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Oakley, Aaron J. A/Prof.

Associate Professor

  • Illawarra Health and Medical Research Institute
  • Centre for Medical and Molecular Bioscience
  • Faculty of Science, Medicine and Health
  • School of Chemistry

Research Overview


  • I am interested in the shape of biological molecules such as proteins and DNA. Knowing the structure can provide a great deal of information about function. In some cases, proteins are targets for the development of inhibitors. Some examples follow:-

    DNA clamps
    A range of enzymes in DNA replication and repair bind to DNA-clamps: torus-shaped proteins that encircle double-stranded DNA and act as mobile tethers.

    Omega Class Glutathione Transferases
    The omega-class glutathione transferases catalyze several reductive reactions in cellular biochemistry, including DHA reduction.

    Lysine-Specific Demethylase 1
    LSD1 has become an important epigenetic target for cancer therapy since its identification in 2004. This enzyme modifies histones, which are a vital class of DNA-packaging proteins in human cells.

Available for Collaborative Projects

Selected Publications


Investigator On


Potential Supervision Topics


  • Discovery of inhibitors of glutathione transferase omega-1

    Understanding the chemistry of coelenterazine-based luciferases

Research Overview


  • I am interested in the shape of biological molecules such as proteins and DNA. Knowing the structure can provide a great deal of information about function. In some cases, proteins are targets for the development of inhibitors. Some examples follow:-

    DNA clamps
    A range of enzymes in DNA replication and repair bind to DNA-clamps: torus-shaped proteins that encircle double-stranded DNA and act as mobile tethers.

    Omega Class Glutathione Transferases
    The omega-class glutathione transferases catalyze several reductive reactions in cellular biochemistry, including DHA reduction.

    Lysine-Specific Demethylase 1
    LSD1 has become an important epigenetic target for cancer therapy since its identification in 2004. This enzyme modifies histones, which are a vital class of DNA-packaging proteins in human cells.

Selected Publications


Investigator On


Potential Supervision Topics


  • Discovery of inhibitors of glutathione transferase omega-1

    Understanding the chemistry of coelenterazine-based luciferases

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