Buckley, Ben J.

Overview

Year	Title
2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer Published in Journal of Medicinal Chemistry
2019	The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets Published in Current Drug Targets

Year

Title

2018

6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer
Published in Journal of Medicinal Chemistry

2019

The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets
Published in Current Drug Targets

Affiliation

Publications

Selected Publications

Journal Article

Year	Title
2022	An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis Published In Communications Biology
2022	Disruption of Water Networks is the Cause of Human/Mouse Species Selectivity in Urokinase Plasminogen Activator (uPA) Inhibitors Derived from Hexamethylene Amiloride (HMA) Published In Journal of Medicinal Chemistry
2022	The Urokinase Plasminogen Activation System in Pancreatic Cancer: Prospective Diagnostic and Therapeutic Targets Published In Biomolecules
2022	Urokinase plasminogen activator as an anti-metastasis target: inhibitor design principles, recent amiloride derivatives, and issues with human/mouse species selectivity Published In Biophysical Reviews
2021	Novel amiloride derivatives that inhibit bacterial motility across multiple strains and stator types Published In Journal of Bacteriology
2021	Roles of the na⁺/h⁺ exchanger isoform 1 and urokinase in prostate cancer cell migration and invasion Published In International Journal of Molecular Sciences
2021	Screening of 5- and 6-substituted amiloride libraries identifies dual-UPA/NHE1 active and single target-selective inhibitors Published In International Journal of Molecular Sciences
2021	Systematic evaluation of structure¿property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride Published In Bioorganic and Medicinal Chemistry
2021	Targeting the urokinase plasminogen activator (uPA) pathway inhibits pancreatic cancer progression Published In Pancreatology
2020	6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease Published In Bioorganic and Medicinal Chemistry Letters
2020	The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets Published In Current Drug Targets
2019	6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease Published In Bioorganic and Medicinal Chemistry Letters
2019	The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets Published In Current Drug Targets
2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer Published In Journal of Medicinal Chemistry
2016	5′-substituted amiloride derivatives as allosteric modulators binding in the sodium ion pocket of the adenosine A_2A receptor Published In Journal of Medicinal Chemistry

Funding

Year	Title
	Novel uPA-targeting small molecules for the treatment of rheumatoid arthritis Awarded by: Arthritis Australia Funding Scheme: Grant-in-Aid

Year

Title

Novel uPA-targeting small molecules for the treatment of rheumatoid arthritis

Awarded by:

Arthritis Australia

Funding Scheme:

Grant-in-Aid

Supervision

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Pharmacological Profiling of Amiloride Analogues as Inhibitors of the Urokinase Plasminogen Activation System in Pancreatic Ductal Adenocarcinoma	Kumar, Ashna

Overview

Year	Title
2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer Published in Journal of Medicinal Chemistry
2019	The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets Published in Current Drug Targets

Year

Title

2018

6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer
Published in Journal of Medicinal Chemistry

2019

The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets
Published in Current Drug Targets

Affiliation

Publications

Year

Title

2022

An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis

Published In

Communications Biology

2022

Disruption of Water Networks is the Cause of Human/Mouse Species Selectivity in Urokinase Plasminogen Activator (uPA) Inhibitors Derived from Hexamethylene Amiloride (HMA)

Published In

Journal of Medicinal Chemistry

2022

The Urokinase Plasminogen Activation System in Pancreatic Cancer: Prospective Diagnostic and Therapeutic Targets

Published In

Biomolecules

2022

Urokinase plasminogen activator as an anti-metastasis target: inhibitor design principles, recent amiloride derivatives, and issues with human/mouse species selectivity

Published In

Biophysical Reviews

2021

Novel amiloride derivatives that inhibit bacterial motility across multiple strains and stator types

Published In

Journal of Bacteriology

2021

Roles of the na⁺/h⁺ exchanger isoform 1 and urokinase in prostate cancer cell migration and invasion

Published In

International Journal of Molecular Sciences

2021

Screening of 5- and 6-substituted amiloride libraries identifies dual-UPA/NHE1 active and single target-selective inhibitors

Published In

International Journal of Molecular Sciences

2021

Systematic evaluation of structure¿property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride

Published In

Bioorganic and Medicinal Chemistry

2021

Targeting the urokinase plasminogen activator (uPA) pathway inhibits pancreatic cancer progression

Published In

Pancreatology

2020

6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease

Published In

Bioorganic and Medicinal Chemistry Letters

2020

The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets

Published In

Current Drug Targets

2019

6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease

Published In

Bioorganic and Medicinal Chemistry Letters

2019

The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets

Published In

Current Drug Targets

2018

6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer

Published In

Journal of Medicinal Chemistry

2016

5′-substituted amiloride derivatives as allosteric modulators binding in the sodium ion pocket of the adenosine A_2A receptor

Published In

Journal of Medicinal Chemistry

Funding

Year	Title
	Novel uPA-targeting small molecules for the treatment of rheumatoid arthritis Awarded by: Arthritis Australia Funding Scheme: Grant-in-Aid

Year

Title

Novel uPA-targeting small molecules for the treatment of rheumatoid arthritis

Awarded by:

Arthritis Australia

Funding Scheme:

Grant-in-Aid

Supervision

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Pharmacological Profiling of Amiloride Analogues as Inhibitors of the Urokinase Plasminogen Activation System in Pancreatic Ductal Adenocarcinoma	Kumar, Ashna

Buckley, Ben J. Dr

Associate Lecturer - School of Chemistry and Molecular Bioscience

Overview

Top Publications

Research Areas

Available as Research Supervisor

Affiliation

Available for Collaborative Projects

Member Of

Has Collaborator

Publications

Selected Publications

Journal Article

Funding

Investigator On

Other Research Activities

Supervision

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Overview

Top Publications

Research Areas

Affiliation

Member Of

Has Collaborator

Publications

Selected Publications

Journal Article

Funding

Investigator On

Other Research Activities

Supervision

Advisees

Graduate Advising Relationship

Visualisations

Research Areas