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Wyatt, Amy R. Dr.

Senior Research Fellow

  • Centre for Medical and Molecular Bioscience
  • Faculty of Science, Medicine and Health
  • School of Biological Sciences

Top Publications


    Year Title
    2014 Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin
    Published in   Proceedings of the National Academy of Sciences of USA
    2011 Clusterin facilitates in vivo clearance of extracellular misfolded proteins
    Published in   Cellular and Molecular Life Sciences
    2013 Extracellular chaperones and proteostasis
    Published in   Annual Review of Biochemistry

Research Overview


  • Inflammation and the accumulation of damaged (misfolded) proteins underlie the pathology of a large number of debilitating human disorders including Alzheimer's disease, atherosclerosis and preeclampsia. My research program focuses on understanding the relationship between inflammation and protein misfolding in disease, with an emphasis on the role of hypochlorite (bleach), a potent inflammatory oxidant and mediator of protien misfolding within the body. 

Available as Research Supervisor

Selected Publications


Available as Research Supervisor

Advisees


  • Graduate Advising Relationship

    Degree Research Title Advisee
    Doctor of Philosophy Investigations of the roles of pregnancy zone protein (PZP) and plasminogen activator inhibitor type-2 (PAl-2) in extracellular proteostasis Cater, Jordan

Top Publications


    Year Title
    2014 Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin
    Published in   Proceedings of the National Academy of Sciences of USA
    2011 Clusterin facilitates in vivo clearance of extracellular misfolded proteins
    Published in   Cellular and Molecular Life Sciences
    2013 Extracellular chaperones and proteostasis
    Published in   Annual Review of Biochemistry

Research Overview


  • Inflammation and the accumulation of damaged (misfolded) proteins underlie the pathology of a large number of debilitating human disorders including Alzheimer's disease, atherosclerosis and preeclampsia. My research program focuses on understanding the relationship between inflammation and protein misfolding in disease, with an emphasis on the role of hypochlorite (bleach), a potent inflammatory oxidant and mediator of protien misfolding within the body. 

Selected Publications


Advisees


  • Graduate Advising Relationship

    Degree Research Title Advisee
    Doctor of Philosophy Investigations of the roles of pregnancy zone protein (PZP) and plasminogen activator inhibitor type-2 (PAl-2) in extracellular proteostasis Cater, Jordan
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