Buckley, Ben J.

Buckley, Ben J. Dr

Associate Lecturer - School of Chemistry and Molecular Bioscience

bbuckley@uow.edu.au

0404408509

Top Publications

Year	Title
2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer Published in Journal of Medicinal Chemistry
2019	The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets Published in Current Drug Targets

Research Areas

Available as Research Supervisor

Available for Collaborative Projects

Member Of

International Society On Thrombosis and Hemostasis Member 2019 -
Australasian Metastasis Research Society (OzMRS) Member 2017 -
Illawarra Health and Medical Research Institute (IHMRI) Affiliate Researcher 2016 -

Has Collaborator

Kelso, Michael Professor
Ranson, Marie Senior Professor

Selected Publications

Journal Article

Year	Title
2022	6-Furopyridine Hexamethylene Amiloride Is a Non-Selective P2X7 Receptor Antagonist Published In Biomolecules
2022	An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis Published In Communications Biology
2022	Disruption of Water Networks is the Cause of Human/Mouse Species Selectivity in Urokinase Plasminogen Activator (uPA) Inhibitors Derived from Hexamethylene Amiloride (HMA) Published In Journal of Medicinal Chemistry
2022	Metastatic phenotype and immunosuppressive tumour microenvironment in pancreatic ductal adenocarcinoma: Key role of the urokinase plasminogen activator (PLAU) Published In Frontiers in Immunology
2022	The Urokinase Plasminogen Activation System in Pancreatic Cancer: Prospective Diagnostic and Therapeutic Targets Published In Biomolecules
2022	Urokinase plasminogen activator as an anti-metastasis target: inhibitor design principles, recent amiloride derivatives, and issues with human/mouse species selectivity Published In Biophysical Reviews
2021	Novel amiloride derivatives that inhibit bacterial motility across multiple strains and stator types Published In Journal of Bacteriology
2021	Roles of the na⁺/h⁺ exchanger isoform 1 and urokinase in prostate cancer cell migration and invasion Published In International Journal of Molecular Sciences
2021	Screening of 5- and 6-substituted amiloride libraries identifies dual-UPA/NHE1 active and single target-selective inhibitors Published In International Journal of Molecular Sciences
2021	Systematic evaluation of structure��property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride Published In Bioorganic and Medicinal Chemistry
2021	Targeting the urokinase plasminogen activator (uPA) pathway inhibits pancreatic cancer progression Published In Pancreatology
2019	6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease Published In Bioorganic and Medicinal Chemistry Letters
2019	The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets Published In Current Drug Targets
2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer Published In Journal of Medicinal Chemistry
2016	5′-substituted amiloride derivatives as allosteric modulators binding in the sodium ion pocket of the adenosine A_2A receptor Published In Journal of Medicinal Chemistry

Conference Paper

Year	Title
2021	Improving delivery of amiloride analogues as uPA selective inhibitors for use in metastatic disease Published In ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
2021	Targeting the Urokinase Plasminogen Activator Pathway in Combination With Chemotherapy Inhibits Pancreatic Cancer Progression Published In PANCREAS
2021	Targeting the urokinase plasminogen activator pathway inhibits pancreatic cancer progression Published In JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
2018	Amiloride Analogues as Inhibitors of Human Urokinase Plasminogen Activator and Anti-Pancreatic Cancer Agents Published In PANCREAS

Investigator On

Year	Title
	Novel uPA-targeting small molecules for the treatment of rheumatoid arthritis Awarded by: Arthritis Australia Funding Scheme: Grant-in-Aid

Other Research Activities

IHMRI Young Investigator Award - High-throughput Screen to Identify Novel Acid-sensing Ion Channel (ASIC) inhibitors Chief Investigator 2019

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Pharmacological Profiling of Amiloride Analogues as Inhibitors of the Urokinase Plasminogen Activation System in Pancreatic Ductal Adenocarcinoma	Kumar, Ashna

Top Publications

Year	Title
2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer Published in Journal of Medicinal Chemistry
2019	The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets Published in Current Drug Targets

Research Areas

Member Of

International Society On Thrombosis and Hemostasis Member 2019 -
Australasian Metastasis Research Society (OzMRS) Member 2017 -
Illawarra Health and Medical Research Institute (IHMRI) Affiliate Researcher 2016 -

Has Collaborator

Kelso, Michael Professor
Ranson, Marie Senior Professor

Selected Publications

Journal Article

Year	Title
2022	6-Furopyridine Hexamethylene Amiloride Is a Non-Selective P2X7 Receptor Antagonist Published In Biomolecules
2022	An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis Published In Communications Biology
2022	Disruption of Water Networks is the Cause of Human/Mouse Species Selectivity in Urokinase Plasminogen Activator (uPA) Inhibitors Derived from Hexamethylene Amiloride (HMA) Published In Journal of Medicinal Chemistry
2022	Metastatic phenotype and immunosuppressive tumour microenvironment in pancreatic ductal adenocarcinoma: Key role of the urokinase plasminogen activator (PLAU) Published In Frontiers in Immunology
2022	The Urokinase Plasminogen Activation System in Pancreatic Cancer: Prospective Diagnostic and Therapeutic Targets Published In Biomolecules
2022	Urokinase plasminogen activator as an anti-metastasis target: inhibitor design principles, recent amiloride derivatives, and issues with human/mouse species selectivity Published In Biophysical Reviews
2021	Novel amiloride derivatives that inhibit bacterial motility across multiple strains and stator types Published In Journal of Bacteriology
2021	Roles of the na⁺/h⁺ exchanger isoform 1 and urokinase in prostate cancer cell migration and invasion Published In International Journal of Molecular Sciences
2021	Screening of 5- and 6-substituted amiloride libraries identifies dual-UPA/NHE1 active and single target-selective inhibitors Published In International Journal of Molecular Sciences
2021	Systematic evaluation of structure��property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride Published In Bioorganic and Medicinal Chemistry
2021	Targeting the urokinase plasminogen activator (uPA) pathway inhibits pancreatic cancer progression Published In Pancreatology
2019	6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease Published In Bioorganic and Medicinal Chemistry Letters
2019	The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets Published In Current Drug Targets
2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer Published In Journal of Medicinal Chemistry
2016	5′-substituted amiloride derivatives as allosteric modulators binding in the sodium ion pocket of the adenosine A_2A receptor Published In Journal of Medicinal Chemistry

Conference Paper

Year	Title
2021	Improving delivery of amiloride analogues as uPA selective inhibitors for use in metastatic disease Published In ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
2021	Targeting the Urokinase Plasminogen Activator Pathway in Combination With Chemotherapy Inhibits Pancreatic Cancer Progression Published In PANCREAS
2021	Targeting the urokinase plasminogen activator pathway inhibits pancreatic cancer progression Published In JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
2018	Amiloride Analogues as Inhibitors of Human Urokinase Plasminogen Activator and Anti-Pancreatic Cancer Agents Published In PANCREAS

Investigator On

Year	Title
	Novel uPA-targeting small molecules for the treatment of rheumatoid arthritis Awarded by: Arthritis Australia Funding Scheme: Grant-in-Aid

Other Research Activities

IHMRI Young Investigator Award - High-throughput Screen to Identify Novel Acid-sensing Ion Channel (ASIC) inhibitors Chief Investigator 2019

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Pharmacological Profiling of Amiloride Analogues as Inhibitors of the Urokinase Plasminogen Activation System in Pancreatic Ductal Adenocarcinoma	Kumar, Ashna

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