Garner, Brett

Top Publications

Year	Title
2018	The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis Published in Journal of Biological Chemistry
2015	Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice Published in Neurobiology of Aging
2014	Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease Published in Brain: a journal of neurology
2013	Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease Published in The Journal of Neuroscience

Research Areas

Selected Publications

Journal Article

Year	Title
2019	Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease Published In The Journal of Neuroscience Volume 39 Pages 9645 - 9659 ISSN 1529-2401 Altmetric
2018	Effect of Fluvoxamine on Amyloid-β Peptide Generation and Memory Published In Journal of Alzheimer's Disease Volume 62 Pages 1777 - 1787 ISSN 1387-2877 Altmetric
2018	Identification of a novel tetrameric structure for human apolipoprotein-D Published In Journal of Structural Biology Volume 203 Pages 205 - 218 ISSN 1047-8477 Altmetric
2018	The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis Published In Journal of Biological Chemistry Volume 293 Pages 4071 - 4084 ISSN 0021-9258 Altmetric
2018	Understanding the Role of ApoE Fragments in Alzheimer’s Disease Published In Neurochemical Research Volume Online First Pages 1 - 9 ISSN 0364-3190 Altmetric
2018	Wnt is here! Could Wnt signalling be promoted to protect against Alzheimer disease? Published In Journal of Neurochemistry Volume 144 Pages 356 - 359 ISSN 0022-3042 Altmetric
2017	The therapeutic potential of the phytocannabinoid cannabidiol for Alzheimer's disease Published In Behavioural Pharmacology Volume 28 Pages 142 - 160 ISSN 0955-8810 Altmetric
2016	ABCA7 deletion does not affect adult neurogenesis in the mouse Published In Bioscience Reports: molecular and cellular biology of the cell surface Volume 36 Pages e00308-1 - e00308-6 ISSN 0144-8463 Altmetric
2016	Beneficial effects of increased lysozyme levels in Alzheimer's disease modelled in Drosophila melanogaster Published In The Federation of European Biochemical Societies (FEBS) Journal Volume 283 Pages 3508 - 3522 ISSN 1742-464X Altmetric
2016	Cell type-specific modulation of cobalamin uptake by bovine serum Published In PLoS One Volume 11 Pages e0167044-1 - e0167044-22 ISSN 1932-6203 Altmetric
2016	Cerebral apolipoprotein-D is hypoglycosylated compared to peripheral tissues and is variably expressed in mouse and human brain regions Published In PLoS One Volume 11 Pages e0148238-1 - e0148238-13 ISSN 1932-6203 Altmetric
2016	Evidence for altered cholesterol metabolism in Huntington's disease post mortem brain tissue Published In Neuropathology and Applied Neurobiology Volume 42 Pages 535 - 546 ISSN 0305-1846 Altmetric
2016	Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease Published In Neurobiology of Aging Volume 43 Pages 89 - 100 ISSN 0197-4580 Altmetric
2015	Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice Published In Neurobiology of Aging Volume 36 Pages 1820 - 1833 ISSN 0197-4580 Altmetric
2015	Brain cholesterol synthesis and metabolism is progressively disturbed in the R6/1 mouse model of Huntington's disease: a targeted GC-MS/MS sterol analysis Published In Journal of Huntington's Disease Volume 4 Pages 305 - 318 Altmetric
2015	Fatty acid composition of the anterior cingulate cortex indicates a high susceptibility to lipid peroxidation in Parkinson's disease Published In Journal of Parkinson's Disease Volume 5 Pages 175 - 185 Altmetric
2015	Impaired lysosomal cobalamin transport in Alzheimer's disease Published In Journal of Alzheimer's Disease Volume 43 Pages 1017 - 1030 ISSN 1387-2877 Altmetric
2015	Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson's disease Published In Movement Disorders Volume 30 Pages 1639 - 1647 ISSN 0885-3185 Altmetric
2015	Understanding the function of ABCA7 in Alzheimer's disease Published In Biochemical Society Transactions Volume 43 Pages 920 - 923 ISSN 0300-5127 Altmetric
2014	Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson’s disease Published In Movement Disorders Volume 29 Pages 518 - 526 ISSN 0885-3185 Altmetric
2014	Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1ΔE9 mice Published In Psychopharmacology Volume 231 Pages 3009 - 3017 ISSN 0033-3158 Altmetric
2014	Long-term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimer's disease transgenic mice Published In Journal of Alzheimer's Disease Volume 42 Pages 1383 - 1396 ISSN 1387-2877 Altmetric
2014	Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis Published In Acta neuropathologica communications Volume 2 Pages 9-1 - 9-13 Altmetric
2014	Novel behavioural characteristics of female APPswe/PS1ΔE9 double transgenic mice Published In Behavioural Brain Research Volume 260 Pages 111 - 118 ISSN 0166-4328 Altmetric
2014	Perturbation of neuronal cobalamin transport by lysosomal enzyme inhibition Published In Bioscience Reports: molecular and cellular biology of the cell surface Volume 34 Pages 43 - 50 ISSN 0144-8463 Altmetric
2014	Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease Published In Brain: a journal of neurology Volume 137 Pages 834 - 848 ISSN 0006-8950 Altmetric
2013	An Improved High-Throughput Lipid Extraction Method for the Analysis of Human Brain Lipids Published In Lipids Volume 48 Pages 307 - 318 ISSN 0024-4201 Altmetric
2013	Analysis of subcellular [57Co] cobalamin distribution in SH-SY5Y neurons and brain tissue Published In Journal of Neuroscience Methods Volume 217 Pages 67 - 74 ISSN 0165-0270 Altmetric
2013	Assessment of ABCA7 function in Alzheimer's disease models Published In Journal of Neurochemistry Volume 125 Pages 39 - 40 ISSN 0022-3042 Altmetric
2013	Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease Published In The Journal of Neuroscience Volume 33 Pages 4387 - 4394 ISSN 1529-2401 Altmetric
2013	Increased apolipoprotein D dimer formation in Alzheimer’s disease hippocampus is associated with lipid conjugated diene levels Published In Journal of Alzheimer's Disease Volume 35 Pages 475 - 486 ISSN 1387-2877 Altmetric
2013	Novel behavioural characteristics of the APPSwe/PS1ΔE9 transgenic mouse model of Alzheimer's disease Published In Behavioural Brain Research Volume 245 Pages 120 - 127 ISSN 0166-4328 Altmetric
2012	Amyloid beta selectively modulates neuronal TrkB alternative transcript expression with implications for Alzheimer's disease Published In Neuroscience Volume 210 Pages 363 - 374 ISSN 0306-4522 Altmetric
2012	Cognitive phenotyping of amyloid precursor protein transgenic J20 mice Published In Behavioural Brain Research Volume 228 Pages 392 - 397 ISSN 0166-4328 Altmetric
2012	Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues Published In Clinical Science Volume 122 Pages 409 - 419 ISSN 0143-5221 Altmetric
2012	Evidence that truncated TrkB isoform, TrkB-Shc can regulate phosphorylated TrkB protein levels Published In Biochemical and Biophysical Research Communications Volume 420 Pages 331 - 335 ISSN 0006-291X Altmetric
2012	Is Seladin-1 really a selective Alzheimer's disease indicator? Published In Journal of Alzheimer's Disease Volume 30 Pages 35 - 39 ISSN 1387-2877 Altmetric
2012	Molecular dynamics analysis of apolipoprotein-D - lipid hydroperoxide interactions: mechanism for selective oxidation of Met-93 Published In PLoS One Volume 7 Pages e34057 - 1 - e34057 - 9 ISSN 1932-6203 Altmetric
2012	Role of abca7 in mouse behaviours relevant to neurodegenerative diseases Published In PLoS One Volume 7 Pages e45959 - 1 - e45959 - 9 ISSN 1932-6203 Altmetric
2012	Selective reduction of hydroperoxyeicosatetraenoic acids to their hydroxy derivatives by apolipoprotein D: implications for lipid antioxidant activity and Alzheimer's disease Published In Biochemical Journal Volume 442 Pages 713 - 721 ISSN 0264-6021 Altmetric
2012	Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content Published In PLoS One Volume 7 Pages e50262 - 1 - e50262 - 11 ISSN 1932-6203 Altmetric
2012	Srp20 regulates TrkB pre-mRNA splicing to generate TrkB-Shc transcripts with implications for Alzheimer's disease Published In Journal of Neurochemistry Volume 123 Pages 159 - 171 ISSN 0022-3042 Altmetric
2012	The therapeutic potential of the endocannabinoid system for Alzheimer's disease Published In Expert Opinion on Therapeutic Targets Volume 16 Pages 407 - 420 ISSN 1472-8222 Altmetric
2011	Age-related lysosomal dysfunction: an unrecognized roadblock for cobalamin trafficking? Published In Cellular and Molecular Life Sciences Volume 68 Pages 3963 - 3969 ISSN 1420-682X Altmetric
2011	Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation Published In American Journal of Pathology Volume 178 Pages 629 - 639 ISSN 0002-9440 Altmetric
2011	Isoform-specific proteolysis of apolipoprotein-E in the brain Published In Neurobiology of Aging Volume 32 Pages 257 - 271 ISSN 0197-4580 Altmetric
2011	Lipid pathway alterations in Parkinson's Disease primary visual cortex Published In PLoS One Volume 6 Pages 1 - 17 ISSN 1932-6203 Altmetric
2011	Mass and relative elution time profiling: Two-dimensional analysis of sphingolipids in Alzheimer's disease brains Published In Biochemical Journal Volume 438 Pages 165 - 175 ISSN 0264-6021 Altmetric
2011	Wild type and Tangier disease ABCA1 mutants modulate cellular amyloid-beta production independent of cholesterol efflux activity Published In Journal of Alzheimer's Disease Volume 27 Pages 441 - 452 ISSN 1387-2877 Altmetric
2010	Apolipoproteins in the brain: implications for neurological and psychiatric disorders Published In Clinical Lipidology Volume 5 Pages 555 - 573 ISSN 1746-0875 Altmetric
2010	Increased ATP-binding cassette transporter A1 expression in Alzheimer's disease hippocampal neurons Published In Journal of Alzheimer's Disease Volume 21 Pages 193 - 205 ISSN 1387-2877 Altmetric
2010	Increased expression of the lysosomal cholesterol transporter NPC1 in Alzheimer's disease Published In BBA: Molecular and Cell Biology of Lipids Volume 1801 Pages 831 - 838 ISSN 1388-1981 Altmetric
2010	Lipids and Alzheimer's disease Published In BBA: Molecular and Cell Biology of Lipids Volume 1801 Pages 747 - 749 ISSN 1388-1981 Altmetric
2010	Modulation of amyloid precursor protein processing by synthetic ceramide analogues Published In BBA: Molecular and Cell Biology of Lipids Volume 1801 Pages 887 - 895 ISSN 1388-1981 Altmetric
2010	Myriocin-mediated up-regulation of hepatocyte apoA-I synthesis is associated with ERK inhibition Published In Clinical Science Volume 118 Pages 727 - 736 ISSN 0143-5221 Altmetric
2010	The kynurenine pathway and inflammation in amyotrophic lateral sclerosis Published In Neurotoxicity Research Volume 18 Pages 132 - 142 ISSN 1029-8428 Altmetric
2010	Vascular pharmacotherapy and dementia Published In Current and Vascular Pharmacology Volume 8 Pages 44 - 50 ISSN 1570-1611 Altmetric
2009	Apolipoprotein-D expression is increased during development and maturation of the human prefrontal cortex Published In Journal of Neurochemistry Volume 109 Pages 1053 - 1066 ISSN 0022-3042 Altmetric
2009	Apolipoprotein-E forms dimers in human frontal cortex and hippocampus Published In BMC Neuroscience Volume 11 Pages 1 - 10 ISSN 1471-2202 Altmetric
2009	Impact of 27-hydroxycholesterol on amyloid-beta peptide production and ATP-binding cassette transporter expression in primary human neurons Published In Journal of Alzheimer's Disease Volume 16 Pages 121 - 131 ISSN 1387-2877
2008	ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro Published In Journal of Neurochemistry Volume 106 Pages 793 - 804 ISSN 0022-3042 Altmetric
2008	Analysis of apolipoprotein E nuclear localization using green fluorescent protein and biotinylation approaches Published In Biochemical Journal Volume 409 Pages 701 - 709 ISSN 0264-6021 Altmetric
2008	Macrophage apolipoprotein-E knockdown modulates caspase-3 activation without altering sensitivity to apoptosis Published In BBA: General Subjects Volume 1780 Pages 145 - 153 ISSN 0304-4165 Altmetric
2008	Modulation of brain metabolism by very low concentrations of the commonly used drug delivery vehicle dimethyl sulfoxide (DMSO) Published In Journal of Neuroscience Research Volume 86 Pages 208 - 214 ISSN 0360-4012 Altmetric
2008	Myriocin as an atherosclerosis inhibitor Published In Clinical Lipidology Volume 3 Pages 221 - 224 ISSN 1746-0875 Altmetric
2008	Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mice Published In Journal of Lipid Research Volume 49 Pages 324 - 331 ISSN 0022-2275 Altmetric
2008	Reduction of plasma glycosphingolipid levels has no impact on atherosclerosis in apolipoprotein E-null mice Published In Journal of Lipid Research Volume 49 Pages 1677 - 1681 ISSN 0022-2275 Altmetric
2008	Regulation of alpha-synuclein expression by liver X receptor ligands in vitro Published In NeuroReport Volume 19 Pages 1685 - 1689 ISSN 0959-4965 Altmetric
2008	Role of ATP-binding cassette transporters in brain lipid transport and neurological disease Published In Journal of Neurochemistry Volume 104 Pages 1145 - 1166 ISSN 0022-3042 Altmetric
2008	The comparative biology of neuromelanin and lipofuscin in the human brain Published In Cellular and Molecular Life Sciences Volume 65 Pages 1669 - 1682 ISSN 1420-682X Altmetric
2007	Alanine metabolism, transport, and cycling in the brain Published In Journal of Neurochemistry Volume 102 Pages 1758 - 1770 ISSN 0022-3042 Altmetric
2007	Apoptosis induces neuronal apolipoprotein-E synthesis and localization in apoptotic bodies Published In Neuroscience Letters Volume 416 Pages 206 - 210 ISSN 0304-3940 Altmetric
2007	Inhibition of atherosclerosis by the serine palmitoyl transferase inhibitor myriocin is associated with reduced plasma glycosphingolipid concentration Published In Biochemical Pharmacology Volume 73 Pages 1340 - 1346 ISSN 0006-2952 Altmetric
2007	Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-β peptide generation Published In Journal of Biological Chemistry Volume 282 Pages 2851 - 2861 ISSN 0021-9258 Altmetric

Conference Paper

Year	Title
2013	Age-related lysosomal alterations perturb intracellular cobalamin trafficking Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants Pages 190 - 190
2013	Antioxidant properties of Apolipoprotein-D methionine- and selenomethioninecontaining peptides Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants Pages 124 - 124
2013	Deletion of abca7 increases cerebral amyloid-β deposition in the J20 mouse model of Alzheimer’s disease Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants Pages 125 - 125
2013	Development of subcellular fractionation techniques to determine the intracellular cobalamin transit in vitro and the impact of lysosomal dysfunction Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants Pages 129 - 129
2013	Global fatty acid composition is altered in Parkinson’s disease anterior cingulate cortex Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants Pages 62 - 62
2013	Improved GC-MS methods for analysis of homocysteine, methionine and methylmalonate in cultured cells Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants Pages 130 - 130
2010	Lipidomic assessment of Parkinson's disease brain Published In Australian Neuroscience Society Annual Meeting, Sydney 2010 Page p. 186

Investigator On

Year	Title
2018 - 2021	Cannabidiol (CBD): A novel therapeutic for Alzheimer's disease? Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2016 - 2020	Defining the mechanisms by which ABCA7 and apoE control Alzheimer's disease risk. Functional characterisation of new therapeutic targets for dementia prevention and treatment Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Research Fellowships
2016 - 2018	Restoring neuroprotective sphingosine 1 - phosphate signalling in Alzheimer's Disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2015 - 2018	Isoform-dependent apoE processing by human induced pluripotent stem cells. A novel pathway linking APOE genotype and Alzheimer's disease risk Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2017	Lumenera Infinity 2-5 microscope colour camera Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2014 - 2017	Supporting a friend: the role of the molecular scaffold CoREST family in chromatin regulation and neuroprotection Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2014	COUNTESS 11 FL Cell Counter and Qubit Quant Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2014	Lysosomal dysfunction as an inhibitor of vitamin B12 utilisation in neurodegenerative diseases Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2014	Regional flow cytometry facility Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2013	A novel intracellular roadblock to cobalamin utilization in ageing and Alzheimer's disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2013	Neon Transfection System: Workstation for transfer of genetic material into hard-to-work-with cells Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2011 - 2013	Defining the function of apolipoprotein-D in Alzheimer's disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2012	Altered myelin sphingolipid homeostasis in Alzheimer's Disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2012	Integrated facility for confocal imaging and single molecule flourescence analysis Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2011	Cellular effects of glucocerebrosidase (GBA) mutations in Lewy body diseases Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2011	Eppendorf MasterCycler Pro thermocycler Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2009	Regulation of amyloid-beta production by glycosphingolipid synthesis inhibition Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2009	Targetting brain lipid homeostasis to treat Alzheimer's disease Awarded by: Australian Research Council (ARC) Funding Scheme: Future Fellowships
	Contributions to Leica Dmi8 microscope Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
	NHMRC SRFA Fellowship Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Research Fellowships

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Understanding the Structure and Function of Apolipoprotein D and its Implications in Alzheimers Disease.	Kielkopf, Claudia

Orcid Id

http://orcid.org/0000-0002-5312-4352 (confirmed)

Top Publications

Year	Title
2018	The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis Published in Journal of Biological Chemistry
2015	Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice Published in Neurobiology of Aging
2014	Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease Published in Brain: a journal of neurology
2013	Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease Published in The Journal of Neuroscience

Research Areas

Selected Publications

Journal Article

Year	Title
2019	Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease Published In The Journal of Neuroscience Volume 39 Pages 9645 - 9659 ISSN 1529-2401 Altmetric
2018	Effect of Fluvoxamine on Amyloid-β Peptide Generation and Memory Published In Journal of Alzheimer's Disease Volume 62 Pages 1777 - 1787 ISSN 1387-2877 Altmetric
2018	Identification of a novel tetrameric structure for human apolipoprotein-D Published In Journal of Structural Biology Volume 203 Pages 205 - 218 ISSN 1047-8477 Altmetric
2018	The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis Published In Journal of Biological Chemistry Volume 293 Pages 4071 - 4084 ISSN 0021-9258 Altmetric
2018	Understanding the Role of ApoE Fragments in Alzheimer’s Disease Published In Neurochemical Research Volume Online First Pages 1 - 9 ISSN 0364-3190 Altmetric
2018	Wnt is here! Could Wnt signalling be promoted to protect against Alzheimer disease? Published In Journal of Neurochemistry Volume 144 Pages 356 - 359 ISSN 0022-3042 Altmetric
2017	The therapeutic potential of the phytocannabinoid cannabidiol for Alzheimer's disease Published In Behavioural Pharmacology Volume 28 Pages 142 - 160 ISSN 0955-8810 Altmetric
2016	ABCA7 deletion does not affect adult neurogenesis in the mouse Published In Bioscience Reports: molecular and cellular biology of the cell surface Volume 36 Pages e00308-1 - e00308-6 ISSN 0144-8463 Altmetric
2016	Beneficial effects of increased lysozyme levels in Alzheimer's disease modelled in Drosophila melanogaster Published In The Federation of European Biochemical Societies (FEBS) Journal Volume 283 Pages 3508 - 3522 ISSN 1742-464X Altmetric
2016	Cell type-specific modulation of cobalamin uptake by bovine serum Published In PLoS One Volume 11 Pages e0167044-1 - e0167044-22 ISSN 1932-6203 Altmetric
2016	Cerebral apolipoprotein-D is hypoglycosylated compared to peripheral tissues and is variably expressed in mouse and human brain regions Published In PLoS One Volume 11 Pages e0148238-1 - e0148238-13 ISSN 1932-6203 Altmetric
2016	Evidence for altered cholesterol metabolism in Huntington's disease post mortem brain tissue Published In Neuropathology and Applied Neurobiology Volume 42 Pages 535 - 546 ISSN 0305-1846 Altmetric
2016	Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease Published In Neurobiology of Aging Volume 43 Pages 89 - 100 ISSN 0197-4580 Altmetric
2015	Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice Published In Neurobiology of Aging Volume 36 Pages 1820 - 1833 ISSN 0197-4580 Altmetric
2015	Brain cholesterol synthesis and metabolism is progressively disturbed in the R6/1 mouse model of Huntington's disease: a targeted GC-MS/MS sterol analysis Published In Journal of Huntington's Disease Volume 4 Pages 305 - 318 Altmetric
2015	Fatty acid composition of the anterior cingulate cortex indicates a high susceptibility to lipid peroxidation in Parkinson's disease Published In Journal of Parkinson's Disease Volume 5 Pages 175 - 185 Altmetric
2015	Impaired lysosomal cobalamin transport in Alzheimer's disease Published In Journal of Alzheimer's Disease Volume 43 Pages 1017 - 1030 ISSN 1387-2877 Altmetric
2015	Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson's disease Published In Movement Disorders Volume 30 Pages 1639 - 1647 ISSN 0885-3185 Altmetric
2015	Understanding the function of ABCA7 in Alzheimer's disease Published In Biochemical Society Transactions Volume 43 Pages 920 - 923 ISSN 0300-5127 Altmetric
2014	Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson’s disease Published In Movement Disorders Volume 29 Pages 518 - 526 ISSN 0885-3185 Altmetric
2014	Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1ΔE9 mice Published In Psychopharmacology Volume 231 Pages 3009 - 3017 ISSN 0033-3158 Altmetric
2014	Long-term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimer's disease transgenic mice Published In Journal of Alzheimer's Disease Volume 42 Pages 1383 - 1396 ISSN 1387-2877 Altmetric
2014	Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis Published In Acta neuropathologica communications Volume 2 Pages 9-1 - 9-13 Altmetric
2014	Novel behavioural characteristics of female APPswe/PS1ΔE9 double transgenic mice Published In Behavioural Brain Research Volume 260 Pages 111 - 118 ISSN 0166-4328 Altmetric
2014	Perturbation of neuronal cobalamin transport by lysosomal enzyme inhibition Published In Bioscience Reports: molecular and cellular biology of the cell surface Volume 34 Pages 43 - 50 ISSN 0144-8463 Altmetric
2014	Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease Published In Brain: a journal of neurology Volume 137 Pages 834 - 848 ISSN 0006-8950 Altmetric
2013	An Improved High-Throughput Lipid Extraction Method for the Analysis of Human Brain Lipids Published In Lipids Volume 48 Pages 307 - 318 ISSN 0024-4201 Altmetric
2013	Analysis of subcellular [57Co] cobalamin distribution in SH-SY5Y neurons and brain tissue Published In Journal of Neuroscience Methods Volume 217 Pages 67 - 74 ISSN 0165-0270 Altmetric
2013	Assessment of ABCA7 function in Alzheimer's disease models Published In Journal of Neurochemistry Volume 125 Pages 39 - 40 ISSN 0022-3042 Altmetric
2013	Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease Published In The Journal of Neuroscience Volume 33 Pages 4387 - 4394 ISSN 1529-2401 Altmetric
2013	Increased apolipoprotein D dimer formation in Alzheimer’s disease hippocampus is associated with lipid conjugated diene levels Published In Journal of Alzheimer's Disease Volume 35 Pages 475 - 486 ISSN 1387-2877 Altmetric
2013	Novel behavioural characteristics of the APPSwe/PS1ΔE9 transgenic mouse model of Alzheimer's disease Published In Behavioural Brain Research Volume 245 Pages 120 - 127 ISSN 0166-4328 Altmetric
2012	Amyloid beta selectively modulates neuronal TrkB alternative transcript expression with implications for Alzheimer's disease Published In Neuroscience Volume 210 Pages 363 - 374 ISSN 0306-4522 Altmetric
2012	Cognitive phenotyping of amyloid precursor protein transgenic J20 mice Published In Behavioural Brain Research Volume 228 Pages 392 - 397 ISSN 0166-4328 Altmetric
2012	Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues Published In Clinical Science Volume 122 Pages 409 - 419 ISSN 0143-5221 Altmetric
2012	Evidence that truncated TrkB isoform, TrkB-Shc can regulate phosphorylated TrkB protein levels Published In Biochemical and Biophysical Research Communications Volume 420 Pages 331 - 335 ISSN 0006-291X Altmetric
2012	Is Seladin-1 really a selective Alzheimer's disease indicator? Published In Journal of Alzheimer's Disease Volume 30 Pages 35 - 39 ISSN 1387-2877 Altmetric
2012	Molecular dynamics analysis of apolipoprotein-D - lipid hydroperoxide interactions: mechanism for selective oxidation of Met-93 Published In PLoS One Volume 7 Pages e34057 - 1 - e34057 - 9 ISSN 1932-6203 Altmetric
2012	Role of abca7 in mouse behaviours relevant to neurodegenerative diseases Published In PLoS One Volume 7 Pages e45959 - 1 - e45959 - 9 ISSN 1932-6203 Altmetric
2012	Selective reduction of hydroperoxyeicosatetraenoic acids to their hydroxy derivatives by apolipoprotein D: implications for lipid antioxidant activity and Alzheimer's disease Published In Biochemical Journal Volume 442 Pages 713 - 721 ISSN 0264-6021 Altmetric
2012	Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content Published In PLoS One Volume 7 Pages e50262 - 1 - e50262 - 11 ISSN 1932-6203 Altmetric
2012	Srp20 regulates TrkB pre-mRNA splicing to generate TrkB-Shc transcripts with implications for Alzheimer's disease Published In Journal of Neurochemistry Volume 123 Pages 159 - 171 ISSN 0022-3042 Altmetric
2012	The therapeutic potential of the endocannabinoid system for Alzheimer's disease Published In Expert Opinion on Therapeutic Targets Volume 16 Pages 407 - 420 ISSN 1472-8222 Altmetric
2011	Age-related lysosomal dysfunction: an unrecognized roadblock for cobalamin trafficking? Published In Cellular and Molecular Life Sciences Volume 68 Pages 3963 - 3969 ISSN 1420-682X Altmetric
2011	Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation Published In American Journal of Pathology Volume 178 Pages 629 - 639 ISSN 0002-9440 Altmetric
2011	Isoform-specific proteolysis of apolipoprotein-E in the brain Published In Neurobiology of Aging Volume 32 Pages 257 - 271 ISSN 0197-4580 Altmetric
2011	Lipid pathway alterations in Parkinson's Disease primary visual cortex Published In PLoS One Volume 6 Pages 1 - 17 ISSN 1932-6203 Altmetric
2011	Mass and relative elution time profiling: Two-dimensional analysis of sphingolipids in Alzheimer's disease brains Published In Biochemical Journal Volume 438 Pages 165 - 175 ISSN 0264-6021 Altmetric
2011	Wild type and Tangier disease ABCA1 mutants modulate cellular amyloid-beta production independent of cholesterol efflux activity Published In Journal of Alzheimer's Disease Volume 27 Pages 441 - 452 ISSN 1387-2877 Altmetric
2010	Apolipoproteins in the brain: implications for neurological and psychiatric disorders Published In Clinical Lipidology Volume 5 Pages 555 - 573 ISSN 1746-0875 Altmetric
2010	Increased ATP-binding cassette transporter A1 expression in Alzheimer's disease hippocampal neurons Published In Journal of Alzheimer's Disease Volume 21 Pages 193 - 205 ISSN 1387-2877 Altmetric
2010	Increased expression of the lysosomal cholesterol transporter NPC1 in Alzheimer's disease Published In BBA: Molecular and Cell Biology of Lipids Volume 1801 Pages 831 - 838 ISSN 1388-1981 Altmetric
2010	Lipids and Alzheimer's disease Published In BBA: Molecular and Cell Biology of Lipids Volume 1801 Pages 747 - 749 ISSN 1388-1981 Altmetric
2010	Modulation of amyloid precursor protein processing by synthetic ceramide analogues Published In BBA: Molecular and Cell Biology of Lipids Volume 1801 Pages 887 - 895 ISSN 1388-1981 Altmetric
2010	Myriocin-mediated up-regulation of hepatocyte apoA-I synthesis is associated with ERK inhibition Published In Clinical Science Volume 118 Pages 727 - 736 ISSN 0143-5221 Altmetric
2010	The kynurenine pathway and inflammation in amyotrophic lateral sclerosis Published In Neurotoxicity Research Volume 18 Pages 132 - 142 ISSN 1029-8428 Altmetric
2010	Vascular pharmacotherapy and dementia Published In Current and Vascular Pharmacology Volume 8 Pages 44 - 50 ISSN 1570-1611 Altmetric
2009	Apolipoprotein-D expression is increased during development and maturation of the human prefrontal cortex Published In Journal of Neurochemistry Volume 109 Pages 1053 - 1066 ISSN 0022-3042 Altmetric
2009	Apolipoprotein-E forms dimers in human frontal cortex and hippocampus Published In BMC Neuroscience Volume 11 Pages 1 - 10 ISSN 1471-2202 Altmetric
2009	Impact of 27-hydroxycholesterol on amyloid-beta peptide production and ATP-binding cassette transporter expression in primary human neurons Published In Journal of Alzheimer's Disease Volume 16 Pages 121 - 131 ISSN 1387-2877
2008	ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro Published In Journal of Neurochemistry Volume 106 Pages 793 - 804 ISSN 0022-3042 Altmetric
2008	Analysis of apolipoprotein E nuclear localization using green fluorescent protein and biotinylation approaches Published In Biochemical Journal Volume 409 Pages 701 - 709 ISSN 0264-6021 Altmetric
2008	Macrophage apolipoprotein-E knockdown modulates caspase-3 activation without altering sensitivity to apoptosis Published In BBA: General Subjects Volume 1780 Pages 145 - 153 ISSN 0304-4165 Altmetric
2008	Modulation of brain metabolism by very low concentrations of the commonly used drug delivery vehicle dimethyl sulfoxide (DMSO) Published In Journal of Neuroscience Research Volume 86 Pages 208 - 214 ISSN 0360-4012 Altmetric
2008	Myriocin as an atherosclerosis inhibitor Published In Clinical Lipidology Volume 3 Pages 221 - 224 ISSN 1746-0875 Altmetric
2008	Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mice Published In Journal of Lipid Research Volume 49 Pages 324 - 331 ISSN 0022-2275 Altmetric
2008	Reduction of plasma glycosphingolipid levels has no impact on atherosclerosis in apolipoprotein E-null mice Published In Journal of Lipid Research Volume 49 Pages 1677 - 1681 ISSN 0022-2275 Altmetric
2008	Regulation of alpha-synuclein expression by liver X receptor ligands in vitro Published In NeuroReport Volume 19 Pages 1685 - 1689 ISSN 0959-4965 Altmetric
2008	Role of ATP-binding cassette transporters in brain lipid transport and neurological disease Published In Journal of Neurochemistry Volume 104 Pages 1145 - 1166 ISSN 0022-3042 Altmetric
2008	The comparative biology of neuromelanin and lipofuscin in the human brain Published In Cellular and Molecular Life Sciences Volume 65 Pages 1669 - 1682 ISSN 1420-682X Altmetric
2007	Alanine metabolism, transport, and cycling in the brain Published In Journal of Neurochemistry Volume 102 Pages 1758 - 1770 ISSN 0022-3042 Altmetric
2007	Apoptosis induces neuronal apolipoprotein-E synthesis and localization in apoptotic bodies Published In Neuroscience Letters Volume 416 Pages 206 - 210 ISSN 0304-3940 Altmetric
2007	Inhibition of atherosclerosis by the serine palmitoyl transferase inhibitor myriocin is associated with reduced plasma glycosphingolipid concentration Published In Biochemical Pharmacology Volume 73 Pages 1340 - 1346 ISSN 0006-2952 Altmetric
2007	Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-β peptide generation Published In Journal of Biological Chemistry Volume 282 Pages 2851 - 2861 ISSN 0021-9258 Altmetric

Conference Paper

Year	Title
2013	Age-related lysosomal alterations perturb intracellular cobalamin trafficking Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants Pages 190 - 190
2013	Antioxidant properties of Apolipoprotein-D methionine- and selenomethioninecontaining peptides Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants Pages 124 - 124
2013	Deletion of abca7 increases cerebral amyloid-β deposition in the J20 mouse model of Alzheimer’s disease Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants Pages 125 - 125
2013	Development of subcellular fractionation techniques to determine the intracellular cobalamin transit in vitro and the impact of lysosomal dysfunction Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants Pages 129 - 129
2013	Global fatty acid composition is altered in Parkinson’s disease anterior cingulate cortex Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants Pages 62 - 62
2013	Improved GC-MS methods for analysis of homocysteine, methionine and methylmalonate in cultured cells Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants Pages 130 - 130
2010	Lipidomic assessment of Parkinson's disease brain Published In Australian Neuroscience Society Annual Meeting, Sydney 2010 Page p. 186

Investigator On

Year	Title
2018 - 2021	Cannabidiol (CBD): A novel therapeutic for Alzheimer's disease? Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2016 - 2020	Defining the mechanisms by which ABCA7 and apoE control Alzheimer's disease risk. Functional characterisation of new therapeutic targets for dementia prevention and treatment Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Research Fellowships
2016 - 2018	Restoring neuroprotective sphingosine 1 - phosphate signalling in Alzheimer's Disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2015 - 2018	Isoform-dependent apoE processing by human induced pluripotent stem cells. A novel pathway linking APOE genotype and Alzheimer's disease risk Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2017	Lumenera Infinity 2-5 microscope colour camera Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2014 - 2017	Supporting a friend: the role of the molecular scaffold CoREST family in chromatin regulation and neuroprotection Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2014	COUNTESS 11 FL Cell Counter and Qubit Quant Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2014	Lysosomal dysfunction as an inhibitor of vitamin B12 utilisation in neurodegenerative diseases Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2014	Regional flow cytometry facility Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2013	A novel intracellular roadblock to cobalamin utilization in ageing and Alzheimer's disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2013	Neon Transfection System: Workstation for transfer of genetic material into hard-to-work-with cells Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2011 - 2013	Defining the function of apolipoprotein-D in Alzheimer's disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2012	Altered myelin sphingolipid homeostasis in Alzheimer's Disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2012	Integrated facility for confocal imaging and single molecule flourescence analysis Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2011	Cellular effects of glucocerebrosidase (GBA) mutations in Lewy body diseases Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2011	Eppendorf MasterCycler Pro thermocycler Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2009	Regulation of amyloid-beta production by glycosphingolipid synthesis inhibition Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2009	Targetting brain lipid homeostasis to treat Alzheimer's disease Awarded by: Australian Research Council (ARC) Funding Scheme: Future Fellowships
	Contributions to Leica Dmi8 microscope Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
	NHMRC SRFA Fellowship Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Research Fellowships

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Understanding the Structure and Function of Apolipoprotein D and its Implications in Alzheimers Disease.	Kielkopf, Claudia

Orcid Id

http://orcid.org/0000-0002-5312-4352 (confirmed)

Garner, Brett Prof.

NHMRC Senior Research Fellow

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Overview

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Journal Article

Conference Paper

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