Garner, Brett

Top Publications

Year	Title
2018	The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis Published in Journal of Biological Chemistry
2015	Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice Published in Neurobiology of Aging
2014	Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease Published in Brain: a journal of neurology
2013	Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease Published in The Journal of Neuroscience

Research Areas

Selected Publications

Journal Article

Year	Title
2021	Generation of APOE knock-down SK-N-SH human neuroblastoma cells using CRISPR/Cas9: a novel cellular model relevant to Alzheimer¿s disease research Published In Bioscience Reports
2021	Small angle X-ray scattering analysis of ligand-bound forms of tetrameric apolipoprotein-D Published In Bioscience Reports
2020	Chronic Treatment with 50 mg/kg Cannabidiol Improves Cognition and Moderately Reduces Aβ40 Levels in 12-Month-Old Male AβPPswe/PS1ΔE9 Transgenic Mice Published In Journal of Alzheimer's Disease
2020	Chronic cannabidiol (CBD) treatment did not exhibit beneficial effects in 4-month-old male TAU58/2 transgenic mice Published In Pharmacology, Biochemistry and Behavior
2019	Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease Published In The Journal of Neuroscience
2018	Effect of Fluvoxamine on Amyloid-β Peptide Generation and Memory Published In Journal of Alzheimer's Disease
2018	Identification of a novel tetrameric structure for human apolipoprotein-D Published In Journal of Structural Biology
2018	The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis Published In Journal of Biological Chemistry
2018	Understanding the Role of ApoE Fragments in Alzheimer’s Disease Published In Neurochemical Research
2018	Wnt is here! Could Wnt signalling be promoted to protect against Alzheimer disease? Published In Journal of Neurochemistry
2017	The therapeutic potential of the phytocannabinoid cannabidiol for Alzheimer's disease Published In Behavioural Pharmacology
2016	ABCA7 deletion does not affect adult neurogenesis in the mouse Published In Bioscience Reports: molecular and cellular biology of the cell surface
2016	Beneficial effects of increased lysozyme levels in Alzheimer's disease modelled in Drosophila melanogaster Published In The Federation of European Biochemical Societies (FEBS) Journal
2016	Cell type-specific modulation of cobalamin uptake by bovine serum Published In PLoS One
2016	Cell type-specific modulation of cobalamin uptake by bovine serumc Published In PLoS One
2016	Cerebral apolipoprotein-D is hypoglycosylated compared to peripheral tissues and is variably expressed in mouse and human brain regions Published In PLoS One
2016	Evidence for altered cholesterol metabolism in Huntington's disease post mortem brain tissue Published In Neuropathology and Applied Neurobiology
2016	Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease Published In Neurobiology of Aging
2016	Therapeutic Effects of Anthocyanins and Environmental Enrichment in R6/1 Huntington's Disease Mice Published In Journal of Huntington's Disease
2015	Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice Published In Neurobiology of Aging
2015	Brain cholesterol synthesis and metabolism is progressively disturbed in the R6/1 mouse model of Huntington's disease: a targeted GC-MS/MS sterol analysis Published In Journal of Huntington's Disease
2015	Fatty acid composition of the anterior cingulate cortex indicates a high susceptibility to lipid peroxidation in Parkinson's disease Published In Journal of Parkinson's Disease
2015	Impaired lysosomal cobalamin transport in Alzheimer's disease Published In Journal of Alzheimer's Disease
2015	Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson's disease Published In Movement Disorders
2015	Understanding the function of ABCA7 in Alzheimer's disease Published In Biochemical Society Transactions
2014	Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson’s disease Published In Movement Disorders
2014	Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1ΔE9 mice Published In Psychopharmacology
2014	Long-term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimer's disease transgenic mice Published In Journal of Alzheimer's Disease
2014	Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis Published In Acta neuropathologica communications
2014	Novel behavioural characteristics of female APPswe/PS1ΔE9 double transgenic mice Published In Behavioural Brain Research
2014	Perturbation of neuronal cobalamin transport by lysosomal enzyme inhibition Published In Bioscience Reports: molecular and cellular biology of the cell surface
2014	Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease Published In Brain: a journal of neurology
2013	An Improved High-Throughput Lipid Extraction Method for the Analysis of Human Brain Lipids Published In Lipids
2013	Analysis of subcellular [57Co] cobalamin distribution in SH-SY5Y neurons and brain tissue Published In Journal of Neuroscience Methods
2013	Assessment of ABCA7 function in Alzheimer's disease models Published In Journal of Neurochemistry
2013	Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease Published In The Journal of Neuroscience
2013	Increased apolipoprotein D dimer formation in Alzheimer’s disease hippocampus is associated with lipid conjugated diene levels Published In Journal of Alzheimer's Disease
2013	Novel behavioural characteristics of the APPSwe/PS1ΔE9 transgenic mouse model of Alzheimer's disease Published In Behavioural Brain Research
2013	P4¿023: Regiospecific loss of essential lipids sphingosine 1¿phosphate and galactosylceramide early in Alzheimer's disease pathogenesis Published In Alzheimer's & Dementia
2012	Amyloid beta selectively modulates neuronal TrkB alternative transcript expression with implications for Alzheimer's disease Published In Neuroscience
2012	Cognitive phenotyping of amyloid precursor protein transgenic J20 mice Published In Behavioural Brain Research
2012	Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues Published In Clinical Science
2012	Evidence that truncated TrkB isoform, TrkB-Shc can regulate phosphorylated TrkB protein levels Published In Biochemical and Biophysical Research Communications
2012	Is Seladin-1 really a selective Alzheimer's disease indicator? Published In Journal of Alzheimer's Disease
2012	Molecular dynamics analysis of apolipoprotein-D - lipid hydroperoxide interactions: mechanism for selective oxidation of Met-93 Published In PLoS One
2012	P3¿076: Lipid antioxidant property of apolipoprotein D and relevance to Alzheimer's disease Published In Alzheimer's & Dementia
2012	P4¿372: Evidence of altered TrkB pre¿mRNA splicing in Alzheimer's disease Published In Alzheimer's & Dementia
2012	Role of abca7 in mouse behaviours relevant to neurodegenerative diseases Published In PLoS One
2012	Selective reduction of hydroperoxyeicosatetraenoic acids to their hydroxy derivatives by apolipoprotein D: implications for lipid antioxidant activity and Alzheimer's disease Published In Biochemical Journal
2012	Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content Published In PLoS One
2012	Srp20 regulates TrkB pre-mRNA splicing to generate TrkB-Shc transcripts with implications for Alzheimer's disease Published In Journal of Neurochemistry
2012	The therapeutic potential of the endocannabinoid system for Alzheimer's disease Published In Expert Opinion on Therapeutic Targets
2011	Age-related lysosomal dysfunction: an unrecognized roadblock for cobalamin trafficking? Published In Cellular and Molecular Life Sciences
2011	Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation Published In American Journal of Pathology
2011	Isoform-specific proteolysis of apolipoprotein-E in the brain Published In Neurobiology of Aging
2011	Lipid pathway alterations in Parkinson's Disease primary visual cortex Published In PLoS One
2011	Mass and relative elution time profiling: Two-dimensional analysis of sphingolipids in Alzheimer's disease brains Published In Biochemical Journal
2011	P3¿170: TrkB alternative transcript expression in Alzheimer's disease Published In Alzheimer's & Dementia
2011	P3¿179: Elucidating the anti¿oxidant function of apoD: Relevance to Alzheimer's disease Published In Alzheimer's & Dementia
2011	Wild type and Tangier disease ABCA1 mutants modulate cellular amyloid-beta production independent of cholesterol efflux activity Published In Journal of Alzheimer's Disease
2010	Apolipoproteins in the brain: implications for neurological and psychiatric disorders Published In Clinical Lipidology
2010	Increased ATP-binding cassette transporter A1 expression in Alzheimer's disease hippocampal neurons Published In Journal of Alzheimer's Disease
2010	Increased expression of the lysosomal cholesterol transporter NPC1 in Alzheimer's disease Published In BBA: Molecular and Cell Biology of Lipids
2010	Lipids and Alzheimer's disease Published In BBA: Molecular and Cell Biology of Lipids
2010	Modulation of amyloid precursor protein processing by synthetic ceramide analogues Published In BBA: Molecular and Cell Biology of Lipids
2010	Myriocin-mediated up-regulation of hepatocyte apoA-I synthesis is associated with ERK inhibition Published In Clinical Science
2010	P2¿211: Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation Published In Alzheimer's & Dementia
2010	P4¿153: Increased Expression of the Lysosomal Cholesterol Transporter NPC1 in Alzheimer's Disease Published In Alzheimer's & Dementia
2010	The kynurenine pathway and inflammation in amyotrophic lateral sclerosis Published In Neurotoxicity Research
2010	Vascular pharmacotherapy and dementia Published In Current and Vascular Pharmacology
2009	Abstract: P405 ANTI-ATHEROGENIC MECHANISMS OF SPHINGOLIPID SYNTHESIS INHIBITOR MYRIOCIN IN HEPATOCYTES Published In Atherosclerosis Supplements
2009	Apolipoprotein-D expression is increased during development and maturation of the human prefrontal cortex Published In Journal of Neurochemistry
2009	Apolipoprotein-E forms dimers in human frontal cortex and hippocampus Published In BMC Neuroscience
2009	Impact of 27-hydroxycholesterol on amyloid-beta peptide production and ATP-binding cassette transporter expression in primary human neurons Published In Journal of Alzheimer's Disease
2009	P1¿005: ATP¿binding cassette transporter A7 inhibits amyloid¿beta production in vitro Published In Alzheimer's & Dementia
2009	S5¿02¿04: Actions of apoE and ABC transporters on APP processing Published In Alzheimer's & Dementia
2008	ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro Published In Journal of Neurochemistry
2008	Analysis of apolipoprotein E nuclear localization using green fluorescent protein and biotinylation approaches Published In Biochemical Journal
2008	Macrophage apolipoprotein-E knockdown modulates caspase-3 activation without altering sensitivity to apoptosis Published In BBA: General Subjects
2008	Modulation of brain metabolism by very low concentrations of the commonly used drug delivery vehicle dimethyl sulfoxide (DMSO) Published In Journal of Neuroscience Research
2008	Myriocin as an atherosclerosis inhibitor Published In Clinical Lipidology
2008	Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mice Published In Journal of Lipid Research
2008	P3¿294: Post¿translational modifications of apolipoprotein¿e in the human brain Published In Alzheimer's & Dementia
2008	Reduction of plasma glycosphingolipid levels has no impact on atherosclerosis in apolipoprotein E-null mice Published In Journal of Lipid Research
2008	Regulation of alpha-synuclein expression by liver X receptor ligands in vitro Published In NeuroReport
2008	Role of ATP-binding cassette transporters in brain lipid transport and neurological disease Published In Journal of Neurochemistry
2008	The comparative biology of neuromelanin and lipofuscin in the human brain Published In Cellular and Molecular Life Sciences
2007	ALANINE METABOLISM, TRANSPORT AND CYCLING IN THE BRAIN Published In Journal of Neurochemistry
2007	Alanine metabolism, transport, and cycling in the brain Published In Journal of Neurochemistry
2007	Apoptosis induces neuronal apolipoprotein-E synthesis and localization in apoptotic bodies Published In Neuroscience Letters
2007	Characterization of the kynurenine pathway in human neurons. Published In The Journal of neuroscience : the official journal of the Society for Neuroscience
2007	Inhibition of atherosclerosis by the serine palmitoyl transferase inhibitor myriocin is associated with reduced plasma glycosphingolipid concentration Published In Biochemical Pharmacology
2007	Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-β peptide generation Published In Journal of Biological Chemistry
2006	09-02 Interaction of apolipoprotein-E with ATP-binding cassette transporters: Impact on neuronal cholesterol homeostasis and amyloid-beta peptide generation. Published In Acta neuropsychiatrica
2004	Heterogeneous expression of apolipoprotein-E by human macrophages. Published In Immunology
2004	Induction of fibroblast apolipoprotein E expression during apoptosis, starvation-induced growth arrest and mitosis. Published In The Biochemical journal
1999	Human endothelial cell attachment to and growth on polypyrrole-heparin is vitronectin dependent Published In Journal of Materials Science: Materials in Medicine
1999	Human lens coloration and aging. Evidence for crystallin modification by the major ultraviolet filter, 3-hydroxy-kynurenine O-ß-D-glucoside Published In Journal of Biological Chemistry
1999	Identification of glutathionyl-3-hydroxykynurenine glucoside as a novel fluorophore associated with aging of the human lens Published In Journal of Biological Chemistry
1999	Polypyrrole-heparin composites as stimulus-responsive substrates for endothelial cell growth Published In Journal of Biomedical Materials Research
1999	Redox availability of lens iron and copper: Implications for HO^. generation in cataract Published In Redox Report
1998	Endogenous ferritin protects cells with iron-laden lysosomes against oxidative stress Published In Free Radical Research
1998	Oxidation of high density lipoproteins. I. Formation of methionine sulfoxide in apolipoproteins AI and AII is an early event that accompanies lipid peroxidation and can be enhanced by alpha-tocopherol. Published In The Journal of biological chemistry
1998	Oxidation of high density lipoproteins. II. Evidence for direct reduction of lipid hydroperoxides by methionine residues of apolipoproteins AI and AII. Published In The Journal of biological chemistry
1997	Direct copper reduction by macrophages. Its role in low density lipoprotein oxidation. Published In The Journal of biological chemistry
1997	On the cytoprotective role of ferritin in macrophages and its ability to enhance lysosomal stability Published In Free Radical Research
1997	Regulation of serum-induced lipid accumulation in human monocyte-derived macrophages by interferon-gamma. Correlations with apolipoprotein E production, lipoprotein lipase activity and LDL receptor-related protein expression. Published In Atherosclerosis
1996	Cell-mediated oxidation of low-density lipoprotein: the elusive mechanism(s). Published In Redox report : communications in free radical research
1994	Human macrophage-mediated oxidation of low-density lipoprotein is delayed and independent of superoxide production. Published In The Biochemical journal
1994	Inhibition by interferon-gamma of human mononuclear cell-mediated low density lipoprotein oxidation. Participation of tryptophan metabolism along the kynurenine pathway. Published In The Journal of clinical investigation

Chapter

Year	Title
2007	Lipid content determines aggregation of neuromelanin granules in vitro. Published In Journal of neural transmission. Supplementum Publisher Springer Vienna
1998	Metal Reduction By Macrophages Published In Plasma Membrane Redox Systems and their Role in Biological Stress and Disease Publisher Springer Netherlands

Conference Paper

Year	Title
2013	Age-related lysosomal alterations perturb intracellular cobalamin trafficking Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
2013	Antioxidant properties of Apolipoprotein-D methionine- and selenomethioninecontaining peptides Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
2013	Deletion of abca7 increases cerebral amyloid-β deposition in the J20 mouse model of Alzheimer’s disease Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
2013	Development of subcellular fractionation techniques to determine the intracellular cobalamin transit in vitro and the impact of lysosomal dysfunction Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
2013	Global fatty acid composition is altered in Parkinson’s disease anterior cingulate cortex Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
2013	Improved GC-MS methods for analysis of homocysteine, methionine and methylmalonate in cultured cells Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
2010	Lipidomic assessment of Parkinson's disease brain Published In Australian Neuroscience Society Annual Meeting, Sydney 2010

Investigator On

Year	Title
2018 - 2021	Cannabidiol (CBD): A novel therapeutic for Alzheimer's disease? Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2016 - 2020	Defining the mechanisms by which ABCA7 and apoE control Alzheimer's disease risk. Functional characterisation of new therapeutic targets for dementia prevention and treatment Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Research Fellowships
2016 - 2018	Restoring neuroprotective sphingosine 1 - phosphate signalling in Alzheimer's Disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2015 - 2018	Isoform-dependent apoE processing by human induced pluripotent stem cells. A novel pathway linking APOE genotype and Alzheimer's disease risk Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2014 - 2017	Supporting a friend: the role of the molecular scaffold CoREST family in chromatin regulation and neuroprotection Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2016	Contributions to Leica Dmi8 microscope Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2014 - 2015	NHMRC SRFA Fellowship Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Research Fellowships
2014	COUNTESS 11 FL Cell Counter and Qubit Quant Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2014	Lysosomal dysfunction as an inhibitor of vitamin B12 utilisation in neurodegenerative diseases Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2014	Regional flow cytometry facility Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2013	A novel intracellular roadblock to cobalamin utilization in ageing and Alzheimer's disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2013	Neon Transfection System: Workstation for transfer of genetic material into hard-to-work-with cells Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2011 - 2013	Defining the function of apolipoprotein-D in Alzheimer's disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2012	Altered myelin sphingolipid homeostasis in Alzheimer's Disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2012	Integrated facility for confocal imaging and single molecule flourescence analysis Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2011	Cellular effects of glucocerebrosidase (GBA) mutations in Lewy body diseases Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2011	Eppendorf MasterCycler Pro thermocycler Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2009	Regulation of amyloid-beta production by glycosphingolipid synthesis inhibition Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2009	Targetting brain lipid homeostasis to treat Alzheimer's disease Awarded by: Australian Research Council (ARC) Funding Scheme: Future Fellowships
	Lumenera Infinity 2-5 microscope colour camera Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Understanding the Structure of Native Apolipoprotein-D Using an Integrative Structural Approach	Kielkopf, Claudia

Orcid Id

http://orcid.org/0000-0002-5312-4352 (confirmed)

Top Publications

Year	Title
2018	The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis Published in Journal of Biological Chemistry
2015	Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice Published in Neurobiology of Aging
2014	Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease Published in Brain: a journal of neurology
2013	Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease Published in The Journal of Neuroscience

Research Areas

Selected Publications

Journal Article

Year	Title
2021	Generation of APOE knock-down SK-N-SH human neuroblastoma cells using CRISPR/Cas9: a novel cellular model relevant to Alzheimer¿s disease research Published In Bioscience Reports
2021	Small angle X-ray scattering analysis of ligand-bound forms of tetrameric apolipoprotein-D Published In Bioscience Reports
2020	Chronic Treatment with 50 mg/kg Cannabidiol Improves Cognition and Moderately Reduces Aβ40 Levels in 12-Month-Old Male AβPPswe/PS1ΔE9 Transgenic Mice Published In Journal of Alzheimer's Disease
2020	Chronic cannabidiol (CBD) treatment did not exhibit beneficial effects in 4-month-old male TAU58/2 transgenic mice Published In Pharmacology, Biochemistry and Behavior
2019	Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease Published In The Journal of Neuroscience
2018	Effect of Fluvoxamine on Amyloid-β Peptide Generation and Memory Published In Journal of Alzheimer's Disease
2018	Identification of a novel tetrameric structure for human apolipoprotein-D Published In Journal of Structural Biology
2018	The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis Published In Journal of Biological Chemistry
2018	Understanding the Role of ApoE Fragments in Alzheimer’s Disease Published In Neurochemical Research
2018	Wnt is here! Could Wnt signalling be promoted to protect against Alzheimer disease? Published In Journal of Neurochemistry
2017	The therapeutic potential of the phytocannabinoid cannabidiol for Alzheimer's disease Published In Behavioural Pharmacology
2016	ABCA7 deletion does not affect adult neurogenesis in the mouse Published In Bioscience Reports: molecular and cellular biology of the cell surface
2016	Beneficial effects of increased lysozyme levels in Alzheimer's disease modelled in Drosophila melanogaster Published In The Federation of European Biochemical Societies (FEBS) Journal
2016	Cell type-specific modulation of cobalamin uptake by bovine serum Published In PLoS One
2016	Cell type-specific modulation of cobalamin uptake by bovine serumc Published In PLoS One
2016	Cerebral apolipoprotein-D is hypoglycosylated compared to peripheral tissues and is variably expressed in mouse and human brain regions Published In PLoS One
2016	Evidence for altered cholesterol metabolism in Huntington's disease post mortem brain tissue Published In Neuropathology and Applied Neurobiology
2016	Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease Published In Neurobiology of Aging
2016	Therapeutic Effects of Anthocyanins and Environmental Enrichment in R6/1 Huntington's Disease Mice Published In Journal of Huntington's Disease
2015	Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice Published In Neurobiology of Aging
2015	Brain cholesterol synthesis and metabolism is progressively disturbed in the R6/1 mouse model of Huntington's disease: a targeted GC-MS/MS sterol analysis Published In Journal of Huntington's Disease
2015	Fatty acid composition of the anterior cingulate cortex indicates a high susceptibility to lipid peroxidation in Parkinson's disease Published In Journal of Parkinson's Disease
2015	Impaired lysosomal cobalamin transport in Alzheimer's disease Published In Journal of Alzheimer's Disease
2015	Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson's disease Published In Movement Disorders
2015	Understanding the function of ABCA7 in Alzheimer's disease Published In Biochemical Society Transactions
2014	Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson’s disease Published In Movement Disorders
2014	Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1ΔE9 mice Published In Psychopharmacology
2014	Long-term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimer's disease transgenic mice Published In Journal of Alzheimer's Disease
2014	Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis Published In Acta neuropathologica communications
2014	Novel behavioural characteristics of female APPswe/PS1ΔE9 double transgenic mice Published In Behavioural Brain Research
2014	Perturbation of neuronal cobalamin transport by lysosomal enzyme inhibition Published In Bioscience Reports: molecular and cellular biology of the cell surface
2014	Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease Published In Brain: a journal of neurology
2013	An Improved High-Throughput Lipid Extraction Method for the Analysis of Human Brain Lipids Published In Lipids
2013	Analysis of subcellular [57Co] cobalamin distribution in SH-SY5Y neurons and brain tissue Published In Journal of Neuroscience Methods
2013	Assessment of ABCA7 function in Alzheimer's disease models Published In Journal of Neurochemistry
2013	Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease Published In The Journal of Neuroscience
2013	Increased apolipoprotein D dimer formation in Alzheimer’s disease hippocampus is associated with lipid conjugated diene levels Published In Journal of Alzheimer's Disease
2013	Novel behavioural characteristics of the APPSwe/PS1ΔE9 transgenic mouse model of Alzheimer's disease Published In Behavioural Brain Research
2013	P4¿023: Regiospecific loss of essential lipids sphingosine 1¿phosphate and galactosylceramide early in Alzheimer's disease pathogenesis Published In Alzheimer's & Dementia
2012	Amyloid beta selectively modulates neuronal TrkB alternative transcript expression with implications for Alzheimer's disease Published In Neuroscience
2012	Cognitive phenotyping of amyloid precursor protein transgenic J20 mice Published In Behavioural Brain Research
2012	Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues Published In Clinical Science
2012	Evidence that truncated TrkB isoform, TrkB-Shc can regulate phosphorylated TrkB protein levels Published In Biochemical and Biophysical Research Communications
2012	Is Seladin-1 really a selective Alzheimer's disease indicator? Published In Journal of Alzheimer's Disease
2012	Molecular dynamics analysis of apolipoprotein-D - lipid hydroperoxide interactions: mechanism for selective oxidation of Met-93 Published In PLoS One
2012	P3¿076: Lipid antioxidant property of apolipoprotein D and relevance to Alzheimer's disease Published In Alzheimer's & Dementia
2012	P4¿372: Evidence of altered TrkB pre¿mRNA splicing in Alzheimer's disease Published In Alzheimer's & Dementia
2012	Role of abca7 in mouse behaviours relevant to neurodegenerative diseases Published In PLoS One
2012	Selective reduction of hydroperoxyeicosatetraenoic acids to their hydroxy derivatives by apolipoprotein D: implications for lipid antioxidant activity and Alzheimer's disease Published In Biochemical Journal
2012	Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content Published In PLoS One
2012	Srp20 regulates TrkB pre-mRNA splicing to generate TrkB-Shc transcripts with implications for Alzheimer's disease Published In Journal of Neurochemistry
2012	The therapeutic potential of the endocannabinoid system for Alzheimer's disease Published In Expert Opinion on Therapeutic Targets
2011	Age-related lysosomal dysfunction: an unrecognized roadblock for cobalamin trafficking? Published In Cellular and Molecular Life Sciences
2011	Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation Published In American Journal of Pathology
2011	Isoform-specific proteolysis of apolipoprotein-E in the brain Published In Neurobiology of Aging
2011	Lipid pathway alterations in Parkinson's Disease primary visual cortex Published In PLoS One
2011	Mass and relative elution time profiling: Two-dimensional analysis of sphingolipids in Alzheimer's disease brains Published In Biochemical Journal
2011	P3¿170: TrkB alternative transcript expression in Alzheimer's disease Published In Alzheimer's & Dementia
2011	P3¿179: Elucidating the anti¿oxidant function of apoD: Relevance to Alzheimer's disease Published In Alzheimer's & Dementia
2011	Wild type and Tangier disease ABCA1 mutants modulate cellular amyloid-beta production independent of cholesterol efflux activity Published In Journal of Alzheimer's Disease
2010	Apolipoproteins in the brain: implications for neurological and psychiatric disorders Published In Clinical Lipidology
2010	Increased ATP-binding cassette transporter A1 expression in Alzheimer's disease hippocampal neurons Published In Journal of Alzheimer's Disease
2010	Increased expression of the lysosomal cholesterol transporter NPC1 in Alzheimer's disease Published In BBA: Molecular and Cell Biology of Lipids
2010	Lipids and Alzheimer's disease Published In BBA: Molecular and Cell Biology of Lipids
2010	Modulation of amyloid precursor protein processing by synthetic ceramide analogues Published In BBA: Molecular and Cell Biology of Lipids
2010	Myriocin-mediated up-regulation of hepatocyte apoA-I synthesis is associated with ERK inhibition Published In Clinical Science
2010	P2¿211: Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation Published In Alzheimer's & Dementia
2010	P4¿153: Increased Expression of the Lysosomal Cholesterol Transporter NPC1 in Alzheimer's Disease Published In Alzheimer's & Dementia
2010	The kynurenine pathway and inflammation in amyotrophic lateral sclerosis Published In Neurotoxicity Research
2010	Vascular pharmacotherapy and dementia Published In Current and Vascular Pharmacology
2009	Abstract: P405 ANTI-ATHEROGENIC MECHANISMS OF SPHINGOLIPID SYNTHESIS INHIBITOR MYRIOCIN IN HEPATOCYTES Published In Atherosclerosis Supplements
2009	Apolipoprotein-D expression is increased during development and maturation of the human prefrontal cortex Published In Journal of Neurochemistry
2009	Apolipoprotein-E forms dimers in human frontal cortex and hippocampus Published In BMC Neuroscience
2009	Impact of 27-hydroxycholesterol on amyloid-beta peptide production and ATP-binding cassette transporter expression in primary human neurons Published In Journal of Alzheimer's Disease
2009	P1¿005: ATP¿binding cassette transporter A7 inhibits amyloid¿beta production in vitro Published In Alzheimer's & Dementia
2009	S5¿02¿04: Actions of apoE and ABC transporters on APP processing Published In Alzheimer's & Dementia
2008	ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro Published In Journal of Neurochemistry
2008	Analysis of apolipoprotein E nuclear localization using green fluorescent protein and biotinylation approaches Published In Biochemical Journal
2008	Macrophage apolipoprotein-E knockdown modulates caspase-3 activation without altering sensitivity to apoptosis Published In BBA: General Subjects
2008	Modulation of brain metabolism by very low concentrations of the commonly used drug delivery vehicle dimethyl sulfoxide (DMSO) Published In Journal of Neuroscience Research
2008	Myriocin as an atherosclerosis inhibitor Published In Clinical Lipidology
2008	Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mice Published In Journal of Lipid Research
2008	P3¿294: Post¿translational modifications of apolipoprotein¿e in the human brain Published In Alzheimer's & Dementia
2008	Reduction of plasma glycosphingolipid levels has no impact on atherosclerosis in apolipoprotein E-null mice Published In Journal of Lipid Research
2008	Regulation of alpha-synuclein expression by liver X receptor ligands in vitro Published In NeuroReport
2008	Role of ATP-binding cassette transporters in brain lipid transport and neurological disease Published In Journal of Neurochemistry
2008	The comparative biology of neuromelanin and lipofuscin in the human brain Published In Cellular and Molecular Life Sciences
2007	ALANINE METABOLISM, TRANSPORT AND CYCLING IN THE BRAIN Published In Journal of Neurochemistry
2007	Alanine metabolism, transport, and cycling in the brain Published In Journal of Neurochemistry
2007	Apoptosis induces neuronal apolipoprotein-E synthesis and localization in apoptotic bodies Published In Neuroscience Letters
2007	Characterization of the kynurenine pathway in human neurons. Published In The Journal of neuroscience : the official journal of the Society for Neuroscience
2007	Inhibition of atherosclerosis by the serine palmitoyl transferase inhibitor myriocin is associated with reduced plasma glycosphingolipid concentration Published In Biochemical Pharmacology
2007	Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-β peptide generation Published In Journal of Biological Chemistry
2006	09-02 Interaction of apolipoprotein-E with ATP-binding cassette transporters: Impact on neuronal cholesterol homeostasis and amyloid-beta peptide generation. Published In Acta neuropsychiatrica
2004	Heterogeneous expression of apolipoprotein-E by human macrophages. Published In Immunology
2004	Induction of fibroblast apolipoprotein E expression during apoptosis, starvation-induced growth arrest and mitosis. Published In The Biochemical journal
1999	Human endothelial cell attachment to and growth on polypyrrole-heparin is vitronectin dependent Published In Journal of Materials Science: Materials in Medicine
1999	Human lens coloration and aging. Evidence for crystallin modification by the major ultraviolet filter, 3-hydroxy-kynurenine O-ß-D-glucoside Published In Journal of Biological Chemistry
1999	Identification of glutathionyl-3-hydroxykynurenine glucoside as a novel fluorophore associated with aging of the human lens Published In Journal of Biological Chemistry
1999	Polypyrrole-heparin composites as stimulus-responsive substrates for endothelial cell growth Published In Journal of Biomedical Materials Research
1999	Redox availability of lens iron and copper: Implications for HO^. generation in cataract Published In Redox Report
1998	Endogenous ferritin protects cells with iron-laden lysosomes against oxidative stress Published In Free Radical Research
1998	Oxidation of high density lipoproteins. I. Formation of methionine sulfoxide in apolipoproteins AI and AII is an early event that accompanies lipid peroxidation and can be enhanced by alpha-tocopherol. Published In The Journal of biological chemistry
1998	Oxidation of high density lipoproteins. II. Evidence for direct reduction of lipid hydroperoxides by methionine residues of apolipoproteins AI and AII. Published In The Journal of biological chemistry
1997	Direct copper reduction by macrophages. Its role in low density lipoprotein oxidation. Published In The Journal of biological chemistry
1997	On the cytoprotective role of ferritin in macrophages and its ability to enhance lysosomal stability Published In Free Radical Research
1997	Regulation of serum-induced lipid accumulation in human monocyte-derived macrophages by interferon-gamma. Correlations with apolipoprotein E production, lipoprotein lipase activity and LDL receptor-related protein expression. Published In Atherosclerosis
1996	Cell-mediated oxidation of low-density lipoprotein: the elusive mechanism(s). Published In Redox report : communications in free radical research
1994	Human macrophage-mediated oxidation of low-density lipoprotein is delayed and independent of superoxide production. Published In The Biochemical journal
1994	Inhibition by interferon-gamma of human mononuclear cell-mediated low density lipoprotein oxidation. Participation of tryptophan metabolism along the kynurenine pathway. Published In The Journal of clinical investigation

Chapter

Year	Title
2007	Lipid content determines aggregation of neuromelanin granules in vitro. Published In Journal of neural transmission. Supplementum Publisher Springer Vienna
1998	Metal Reduction By Macrophages Published In Plasma Membrane Redox Systems and their Role in Biological Stress and Disease Publisher Springer Netherlands

Conference Paper

Year	Title
2013	Age-related lysosomal alterations perturb intracellular cobalamin trafficking Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
2013	Antioxidant properties of Apolipoprotein-D methionine- and selenomethioninecontaining peptides Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
2013	Deletion of abca7 increases cerebral amyloid-β deposition in the J20 mouse model of Alzheimer’s disease Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
2013	Development of subcellular fractionation techniques to determine the intracellular cobalamin transit in vitro and the impact of lysosomal dysfunction Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
2013	Global fatty acid composition is altered in Parkinson’s disease anterior cingulate cortex Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
2013	Improved GC-MS methods for analysis of homocysteine, methionine and methylmalonate in cultured cells Published In 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants
2010	Lipidomic assessment of Parkinson's disease brain Published In Australian Neuroscience Society Annual Meeting, Sydney 2010

Investigator On

Year	Title
2018 - 2021	Cannabidiol (CBD): A novel therapeutic for Alzheimer's disease? Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2016 - 2020	Defining the mechanisms by which ABCA7 and apoE control Alzheimer's disease risk. Functional characterisation of new therapeutic targets for dementia prevention and treatment Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Research Fellowships
2016 - 2018	Restoring neuroprotective sphingosine 1 - phosphate signalling in Alzheimer's Disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2015 - 2018	Isoform-dependent apoE processing by human induced pluripotent stem cells. A novel pathway linking APOE genotype and Alzheimer's disease risk Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2014 - 2017	Supporting a friend: the role of the molecular scaffold CoREST family in chromatin regulation and neuroprotection Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2016	Contributions to Leica Dmi8 microscope Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2014 - 2015	NHMRC SRFA Fellowship Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Research Fellowships
2014	COUNTESS 11 FL Cell Counter and Qubit Quant Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2014	Lysosomal dysfunction as an inhibitor of vitamin B12 utilisation in neurodegenerative diseases Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2014	Regional flow cytometry facility Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2013	A novel intracellular roadblock to cobalamin utilization in ageing and Alzheimer's disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2013	Neon Transfection System: Workstation for transfer of genetic material into hard-to-work-with cells Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2011 - 2013	Defining the function of apolipoprotein-D in Alzheimer's disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2012	Altered myelin sphingolipid homeostasis in Alzheimer's Disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2012	Integrated facility for confocal imaging and single molecule flourescence analysis Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2011	Cellular effects of glucocerebrosidase (GBA) mutations in Lewy body diseases Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2011	Eppendorf MasterCycler Pro thermocycler Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2009	Regulation of amyloid-beta production by glycosphingolipid synthesis inhibition Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2009	Targetting brain lipid homeostasis to treat Alzheimer's disease Awarded by: Australian Research Council (ARC) Funding Scheme: Future Fellowships
	Lumenera Infinity 2-5 microscope colour camera Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Understanding the Structure of Native Apolipoprotein-D Using an Integrative Structural Approach	Kielkopf, Claudia

Orcid Id

http://orcid.org/0000-0002-5312-4352 (confirmed)

Garner, Brett Prof.

NHMRC Senior Research Fellow

Overview

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Overview

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