Clinical Pathology
2019	Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma Published In Journal of Investigative Dermatology
2019	Sentinel Node Biopsy in 105 High-Risk Cutaneous SCCs of the Head and Neck: Results of a Multicenter Prospective Study Published In Annals of Surgical Oncology
2018	Analysis and Comparison of the 8th Edition American Joint Committee on Cancer (AJCC) Nodal Staging System in Cutaneous and Oral Squamous Cell Cancer of the Head and Neck Published In Annals of Surgical Oncology
2018	Analysis of clinically relevant somatic mutations in high-risk head and neck cutaneous squamous cell carcinoma Published In Modern Pathology
2018	Lymph node ratio as a prognostic factor in metastatic cutaneous head and neck squamous cell carcinoma Published In Head and Neck: journal for the sciences and specialities of the head and neck
2018	Lymph node ratio as a prognostic factor in metastatic cutaneous head and neck squamous cell carcinoma Published In Pathology
2018	Predictive value of the 8th edition American Joint Commission Cancer (AJCC) nodal staging system for patients with cutaneous squamous cell carcinoma of the head and neck Published In Journal of Surgical Oncology
2018	Prognostic implications of the 8th edition American Joint Committee on Cancer (AJCC) staging system in oral cavity squamous cell carcinoma Published In Oral Oncology
2018	Supraclavicular flap repair in the free flap era Published In ANZ Journal of Surgery
2017	A first look at the genomic landscape of non-metastatic cutaneous squamous cell carcinoma Published In Pathology
2017	Bone resection for facial cutaneous malignancies. Published In Journal of surgical oncology
2017	Cribriform adenocarcinoma of the minor salivary gland: a case report and review of literature Published In Pathology
2017	Education and support needs in patients with head and neck cancer: A multi-institutional survey. Published In Cancer
2017	Laparoscopic harvest of the gastro-omental free flap for reconstruction after total pharyngolaryngectomy: Operative technique Published In Head and Neck
2017	Metastases to the parotid gland - A review of the clinicopathological evolution, molecular mechanisms and management. Published In Surgical oncology
2017	PD-L1 expression predicts longer disease free survival in high risk head and neck cutaneous squamous cell carcinoma Published In Pathology
2017	RNA sequencing of metastatic cutaneous SCC with nano-string: preliminary results Published In Pathology
2017	Reviewing the genetic alterations in high-risk cutaneous squamous cell carcinoma: A search for prognostic markers and therapeutic targets Published In Head and Neck
2017	Single innervated segmented vastus lateralis for midfacial reanimation during radical parotidectomy. Published In Head & neck
2017	p16 expression in cutaneous squamous cell carcinoma (cSCC) of the head and neck Published In Pathology
2017	p16 expression in cutaneous squamous cell carcinoma of the head and neck is not associated with integration of high risk HPV DNA or prognosis Published In Pathology
2016	Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma: a pilot study Published In Oncotarget
2016	Oropharyngeal cancer and human papilloma virus: evolving diagnostic and management paradigms Published In ANZ Journal of Surgery
2015	Anatomical Mapping of the Omental Vasculature to Refine its Optimal Use in Free Flap Transfer Published In The FASEB Journal
2015	Contralateral neck failure in lateralized oral squamous cell carcinoma. Published In ANZ journal of surgery
2015	Prospective study of sentinel node biopsy for high-risk cutaneous squamous cell carcinoma of the head and neck. Published In Head & neck
2013	A rare case of submandibular abscess complicated by stroke. Published In JRSM short reports
2013	Alignment of the double-barrel fibula free flap for better cosmesis and bone height for osseointegrated dental implants. Published In Plastic and reconstructive surgery
2013	Options for configuring the scapular free flap in maxillary, mandibular, and calvarial reconstruction. Published In Plastic and reconstructive surgery
2012	"The Practical Perforator Flap": the sural artery flap for lower extremity soft tissue reconstruction in wounds of war. Published In European journal of orthopaedic surgery & traumatology : orthopedie traumatologie
2012	Reconstruction of post-radical parotidectomy defects. Published In Plastic and reconstructive surgery
2012	Reconstruction of the (Crico)trachea for malignancy in the virgin and irradiated neck. Published In Journal of plastic, reconstructive & aesthetic surgery : JPRAS
2011	Improved survival with elective neck dissection in thick early-stage oral squamous cell carcinoma. Published In Head & neck
2011	Temporoparietal fascia free flap for pharyngeal coverage after salvage total laryngectomy. Published In The Laryngoscope
2010	Advances in temporomandibular joint reconstruction. Published In Current opinion in otolaryngology & head and neck surgery
2010	Double helix flap to close a massive circular soft-tissue defect. Published In Journal of plastic, reconstructive & aesthetic surgery : JPRAS
2009	Cricotracheal reconstruction following external beam radiotherapy for recurrent thyroid cancer. Published In ANZ journal of surgery
2009	Internal mammary artery perforator flap for head and neck reconstruction. Published In ANZ journal of surgery

Chapter

Year	Title
2013	Head and Neck Cancer Surveillance Published In Encyclopedia of Otolaryngology, Head and Neck Surgery Publisher Springer Berlin Heidelberg
2013	Head and Neck Sarcoma Published In Encyclopedia of Otolaryngology, Head and Neck Surgery Publisher Springer Berlin Heidelberg
2013	Laryngeal Mucosal Melanoma Published In Encyclopedia of Otolaryngology, Head and Neck Surgery Publisher Springer Berlin Heidelberg
2013	Oral Mucosal Melanoma Published In Encyclopedia of Otolaryngology, Head and Neck Surgery Publisher Springer Berlin Heidelberg
2013	Sinonasal Mucosal Melanoma Published In Encyclopedia of Otolaryngology, Head and Neck Surgery Publisher Springer Berlin Heidelberg

Presentations

Invited Talk
- Mutational landscape of metastatic cSCC, University of Toronto Otolaryngology Grand Rounds 2020

Investigator On

Year	Title
2020 - 2023	Cutaneous Squamous Cell Carcinoma: defining prognostic markers of metastasis Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Ideas Grant
2020 - 2021	Establishing a molecular signature of risk of metastasis and progression in primary cutaneou s squamous cell carcinoma Awarded by: Tour de Cure Research Funding Scheme: Early Career Research Grant
2020	Reducing the Morbidity of Head and Neck Cancer Treatment Awarded by: Cancer Institute NSW Funding Scheme: Translational Program Grant (TPG)
2016	Unravelling genetic markers of progression and metastases in head and neck cutaneous squamous cell carcinoma Awarded by: Australian and New Zealand Head and Neck Cancer Society Research Foundation Funding Scheme: Research Grant
2015	Use of Smart Polymers in a 3D printed upper airway model of obstructive sleep apnoea Awarded by: The Garnett Passe and Rodney Williams Memorial Foundation Funding Scheme: Conjoint Grant

Other Research Activities

Tour de Cure Early Career Researcher 2020 - 2021

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Master of Philosophy -SMAH	The Role of Phenotyping in the Personalised Management of OSA	Lam, Matt
Doctor of Philosophy	A band aid over a gaping wound: An exploration of wellbeing in Australian surgical trainees	Balhatchet, Belinda
Doctor of Philosophy	Metastatic cutaneous squamous cell carcinoma (cSCC): development of 3- dimensional patient-derived cultures for functional genomics and drug response profiling.	Genenger, Benjamin

Education And Training

Ph.D. in Mutational profile of metastatic cutaneous SCC, Chemistry and Molecular Biosciences, Prof Marie Ranson 2014 - 2019
University of Queensland, Medicine 1999
University of Queensland, Dentistry 1991

Orcid Id

http://orcid.org/0000-0003-4547-6611 (confirmed)

Top Publications

Year	Title
2019	Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma Published in Journal of Investigative Dermatology
2018	Supraclavicular flap repair in the free flap era Published in ANZ Journal of Surgery

Research Overview

My primary area of research interest is in high risk and metastatic skin cancers. We are interested in understanding the genomic and transcriptomic events that predispose to recurrence, perineurial invasion and metastasis in cutaneous SCC My research activity stems directly from my clinical role as a Head & Neck Surgeon.

Head Of

Illawarra Shoalhaven Local Health District Executive Director of Research 2020 -

Member Of

Cancer Cell and Molecular Biology Investigator 2019 -

Clinical Activities

Illawarra Shoalhaven Local Health District Senior Staff Specialist Surgeon 2008 -

Selected Publications

Journal Article

Year	Title
2021	Demystifying emerging bulk RNA-Seq applications: the application and utility of bioinformatic methodology. Published In Briefings in bioinformatics
2021	Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma Published In Scientific Reports
2021	P-115 The potential of panel-based gene expression analysis in the identification of head and neck cutaneous squamous cell carcinoma with high risk of lymph node metastasis Published In Oral Oncology
2021	Targeted ordering of investigations reduces costs of treatment for surgical inpatients Published In International Journal for Quality in Health Care
2021	The Vastus Lateralis Free Flap and Donor-Site Morbidity. A Systematic Review Published In Craniomaxillofacial Trauma & Reconstruction Open
2020	Comprehensive mutational and phenotypic characterization of new metastatic cutaneous squamous cell carcinoma cell lines reveal novel drug susceptibilities Published In International Journal of Molecular Sciences
2020	Gallstone Ileus Decades after Cholecystectomy and Pylorus-Preserving Whipples. Published In Case reports in surgery
2020	Thulium oxide nanoparticles as radioenhancers for the treatment of metastatic cutaneous squamous cell carcinoma Published In Physics in Medicine and Biology
2019	Chimeric Vastus Lateralis and Anterolateral Thigh Flap for Restoring Facial Defects and Dynamic Function following Radical Parotidectomy Published In Plastic and Reconstructive Surgery
2019	Is high-risk cutaneous squamous cell carcinoma of the head and neck a suitable candidate for current targeted therapies? Published In Journal of Clinical Pathology
2019	Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma Published In Journal of Investigative Dermatology
2019	Sentinel Node Biopsy in 105 High-Risk Cutaneous SCCs of the Head and Neck: Results of a Multicenter Prospective Study Published In Annals of Surgical Oncology
2018	Analysis and Comparison of the 8th Edition American Joint Committee on Cancer (AJCC) Nodal Staging System in Cutaneous and Oral Squamous Cell Cancer of the Head and Neck Published In Annals of Surgical Oncology
2018	Analysis of clinically relevant somatic mutations in high-risk head and neck cutaneous squamous cell carcinoma Published In Modern Pathology
2018	Lymph node ratio as a prognostic factor in metastatic cutaneous head and neck squamous cell carcinoma Published In Head and Neck: journal for the sciences and specialities of the head and neck
2018	Lymph node ratio as a prognostic factor in metastatic cutaneous head and neck squamous cell carcinoma Published In Pathology
2018	Predictive value of the 8th edition American Joint Commission Cancer (AJCC) nodal staging system for patients with cutaneous squamous cell carcinoma of the head and neck Published In Journal of Surgical Oncology
2018	Prognostic implications of the 8th edition American Joint Committee on Cancer (AJCC) staging system in oral cavity squamous cell carcinoma Published In Oral Oncology
2018	Supraclavicular flap repair in the free flap era Published In ANZ Journal of Surgery
2017	A first look at the genomic landscape of non-metastatic cutaneous squamous cell carcinoma Published In Pathology
2017	Bone resection for facial cutaneous malignancies. Published In Journal of surgical oncology
2017	Cribriform adenocarcinoma of the minor salivary gland: a case report and review of literature Published In Pathology
2017	Education and support needs in patients with head and neck cancer: A multi-institutional survey. Published In Cancer
2017	Laparoscopic harvest of the gastro-omental free flap for reconstruction after total pharyngolaryngectomy: Operative technique Published In Head and Neck
2017	Metastases to the parotid gland - A review of the clinicopathological evolution, molecular mechanisms and management. Published In Surgical oncology
2017	PD-L1 expression predicts longer disease free survival in high risk head and neck cutaneous squamous cell carcinoma Published In Pathology
2017	RNA sequencing of metastatic cutaneous SCC with nano-string: preliminary results Published In Pathology
2017	Reviewing the genetic alterations in high-risk cutaneous squamous cell carcinoma: A search for prognostic markers and therapeutic targets Published In Head and Neck
2017	Single innervated segmented vastus lateralis for midfacial reanimation during radical parotidectomy. Published In Head & neck
2017	p16 expression in cutaneous squamous cell carcinoma (cSCC) of the head and neck Published In Pathology
2017	p16 expression in cutaneous squamous cell carcinoma of the head and neck is not associated with integration of high risk HPV DNA or prognosis Published In Pathology
2016	Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma: a pilot study Published In Oncotarget
2016	Oropharyngeal cancer and human papilloma virus: evolving diagnostic and management paradigms Published In ANZ Journal of Surgery
2015	Anatomical Mapping of the Omental Vasculature to Refine its Optimal Use in Free Flap Transfer Published In The FASEB Journal
2015	Contralateral neck failure in lateralized oral squamous cell carcinoma. Published In ANZ journal of surgery
2015	Prospective study of sentinel node biopsy for high-risk cutaneous squamous cell carcinoma of the head and neck. Published In Head & neck
2013	A rare case of submandibular abscess complicated by stroke. Published In JRSM short reports
2013	Alignment of the double-barrel fibula free flap for better cosmesis and bone height for osseointegrated dental implants. Published In Plastic and reconstructive surgery
2013	Options for configuring the scapular free flap in maxillary, mandibular, and calvarial reconstruction. Published In Plastic and reconstructive surgery
2012	"The Practical Perforator Flap": the sural artery flap for lower extremity soft tissue reconstruction in wounds of war. Published In European journal of orthopaedic surgery & traumatology : orthopedie traumatologie
2012	Reconstruction of post-radical parotidectomy defects. Published In Plastic and reconstructive surgery
2012	Reconstruction of the (Crico)trachea for malignancy in the virgin and irradiated neck. Published In Journal of plastic, reconstructive & aesthetic surgery : JPRAS
2011	Improved survival with elective neck dissection in thick early-stage oral squamous cell carcinoma. Published In Head & neck
2011	Temporoparietal fascia free flap for pharyngeal coverage after salvage total laryngectomy. Published In The Laryngoscope
2010	Advances in temporomandibular joint reconstruction. Published In Current opinion in otolaryngology & head and neck surgery
2010	Double helix flap to close a massive circular soft-tissue defect. Published In Journal of plastic, reconstructive & aesthetic surgery : JPRAS
2009	Cricotracheal reconstruction following external beam radiotherapy for recurrent thyroid cancer. Published In ANZ journal of surgery
2009	Internal mammary artery perforator flap for head and neck reconstruction. Published In ANZ journal of surgery

Chapter

Year	Title
2013	Head and Neck Cancer Surveillance Published In Encyclopedia of Otolaryngology, Head and Neck Surgery Publisher Springer Berlin Heidelberg
2013	Head and Neck Sarcoma Published In Encyclopedia of Otolaryngology, Head and Neck Surgery Publisher Springer Berlin Heidelberg
2013	Laryngeal Mucosal Melanoma Published In Encyclopedia of Otolaryngology, Head and Neck Surgery Publisher Springer Berlin Heidelberg
2013	Oral Mucosal Melanoma Published In Encyclopedia of Otolaryngology, Head and Neck Surgery Publisher Springer Berlin Heidelberg
2013	Sinonasal Mucosal Melanoma Published In Encyclopedia of Otolaryngology, Head and Neck Surgery Publisher Springer Berlin Heidelberg

Presentations

Invited Talk
- Mutational landscape of metastatic cSCC, University of Toronto Otolaryngology Grand Rounds 2020

Investigator On

Year	Title
2020 - 2023	Cutaneous Squamous Cell Carcinoma: defining prognostic markers of metastasis Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Ideas Grant
2020 - 2021	Establishing a molecular signature of risk of metastasis and progression in primary cutaneou s squamous cell carcinoma Awarded by: Tour de Cure Research Funding Scheme: Early Career Research Grant
2020	Reducing the Morbidity of Head and Neck Cancer Treatment Awarded by: Cancer Institute NSW Funding Scheme: Translational Program Grant (TPG)
2016	Unravelling genetic markers of progression and metastases in head and neck cutaneous squamous cell carcinoma Awarded by: Australian and New Zealand Head and Neck Cancer Society Research Foundation Funding Scheme: Research Grant
2015	Use of Smart Polymers in a 3D printed upper airway model of obstructive sleep apnoea Awarded by: The Garnett Passe and Rodney Williams Memorial Foundation Funding Scheme: Conjoint Grant

Other Research Activities

Tour de Cure Early Career Researcher 2020 - 2021

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Master of Philosophy -SMAH	The Role of Phenotyping in the Personalised Management of OSA	Lam, Matt
Doctor of Philosophy	A band aid over a gaping wound: An exploration of wellbeing in Australian surgical trainees	Balhatchet, Belinda
Doctor of Philosophy	Metastatic cutaneous squamous cell carcinoma (cSCC): development of 3- dimensional patient-derived cultures for functional genomics and drug response profiling.	Genenger, Benjamin

Education And Training

Ph.D. in Mutational profile of metastatic cutaneous SCC, Chemistry and Molecular Biosciences, Prof Marie Ranson 2014 - 2019
University of Queensland, Medicine 1999
University of Queensland, Dentistry 1991

Orcid Id

http://orcid.org/0000-0003-4547-6611 (confirmed)

Overview

Top Publications

Research Overview

Affiliation

Head Of

Member Of

Clinical Activities

Publications

Selected Publications

Journal Article

Chapter

Presentations

Invited Talk

Funding

Investigator On

Other Research Activities

Supervision

Advisees

Graduate Advising Relationship

Background

Education And Training

Identity

Orcid Id

Overview

Top Publications

Research Overview

Affiliation

Head Of

Member Of

Clinical Activities

Publications

Selected Publications

Journal Article

Chapter

Presentations

Invited Talk

Funding

Investigator On

Other Research Activities

Supervision

Advisees

Graduate Advising Relationship

Background

Education And Training

Identity

Orcid Id

Visualisations