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Oakley, Aaron A/Prof.

Associate Professor

  • Illawarra Health and Medical Research Institute
  • Centre for Medical and Molecular Bioscience
  • Faculty of Science, Medicine and Health
  • School of Chemistry & Molecular Bioscience

Overview


"It is very easy to answer many fundamental biological questions; you just look at the thing!" –Richard Feynman.

Aaron Oakley uses experimental and theoretical approaches to look at biological molecules and answering fundamental questions about how they work, and in the case of drug targets, how they can be switched off.

Top Publications


Research Overview


  • DNA clamps
    A range of enzymes in DNA replication and repair bind to DNA-clamps: torus-shaped proteins that encircle double-stranded DNA and act as mobile tethers. The bacterial DNA clamps are an excellent target for the development of new classes of antibacterial agents.

    Omega Class Glutathione Transferases
    The omega-class glutathione transferases catalyze several reductive reactions in cellular biochemistry, including dehydroascorbate reduction. Glutathione transferase O1-1 has an essential role in bacterial lipopolysaccharide (LPS) stimulated inflammatory responses. The inhibition of GSTO1 could be effective for the treatment of acute and life-threatening inflammatory responses such as those involved in sepsis.

Available for Collaborative Projects

Selected Publications


Investigator On


Potential Supervision Topics


  • Discovery of inhibitors of glutathione transferase omega-1

    Understanding the chemistry of coelenterazine-based luciferases

Advisees


  • Graduate Advising Relationship

    Degree Research Title Advisee
    Doctor of Philosophy Understanding the Molecular Mechanisms of Single-strand Annealing Homologous DNA Recombination in Herpes Viruses, by cryo-EM Newing, Timothy
    Doctor of Philosophy Design, Synthesis and Evaluation of Irreversible Inhibitors of Bacterial Sliding Clamps as New Antibacterials Smith, Zander
    Doctor of Philosophy Structural Determination of Nucleic Acid-binding Proteins using Cryogenic Electron Microscopy Nicholls, Jordan

Top Publications


Research Overview


  • DNA clamps
    A range of enzymes in DNA replication and repair bind to DNA-clamps: torus-shaped proteins that encircle double-stranded DNA and act as mobile tethers. The bacterial DNA clamps are an excellent target for the development of new classes of antibacterial agents.

    Omega Class Glutathione Transferases
    The omega-class glutathione transferases catalyze several reductive reactions in cellular biochemistry, including dehydroascorbate reduction. Glutathione transferase O1-1 has an essential role in bacterial lipopolysaccharide (LPS) stimulated inflammatory responses. The inhibition of GSTO1 could be effective for the treatment of acute and life-threatening inflammatory responses such as those involved in sepsis.

Selected Publications


Investigator On


Potential Supervision Topics


  • Discovery of inhibitors of glutathione transferase omega-1

    Understanding the chemistry of coelenterazine-based luciferases

Advisees


  • Graduate Advising Relationship

    Degree Research Title Advisee
    Doctor of Philosophy Understanding the Molecular Mechanisms of Single-strand Annealing Homologous DNA Recombination in Herpes Viruses, by cryo-EM Newing, Timothy
    Doctor of Philosophy Design, Synthesis and Evaluation of Irreversible Inhibitors of Bacterial Sliding Clamps as New Antibacterials Smith, Zander
    Doctor of Philosophy Structural Determination of Nucleic Acid-binding Proteins using Cryogenic Electron Microscopy Nicholls, Jordan
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