Wyatt, Amy R.

Top Publications

Year	Title
2014	Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin Published in Proceedings of the National Academy of Sciences of USA
2011	Clusterin facilitates in vivo clearance of extracellular misfolded proteins Published in Cellular and Molecular Life Sciences
2013	Extracellular chaperones and proteostasis Published in Annual Review of Biochemistry

Research Areas

0601 - BIOCHEMISTRY AND CELL BIOLOGY

Research Overview

Inflammation and the accumulation of damaged (misfolded) proteins underlie the pathology of a large number of debilitating human disorders including Alzheimer's disease, atherosclerosis and preeclampsia. My research program focuses on understanding the relationship between inflammation and protein misfolding in disease, with an emphasis on the role of hypochlorite (bleach), a potent inflammatory oxidant and mediator of protien misfolding within the body.

Available as Research Supervisor

Available for Collaborative Projects

Member Of

Australian Society for Medical Research Member 2016 -
NHMRC National Institute for Dementia Research Member 2016 -
Australian Society for Biochemistry and Molecular Biology (ASBMB) Member 2015 -
Centre for Medical and Molecular Bioscience Member 2013 -
Illawarra Health and Medial Research Institute Affiliated Researcher 2011 -
Proteostasis and Disease Research Centre Member 2011 -

Selected Publications

Journal Article

Year	Title
2019	Alpha-2-Macroglobulin, a Hypochlorite-Regulated Chaperone and Immune System Modulator Published In Oxidative Medicine and Cellular Longevity Volume 2019 Pages 5410657-1 - 5410657-9 ISSN 1942-0900 Altmetric
2019	Human pregnancy zone protein stabilizes misfoldedproteins including preeclampsia- and Alzheimer’s-associated amyloid beta peptide Published In Proceedings of the National Academy of Sciences of USA Volume 116 Pages 6101 - 6110 ISSN 1091-6490 Altmetric
2017	Amorphous protein aggregates stimulate plasminogen activation, leading to release of cytotoxic fragments that are clients for extracellular chaperones Published In Journal of Biological Chemistry Volume 292 Pages 14425 - 14437 ISSN 0021-9258 Altmetric
2017	How to find success as a woman in science Published In The Conversation Volume 10 February 2017 Pages 1 - 5
2016	Extracellular chaperones and proteostasis Published In Australian Biochemist Volume 47 Pages 14 - 17
2016	PZP and PAI-2: structurally-diverse, functionally similar pregnancy proteins? Published In The International Journal of Biochemistry and Cell Biology Volume 79 Pages 113 - 117 ISSN 1357-2725 Altmetric
2015	Alpha-2-macroglobulin is acutely sensitive to freezing and lyophilization: implications for structural and functional studies Published In PLoS One Volume 10 Pages e0130036-1 - e0130036-19 ISSN 1932-6203 Altmetric
2014	Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin Published In Proceedings of the National Academy of Sciences of USA Volume 111 Pages E2081 - E2090 ISSN 1091-6490 Altmetric
2013	Acute phase proteins are major clients for the chaperone action of α2-macroglobulin in human plasma Published In Cell Stress and Chaperones Volume 18 Pages 161 - 170 ISSN 1355-8145 Altmetric
2013	Extracellular chaperones and proteostasis Published In Annual Review of Biochemistry Volume 82 Pages 295 - 322 ISSN 0066-4154 Altmetric
2013	Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms Published In FEBS Letters Volume 587 Pages 398 - 403 ISSN 0014-5793 Altmetric
2012	Roles of extracellular chaperones in amyloidosis Published In Journal of Molecular Biology Volume 421 Pages 499 - 516 ISSN 0022-2836 Altmetric
2011	Clusterin facilitates in vivo clearance of extracellular misfolded proteins Published In Cellular and Molecular Life Sciences Volume 68 Pages 3919 - 3931 ISSN 1420-9071 Altmetric
2010	Identification of human plasma proteins as major clients for the extracellular chaperone clusterin Published In Journal of Biological Chemistry Volume 285 Pages 3532 - 3539 ISSN 0021-9258 Altmetric
2009	Structural characterization of clusterin-chaperone client protein complexes Published In Journal of Biological Chemistry Volume 284 Pages 21920 - 21927 ISSN 0021-9258 Altmetric
2009	Therapeutic targets in extracellular protein deposition diseases Published In Current Medicinal Chemistry Volume 16 Pages 2855 - 2866 ISSN 0929-8673 Altmetric

Chapter

Year	Title
2013	Extracellular chaperones Published In Molecular Chaperones Publisher Berlin: Springer Berlin Heidelberg Pages 241 - 268 Altmetric
2009	The chaperone action of clusterin and its putative role in quality control of extracellular protein folding Published In Advances in cancer research Publisher San Diego, California, USA : Elsevier Pages 89 - 114 Altmetric

Investigator On

Year	Title
2016 - 2019	The effect of hypochlorite on the toxicity and clearance of the Alzheimer's disease-associated amyloid beta peptide Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2016	Contributions to Leica Dmi8 microscope Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2011 - 2016	The role of clusterin in preventing atherosclerosis Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Training Fellowships
2011	The role of clusterin in preventing dementia Awarded by: Alzheimer's Australia Research (AAR) Funding Scheme: Postdoctoral Fellowship in Dementia

Other Research Activities

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Investigations of the roles of pregnancy zone protein (PZP) and plasminogen activator inhibitor type-2 (PAl-2) in extracellular proteostasis	Cater, Jordan

Professional Service Activities

National Health and Medical Research Council (NHMRC) Project Grant Review Panel Member 2016 -

Education And Training

University of Cambridge, UK, Department of Chemistry 2011 - 2013

Awards And Honors

Pitch Winner (Staff Category), conferred by iAccelerate, University of Wollongong, 2015
Combio Award, conferred by Queensland Protein Group, 2015
Junior Research Fellow, conferred by Wolfson College, Cambridge, 2011 - 2013

Top Publications

Year	Title
2014	Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin Published in Proceedings of the National Academy of Sciences of USA
2011	Clusterin facilitates in vivo clearance of extracellular misfolded proteins Published in Cellular and Molecular Life Sciences
2013	Extracellular chaperones and proteostasis Published in Annual Review of Biochemistry

Research Areas

0601 - BIOCHEMISTRY AND CELL BIOLOGY

Research Overview

Inflammation and the accumulation of damaged (misfolded) proteins underlie the pathology of a large number of debilitating human disorders including Alzheimer's disease, atherosclerosis and preeclampsia. My research program focuses on understanding the relationship between inflammation and protein misfolding in disease, with an emphasis on the role of hypochlorite (bleach), a potent inflammatory oxidant and mediator of protien misfolding within the body.

Member Of

Australian Society for Medical Research Member 2016 -
NHMRC National Institute for Dementia Research Member 2016 -
Australian Society for Biochemistry and Molecular Biology (ASBMB) Member 2015 -
Centre for Medical and Molecular Bioscience Member 2013 -
Illawarra Health and Medial Research Institute Affiliated Researcher 2011 -
Proteostasis and Disease Research Centre Member 2011 -

Selected Publications

Journal Article

Year	Title
2019	Alpha-2-Macroglobulin, a Hypochlorite-Regulated Chaperone and Immune System Modulator Published In Oxidative Medicine and Cellular Longevity Volume 2019 Pages 5410657-1 - 5410657-9 ISSN 1942-0900 Altmetric
2019	Human pregnancy zone protein stabilizes misfoldedproteins including preeclampsia- and Alzheimer’s-associated amyloid beta peptide Published In Proceedings of the National Academy of Sciences of USA Volume 116 Pages 6101 - 6110 ISSN 1091-6490 Altmetric
2017	Amorphous protein aggregates stimulate plasminogen activation, leading to release of cytotoxic fragments that are clients for extracellular chaperones Published In Journal of Biological Chemistry Volume 292 Pages 14425 - 14437 ISSN 0021-9258 Altmetric
2017	How to find success as a woman in science Published In The Conversation Volume 10 February 2017 Pages 1 - 5
2016	Extracellular chaperones and proteostasis Published In Australian Biochemist Volume 47 Pages 14 - 17
2016	PZP and PAI-2: structurally-diverse, functionally similar pregnancy proteins? Published In The International Journal of Biochemistry and Cell Biology Volume 79 Pages 113 - 117 ISSN 1357-2725 Altmetric
2015	Alpha-2-macroglobulin is acutely sensitive to freezing and lyophilization: implications for structural and functional studies Published In PLoS One Volume 10 Pages e0130036-1 - e0130036-19 ISSN 1932-6203 Altmetric
2014	Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin Published In Proceedings of the National Academy of Sciences of USA Volume 111 Pages E2081 - E2090 ISSN 1091-6490 Altmetric
2013	Acute phase proteins are major clients for the chaperone action of α2-macroglobulin in human plasma Published In Cell Stress and Chaperones Volume 18 Pages 161 - 170 ISSN 1355-8145 Altmetric
2013	Extracellular chaperones and proteostasis Published In Annual Review of Biochemistry Volume 82 Pages 295 - 322 ISSN 0066-4154 Altmetric
2013	Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms Published In FEBS Letters Volume 587 Pages 398 - 403 ISSN 0014-5793 Altmetric
2012	Roles of extracellular chaperones in amyloidosis Published In Journal of Molecular Biology Volume 421 Pages 499 - 516 ISSN 0022-2836 Altmetric
2011	Clusterin facilitates in vivo clearance of extracellular misfolded proteins Published In Cellular and Molecular Life Sciences Volume 68 Pages 3919 - 3931 ISSN 1420-9071 Altmetric
2010	Identification of human plasma proteins as major clients for the extracellular chaperone clusterin Published In Journal of Biological Chemistry Volume 285 Pages 3532 - 3539 ISSN 0021-9258 Altmetric
2009	Structural characterization of clusterin-chaperone client protein complexes Published In Journal of Biological Chemistry Volume 284 Pages 21920 - 21927 ISSN 0021-9258 Altmetric
2009	Therapeutic targets in extracellular protein deposition diseases Published In Current Medicinal Chemistry Volume 16 Pages 2855 - 2866 ISSN 0929-8673 Altmetric

Chapter

Year	Title
2013	Extracellular chaperones Published In Molecular Chaperones Publisher Berlin: Springer Berlin Heidelberg Pages 241 - 268 Altmetric
2009	The chaperone action of clusterin and its putative role in quality control of extracellular protein folding Published In Advances in cancer research Publisher San Diego, California, USA : Elsevier Pages 89 - 114 Altmetric

Investigator On

Year	Title
2016 - 2019	The effect of hypochlorite on the toxicity and clearance of the Alzheimer's disease-associated amyloid beta peptide Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2016	Contributions to Leica Dmi8 microscope Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2011 - 2016	The role of clusterin in preventing atherosclerosis Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Training Fellowships
2011	The role of clusterin in preventing dementia Awarded by: Alzheimer's Australia Research (AAR) Funding Scheme: Postdoctoral Fellowship in Dementia

Other Research Activities

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Investigations of the roles of pregnancy zone protein (PZP) and plasminogen activator inhibitor type-2 (PAl-2) in extracellular proteostasis	Cater, Jordan

Professional Service Activities

National Health and Medical Research Council (NHMRC) Project Grant Review Panel Member 2016 -

Education And Training

University of Cambridge, UK, Department of Chemistry 2011 - 2013

Awards And Honors

Pitch Winner (Staff Category), conferred by iAccelerate, University of Wollongong, 2015
Combio Award, conferred by Queensland Protein Group, 2015
Junior Research Fellow, conferred by Wolfson College, Cambridge, 2011 - 2013

Overview

Top Publications

Research Areas

Research Overview

Available as Research Supervisor

Affiliation

Available for Collaborative Projects

Member Of

Publications

Selected Publications

Journal Article

Chapter

Funding

Investigator On

Other Research Activities

Supervision

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Service

Professional Service Activities

Background

Education And Training

Awards And Honors

Overview

Top Publications

Research Areas

Research Overview

Affiliation

Member Of

Publications

Selected Publications

Journal Article

Chapter

Funding

Investigator On

Other Research Activities

Supervision

Advisees

Graduate Advising Relationship

Service

Professional Service Activities

Background

Education And Training

Awards And Honors

Visualisations

Research Areas