Buckley, Benjamin J.

Buckley, Benjamin J. Dr

Associate Lecturer - School of Chemistry and Molecular Bioscience

bbuckley@uow.edu.au

0404408509

Top Publications

Year	Title
2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer Published in Journal of Medicinal Chemistry
2019	The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets Published in Current Drug Targets

Research Areas

Available as Research Supervisor

Available for Collaborative Projects

Member Of

International Society On Thrombosis and Hemostasis Member 2019 -
Australasian Metastasis Research Society (OzMRS) Member 2017 -
Illawarra Health and Medical Research Institute (IHMRI) Affiliate Researcher 2016 -

Has Collaborator

Kelso, Michael J. Professor
Ranson, Marie Professor

Selected Publications

Journal Article

Year	Title
2019	6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease Published In Bioorganic and Medicinal Chemistry Letters Volume 29 Pages 126753-1 - 126753-6 ISSN 0960-894X Altmetric
2019	The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets Published In Current Drug Targets Volume 20 Pages 970 - 981 ISSN 1389-4501 Altmetric
2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer Published In Journal of Medicinal Chemistry Volume 61 Pages 8299 - 8320 ISSN 0022-2623 Altmetric
2016	5′-substituted amiloride derivatives as allosteric modulators binding in the sodium ion pocket of the adenosine A_2A receptor Published In Journal of Medicinal Chemistry Volume 59 Pages 4769 - 4777 ISSN 0022-2623 Altmetric

Investigator On

Year	Title
2019	Novel uPA-targeting small molecules for the treatment of rheumatoid arthritis Awarded by: Arthritis Australia Funding Scheme: Grant-in-Aid

Other Research Activities

IHMRI Young Investigator Award - High-throughput Screen to Identify Novel Acid-sensing Ion Channel (ASIC) inhibitors Chief Investigator 2019

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Biochemical, cell biology and pharmacological evaluation of novel 6-substituted amiloride and 6-substituted hexamethyleneamiloride (HMA) derivatives as new agents for breast cancer	Ali, Umar
Doctor of Philosophy	A Two-Pronged Approach for Treating Ischaemic Reperfusion Injury Following Stroke Using In-house Derived Amiloride Analogues	Kumar, Ashna

Top Publications

Year	Title
2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer Published in Journal of Medicinal Chemistry
2019	The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets Published in Current Drug Targets

Research Areas

Member Of

International Society On Thrombosis and Hemostasis Member 2019 -
Australasian Metastasis Research Society (OzMRS) Member 2017 -
Illawarra Health and Medical Research Institute (IHMRI) Affiliate Researcher 2016 -

Has Collaborator

Kelso, Michael J. Professor
Ranson, Marie Professor

Selected Publications

Journal Article

Year	Title
2019	6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease Published In Bioorganic and Medicinal Chemistry Letters Volume 29 Pages 126753-1 - 126753-6 ISSN 0960-894X Altmetric
2019	The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets Published In Current Drug Targets Volume 20 Pages 970 - 981 ISSN 1389-4501 Altmetric
2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer Published In Journal of Medicinal Chemistry Volume 61 Pages 8299 - 8320 ISSN 0022-2623 Altmetric
2016	5′-substituted amiloride derivatives as allosteric modulators binding in the sodium ion pocket of the adenosine A_2A receptor Published In Journal of Medicinal Chemistry Volume 59 Pages 4769 - 4777 ISSN 0022-2623 Altmetric

Investigator On

Year	Title
2019	Novel uPA-targeting small molecules for the treatment of rheumatoid arthritis Awarded by: Arthritis Australia Funding Scheme: Grant-in-Aid

Other Research Activities

IHMRI Young Investigator Award - High-throughput Screen to Identify Novel Acid-sensing Ion Channel (ASIC) inhibitors Chief Investigator 2019

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Biochemical, cell biology and pharmacological evaluation of novel 6-substituted amiloride and 6-substituted hexamethyleneamiloride (HMA) derivatives as new agents for breast cancer	Ali, Umar
Doctor of Philosophy	A Two-Pronged Approach for Treating Ischaemic Reperfusion Injury Following Stroke Using In-house Derived Amiloride Analogues	Kumar, Ashna

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Investigator Network

Collaborator Map

Research Areas