van Oijen, Antoine M.

Top Publications

Year	Title
2018	The transcription-repair coupling factor Mfd associates with RNA polymerase in the absence of exogenous damage Published in Nature Communications
2017	Single-molecule visualization of conformational changes and substrate transport in the vitamin B12ABC importer BtuCD-F Published in Nature Communications
2017	Single-molecule visualization of fast polymerase turnover in the bacterial replisome Published in eLife
2013	Bacterial replication, transcription and translation: mechanistic insights from single-molecule biochemical studies Published in Nature Reviews Microbiology
2013	Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters Published in Nature
2012	A general approach to break the concentration barrier in single-molecule imaging Published in Nature Methods
2009	Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis Published in Nature

Research Areas

Research Overview

Antoine van Oijen obtained his BSc and PhD degrees in the Netherlands, where he was trained as a physicist. A growing fascination for biology resulted in him moving to the USA and establishing a research group at Harvard Medical School. Subsequently, he was appointed as full professor at Groningen University in the Netherlands where he established a thriving biophysics research program focused on the development of single-molecule visualization techniques and their applications in basic and applied science. Recently, he moved to the UOW and was awarded a prestigious Laureate Fellowship by the Australian Research Council to further develop biophysical approaches to visualize the molecular processes that define life.

Selected Publications

Journal Article

Year	Title
2019	Identification of Multiple Kinetic Populations of DNA-Binding Proteins in Live Cells Published In Biophysical Journal Volume 117 Pages 950 - 961 ISSN 0006-3495 Altmetric
2019	Nuclease dead Cas9 is a programmable roadblock for DNA replication Published In Scientific Reports Volume 9 Pages 13292-1 - 13292-9 ISSN 2045-2322 Altmetric
2019	RecFOR epistasis group: RecF and RecO have distinct localizations and functions in Escherichia coli Published In Nucleic Acids Research Volume 47 Pages 2946 - 2965 ISSN 0305-1048 Altmetric
2019	Recycling of single-stranded DNA-binding protein by the bacterial replisome Published In Nucleic Acids Research Volume 47 Pages 4111 - 4123 ISSN 0305-1048 Altmetric
2019	Shining a spotlight on DNA: Single-molecule methods to visualise DNA Published In Molecules Volume 24 Pages 491-1 - 491-20 ISSN 1420-3049 Altmetric
2019	Spatial and temporal organization of RecA in the Escherichia coli DNA-damage response Published In eLife Volume 8 Pages e42761-1 - e42761-37 ISSN 2050-084X Altmetric
2019	Spy-ing on Cas9: Single-molecule tools reveal the enzymology of Cas9 Published In Current Opinion in Biomedical Engineering Volume 12 Pages 25 - 33 Altmetric
2019	The drivers of antibiotic use and misuse: the development and investigation of a theory driven community measure Published In BMC Public Health Volume 19 Pages 1425-1 - 1425-11 ISSN 1471-2458 Altmetric
2019	When proteins play tag: the dynamic nature of the replisome Published In Biophysical Reviews Volume Online First Pages 1 - 11 Altmetric
2018	Anisotropic functionalization of upconversion nanoparticles Published In Chemical Science Volume 9 Pages 4352 - 4358 ISSN 2041-6520 Altmetric
2018	DNA polymerase IV primarily operates outside of DNA replication forks in Escherichia coli Published In PLoS Genetics Volume 14 Pages e1007161-1 - e1007161-29 ISSN 1553-7404 Altmetric
2018	Design of DNA rolling-circle templates with controlled fork topology to study mechanisms of DNA replication Published In Analytical Biochemistry Volume 557 Pages 42 - 45 ISSN 0003-2697 Altmetric
2018	Detection of kinetic change points in piece-wise linear single molecule motion Published In Journal of Chemical Physics Volume 148 Pages 123317-1 - 123317-9 ISSN 0021-9606 Altmetric
2018	Nanoparticles for super-resolution microscopy and single-molecule tracking Published In Nature Methods Volume 15 Pages 415 - 423 ISSN 1548-7091 Altmetric
2018	Quantification of ligand density and stoichiometry on the surface of liposomes using single-molecule fluorescence imaging Published In Journal of Controlled Release Volume 278 Pages 80 - 86 ISSN 0168-3659 Altmetric
2018	Single-molecule live-cell imaging of bacterial DNA repair and damage tolerance Published In Biochemical Society Transactions Volume 46 Pages 23 - 35 ISSN 0300-5127 Altmetric
2018	Single-particle fusion of influenza viruses reveals complex interactions with target membranes Published In Journal of Physics: Condensed Matter Volume 30 Pages 204005-1 - 204005-7 ISSN 0953-8984 Altmetric
2018	Special Issue on Cell Biophysics Published In Biophysical Journal Volume 115 Pages E01 - E02 ISSN 0006-3495 Altmetric
2018	Specialised DNA polymerases in Escherichia coli: roles within multiple pathways Published In Current Genetics: lower eukaryotes and organelles Volume Online First Pages 1 - 8 ISSN 0172-8083 Altmetric
2018	The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity Published In Journal of Biological Chemistry Volume 293 Pages 4486 - 4497 ISSN 0021-9258 Altmetric
2018	The transcription-repair coupling factor Mfd associates with RNA polymerase in the absence of exogenous damage Published In Nature Communications Volume 9 Pages 1570-1 - 1570-12 ISSN 2041-1723 Altmetric
2018	Using single-molecule approaches to understand the molecular mechanisms of heat-shock protein chaperone function Published In American Journal of Molecular Biology Volume 430 Pages 4525 - 4546 Altmetric
2017	Architecture of the Nucleosome Remodeling and Deacetylase (NuRD) Complex Published In The FASEB Journal Volume 31 Pages 594.3-1 - 594.3-1 ISSN 0892-6638 Altmetric
2017	Diatrack particle tracking software: Review of applications and performance evaluation Published In Traffic Volume 18 Pages 840 - 852 ISSN 1398-9219 Altmetric
2017	Mechanism of membrane fusion induced by vesicular stomatitis virus G protein Published In Proceedings of the National Academy of Sciences of USA Volume 114 Pages E28 - E36 ISSN 0027-8424 Altmetric
2017	Single-Molecule Fluorescence Studies of Membrane Transporters Using Total Internal Reflection Microscopy Published In Methods in Enzymology Volume 594 Pages 101 - 121 ISSN 0076-6879 Altmetric
2017	Single-molecule visualization of Saccharomyces cerevisiae leading-strand synthesis reveals dynamic interaction between MTC and the replisome Published In Proceedings of the National Academy of Sciences of USA Volume 114 Pages 10630 - 10635 ISSN 0027-8424 Altmetric
2017	Single-molecule visualization of conformational changes and substrate transport in the vitamin B12ABC importer BtuCD-F Published In Nature Communications Volume 8 Pages 1652-1 - 1652-10 ISSN 2041-1723 Altmetric
2017	Single-molecule visualization of fast polymerase turnover in the bacterial replisome Published In eLife Volume 6 Pages e23932-1 - e23932-17 ISSN 2050-084X Altmetric
2017	The more the merrier: high-throughput single-molecule techniques Published In Biochemical Society Transactions Volume 45 Pages 759 - 769 ISSN 0300-5127 Altmetric
2017	Watching cellular machinery in action, one molecule at a time Published In The Journal of Cell Biology Volume 216 Pages 41 - 51 ISSN 1540-8140 Altmetric
2016	A tool for alignment and averaging of sparse fluorescence signals in rod-shaped bacteria Published In Biophysical Journal Volume 110 Pages 1708 - 1715 ISSN 0006-3495 Altmetric
2016	Bisecting Microfluidic Channels with Metallic Nanowires Fabricated by Nanoskiving Published In ACS Nano Volume 10 Pages 2852 - 2859 ISSN 1936-0851 Altmetric
2016	Droplet microfluidics for kinetic studies of viral fusion Published In Biomicrofluidics Volume 10 Pages 024102-1 - 024102-8 ISSN 1932-1058 Altmetric
2016	Droplet microfluidics: a tool for biology, chemistry and nanotechnology Published In Trends in Analytical Chemistry Volume 82 Pages 118 - 125 ISSN 0167-2940 Altmetric
2016	Lipids activate SecA for high affinity binding to the SecYEG complex Published In Journal of Biological Chemistry Volume 291 Pages 22534 - 22543 ISSN 0021-9258 Altmetric
2016	Mechanisms of influenza viral membrane fusion Published In Seminars in Cell and Developmental Biology Volume 60 Pages 78 - 88 ISSN 1096-3634 Altmetric
2016	Mutations for worse or better: low-fidelity DNA Synthesis by SOS DNA polymerase v is a tightly regulated double-edged sword Published In Biochemistry Volume 55 Pages 2309 - 2318 ISSN 0006-2960 Altmetric
2016	On the spatial organization of mRNA, plasmids, and ribosomes in a bacterial host overexpressing membrane proteins Published In PLoS Genetics Volume 12 Pages e1006523-1 - e1006523-27 ISSN 1553-7404 Altmetric
2016	Simultaneous real-time imaging of leading and lagging strand synthesis reveals the coordination dynamics of single replisomes Published In Molecular Cell Volume 64 Pages 1035 - 1047 ISSN 1097-2765 Altmetric
2016	Single-molecule specific mislocalization of red fluorescent proteins in live Escherichia coli Published In Biophysical Journal Volume 111 Pages 25 - 27 ISSN 0006-3495 Altmetric
2016	Speeding up biomolecular interactions by molecular sledding Published In Chemical Science Volume 7 Pages 916 - 920 ISSN 2041-6520 Altmetric
2016	Stability versus exchange: a paradox in DNA replication Published In Nucleic Acids Research Volume 44 Pages 4846 - 4854 ISSN 0305-1048 Altmetric
2015	Chikungunya virus fusion properties elucidated by single-particle and bulk approaches Published In Journal of General Virology Volume 96 Pages 2122 - 2132 ISSN 0022-1317 Altmetric
2015	External control of reactions in microdroplets Published In Scientific Reports Volume 5 Pages 11837-1 - 11837-8 ISSN 2045-2322 Altmetric
2015	ISBatch: a batch-processing platform for data analysis and exploration of live-cell single-molecule microscopy images and other hierarchical datasets Published In Molecular Biosystems Volume 11 Pages 2699 - 2708 ISSN 1742-2051 Altmetric
2015	In vivo single-molecule studies of DNA repair in E. Coli Published In The FASEB Journal Volume 29 Page p. 225.3 ISSN 0892-6638
2015	Probing molecular choreography through single-molecule biochemistry Published In Nature Structural and Molecular Biology Volume 22 Pages 948 - 952 ISSN 1545-9993 Altmetric
2015	Regulation of mutagenic DNA polymerase V activation in space and time Published In PLoS Genetics Volume 11 Pages 1005482-1 - 1005482-30 ISSN 1553-7404 Altmetric
2015	Single-molecule imaging at high fluorophore concentrations by local activation of dye Published In Biophysical Journal Volume 108 Pages 949 - 956 ISSN 0006-3495 Altmetric
2015	Single-molecule observation of prokaryotic DNA replication Published In Methods in Molecular Biology Volume 1300 Pages 219 - 238 ISSN 1064-3745 Altmetric
2015	The innate immune sensor IFI16 recognizes foreign DNA in the nucleus by scanning along the duplex Published In eLife Volume 4 Pages e11721-1 - e11721-13 ISSN 2050-084X Altmetric
2015	Theory of bimolecular reactions in a solution with linear traps: application to the problem of target search on DNA Published In Physical Review E: Statistical, Nonlinear, and Soft Matter Physics Volume 92 Pages 52703-1 - 52703-14 ISSN 1539-3755 Altmetric
2014	A versatile approach to the generation of fluid supported lipid bilayers and its applications Published In Biotechnology and Bioengineering Volume 111 Pages 2076 - 2081 ISSN 0006-3592 Altmetric
2014	DNA replication at the single-molecule level Published In Chemical Society Reviews Volume 43 Pages 1201 - 1220 ISSN 0306-0012 Altmetric
2014	Membrane-on-a-Chip: Microstructured Silicon/Silicon-Dioxide Chips for High-Throughput Screening of Membrane Transport and Viral Membrane Fusion Published In ACS Nano Volume 8 Pages 3380 - 3392 ISSN 1936-0851 Altmetric
2014	ParB spreading requires DNA bridging Published In Genes and Development Volume 28 Pages 1228 - 1238 ISSN 0890-9369 Altmetric
2014	Relating influenza virus membrane fusion kinetics to stoichiometry of neutralizing antibodies at the single-particle level Published In Proceedings of the National Academy of Sciences of USA Volume 111 Pages E5143 - E5148 ISSN 0027-8424 Altmetric
2014	Single-molecule studies of polymerase dynamics and stoichiometry at the bacteriophage T7 replication machinery Published In Proceedings of the National Academy of Sciences of USA Volume 111 Pages 4073 - 4078 ISSN 0027-8424 Altmetric
2013	A direct proofreader-clamp interaction stabilizes the Pol III replicase in the polymerization mode Published In The EMBO Journal Volume 32 Pages 1322 - 1333 ISSN 0261-4189 Altmetric
2013	A single-molecule view of DNA replication: the dynamic nature of multi-protein complexes revealed Published In Current Opinion in Structural Biology Volume 23 Pages 788 - 793 ISSN 0959-440X Altmetric
2013	Bacterial replication, transcription and translation: mechanistic insights from single-molecule biochemical studies Published In Nature Reviews Microbiology Volume 11 Pages 303 - 315 ISSN 1740-1526 Altmetric
2013	Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates Published In eLife Volume 2 Pages e00333-1 - e00333-20 ISSN 2050-084X Altmetric
2013	Mechanisms of hemagglutinin targeted influenza virus neutralization Published In PLoS One Volume 8 Pages e80034-1 - e80034-14 ISSN 1932-6203 Altmetric
2013	Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters Published In Nature Volume 502 Pages 119 - 123 ISSN 0028-0836 Altmetric
2013	Visualization of membrane fusion, one particle at a time Published In Biochemistry Volume 52 Pages 1654 - 1668 ISSN 0006-2960 Altmetric
2012	A general approach to break the concentration barrier in single-molecule imaging Published In Nature Methods Volume 9 Pages 987 - 992 ISSN 1548-7091 Altmetric
2012	Bypass of a protein barrier by a replicative DNA helicase Published In Nature Volume 492 Pages 205 - 209 ISSN 0028-0836 Altmetric
2012	How DNA-repair proteins find their targets Published In Proceedings of the National Academy of Sciences of USA Volume 109 Pages 18243 - 18244 ISSN 0027-8424 Altmetric
2012	Kinetics of proton transport into influenza virions by the viral M2 channel Published In PLoS One Volume 7 Pages e31566-1 - e31566-9 ISSN 1932-6203 Altmetric
2012	Sequence-dependent sliding kinetics of p53 Published In Proceedings of the National Academy of Sciences of USA Volume 109 Pages 16552 - 16557 ISSN 0027-8424 Altmetric
2012	Single-molecule analysis of DNA replication in Xenopus egg extracts Published In Methods Volume 57 Pages 179 - 186 ISSN 1046-2023 Altmetric
2012	Spotting the mistakes, one molecule at a time Published In Structure Volume 20 Pages 1130 - 1132 ISSN 0969-2126 Altmetric
2011	A single molecule DNA flow stretching microscope for undergraduates Published In American Journal of Physics Volume 79 Pages 1112 - 1120 ISSN 0002-9505 Altmetric
2011	A single-molecule characterization of p53 search on DNA Published In Proceedings of the National Academy of Sciences of USA Volume 108 Pages 563 - 568 ISSN 0027-8424 Altmetric
2011	Coupling dTTP hydrolysis with DNA unwinding by the DNA helicase of bacteriophage T7 Published In Journal of Biological Chemistry Volume 286 Pages 34468 - 34478 ISSN 0021-9258 Altmetric
2011	DNA is a co-factor for its own replication in Xenopus egg extracts Published In Nucleic Acids Research Volume 39 Pages 545 - 555 ISSN 0305-1048 Altmetric
2011	Dancing on DNA: kinetic aspects of search processes on DNA Published In ChemPhysChem: a European journal of chemical physics and physical chemistry Volume 12 Pages 1481 - 1489 ISSN 1439-4235 Altmetric
2011	E. coli DNA replication in the absence of free β clamps Published In The EMBO Journal Volume 30 Pages 1830 - 1840 ISSN 0261-4189 Altmetric
2011	Pyrovanadolysis, a pyrophosphorolysis-like reaction mediated by pyrovanadate, Mn2+, and DNA polymerase of bacteriophage T7 Published In Journal of Biological Chemistry Volume 286 Pages 29146 - 29157 ISSN 0021-9258 Altmetric
2011	Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase Published In Cell Volume 146 Pages 931 - 941 ISSN 0092-8674 Altmetric
2011	Simultaneous single-molecule measurements of phage T7 replisome composition and function reveal the mechanism of polymerase exchange Published In Proceedings of the National Academy of Sciences of USA Volume 108 Pages 3584 - 3589 ISSN 0027-8424 Altmetric
2011	Single-molecule approaches to characterizing kinetics of biomolecular interactions Published In Current Opinion in Biotechnology Volume 22 Pages 75 - 80 ISSN 0958-1669 Altmetric
2010	Analysis of kinetic intermediates in single-particle dwell-Time distributions Published In Biophysical Journal Volume 99 Pages 360 - 366 ISSN 0006-3495 Altmetric
2010	CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule Published In Developmental Cell Volume 19 Pages 245 - 258 ISSN 1534-5807 Altmetric
2010	Direct observation of enzymes replicating DNA using a single-molecule DNA stretching assay Published In Journal of Visualized Experiments Volume 37 Pages e1689-1 - e1689-6 ISSN 1940-087X Altmetric
2010	Residues in the central β-hairpin of the DNA helicase of bacteriophage T7 are important in DNA unwinding Published In Proceedings of the National Academy of Sciences of USA Volume 107 Pages 6782 - 6787 ISSN 0027-8424 Altmetric
2010	Single-molecule binding experiments on long time scales Published In Review of Scientific Instruments Volume 81 Pages 083705-1 - 083705-9 ISSN 0034-6748 Altmetric
2010	Single-molecule studies of the replisome Published In Annual Review of Biophysics Volume 39 Pages 429 - 448 ISSN 1936-122X Altmetric
2010	Thioredoxin suppresses microscopic hopping of T7 DNA polymerase on duplex DNA Published In Proceedings of the National Academy of Sciences of USA Volume 107 Pages 1900 - 1905 ISSN 0027-8424 Altmetric
2010	Timing, coordination, and rhythm: acrobatics at the DNA replication fork Published In Journal of Biological Chemistry Volume 285 Pages 18979 - 18983 ISSN 0021-9258 Altmetric
2010	Uncoupling of sister replisomes during eukaryotic DNA replication Published In Molecular Cell Volume 40 Pages 834 - 840 ISSN 1097-2765 Altmetric
2010	Visualizing DNA replication at the single-molecule level Published In Methods in Enzymology Volume 475 Pages 259 - 278 ISSN 0076-6879 Altmetric
2009	Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis Published In Nature Volume 457 Pages 336 - 339 ISSN 0028-0836 Altmetric
2009	Method for measurement of viral fusion kinetics at the single particle level Published In Journal of Visualized Experiments Volume 31 Pages e1484-1 - e1484-5 ISSN 1940-087X Altmetric
2009	Nudging through a nucleosome Published In Science Volume 325 Pages 547 - 548 ISSN 1095-9203 Altmetric
2009	Proliferating cell nuclear antigen uses two distinct modes to move along DNA Published In Journal of Biological Chemistry Volume 284 Pages 17700 - 17710 ISSN 0021-9258 Altmetric
2009	Real-time single-molecule observation of rolling-circle DNA replication Published In Nucleic Acids Research Volume 37 Pages 1 - 6 ISSN 0305-1048 Altmetric
2009	Single-molecule imaging of an in vitro-evolved RNA aptamer reveals homogeneous ligand binding kinetics Published In Journal of the American Chemical Society Volume 131 Pages 9866 - 9867 ISSN 0002-7863 Altmetric
2009	Single-molecule observation of prokaryotic DNA replication Published In Methods in Molecular Biology Volume 521 Pages 397 - 410 ISSN 1064-3745 Altmetric
2009	Visualizing single-molecule DNA replication with fluorescence microscopy Published In Journal of Visualized Experiments Volume 32 Pages e1529-1 - e1529-5 ISSN 1940-087X Altmetric
2008	Cutting the forest to see a single tree? Published In Nature Chemical Biology Volume 4 Pages 440 - 443 ISSN 1552-4450 Altmetric
2008	Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusion Published In Proceedings of the National Academy of Sciences of USA Volume 105 Pages 10721 - 10726 ISSN 0027-8424 Altmetric
2008	Single-molecule studies of fork dynamics in Escherichia coli DNA replication Published In Nature Structural and Molecular Biology Volume 15 Pages 170 - 176 ISSN 1545-9993 Altmetric
2008	Single-particle kinetics of influenza virus membrane fusion Published In Proceedings of the National Academy of Sciences of USA Volume 105 Pages 15382 - 15387 ISSN 0027-8424 Altmetric
2008	Tumor suppressor p53 slides on DNA with low friction and high stability Published In Biophysical Journal Volume 95 Pages L01 - L03 ISSN 0006-3495 Altmetric
2008	mKikGR, a monomeric photoswitchable fluorescent protein Published In PLoS One Volume 3 Pages e3944-1 - e3944-9 ISSN 1932-6203 Altmetric

Chapter

Year	Title
2013	Replication-fork dynamics Published In DNA Replication: a Subject Collection from Cold Spring Harbor Perspectives in Biology Publisher New York: Cold Spring Harbor Laboratory Press Pages 147 - 163 Altmetric
2009	Single molecule studies of nucleic acid enzymes Published In Single Molecule Biology Publisher Elsevier Pages 173 - 193
2009	Single-molecule enzymology Published In Handbook of Single-Molecule Biophysics Publisher Dordrecht: Springer Pages 165 - 182 ISBN 9780387764962 Altmetric

Editor Of

Book
- Handbook of Single-Molecule Biophysics. Dordrecht. 2009

Investigator On

Year	Title
2017 - 2022	Structure and function of a cancer-linked co-regulator complex Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2019 - 2021	Antibiotic resistance: combining microscopy, microfluidics and genomics to target bacterial DNA repair pathways Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2019 - 2021	Creation and Repair of Postreplicative DNA Gaps Awarded by: National Institute of Health (NIH) Funding Scheme: Grant
2018 - 2020	A functional dissection of the bacterial replisome Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2019	Antimicrobial Research Taskforce Awarded by: NUW Alliance Funding Scheme: Grant
2019	Use of disruptive technologies to trace, track and tackle antibiotic resistance Awarded by: Department of Industry, Innovation and Science Funding Scheme: Medical Research Future Fund Frontier Health and Medical Research Program
2019	Volumetric Imaging Facility: Observing the Cell in its Native Environment Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2018	High-throughput portable and wearable device fabrication facility Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2018	Pushing the Limits of Fluorescence Microscopy with Adaptive Optics Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2016 - 2018	Formin' actin filaments associated with cancer Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2017	Australia-China Joint Research Centre for Point-of-Care Testing Awarded by: Department of Innovation, Industry, Science and Research (DIISR) Funding Scheme: Australia-China Science and Research Fund
2016	Superresolution fluorescence imaging in microbiology Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2015	Functional dissection of the bacterial replisome Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2015	Rescuing Stalled Replisomes by Accessory Helicases at the Single-Molecule Level Awarded by: KAUST - King Abdullah University of Science and Technology Funding Scheme: Competitive Research Grant Scheme (CRG)
2015	Single molecule imaging laboratory Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2015	Under the hood: single-molecule studies of multi-protein machines Awarded by: Australian Research Council (ARC) Funding Scheme: Australian Laureate Fellowships
2008	Functional Dissection of the Bacterial Replisome Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2008	Mass Spectrometric Investigations of Conformation and Dynamics of Biological Complexes Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage International

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Following the DNA damage response in Escherichia coli: Single-molecule studies of proteins in live cells
Doctor of Philosophy	Functional Implications of RarA at the Escherichia Coli Replication Fork
Doctor of Philosophy	Visualisation of Transcription-coupled Repair in Live Eschericha Coli	Ho, Han Ngoc
Doctor of Philosophy	Single-Molecule Studies of the Eukaryotic DNA Replication Machinery	Natarajan, Varsha
Master of Philosophy	Single-Molecule Studies of Exonuclease Proteins	Muir, Ryan
Doctor of Philosophy	Investigating how small heat shock proteins prevent protein aggregation using single-molecule fluorescence microscopy	Johnston, Caitlin
Doctor of Philosophy	The role of translesion DNA synthesis in the development of antibiotic resistance	Cherry, Megan
Doctor of Philosophy	The development of a protein folding-sensor to study molecular chaperones at the single-molecule level	Marzano, Nicholas
Doctor of Philosophy	Single-molecule visualisation of engine choreography during Escherichia Coli DNA Replication	Spinks, Richard
Doctor of Philosophy	Single-molecule studies of the bacterial replisome	Mueller, Stefan
Doctor of Philosophy	Visualising Single-Strand Gap Repair in Live Escherichia Coli Cells	Armstrong, Thomas
Doctor of Philosophy	Dynamic Iinteractions of E. coli Accessory Helicases Rep and UvrD with Stalled Replication Forks	Whinn, Kelsey
Doctor of Philosophy	Antibiotic-induced evolution: combining microscopy, microfluidics and genomics to study resistance in individual bacterial cells	Ripandelli, Remy

Awards And Honors

Biochemistry and Molecular Biology Award , conferred by Dutch Society, 2011
C.J. Kok Prize, conferred by Leiden University, 2002
Starting Grant , conferred by European Research Council, 2012 - 2017
Vici Award, conferred by Dutch Science Foundation, 2011 - 2016
NSF CAREER Award, conferred by National Science Foundation, 2006 - 2011
Searle Scholar, 2005 - 2008
Armenise-Harvard Junior Faculty Award, conferred by Armenise-Harvard Foundation, 2005 - 2007
Long-term postdoctoral fellowship , conferred by Human Frontier Science Program, 2002 - 2004
Postdoctoral fellowship, conferred by Niels Stensen Foundation, 2000 - 2002
Australian Research Council Laureate Fellow, conferred by Australian Research Council, 2015 -

Top Publications

Year	Title
2018	The transcription-repair coupling factor Mfd associates with RNA polymerase in the absence of exogenous damage Published in Nature Communications
2017	Single-molecule visualization of conformational changes and substrate transport in the vitamin B12ABC importer BtuCD-F Published in Nature Communications
2017	Single-molecule visualization of fast polymerase turnover in the bacterial replisome Published in eLife
2013	Bacterial replication, transcription and translation: mechanistic insights from single-molecule biochemical studies Published in Nature Reviews Microbiology
2013	Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters Published in Nature
2012	A general approach to break the concentration barrier in single-molecule imaging Published in Nature Methods
2009	Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis Published in Nature

Research Areas

Research Overview

Antoine van Oijen obtained his BSc and PhD degrees in the Netherlands, where he was trained as a physicist. A growing fascination for biology resulted in him moving to the USA and establishing a research group at Harvard Medical School. Subsequently, he was appointed as full professor at Groningen University in the Netherlands where he established a thriving biophysics research program focused on the development of single-molecule visualization techniques and their applications in basic and applied science. Recently, he moved to the UOW and was awarded a prestigious Laureate Fellowship by the Australian Research Council to further develop biophysical approaches to visualize the molecular processes that define life.

Selected Publications

Journal Article

Year	Title
2019	Identification of Multiple Kinetic Populations of DNA-Binding Proteins in Live Cells Published In Biophysical Journal Volume 117 Pages 950 - 961 ISSN 0006-3495 Altmetric
2019	Nuclease dead Cas9 is a programmable roadblock for DNA replication Published In Scientific Reports Volume 9 Pages 13292-1 - 13292-9 ISSN 2045-2322 Altmetric
2019	RecFOR epistasis group: RecF and RecO have distinct localizations and functions in Escherichia coli Published In Nucleic Acids Research Volume 47 Pages 2946 - 2965 ISSN 0305-1048 Altmetric
2019	Recycling of single-stranded DNA-binding protein by the bacterial replisome Published In Nucleic Acids Research Volume 47 Pages 4111 - 4123 ISSN 0305-1048 Altmetric
2019	Shining a spotlight on DNA: Single-molecule methods to visualise DNA Published In Molecules Volume 24 Pages 491-1 - 491-20 ISSN 1420-3049 Altmetric
2019	Spatial and temporal organization of RecA in the Escherichia coli DNA-damage response Published In eLife Volume 8 Pages e42761-1 - e42761-37 ISSN 2050-084X Altmetric
2019	Spy-ing on Cas9: Single-molecule tools reveal the enzymology of Cas9 Published In Current Opinion in Biomedical Engineering Volume 12 Pages 25 - 33 Altmetric
2019	The drivers of antibiotic use and misuse: the development and investigation of a theory driven community measure Published In BMC Public Health Volume 19 Pages 1425-1 - 1425-11 ISSN 1471-2458 Altmetric
2019	When proteins play tag: the dynamic nature of the replisome Published In Biophysical Reviews Volume Online First Pages 1 - 11 Altmetric
2018	Anisotropic functionalization of upconversion nanoparticles Published In Chemical Science Volume 9 Pages 4352 - 4358 ISSN 2041-6520 Altmetric
2018	DNA polymerase IV primarily operates outside of DNA replication forks in Escherichia coli Published In PLoS Genetics Volume 14 Pages e1007161-1 - e1007161-29 ISSN 1553-7404 Altmetric
2018	Design of DNA rolling-circle templates with controlled fork topology to study mechanisms of DNA replication Published In Analytical Biochemistry Volume 557 Pages 42 - 45 ISSN 0003-2697 Altmetric
2018	Detection of kinetic change points in piece-wise linear single molecule motion Published In Journal of Chemical Physics Volume 148 Pages 123317-1 - 123317-9 ISSN 0021-9606 Altmetric
2018	Nanoparticles for super-resolution microscopy and single-molecule tracking Published In Nature Methods Volume 15 Pages 415 - 423 ISSN 1548-7091 Altmetric
2018	Quantification of ligand density and stoichiometry on the surface of liposomes using single-molecule fluorescence imaging Published In Journal of Controlled Release Volume 278 Pages 80 - 86 ISSN 0168-3659 Altmetric
2018	Single-molecule live-cell imaging of bacterial DNA repair and damage tolerance Published In Biochemical Society Transactions Volume 46 Pages 23 - 35 ISSN 0300-5127 Altmetric
2018	Single-particle fusion of influenza viruses reveals complex interactions with target membranes Published In Journal of Physics: Condensed Matter Volume 30 Pages 204005-1 - 204005-7 ISSN 0953-8984 Altmetric
2018	Special Issue on Cell Biophysics Published In Biophysical Journal Volume 115 Pages E01 - E02 ISSN 0006-3495 Altmetric
2018	Specialised DNA polymerases in Escherichia coli: roles within multiple pathways Published In Current Genetics: lower eukaryotes and organelles Volume Online First Pages 1 - 8 ISSN 0172-8083 Altmetric
2018	The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity Published In Journal of Biological Chemistry Volume 293 Pages 4486 - 4497 ISSN 0021-9258 Altmetric
2018	The transcription-repair coupling factor Mfd associates with RNA polymerase in the absence of exogenous damage Published In Nature Communications Volume 9 Pages 1570-1 - 1570-12 ISSN 2041-1723 Altmetric
2018	Using single-molecule approaches to understand the molecular mechanisms of heat-shock protein chaperone function Published In American Journal of Molecular Biology Volume 430 Pages 4525 - 4546 Altmetric
2017	Architecture of the Nucleosome Remodeling and Deacetylase (NuRD) Complex Published In The FASEB Journal Volume 31 Pages 594.3-1 - 594.3-1 ISSN 0892-6638 Altmetric
2017	Diatrack particle tracking software: Review of applications and performance evaluation Published In Traffic Volume 18 Pages 840 - 852 ISSN 1398-9219 Altmetric
2017	Mechanism of membrane fusion induced by vesicular stomatitis virus G protein Published In Proceedings of the National Academy of Sciences of USA Volume 114 Pages E28 - E36 ISSN 0027-8424 Altmetric
2017	Single-Molecule Fluorescence Studies of Membrane Transporters Using Total Internal Reflection Microscopy Published In Methods in Enzymology Volume 594 Pages 101 - 121 ISSN 0076-6879 Altmetric
2017	Single-molecule visualization of Saccharomyces cerevisiae leading-strand synthesis reveals dynamic interaction between MTC and the replisome Published In Proceedings of the National Academy of Sciences of USA Volume 114 Pages 10630 - 10635 ISSN 0027-8424 Altmetric
2017	Single-molecule visualization of conformational changes and substrate transport in the vitamin B12ABC importer BtuCD-F Published In Nature Communications Volume 8 Pages 1652-1 - 1652-10 ISSN 2041-1723 Altmetric
2017	Single-molecule visualization of fast polymerase turnover in the bacterial replisome Published In eLife Volume 6 Pages e23932-1 - e23932-17 ISSN 2050-084X Altmetric
2017	The more the merrier: high-throughput single-molecule techniques Published In Biochemical Society Transactions Volume 45 Pages 759 - 769 ISSN 0300-5127 Altmetric
2017	Watching cellular machinery in action, one molecule at a time Published In The Journal of Cell Biology Volume 216 Pages 41 - 51 ISSN 1540-8140 Altmetric
2016	A tool for alignment and averaging of sparse fluorescence signals in rod-shaped bacteria Published In Biophysical Journal Volume 110 Pages 1708 - 1715 ISSN 0006-3495 Altmetric
2016	Bisecting Microfluidic Channels with Metallic Nanowires Fabricated by Nanoskiving Published In ACS Nano Volume 10 Pages 2852 - 2859 ISSN 1936-0851 Altmetric
2016	Droplet microfluidics for kinetic studies of viral fusion Published In Biomicrofluidics Volume 10 Pages 024102-1 - 024102-8 ISSN 1932-1058 Altmetric
2016	Droplet microfluidics: a tool for biology, chemistry and nanotechnology Published In Trends in Analytical Chemistry Volume 82 Pages 118 - 125 ISSN 0167-2940 Altmetric
2016	Lipids activate SecA for high affinity binding to the SecYEG complex Published In Journal of Biological Chemistry Volume 291 Pages 22534 - 22543 ISSN 0021-9258 Altmetric
2016	Mechanisms of influenza viral membrane fusion Published In Seminars in Cell and Developmental Biology Volume 60 Pages 78 - 88 ISSN 1096-3634 Altmetric
2016	Mutations for worse or better: low-fidelity DNA Synthesis by SOS DNA polymerase v is a tightly regulated double-edged sword Published In Biochemistry Volume 55 Pages 2309 - 2318 ISSN 0006-2960 Altmetric
2016	On the spatial organization of mRNA, plasmids, and ribosomes in a bacterial host overexpressing membrane proteins Published In PLoS Genetics Volume 12 Pages e1006523-1 - e1006523-27 ISSN 1553-7404 Altmetric
2016	Simultaneous real-time imaging of leading and lagging strand synthesis reveals the coordination dynamics of single replisomes Published In Molecular Cell Volume 64 Pages 1035 - 1047 ISSN 1097-2765 Altmetric
2016	Single-molecule specific mislocalization of red fluorescent proteins in live Escherichia coli Published In Biophysical Journal Volume 111 Pages 25 - 27 ISSN 0006-3495 Altmetric
2016	Speeding up biomolecular interactions by molecular sledding Published In Chemical Science Volume 7 Pages 916 - 920 ISSN 2041-6520 Altmetric
2016	Stability versus exchange: a paradox in DNA replication Published In Nucleic Acids Research Volume 44 Pages 4846 - 4854 ISSN 0305-1048 Altmetric
2015	Chikungunya virus fusion properties elucidated by single-particle and bulk approaches Published In Journal of General Virology Volume 96 Pages 2122 - 2132 ISSN 0022-1317 Altmetric
2015	External control of reactions in microdroplets Published In Scientific Reports Volume 5 Pages 11837-1 - 11837-8 ISSN 2045-2322 Altmetric
2015	ISBatch: a batch-processing platform for data analysis and exploration of live-cell single-molecule microscopy images and other hierarchical datasets Published In Molecular Biosystems Volume 11 Pages 2699 - 2708 ISSN 1742-2051 Altmetric
2015	In vivo single-molecule studies of DNA repair in E. Coli Published In The FASEB Journal Volume 29 Page p. 225.3 ISSN 0892-6638
2015	Probing molecular choreography through single-molecule biochemistry Published In Nature Structural and Molecular Biology Volume 22 Pages 948 - 952 ISSN 1545-9993 Altmetric
2015	Regulation of mutagenic DNA polymerase V activation in space and time Published In PLoS Genetics Volume 11 Pages 1005482-1 - 1005482-30 ISSN 1553-7404 Altmetric
2015	Single-molecule imaging at high fluorophore concentrations by local activation of dye Published In Biophysical Journal Volume 108 Pages 949 - 956 ISSN 0006-3495 Altmetric
2015	Single-molecule observation of prokaryotic DNA replication Published In Methods in Molecular Biology Volume 1300 Pages 219 - 238 ISSN 1064-3745 Altmetric
2015	The innate immune sensor IFI16 recognizes foreign DNA in the nucleus by scanning along the duplex Published In eLife Volume 4 Pages e11721-1 - e11721-13 ISSN 2050-084X Altmetric
2015	Theory of bimolecular reactions in a solution with linear traps: application to the problem of target search on DNA Published In Physical Review E: Statistical, Nonlinear, and Soft Matter Physics Volume 92 Pages 52703-1 - 52703-14 ISSN 1539-3755 Altmetric
2014	A versatile approach to the generation of fluid supported lipid bilayers and its applications Published In Biotechnology and Bioengineering Volume 111 Pages 2076 - 2081 ISSN 0006-3592 Altmetric
2014	DNA replication at the single-molecule level Published In Chemical Society Reviews Volume 43 Pages 1201 - 1220 ISSN 0306-0012 Altmetric
2014	Membrane-on-a-Chip: Microstructured Silicon/Silicon-Dioxide Chips for High-Throughput Screening of Membrane Transport and Viral Membrane Fusion Published In ACS Nano Volume 8 Pages 3380 - 3392 ISSN 1936-0851 Altmetric
2014	ParB spreading requires DNA bridging Published In Genes and Development Volume 28 Pages 1228 - 1238 ISSN 0890-9369 Altmetric
2014	Relating influenza virus membrane fusion kinetics to stoichiometry of neutralizing antibodies at the single-particle level Published In Proceedings of the National Academy of Sciences of USA Volume 111 Pages E5143 - E5148 ISSN 0027-8424 Altmetric
2014	Single-molecule studies of polymerase dynamics and stoichiometry at the bacteriophage T7 replication machinery Published In Proceedings of the National Academy of Sciences of USA Volume 111 Pages 4073 - 4078 ISSN 0027-8424 Altmetric
2013	A direct proofreader-clamp interaction stabilizes the Pol III replicase in the polymerization mode Published In The EMBO Journal Volume 32 Pages 1322 - 1333 ISSN 0261-4189 Altmetric
2013	A single-molecule view of DNA replication: the dynamic nature of multi-protein complexes revealed Published In Current Opinion in Structural Biology Volume 23 Pages 788 - 793 ISSN 0959-440X Altmetric
2013	Bacterial replication, transcription and translation: mechanistic insights from single-molecule biochemical studies Published In Nature Reviews Microbiology Volume 11 Pages 303 - 315 ISSN 1740-1526 Altmetric
2013	Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates Published In eLife Volume 2 Pages e00333-1 - e00333-20 ISSN 2050-084X Altmetric
2013	Mechanisms of hemagglutinin targeted influenza virus neutralization Published In PLoS One Volume 8 Pages e80034-1 - e80034-14 ISSN 1932-6203 Altmetric
2013	Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters Published In Nature Volume 502 Pages 119 - 123 ISSN 0028-0836 Altmetric
2013	Visualization of membrane fusion, one particle at a time Published In Biochemistry Volume 52 Pages 1654 - 1668 ISSN 0006-2960 Altmetric
2012	A general approach to break the concentration barrier in single-molecule imaging Published In Nature Methods Volume 9 Pages 987 - 992 ISSN 1548-7091 Altmetric
2012	Bypass of a protein barrier by a replicative DNA helicase Published In Nature Volume 492 Pages 205 - 209 ISSN 0028-0836 Altmetric
2012	How DNA-repair proteins find their targets Published In Proceedings of the National Academy of Sciences of USA Volume 109 Pages 18243 - 18244 ISSN 0027-8424 Altmetric
2012	Kinetics of proton transport into influenza virions by the viral M2 channel Published In PLoS One Volume 7 Pages e31566-1 - e31566-9 ISSN 1932-6203 Altmetric
2012	Sequence-dependent sliding kinetics of p53 Published In Proceedings of the National Academy of Sciences of USA Volume 109 Pages 16552 - 16557 ISSN 0027-8424 Altmetric
2012	Single-molecule analysis of DNA replication in Xenopus egg extracts Published In Methods Volume 57 Pages 179 - 186 ISSN 1046-2023 Altmetric
2012	Spotting the mistakes, one molecule at a time Published In Structure Volume 20 Pages 1130 - 1132 ISSN 0969-2126 Altmetric
2011	A single molecule DNA flow stretching microscope for undergraduates Published In American Journal of Physics Volume 79 Pages 1112 - 1120 ISSN 0002-9505 Altmetric
2011	A single-molecule characterization of p53 search on DNA Published In Proceedings of the National Academy of Sciences of USA Volume 108 Pages 563 - 568 ISSN 0027-8424 Altmetric
2011	Coupling dTTP hydrolysis with DNA unwinding by the DNA helicase of bacteriophage T7 Published In Journal of Biological Chemistry Volume 286 Pages 34468 - 34478 ISSN 0021-9258 Altmetric
2011	DNA is a co-factor for its own replication in Xenopus egg extracts Published In Nucleic Acids Research Volume 39 Pages 545 - 555 ISSN 0305-1048 Altmetric
2011	Dancing on DNA: kinetic aspects of search processes on DNA Published In ChemPhysChem: a European journal of chemical physics and physical chemistry Volume 12 Pages 1481 - 1489 ISSN 1439-4235 Altmetric
2011	E. coli DNA replication in the absence of free β clamps Published In The EMBO Journal Volume 30 Pages 1830 - 1840 ISSN 0261-4189 Altmetric
2011	Pyrovanadolysis, a pyrophosphorolysis-like reaction mediated by pyrovanadate, Mn2+, and DNA polymerase of bacteriophage T7 Published In Journal of Biological Chemistry Volume 286 Pages 29146 - 29157 ISSN 0021-9258 Altmetric
2011	Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase Published In Cell Volume 146 Pages 931 - 941 ISSN 0092-8674 Altmetric
2011	Simultaneous single-molecule measurements of phage T7 replisome composition and function reveal the mechanism of polymerase exchange Published In Proceedings of the National Academy of Sciences of USA Volume 108 Pages 3584 - 3589 ISSN 0027-8424 Altmetric
2011	Single-molecule approaches to characterizing kinetics of biomolecular interactions Published In Current Opinion in Biotechnology Volume 22 Pages 75 - 80 ISSN 0958-1669 Altmetric
2010	Analysis of kinetic intermediates in single-particle dwell-Time distributions Published In Biophysical Journal Volume 99 Pages 360 - 366 ISSN 0006-3495 Altmetric
2010	CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule Published In Developmental Cell Volume 19 Pages 245 - 258 ISSN 1534-5807 Altmetric
2010	Direct observation of enzymes replicating DNA using a single-molecule DNA stretching assay Published In Journal of Visualized Experiments Volume 37 Pages e1689-1 - e1689-6 ISSN 1940-087X Altmetric
2010	Residues in the central β-hairpin of the DNA helicase of bacteriophage T7 are important in DNA unwinding Published In Proceedings of the National Academy of Sciences of USA Volume 107 Pages 6782 - 6787 ISSN 0027-8424 Altmetric
2010	Single-molecule binding experiments on long time scales Published In Review of Scientific Instruments Volume 81 Pages 083705-1 - 083705-9 ISSN 0034-6748 Altmetric
2010	Single-molecule studies of the replisome Published In Annual Review of Biophysics Volume 39 Pages 429 - 448 ISSN 1936-122X Altmetric
2010	Thioredoxin suppresses microscopic hopping of T7 DNA polymerase on duplex DNA Published In Proceedings of the National Academy of Sciences of USA Volume 107 Pages 1900 - 1905 ISSN 0027-8424 Altmetric
2010	Timing, coordination, and rhythm: acrobatics at the DNA replication fork Published In Journal of Biological Chemistry Volume 285 Pages 18979 - 18983 ISSN 0021-9258 Altmetric
2010	Uncoupling of sister replisomes during eukaryotic DNA replication Published In Molecular Cell Volume 40 Pages 834 - 840 ISSN 1097-2765 Altmetric
2010	Visualizing DNA replication at the single-molecule level Published In Methods in Enzymology Volume 475 Pages 259 - 278 ISSN 0076-6879 Altmetric
2009	Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis Published In Nature Volume 457 Pages 336 - 339 ISSN 0028-0836 Altmetric
2009	Method for measurement of viral fusion kinetics at the single particle level Published In Journal of Visualized Experiments Volume 31 Pages e1484-1 - e1484-5 ISSN 1940-087X Altmetric
2009	Nudging through a nucleosome Published In Science Volume 325 Pages 547 - 548 ISSN 1095-9203 Altmetric
2009	Proliferating cell nuclear antigen uses two distinct modes to move along DNA Published In Journal of Biological Chemistry Volume 284 Pages 17700 - 17710 ISSN 0021-9258 Altmetric
2009	Real-time single-molecule observation of rolling-circle DNA replication Published In Nucleic Acids Research Volume 37 Pages 1 - 6 ISSN 0305-1048 Altmetric
2009	Single-molecule imaging of an in vitro-evolved RNA aptamer reveals homogeneous ligand binding kinetics Published In Journal of the American Chemical Society Volume 131 Pages 9866 - 9867 ISSN 0002-7863 Altmetric
2009	Single-molecule observation of prokaryotic DNA replication Published In Methods in Molecular Biology Volume 521 Pages 397 - 410 ISSN 1064-3745 Altmetric
2009	Visualizing single-molecule DNA replication with fluorescence microscopy Published In Journal of Visualized Experiments Volume 32 Pages e1529-1 - e1529-5 ISSN 1940-087X Altmetric
2008	Cutting the forest to see a single tree? Published In Nature Chemical Biology Volume 4 Pages 440 - 443 ISSN 1552-4450 Altmetric
2008	Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusion Published In Proceedings of the National Academy of Sciences of USA Volume 105 Pages 10721 - 10726 ISSN 0027-8424 Altmetric
2008	Single-molecule studies of fork dynamics in Escherichia coli DNA replication Published In Nature Structural and Molecular Biology Volume 15 Pages 170 - 176 ISSN 1545-9993 Altmetric
2008	Single-particle kinetics of influenza virus membrane fusion Published In Proceedings of the National Academy of Sciences of USA Volume 105 Pages 15382 - 15387 ISSN 0027-8424 Altmetric
2008	Tumor suppressor p53 slides on DNA with low friction and high stability Published In Biophysical Journal Volume 95 Pages L01 - L03 ISSN 0006-3495 Altmetric
2008	mKikGR, a monomeric photoswitchable fluorescent protein Published In PLoS One Volume 3 Pages e3944-1 - e3944-9 ISSN 1932-6203 Altmetric

Chapter

Year	Title
2013	Replication-fork dynamics Published In DNA Replication: a Subject Collection from Cold Spring Harbor Perspectives in Biology Publisher New York: Cold Spring Harbor Laboratory Press Pages 147 - 163 Altmetric
2009	Single molecule studies of nucleic acid enzymes Published In Single Molecule Biology Publisher Elsevier Pages 173 - 193
2009	Single-molecule enzymology Published In Handbook of Single-Molecule Biophysics Publisher Dordrecht: Springer Pages 165 - 182 ISBN 9780387764962 Altmetric

Editor Of

Book
- Handbook of Single-Molecule Biophysics. Dordrecht. 2009

Investigator On

Year	Title
2017 - 2022	Structure and function of a cancer-linked co-regulator complex Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2019 - 2021	Antibiotic resistance: combining microscopy, microfluidics and genomics to target bacterial DNA repair pathways Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2019 - 2021	Creation and Repair of Postreplicative DNA Gaps Awarded by: National Institute of Health (NIH) Funding Scheme: Grant
2018 - 2020	A functional dissection of the bacterial replisome Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2019	Antimicrobial Research Taskforce Awarded by: NUW Alliance Funding Scheme: Grant
2019	Use of disruptive technologies to trace, track and tackle antibiotic resistance Awarded by: Department of Industry, Innovation and Science Funding Scheme: Medical Research Future Fund Frontier Health and Medical Research Program
2019	Volumetric Imaging Facility: Observing the Cell in its Native Environment Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2018	High-throughput portable and wearable device fabrication facility Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2018	Pushing the Limits of Fluorescence Microscopy with Adaptive Optics Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2016 - 2018	Formin' actin filaments associated with cancer Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2017	Australia-China Joint Research Centre for Point-of-Care Testing Awarded by: Department of Innovation, Industry, Science and Research (DIISR) Funding Scheme: Australia-China Science and Research Fund
2016	Superresolution fluorescence imaging in microbiology Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2015	Functional dissection of the bacterial replisome Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2015	Rescuing Stalled Replisomes by Accessory Helicases at the Single-Molecule Level Awarded by: KAUST - King Abdullah University of Science and Technology Funding Scheme: Competitive Research Grant Scheme (CRG)
2015	Single molecule imaging laboratory Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2015	Under the hood: single-molecule studies of multi-protein machines Awarded by: Australian Research Council (ARC) Funding Scheme: Australian Laureate Fellowships
2008	Functional Dissection of the Bacterial Replisome Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2008	Mass Spectrometric Investigations of Conformation and Dynamics of Biological Complexes Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage International

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Following the DNA damage response in Escherichia coli: Single-molecule studies of proteins in live cells
Doctor of Philosophy	Functional Implications of RarA at the Escherichia Coli Replication Fork
Doctor of Philosophy	Visualisation of Transcription-coupled Repair in Live Eschericha Coli	Ho, Han Ngoc
Doctor of Philosophy	Single-Molecule Studies of the Eukaryotic DNA Replication Machinery	Natarajan, Varsha
Master of Philosophy	Single-Molecule Studies of Exonuclease Proteins	Muir, Ryan
Doctor of Philosophy	Investigating how small heat shock proteins prevent protein aggregation using single-molecule fluorescence microscopy	Johnston, Caitlin
Doctor of Philosophy	The role of translesion DNA synthesis in the development of antibiotic resistance	Cherry, Megan
Doctor of Philosophy	The development of a protein folding-sensor to study molecular chaperones at the single-molecule level	Marzano, Nicholas
Doctor of Philosophy	Single-molecule visualisation of engine choreography during Escherichia Coli DNA Replication	Spinks, Richard
Doctor of Philosophy	Single-molecule studies of the bacterial replisome	Mueller, Stefan
Doctor of Philosophy	Visualising Single-Strand Gap Repair in Live Escherichia Coli Cells	Armstrong, Thomas
Doctor of Philosophy	Dynamic Iinteractions of E. coli Accessory Helicases Rep and UvrD with Stalled Replication Forks	Whinn, Kelsey
Doctor of Philosophy	Antibiotic-induced evolution: combining microscopy, microfluidics and genomics to study resistance in individual bacterial cells	Ripandelli, Remy

Awards And Honors

Biochemistry and Molecular Biology Award , conferred by Dutch Society, 2011
C.J. Kok Prize, conferred by Leiden University, 2002
Starting Grant , conferred by European Research Council, 2012 - 2017
Vici Award, conferred by Dutch Science Foundation, 2011 - 2016
NSF CAREER Award, conferred by National Science Foundation, 2006 - 2011
Searle Scholar, 2005 - 2008
Armenise-Harvard Junior Faculty Award, conferred by Armenise-Harvard Foundation, 2005 - 2007
Long-term postdoctoral fellowship , conferred by Human Frontier Science Program, 2002 - 2004
Postdoctoral fellowship, conferred by Niels Stensen Foundation, 2000 - 2002
Australian Research Council Laureate Fellow, conferred by Australian Research Council, 2015 -

van Oijen, Antoine M. Distinguished Professor

ARC Laureate Fellow

Overview

Top Publications

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Research Overview

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Selected Publications

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Chapter

Editor Of

Book

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Investigator On

Supervision

Advisees

Graduate Advising Relationship

Background

Awards And Honors

Overview

Top Publications

Research Areas

Research Overview

Publications

Selected Publications

Journal Article

Chapter

Editor Of

Book

Funding

Investigator On

Supervision

Advisees

Graduate Advising Relationship

Background

Awards And Honors

Visualisations

Research Areas